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001-es BibID:	BIBFORM119027
035-os BibID:	(WoS)001176963700001 (Scopus)85185862380
Első szerző:	Ngo, Minh Toan
Cím:	The Impact of Chemotherapy on Cardiovascular Mortality across Breast Cancer Subtypes / Toàn Minh Ngô, Ánh Ngọc Lê, Dương Phạm Hoàng Dinh
Dátum:	2024
ISSN:	1718-7729
Megjegyzések:	Breast cancer is associated with cardiovascular mortality as an adverse effect of chemotherapy. Considering the variances across breast cancer subtypes, this study aims to investigate the cardiovascular mortality patterns in each subtype. METHODS: This retrospective study used the SEER database of chemotherapy-receiving breast cancer patients (diagnosed in 2013-2020). The study population was categorized by cancer subtype, stage, patient age, and cause of death (COD). The percentage of cardiovascular CODs, odds ratio (ORs), 5-year cumulative crude probability of death, and standardized mortality ratios (SMRs) of each group were analyzed. RESULTS: Among 23,263 nonsurviving breast cancer patients, 5.8% died from cardiovascular disease, whereas the HER2+/HR+ and HER2+/HR- subtypes exhibited the highest ORs of cardiovascular death and percentages of cardiovascular CODs, at 8.21% and 6.55%, respectively. The cardiovascular SMR increased with advancing stages and decreasing patient age. The HER2+/HR- subtype had the highest cardiovascular SMR, at 0.83 (p < 0.05), followed by TNBC, at 0.78 (p < 0.05). The 5-year cumulative probability of cardiovascular CODs also showed the highest risk in the HER2+/HR- subtype (1.02 ? 0.11%) and the TNBC subtype (0.95 ? 0.07%). CONCLUSION: Breast cancer patients on chemotherapy face an elevated cardiovascular mortality risk, especially with aggressive subtypes (HER2-enriched, TNBC), advanced age, or HER2+/HR+ cancer receiving long-term treatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk breast cancer cardiovascular disease chemotherapy molecular subtypes
Megjelenés:	Current Oncology. - 31 : 2 (2024), p. 649-659. -
További szerzők:	Lê, Ánh Ngọc Đinh, Dương Phạm Hoàng
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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