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001-es BibID:	BIBFORM109465
035-os BibID:	(cikkazonosító)666 (Scopus)85151111518 (WoS)000968394300001
Első szerző:	Kurshed, Ali Abbas Mohammad
Cím:	Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations / Ali Abbas Mohammad Kurshed, Ferenc Vincze, Péter Pikó, Zsigmond Kósa, János Sándor, Róza Ádány, Judit Diószegi
Dátum:	2023
ISSN:	2073-4425
Megjegyzések:	Harmful alcohol consumption has been considered a major public health issue globally, with the amounts of alcohol drunk being highest in the WHO European Region including Hungary. Alcohol consumption behaviors are complex human traits influenced by environmental factors and numerous genes. Beyond alcohol metabolization and neurotransmitter gene polymorphisms, taste preference-related genetic variants may also mediate alcohol consumption behaviors. Applying the Alcohol Use Disorders Identification Test (AUDIT) we aimed to elucidate the underlying genetic determinants of alcohol consumption patterns considering taste preference gene polymorphisms (TAS1R3 rs307355, TAS2R38 rs713598, TAS2R19 rs10772420 and CA6 rs2274333) in the Hungarian general (HG) and Roma (HR) populations. Alcohol consumption assessment was available for 410 HG and 387 HR individuals with 405 HG and 364 HR DNA samples being obtained for genotyping. No significant associations were found between TAS1R3 rs307355, TAS2R19 rs10772420, and CA6 rs2274333 polymorphisms and alcohol consumption phenotypes. Significant associations were identified between TAS2R38 rs713598 and the number of standard drinks consumed in the HG sample (genotype GG negatively correlated with the number of standard drinks; coef: ?0.136, p = 0.028) and the prevalence of having six or more drinks among Roma (a negative correlation was identified in the recessive model; genotype GG, coef: ?0.170, p = 0.049), although, none of these findings passed the Bonferroni-corrected probability criterion (p > 0.05). Nevertheless, our findings may suggest that alcohol consumption is partially driven by genetically determined taste preferences in our study populations. Further studies are required to strengthen the findings and to understand the drivers of alcohol consumption behavior in more depth.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk alcohol consumption AUDIT taste preference genetic polymorphisms genetic association Hungarian population Roma population
Megjelenés:	Genes. - 14 : 3 (2023), p. 1-16. -
További szerzők:	Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 Egyéb Hungarian Academy of Sciences TK2016-78 Egyéb Eötvös Loránd Research Network (TKCS-2021/32) Egyéb 135784 National Research, Development, and Innovation Fund of Hungary Egyéb
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001-es BibID:	BIBFORM111155
035-os BibID:	(cikkazonosító)1033 (Scopus)85160375440 (WoS)000997290400001
Első szerző:	Nasr, Nayla Mohamed Gomaa
Cím:	Comparison of Genetic Susceptibility to Coronary Heart Disease in the Hungarian Populations : Risk Prediction Models for Coronary Heart Disease / Nayla Nasr, Beáta Soltész, János Sándor, Róza Ádány, Szilvia Fiatal
Dátum:	2023
ISSN:	2073-4425
Megjegyzések:	Background and Aim: It was evaluated whether the integration of genetic risk scores (GRS-unweighted, wGRS-weighted) into conventional risk factor (CRF) models for coronary heart disease or acute myocardial infarction (CHD/AMI) could improve the predictive ability of the models. Methods: Subjects and data collected in a previous survey were used to perform regression and ROC curve analyses as well as to examine the role of genetic components. Thirty SNPs were selected, and genotype and phenotype data were available for 558 participants (general: N = 279 and Roma: N = 279). Results: The mean GRS (27.27 ? 3.43 vs. 26.68 ? 3.51, p = 0.046) and wGRS (3.52 ? 0.68 vs. 3.33 ? 0.62, p = 0.001) were significantly higher in the general population. The addition of the wGRS to the CRF model yielded the strongest improvement in discrimination among Roma (from 0.8616 to 0.8674), while the addition of GRS to the CRF model yielded the strongest improvement in discrimination in the general population (from 0.8149 to 0.8160). In addition to that, the Roma individuals were likely to develop CHD/AMI at a younger age than subjects in the general population. Conclusions: The combination of the CRFs and genetic components improved the model's performance and predicted AMI/CHD better than CRFs alone.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk coronary heart disease developmental models genetic risk factors conventional risk factors
Megjelenés:	Genes. - 14 : 5 (2023), p. 1-16. -
További szerzők:	Soltész Beáta Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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