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001-es BibID:	BIBFORM117957
035-os BibID:	(cikkazonosító)e2300640 (WoS)001142691900001 (Scopus)85182493230
Első szerző:	Wang, Huan
Cím:	Current scenario of chalcone hybrids with antibreast cancer therapeutic applications / Huan Wang, Juanying Zhu, Qianru Zhang, Jie Tang, Xufeng Huang
Dátum:	2024
ISSN:	0365-6233 1521-4184
Megjegyzések:	Breast cancer, an epithelial malignant tumor that occurs in the terminal ducts of the breast, is the most common female malignancy. Currently, approximately 70%-80% of breast cancer with early-stage, nonmetastatic disorder is curable, but the emergency of drug resistance often leads to treatment failure. Moreover, advanced breast cancer with distant organ metastases is incurable with the available therapeutics, creating an urgent demand to explore novel antibreast cancer agents. Chalcones, the precursors for flavonoids and isoflavonoids, exhibit promising activity against various breast cancer hallmarks, inclusive of proliferation, angiogenesis, invasion, metastasis, inflammation, stemness, and regulation of cancer epigenetics, representing useful scaffolds for the discovery of novel antibreast cancer chemotherapeutic candidates. In particular, chalcone hybrids could act on two or more different biological targets simultaneously with more efficacy, lower toxicity, and less susceptibility to resistance. Accordingly, there is a huge scope for application of chalcone hybrids to tackle the present difficulties in breast cancer therapy. This review outlines the chalcone hybrids with antibreast cancer potential developed from 2018. The structure-activity relationships as well as mechanisms of action are also discussed to shed light on the development of more effective and multitargeted chalcone candidates. The current review outlines the antibreast cancer potential along with mechanisms of action and structure-activity relationships of chalcone hybrids reported since 2018, to shed light on the development of more effective and multitargeted chalcone candidates.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Archiv der Pharmazie. - [Epub ahead of print] (2024). -
További szerzők:	Zhu, Juanying Zhang, Qianru Tang, Jie Huang, Xufeng (1997-) (fogorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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