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1.

001-es BibID:BIBFORM086008
Első szerző:Bak István (vegyész, analitikus, farmakológus)
Cím:Heme oxygenase related carbon monoxide and ventricular fibrillation / Istvan Bak, Gabor Papp, Ferenc Joo, Arpad Tosaki
Dátum:2002
ISSN:0022-2828
Tárgyszavak:Természettudományok Kémiai tudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Journal of Molecular and Cellular Cardiology. - 34 : 6 (2002), p. A6. -
További szerzők:Papp Gábor (1976-) (vegyész, kémikus) Joó Ferenc (1949-) (vegyész) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész)
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2.

001-es BibID:BIBFORM096085
035-os BibID:(WoS)000688514700002 (Scopus)85108233557 (PubMed)34089737
Első szerző:Horváth Balázs (élettanász)
Cím:Ion current profiles in canine ventricular myocytes obtained by the "onion peeling" technique / Horváth Balázs, Kiss Dénes, Dienes Csaba, Hézső Tamás, Kovács Zsigmond, Szentandrássy Norbert, Almássy János, Magyar János, Bányász Tamás, Nánási Péter P.
Dátum:2021
ISSN:0022-2828
Megjegyzések:The profiles of ion currents during the cardiac action potential can be visualized by the action potential voltage clamp technique. To obtain multiple ion current data from the same cell, the "onion peeling" technique, based on sequential pharmacological dissection of ion currents, has to be applied. Combination of the two methods allows recording of several ion current profiles from the same myocyte under largely physiological conditions. Using this approach, we have studied the densities and integrals of the major cardiac inward (ICa, INCX, INa-late) and outward (IKr, IKs, IK1) currents in canine ventricular cells and studied the correlation between them. For this purpose, canine ventricular cardiomyocytes were chosen because their electrophysiological properties are similar to those of human ones. Significant positive correlation was observed between the density and integral of ICa and IKr, and positive correlation was found also between the integral of ICa and INCX. No further correlations were detected. The Ca2+-sensitivity of K+ currents was studied by comparing their parameters in the case of normal calcium homeostasis and following blockade of ICa. Out of the three K+ currents studied, only IKs was Ca2+-sensitive. The density and integral of IKs was significantly greater, while its time-to-peak value was shorter at normal Ca2+ cycling than following ICa blockade. No differences were detected for IKr or IK1 in this regard. Present results indicate that the positive correlation between ICa and IKr prominently contribute to the balance between inward and outward fluxes during the action potential plateau in canine myocytes. The results also suggest that the profiles of cardiac ion currents have to be studied under physiological conditions, since their behavior may strongly be influenced by the intracellular Ca2+ homeostasis and the applied membrane potential protocol.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
cardiac ion currents
dog myocytes
action potential voltage clamp
sequential dissection of ionic currents
onion peeling technique
Ca2+ sensitive ion currents
Megjelenés:Journal Of Molecular And Cellular Cardiology. - 158 (2021), p. 153-162. -
További szerzők:Kiss Dénes Zsolt (1995-) (orvos, élettanász) Dienes Csaba (1995-) (gyógyszerész) Hézső Tamás (1993-) (élettanász) Kovács Zsigmond Máté (1995-) (orvos) Szentandrássy Norbert (1976-) (élettanász) Almássy János (1981-) (élettanász, biológus, angol-magyar szakfordító) Magyar János (1961-) (élettanász) Bányász Tamás (1960-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:FK128116
OTKA
PD120794
NKFIH
FK128116
NKFIH
GINOP-2.3.2.-15-2016-00040
GINOP
ÚNKP-20-2
Egyéb
ÚNKP-20-3
Egyéb
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM083023
035-os BibID:(WoS)000522138400002 (Scopus)85078193947 (PubMed)31958464
Első szerző:Horváth Balázs (élettanász)
Cím:Late sodium current in human, canine and guinea pig ventricular myocardium / Balázs Horváth, Tamás Hézső, Norbert Szentandrássy, Kornél Kistamás, Tamás Árpádffy-Lovas, Richárd Varga, Péter Gazdag, Roland Veress, Csaba Dienes, Dóra Baranyai, János Almássy, László Virág, Norbert Nagy, István Baczkó, János Magyar, Tamás Bányász, András Varró, Péter P. Nánási
Dátum:2020
ISSN:0022-2828
Megjegyzések:Although late sodium current (INa-late) has long been known to contribute to plateau formation of mammalian cardiac action potentials, lately it was considered as possible target for antiarrhythmic drugs. However, many aspects of this current are still poorly understood. The present work was designed to study the true profile of INa-late in canine and guinea pig ventricular cells and compare them to INa-late recorded in undiseased human hearts. INa-late was defined as a tetrodotoxin-sensitive current, recorded under action potential voltage clamp conditions using either canonic- or self-action potentials as command signals. Under action potential voltage clamp conditions the amplitude of canine and human INa-late monotonically decreased during the plateau (decrescendo-profile), in contrast to guinea pig, where its amplitude increased during the plateau (crescendo profile). The decrescendo-profile of canine INa-late could not be converted to a crescendo-morphology by application of ramp-like command voltages or command action potentials recorded from guinea pig cells. Conventional voltage clamp experiments revealed that the crescendo INa-late profile in guinea pig was due to the slower decay of INa-late in this species. When action potentials were recorded from multicellular ventricular preparations with sharp microelectrode, action potentials were shortened by tetrodotoxin, which effect was the largest in human, while smaller in canine, and the smallest in guinea pig preparations. It is concluded that important interspecies differences exist in the behavior of INa-late. At present canine myocytes seem to represent the best model of human ventricular cells regarding the properties of INa-late. These results should be taken into account when pharmacological studies with INa-late are interpreted and extrapolated to human. Accordingly, canine ventricular tissues or myocytes are suggested for pharmacological studies with INa-late inhibitors or modifiers. Incorporation of present data to human action potential models may yield a better understanding of the role of INa-late in action potential morphology, arrhythmogenesis, and intracellular calcium dynamics.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Late Na+ current
Ventricular repolarization
Action potential voltage clamp
Dog myocytes
Human myocytes
Megjelenés:Journal of Molecular and Cellular Cardiology. - 139 (2020), p. 14-23. -
További szerzők:Hézső Tamás (1993-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Kistamás Kornél (1986-) (biológus) Árpádffy-Lovas Tamás Varga Richárd Gazdag Péter Veress Roland (1992-) (molekuláris biológus) Dienes Csaba (1995-) (gyógyszerész) Baranyai Dóra Almássy János (1981-) (élettanász, biológus, angol-magyar szakfordító) Virág László (élettanász Szeged) Nagy Norbert (1977-) (kísérletes farmakológus) Baczkó István Magyar János (1961-) (élettanász) Bányász Tamás (1960-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:GINOP-2.3.2.-15-2016-00040
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
ÚNKP-19-4
Egyéb
ÚNKP-19-2
Egyéb
NKFIH-K115397
NKFIH
NKFIH-PD120794
NKFIH
NKFIH-FK128116
NKFIH
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM005201
Első szerző:Malik, Gautam
Cím:Role of glutaredoxin-1 in cardioprotection : an insight with Glrx1 transgenic and knockout animals / Gautam Malik, Norbert Nagy, Ye-Shih Ho, Nilanjana Maulik, Dipak K. Das
Dátum:2008
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Molecular and Cellular Cardiology. - 44 : 2 (2008), p. 261-269. -
További szerzők:Nagy Norbert (1977-) (kísérletes farmakológus) Ho, Ye-Shih Maulik, Nilanjana Das, Dipak Kumar
Internet cím:elektronikus változat
DOI
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5.

001-es BibID:BIBFORM009105
Első szerző:Nagy Norbert (kísérletes farmakológus)
Cím:Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization? / Nagy, N., Szuts, V., Horvath, Z., Seprenyi, G., Farkas, A. S., Acsai, K., Prorok, J., Bitay, M., Kun, A., Pataricza, J., Papp, J. G., Nanasi, P. P., Varro, A., Toth, A.
Dátum:2009
ISSN:0022-2828 (Print)
Megjegyzések:Small-conductance calcium-activated potassium channels (SK channels) have a significant role in neurons. Since they directly integrate calcium handling with repolarization, in heart their role would be particularly important. However, their contribution to cardiac repolarization is still unclear. A previous study reported a significant lengthening effect of apamin, a selective SK channel inhibitor, on the action potential duration in atrial and ventricular mouse cardiomyocytes and human atrial cells. They concluded that these channels provide an important functional link between intracellular calcium handling and action potential kinetics. These findings seriously contradict our studies on cardiac "repolarization reserve", where we demonstrated that inhibition of a potassium current is not likely to cause excessive APD lengthening, since its decrease is mostly compensated by a secondary increase in other, unblocked potassium currents. To clarify this contradiction, we reinvestigated the role of the SK current in cardiac repolarization, using conventional microelectrode and voltage-clamp techniques in rat and dog atrial and ventricular multicellular preparations, and in isolated cardiomyocytes. SK2 channel expression was confirmed with immunoblot technique and confocal microscopy. We found, that while SK2 channels are expressed in the myocardium, a full blockade of these channels by 100 nM apamin--in contrast to the previous report--did not cause measurable electrophysiological changes in mammalian myocardium, even when the repolarization reserve was blunted. These results clearly demonstrate that in rat, dog and human ventricular cells under normal physiological conditions--though present--SK2 channels are not active and do not contribute to action potential repolarization.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Molecular and Cellular Cardiology. - 47 : 5 (2009), p. 656-663. -
További szerzők:Szűts Viktória (farmakológus Szeged) Horváth Zoltán Seprényi György Farkas Attila (1961-) (farmakológus) Acsai Károly Prorok János Bitay Miklós Kun Attila Pataricza János Papp Gy. Julius (Szeged) Nánási Péter Pál (1956-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Tóth András (farmakológus)
Internet cím:DOI
elektronikus változat
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6.

001-es BibID:BIBFORM005161
Első szerző:Nagy Norbert (kísérletes farmakológus)
Cím:Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis / Norbert Nagy, Gautam Malik, Arpad Tosaki, Ye-Shih Ho, Nilanjana Maulik, Dipak K. Das
Dátum:2008
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Molecular and Cellular Cardiology. - 44 : 2 (2008), p. 252-260. -
További szerzők:Malik, Gautam Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Ho, Ye-Shih Maulik, Nilanjana Das, Dipak Kumar
Internet cím:elektronikus változat
DOI
Borító:

7.

001-es BibID:BIBFORM002214
035-os BibID:PMID:17397860
Első szerző:Nagy Norbert (kísérletes farmakológus)
Cím:Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target / Norbert Nagy, Keisuke Shiroto, Gautam Malik, Chi-Kuang Huang, Mathias Gaestel, Maha Abdellatif, Arpad Tosaki, Nilanjana Maulik, Dipak K. Das
Dátum:2007
Megjegyzések:The existing literature indicates a crucial role of p38 MAP (mitogen-activated protein) kinase (p38MAPK) and its downstream target MAPKAP kinase 2 (MK2) in ischemic preconditioning (IPC). Accordingly, deletion of MK2 gene should abolish the cardioprotective ability of IPC. Interestingly, we were able to partially precondition the hearts from MK2(-/-) knockout mice suggesting the existence of an as yet unknown alternative downstream target of p38MAPK. A recent study from our laboratory also determined a crucial role of CREB (cyclic AMP response element binding protein) in IPC. Since CREB is a downstream target of MSK-1 (mitogen- and stress-activated protein kinase-1) situated at the crossroad of ERK (extracellular receptor kinase) and p38MAPK signaling pathways, we reasoned that MSK-1 could be a downstream molecular target for p38MAPK and ERK signaling in the IPC hearts. To test this hypothesis, the rat hearts were subjected to IPC by four cyclic episodes of 5 min ischemia and 10 min reperfusion. As expected, IPC induced the activation of ERK1/2, p38MAPK, MK2 and HSP (heat shock protein) 27 as evidenced by their increased phosphorylation; and the inhibition of p38MAPK with SB203580 almost completely, and the inhibition of ERK1/2 with PD098059 partially, abolished cardioprotective effects of IPC. Inhibition of MSK-1 with short hairpin RNA (shRNA) also abolished the IPC-induced cardioprotection. SB203580 partially blocked the effects of MSK-1 suggesting that MSK-1 sits downstream of p38MAPK. shRNA-MSK-1 blocked the contribution of both p38MAPK and ERK1/2 as it is uniquely situated at the downstream crossroad of both of these MAP kinases. Although MSK-1 sits downstream of both ERK1/2 and p38MAPK, ERK1/2 activation appears to play less significant role compared to p38MAPK, since its inhibition blocked MSK activation only partially. Consistent with these results, shRNA-MSK-1 blocked the partial PC in MK2(-/-) hearts, and in combination with SB203580, completely abolished the PC effects in the wild-type hearts. The IPC-induced survival signaling was almost completely inhibited with SB203580, and only partially with PD 098059 as evidenced from the inhibition patterns of IPC induced activation of CREB, Akt and Bcl-2. Again SB203580 alone or in combination with shRNA-MSK-1 inhibited IPC induced survival signal comparatively, suggesting that MSK-1 exists downstream of p38MAPK. Taken together, these results indicate for the first time MSK-1 as an alternative (other than MK2) downstream target for p38MAPK, which also transmits survival signal through the activation of CREB.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Journal of Molecular and Cellular Cardiology 42 : 5 (2007), p. 981-990. -
További szerzők:Shiroto, Keisuke Malik, Gautam Huang, Chi-Kuang Gaestel, Mathias Abdellatif, Maha Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Maulik, Nilanjana Das, Dipak Kumar
Internet cím:elektronikus változat
DOI
Borító:

8.

001-es BibID:BIBFORM002225
Első szerző:Penumathsa, Suresh Varma
Cím:Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat / Suresh Varma Penumathsa, Mahesh Thirunavukkarasu, Srikanth Koneru, Bela Juhasz, Lijun Zhan, Rima Pant, Venugopal P. Menon, Hajime Otani, Nilanjana Maulik
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Molecular and Cellular Cardiology. - 42 : 3 (2007), p. 508-516. -
További szerzők:Thirunavukkarasu, Mahesh Koneru, Srikanth Juhász Béla (1978-) (kísérletes farmakológus) Zhan, Lijun Pant, Rima Menon, Venugopal P. Otani, Hajime Maulik, Nilanjana
Internet cím:elektronikus változat
DOI
Borító:

9.

001-es BibID:BIBFORM091600
035-os BibID:(WoS)000635517300013 (Scopus)85099368265 (PubMed)33383036
Első szerző:Szlovák Jozefina
Cím:Blockade of sodium-calcium exchanger via ORM-10962 attenuates cardiac alternans / Szlovák Jozefina, Tomek Jakub, Zhou Xin, Tóth Noémi, Veress Roland, Horváth Balázs, Szentandrássy Norbert, Levijoki Jouko, Papp Julius Gy., Herring Neil, Varró András, Eisner David A., Rodriguez Blanca, Nagy Norbert
Dátum:2021
ISSN:0022-2828
Megjegyzések:Repolarization alternans, a periodic oscillation of long-short action potential duration, is an important source of arrhythmogenic substrate, although the mechanisms driving it are insufficiently understood. Despite its relevance as an arrhythmia precursor, there are no successful therapies able to target it specifically. We hypothesized that blockade of the sodium?calcium exchanger (NCX) could inhibit alternans. The effects of the selective NCX blocker ORM-10962 were evaluated on action potentials measured with microelectrodes from canine papillary muscle preparations, and calcium transients measured using Fluo4-AM from isolated ventricular myocytes paced to evoke alternans. Computer simulations were used to obtain insight into the drug's mechanisms of action. ORM-10962 attenuated cardiac alternans, both in action potential duration and calcium transient amplitude. Three morphological types of alternans were observed, with differential response to ORM-10962 with regards to APD alternans attenuation. Analysis of APD restitution indicates that calcium oscillations underlie alternans formation. Furthermore, ORM-10962 did not markedly alter APD restitution, but increased post-repolarization refractoriness, which may be mediated by indirectly reduced L-type calcium current. Computer simulations reproduced alternans attenuation via ORM-10962, suggesting that it is acts by reducing sarcoplasmic reticulum release refractoriness. This results from the ORM-10962-induced sodium?calcium exchanger block accompanied by an indirect reduction in L-type calcium current. Using a computer model of a heart failure cell, we furthermore demonstrate that the anti-alternans effect holds also for this disease, in which the risk of alternans is elevated. Targeting NCX may therefore be a useful anti-arrhythmic strategy to specifically prevent calcium driven alternans.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Alternans
Sodium-calcium exchanger
Sodium-calcium exchanger inhibition
Canine myocytes
Cardiac simulation
Megjelenés:Journal Of Molecular And Cellular Cardiology. - 153 (2021), p. 111-122. -
További szerzők:Tomek, Jakub Zhou, Xin Tóth Noémi Veress Roland (1992-) (molekuláris biológus) Horváth Balázs (1981-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Levijoki, Jouko Papp Gy. Julius (Szeged) Herring, Neil Varró András (1954-) (farmakológus, klinikai farmakológus) Eisner, David A. Rodríguez, Blanca Nagy Norbert (1977-) (kísérletes farmakológus)
Pályázati támogatás:PD-125402
OTKA
FK-129117
OTKA
GINOP-2.3.2-15-2016-00006
GINOP
GINOP-2.3.2-15-2016-00012
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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