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001-es BibID:	BIBFORM091495
035-os BibID:	(cikkazonosító)e0246062 (WOS)000617533000025 (Scopus)85101335037
Első szerző:	Besenczi Renátó (mérnökinformatikus)
Cím:	Large-scale simulation of traffic flow using Markov model / Renátó Besenczi, Norbert Bátfai, Péter Jeszenszky, Roland Major, Fanny Monori, Márton Ispány
Dátum:	2021
ISSN:	1932-6203
Megjegyzések:	Modeling and simulating movement of vehicles in established transportation infrastructures, especially in large urban road networks is an important task. It helps in understanding and handling traffic problems, optimizing traffic regulations and adapting the traffic management in real time for unexpected disaster events. A mathematically rigorous stochastic model that can be used for traffic analysis was proposed earlier by other researchers which is based on an interplay between graph and Markov chain theories. This model provides a transition probability matrix which describes the traffic's dynamic with its unique stationary distribution of the vehicles on the road network. In this paper, a new parametrization is presented for this model by introducing the concept of two-dimensional stationary distribution which can handle the traffic's dynamic together with the vehicles' distribution. In addition, the weighted least squares estimation method is applied for estimating this new parameter matrix using trajectory data. In a case study, we apply our method on the Taxi Trajectory Prediction dataset and road network data from the OpenStreetMap project, both available publicly. To test our approach, we have implemented the proposed model in software. We have run simulations in medium and large scales and both the model and estimation procedure, based on artificial and real datasets, have been proved satisfactory and superior to the frequency based maximum likelihood method. In a real application, we have unfolded a stationary distribution on the map graph of Porto, based on the dataset. The approach described here combines techniques which, when used together to analyze traffic on large road networks, has not previously been reported.
Tárgyszavak:	Műszaki tudományok Informatikai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Simulation and modeling graph theory ergodicity probability distribution markov models directed graphs smart city markov traffic
Megjelenés:	Plos One. - 16 : 2 (2021), p. 1-31. -
További szerzők:	Bátfai Norbert (1972-2020) (informatikus) Jeszenszky Péter (1975-) (programtervező matematikus) Major Sándor Roland (1988-) (informatikus) Monori Fanny (mérnökinformatikus) Ispány Márton (1966-) (informatikus, matematikus)
Pályázati támogatás:	EFOP-3.6.1-16-2016-00022 EFOP
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001-es BibID:	BIBFORM051501
035-os BibID:	(cikkazonosító)e55168 (WoS)000314610600070 (Scopus)84873137070
Első szerző:	Czimmerer Zsolt (molekuláris biológus)
Cím:	A versatile method to design stem-loop primer-based quantitative PCR assays for detecting small regulatory RNA molecules / Zsolt Czimmerer, Julianna Hulvely, Zoltan Simandi, Eva Varallyay, Zoltan Havelda, Erzsebet Szabo, Attila Varga, Balazs Dezso, Maria Balogh, Attila Horvath, Balint Domokos, Zsolt Torok, Laszlo Nagy, Balint L. Balint
Dátum:	2013
ISSN:	1932-6203
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	PLoS One. - 8 : 1 (2013), p. 1-10. -
További szerzők:	Hulvely Julianna Simándi Zoltán (1984-) (Ph.D. hallgató, molekuláris biológus) Varallyay Éva Havelda Zoltán Szabó Erzsébet (1973-) (molekuláris biológus) Varga Attila (Astrid Research Ltd. Debrecen) Dezső Balázs (1951-) (pathológus) Balogh Mária Horváth Attila (1988-) (programtervező informatikus) Domokos Bálint (1974-) (programtervező matematikus) Török Zsolt (1975-) (orvos) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Bálint Bálint László (1971-) (kutató orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM059122
035-os BibID:	e0118089
Első szerző:	Kiss Balázs
Cím:	Analysis of the Effect of Locally Applied Inhomogeneous Static Magnetic Field-Exposure on Mouse Ear Edema : a Double Blind Study / Balázs Kiss, János F. László, Andrea Szalai, Róbert Pórszász
Dátum:	2015
ISSN:	1932-6203
Megjegyzések:	The effect static magnetic field (SMF)-exposure may exert on edema development has been investigated. A 6 h long whole-body (WBSMF) or local (LSMF), continuous, inhomogeneous SMF-exposure was applied on anesthetized mice in an in vivo model of mustard oil (MO)-induced ear edema. LSMF was applied below the treated ear, below the lumbar spine, or below the mandible. Ear thickness (v) was checked 8 times during the exposure period (at 0, 0.25, 1, 2, 3, 4, 5, and 6 h). The effect size of the applied treatment (?) on ear thickness was calculated by the formula ? = 100% ? (1?vj/vi), where group i is the control group and j is the treated group. Results showed that MO treatment in itself induced a significant ear edema with an effect of 9% (p<0.001). WBSMF or LSMF on the spine in combination with MO treatment increased ear thickness even further resulting in an effect of ?>11% in both cases compared to SMF-exposure alone (p<0.001). In these cases SMF-exposure alone without MO treatment reduced ear thickness significantly (p<0.05), but within estimated experimental error. In cases of LSMF-exposure on the head, a significant SMF-exposure induced ear thickness reduction was found (? = 5%, p<0.05). LSMF-exposure on the spine affected ear thickness with and without MO treatment almost identically, which provides evidence that the place of local SMF action may be in the lower spinal region.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Edema Magnets Spine Ears Magnetic Fields Histamine Inflammation Rodents
Megjelenés:	Plos One. - 10 : 2 (2015), p. 1-14. -
További szerzők:	László F. János (1956-) (fizikus) Szalai Andrea (1968-) (analitikus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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001-es BibID:	BIBFORM059231
035-os BibID:	(WoS)000324228800065 (Scopus)84883124939
Első szerző:	Vergallo, Cristian
Cím:	In Vitro Analysis of the Anti-Inflammatory Effect of Inhomogeneous Static Magnetic Field-Exposure on Human Macrophages and Lymphocytes / Cristian Vergallo, Luciana Dini, Zsuzsanna Szamosvölgyi, Bernardetta Anna Tenuzzo, Elisabetta Carata, Elisa Panzarini, János F. László
Dátum:	2013
ISSN:	1932-6203
Megjegyzések:	The effect of inhomogeneous static magnetic field (SMF)-exposure on the production of different cytokines from human peripheral blood mononuclear cells (PMBC), i.e., lymphocytes and macrophages, was tested in vitro. Some cultures were activated with lipopolysaccharide (LPS) at time point 23 h and were either left alone (positive control) or exposed to SMF continuously from 0 until 6, 18, or 24 h. The secretion of interleukin IL-6, IL-8, tumor necrosis factor TNF-alpha, and IL-10 was tested by ELISA. SMF-exposure caused visible morphological changes on macrophages as well as on lymphocytes, and also seemed to be toxic to lymphocytes ([36.58; 41.52]%, 0.308 <= p <= 0.444), but not to macrophages (<1.43%, p >= 0.987). Analysis of concentrations showed a significantly reduced production of pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha from macrophages compared to negative control ([56.78; 87.52]%, p = 0.031) and IL-6 compared to positive control ([45.15; 56.03]%, p = 0.035). The production of anti-inflammatory cytokine IL-10 from macrophages and from lymphocytes was enhanced compared to negative control, significantly from lymphocytes ([-183.62; -28.75]%, p = 0.042). The secretion of IL-6 from lymphocytes was significantly decreased compared to positive control ([-115.15; -26.84]%, p = 0.039). This massive in vitro evidence supports the hypotheses that SMF-exposure (i) is harmful to lymphocytes in itself, (ii) suppresses the release of pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha, and (iii) assists the production of anti-inflammatory cytokine IL-10; thus providing a background mechanism of the earlier in vivo demonstrated anti-inflammatory effects of SMF-exposure.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cytokines endotoxins lymphocytes macrophages magnetic field magnets monocytes secretion
Megjelenés:	Plos One. - 8 : 8 (2013), p. e72374-. -
További szerzők:	Dini, Luciana Szamosvölgyi Zsuzsanna Tenuzzo, Bernardetta Anna Carata, Elisabetta Panzarini, Elisa László F. János (1956-) (fizikus)
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