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001-es BibID:	BIBFORM088329
Első szerző:	Mirolovics Ágnes
Cím:	Notification Strategy and Predictors of Outcome in Stroke Ineligible for Reperfusion Therapies / Mirolovics Ágnes, Bokor Magdolna, Dobi Balázs, Zsuga Judit, Bereczki Dániel
Dátum:	2019
ISSN:	1664-2295 1664-2295
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk stroke reperfusion therapy
Megjelenés:	Frontiers in Neurology. - 10 (2019), p. 1-8. -
További szerzők:	Bokor Magdolna Dobi Balázs Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Bereczki Dániel (1960-) (neurológus)
Pályázati támogatás:	TAMOP-4.2.1.B-09/1/KMR TÁMOP EFOP-3.6.3-VEKOP-16-2017- 00009 EFOP UNKP-17-3 Egyéb
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001-es BibID:	BIBFORM077719
Első szerző:	Sorinola, Abayomi
Cím:	Risk Factors of External Ventricular Drain Infection : proposing a Model for Future Studies / Abayomi Sorinola, Andras Buki, Janos Sandor, Endre Czeiter
Dátum:	2019
ISSN:	1664-2295 1664-2295
Megjegyzések:	Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this review was to identify risk factors that affect the incidence of EVD infection and create a model, which can be used in future studies in order to contribute to elaborations on guideline for EVD. Methods: A PubMed and Google Scholar literature search was performed and data were extracted from studies published from 1966 through 2017. The search of the databases generated 604 articles and 28 articles of these were found to be relevant. A manual search of the 28 relevant papers generated 4 new articles. Of the 32 relevant articles, 20 articles that performed a multivariate analysis of the suspected risk factors of EVD infection and had a positive culture as a mandatory component in diagnosis were selected for data collection and analysis. Results: Because reviewed papers investigated only a few influencing factors, and could not determine convincingly the real risk factors of EVD infection and their real strengths. A total of 15 supposed influencing factors which includes: age, age & sex interactions, coinfection, catheter insertion outside the hospital, catheter type, CSF leakage, CSF sampling frequency, diagnosis, duration of catheterization, ICP > 20 mmHg, irrigation, multiple catheter, neurosurgical operation, reduced CSF glucose at catheter insertion and sex were identified. Conclusion: This review summarizes a set of variables which have to be covered by future clinical epidemiological investigations in order to describe the etiological background of EVD infection.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban external ventricular drain, EVD infection, ventricular catheter ventricular catheter infection, risk factors
Megjelenés:	Frontiers in Neurology. - 10 : 226 (2019), p. 1-8. -
További szerzők:	Buki András Sándor János (1966-) (orvos-epidemiológus) Czeiter Endre
Pályázati támogatás:	Hungarian Brain Research Program 2.0?Grant No. 2017- 1.2.1-NKP-2017-00002 Egyéb EFOP-3.6.2.-16-2017-00008 EFOP Higher Education Institutional Excellence Programme - Grant No. 20765-3/2018/FEKUTSTRAT Egyéb GINOP-2.3.2-15-2016-00048 GINOP GINOP-2.3.3-15-2016-00032 GINOP
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001-es BibID:	BIBFORM075286
035-os BibID:	(cikkazonosító)818
Első szerző:	Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:	Blind spot for sedentarism : redefining the diseasome of physical inactivity in view of circadian system and the irisin/BDNF axis / Judit Zsuga, Csaba E. More, Tamas Erdei, Csaba Papp, Szilvia Harsanyi, Rudolf Gesztelyi
Dátum:	2018
ISSN:	1664-2295
Megjegyzések:	Introduction: The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering of chronic diseases linked to physical inactivity. Accordingly, physical inactivity per se contributes to the accumulation of visceral fat, which, generates chronic low-grade systemic inflammation, contributes to emergence of chronic, non-communicable diseases. Diversity of these disorders posits the possible involvement of a supraphysiological system. Methods: Hypothesis driven literature search and deductive reasoning was used to review relevant literature and formulate a novel theory. Results: We have identified the circadian system, omnipresent in virtually every cell, as a possible vehicle for brain muscle crosstalk, explaining some aspects of the diseasome of physical inactivity This system is hierarchically organized, with the suprachiasmatic nucleus (SCN) being the master clock that entrains to the dark/light cycle and synchronizes subsidiary molecular clocks in the periphery. Insufficient photic entrainment also causes chronic disease evolution. The recently identified irisin, was shown to induce brain-derived neurotrophic factor (BDNF) production in several brain areas. BDNF assumes significant role in gating light's influence in the retinohypothalamic synapse, by having a permissive effect on glutamate signal transduction underlying photic entrainment. Conclusions: Here we provide theoretical evidence to support the hypothesis that irisin may facilitate photic entrainment of the SCN, via BDNF. By this irisin opens up possible pathways for peripheral non-photic entrainment signals to exert influence on the master clock that is otherwise resistant to these. Furthermore, we suggest that intertwining processes of circadian, redox, inflammatory and myokine systems lay underneath the diseasome of physical inactivity.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cirkadián ritmus circadian rhythm irisin BDNF
Megjelenés:	Frontiers in Neurology. - 9 (2018), p. 1-13. -
További szerzők:	Móré Elek Csaba (1966-) (pszichiáter szakorvos) Erdei Tamás Dániel (1992-) (kísérletes farmakológus) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Kolozsváriné Harsányi Szilvia (1983-) (okleveles egészségpolitikai szakértő) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00009 EFOP Establishing Thematic Scientific and Cooperation Network for Clinical Research GINOP-2.3.2-15-2016-00005 GINOP 2017-1.2.1-NKP-2017-00002 egyéb
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