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001-es BibID:BIBFORM119520
035-os BibID:(cikkazonosító)100529
Első szerző:Dibello, Estefanía
Cím:Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity / Estefaní Dibello, Natalia Oddone, Jaime Franco, Tünde-Zit Illyés, Andrea Medeiros, Attila Kiss, Fanni Hőgye, Katalin E. Kövér, László Szilágyi, Marcelo A. Comini
Dátum:2024
ISSN:2211-3207
Megjegyzések:Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 ?M) but poorly selective (selectivity index <10). Here we extended the study to 33 new seleno-glycoconjugates with the aim to improve potency and selectivity. Three selenoglycosides and three glycosyl selenenylsulfides displayed IC50 against bloodstream Trypanosoma brucei in the sub-?M range (IC50 0.35?0.77 ?M) and four of them showed an improved selectivity (selectivity index >38-folds vs. murine and human macrohages). For the glycosyl selenylsulfides, the anti-trypanosomal activity was not significantly influenced by the nature of the moiety attached to the sulfur atom. Except for a quinoline-, and to a minor extent a nitro-derivative, the most selective hits induced a rapid (within 60 min) and marked perturbation of the LMWTredox homeostasis. The formation of selenenylsulfide glycoconjugates with free thiols has been identified as a potential mechanism involved in this process.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Selenoglycosides
Bloodstream trypanosoma
Macrophage
Redox biosensor
Oxidative stress
Megjelenés:International Journal for Parasitology: Drugs and Drug Resistance. - 24 (2024), p.1-6. -
További szerzők:Oddone, Natalia Franco, Jaime Illyés Tünde Zita (1970-) (kémia-fizika szakos tanár) Medeiros, Andrea Kiss-Szikszai Attila (1975-) (vegyész) Hőgye Fanni Kövér Katalin, E. (1956-2023) (vegyész) Szilágyi László (1941-) (vegyész) Comini, Marcelo A.
Pályázati támogatás:NN-128368
OTKA
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2.

001-es BibID:BIBFORM070148
Első szerző:Franco, Jaime
Cím:Diselenide diglycosides alter redox homeostasis and glucose consumption of infective African trypanosomes / Jaime Franco, Florencia Sardi, László Szilágyi, Katalin E. Kövér, Krisztina Fehér, Marcelo A. Comini
Dátum:2017
ISSN:2211-3207
Megjegyzések:With the aim to develop compounds able to target multiple metabolic pathways and, thus, to lower the chances of drug resistance, we investigated the anti-trypanosomal activity and selectivity of a series of symmetric diglycosyl diselenides and disulfides. Of 18 compounds tested the fully acetylated forms of di-?-D-glucopyranosyl and di-?-D-galactopyranosyl diselenides (13 and 15, respectively) displayed strong growth inhibition against the bloodstream stage of African trypanosomes (EC50 0.54 ?M for 13 and 1.49 ?M for 15) although with rather low selectivity (SI <10 assayed with murine macrophages). Nonacetylated versions of the same sugar diselenides proved to be, however, much less efficient or completely inactive to suppress trypanosome growth. Significantly, the galactosyl (15), and to a minor extent the glucosyl (13), derivative inhibited glucose catabolism but not its uptake. Both compounds induced redox unbalance in the pathogen. In vitro NMR analysis indicated that diglycosyl diselenides react with glutathione, under physiological conditions, via formation of selenenylsulfide bonds. Our results suggest that non-specific cellular targets as well as components actors of the glucose and the redox metabolism of the parasite may be affected. These molecules are therefore promising leads for the development of novel multitarget antitrypanosomal agents.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Trypanosome inhibition
Megjelenés:International Journal for Parasitology: Drugs and Drug Resistance. - 7 : 3 (2017), p. 303-313. -
További szerzők:Sardi, Florencia Szilágyi László (1941-) (vegyész) Kövér Katalin, E. (1956-2023) (vegyész) Fehér Krisztina (1974-) (vegyész) Comini, Marcelo A.
Pályázati támogatás:OTKA-109671
OTKA
Internet cím:DOI
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3.

001-es BibID:BIBFORM067087
Első szerző:Pap Péter László (ökológus)
Cím:Sex ratio and sexual dimorphism of three lice species with contrasting prevalence parasitizing the house sparrow / Péter László Pap, Costică Adam, Csongor István Vágási, Zoltán Benkő, Orsolya Vincze
Dátum:2013
ISSN:0022-3395
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Parasitology 99 : 1 (2013), p. 24-30. -
További szerzők:Costică, Adam Vágási Csongor István Benkő Zoltán Vincze Orsolya (1988-) (biológus)
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4.

001-es BibID:BIBFORM085415
Első szerző:Reiczigel Jenő (matematikus)
Cím:Properties of crowding indices and statistical tools to analyze parasite crowding data / Jenö Reiczigel, Zsolt Lang, Lajos Rózsa, Béla Tóthmérész
Dátum:2005
Megjegyzések:Crowding, i.e., the size of the infrapopulation inhabiting an individual host, is a major component of parasites' environment, which often influences both morphological and life-history characters (the so-called density-dependent characters) in different parasite taxa. Although crowding equals intensity in case of a single parasite individual, mean intensity of the host population does not define mean crowding of the parasite population. Crowding indices are notoriously hard to handle statistically because of the inherently large number of nonindependent values in data. In this study, we aim to investigate the apparently paradox features of crowding indices and to make some proposals and also to introduce statistical methods to calculate confidence intervals and 1-sample and 2-sample tests for mean crowding. All methods described in this study are supported by the freely distributed statistical software Quantitative Parasitology.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:The journal of parasitology. - 91 : 2 (2005), p. 245-252. -
További szerzők:Lang Zsolt Rózsa Lajos Tóthmérész Béla (1960-) (ökológus)
Pályázati támogatás:T 035150
OTKA
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5.

001-es BibID:BIBFORM065614
Első szerző:Szabó Krisztián (zoológus)
Cím:Adaptive Host-Abandonment of Ectoparasites Before Fledging? Within-Brood Distribution of Nest Mites in House Sparrow Broods / Krisztián Szabó, Anita Szalmás, András Liker, Zoltán Barta
Dátum:2008
ISSN:0022-3395
Megjegyzések:We studied the within-brood distribution of a haematophagous mite Pellonyssus reedi living on nestling house sparrows (Passer domesticus) near the time of fledging. We measured the natural level of infestation of individual nestlings, and determined the feeding efficiency of mites, by scoring their feeding status. Within-brood distribution of mite loads was unrelated to nestling body mass, tarsus length, or immunocompetence. These results did not support parasite preference for large or susceptible hosts. Mite feeding-efficiency was also unrelated to these nestling characteristics, confirming that large nestlings or nestlings with less-developed immunocompetence did not provide superior feeding conditions for mites. Therefore, our results do not support the hypothesis that within-brood distribution of avian ectoparasites is explained by the parasites' preferences for characteristics, such as large body size or low immunocompetence, that make nestlings suitable hosts. On the other hand, we found that mite loads were negatively correlated with nestling age and feather length, suggesting that nestlings closer to fledging harbored fewer mites then their less-developed nestmates. Furthermore, feather length had a stronger relationship with parasite distribution than did nestling age. We presume, therefore, that feather characteristics, i.e., length, may serve as a signal for mites to perceive the ready-to-fledge state of nestlings, inducing abandonment behavior. These results support another, largely neglected hypothesis, i.e., that the avoidance or abandonment of those nestlings that are close to fledging may also explain the parasites' distribution in a brood. This hypothesis is based on the argument that many nest-dwelling ectoparasites breed in the nest material and emerge only periodically to feed on nestlings. In such parasites, the ability to recognize and avoid mature fledglings can be adaptive because this may help the parasites to avoid their removal from the nest so they can continue to reproduce by feeding on unfledged chicks of the current or later broods. Our results suggest that adaptive host-abandonment by nest-dwelling ectoparasites can influence within-brood parasite distributions around the time of fledging.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
house sparrow
haematophagous mite
ectoparasite
nest mites
Pellonyssus reedi
abandonment behaviour
within-brood distribution
Megjelenés:Journal Of Parasitology 94 : 5 (2008), p. 1038-1043. -
További szerzők:Szalmás Anita (1978-) (biológus, mikrobiológus, klinikai mikrobiológus) Liker András Barta Zoltán (1967-) (biológus, zoológus)
Pályázati támogatás:T046661
OTKA
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