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001-es BibID:	BIBFORM112910
035-os BibID:	(wos)001011827700001 (scopus)85162693630
Első szerző:	Fuchs-Buder, Thomas
Cím:	Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents : The 2023 Geneva revision / Fuchs-Buder Thomas, Brull Sorin J., Fagerlund Malin Jonsson, Renew Ross J., Cammu Guy, Murphy Glenn S., Warlé Michiel, Vested Matias, Fülesdi Béla, Nemes Reka, Columb Malachy O., Damian Daniela, Davis Peter J., Iwasaki Haijme, Eriksson Lars I.
Dátum:	2023
ISSN:	0001-5172
Megjegyzések:	The set of guidelines for good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents was developed following an international consensus conference in Copenhagen in 1996 (Viby-Mogensen et al., Acta Anaesthesiol Scand 1996, 40, 59?74); the guidelines were later revised and updated following the second consensus conference in Stockholm in 2005 (Fuchs-Buder et al., Acta Anaesthesiol Scand 2007, 51, 789?808). In view of new devices and further development of monitoring technologies that emerged since then, (e.g., electromyography, three-dimensional acceleromyography, kinemyography) as well as novel compounds (e.g., sugammadex) a review and update of these recommendations became necessary. The intent of these revised guidelines is to continue to help clinical researchers to conduct high-quality work and advance the field by enhancing the standards, consistency, and comparability of clinical studies. There is growing awareness of the importance of consensus-based reporting standards in clinical trials and observational studies. Such global initiatives are necessary in order to minimize heterogeneous and inadequate data reporting and to improve clarity and comparability between different studies and study cohorts. Variations in definitions of endpoints or outcome variables can introduce confusion and difficulties in interpretation of data, but more importantly, it may preclude building of an adequate body of evidence to achieve reliable conclusions and recommendations. Clinical research in neuromuscular pharmacology and physiology is no exception.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk depth of neuromuscular blockade neuromuscular monitoring neuromuscular research pharmacodynamics postoperative pulmonary complications time course of neuromuscular blockade
Megjelenés:	Acta Anaesthesiologica Scandinavica. - 67 : 8 (2023), p. 994-1017. -
További szerzők:	Brull, Sorin J. Fagerlund, Malin Jonsson Renew, J. Ross Cammu, Guy Murphy, Glenn S. Warlé, Michiel Vested, Matias Fülesdi Béla (1961-) (aneszteziológus) Nemes Réka (1985-) (aneszteziológus, intenzív terápiás szakorvos) Columb, Malachy O. Damian, Daniela Davis, Peter J. Iwasaki, Haijme Eriksson, Lars I.
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001-es BibID:	BIBFORM002180
Első szerző:	Soukup, Jens
Cím:	Temperature gradient between brain tissue and arterial blood mirrors the flow-metabolism relationship in uninjured brain : an experimental study / Soukup J., Rieger A., Holz C., Mikó I., Németh N., Menzel M.
Dátum:	2007
Megjegyzések:	BACKGROUND: The purpose of the present experimental study was to determine the feasibility and usefulness of brain temperature measurement (T(br)) and the calculated difference between brain temperature and arterial blood temperature (DeltaT(br-a)) in uninjured brain during variations of cerebral perfusion pressure (CPP) and concomitant changes of the regional cerebral blood flow (rCBF). METHODS: Nine anaesthetized pigs were subjected to controlled CPP decrease to assess the lower cerebral autoregulation threshold. A parenchymal intracranial pressure (ICP) sensor combined with a microthermistor for temperature measurement, a miniaturized Clark-type electrode measuring brain tissue oxygenation (p(ti)O(2)), a small flexible intraparenchymal thermodilution probe for measuring rCBF and cerebral microdialysis were inserted carefully in the frontal white matter. RESULTS: Analysing the p(ti)O(2) during controlled CPP decrease, we found significant breakpoints of p(ti)O(2) at a CPP of 40 mmHg and 20 mmHg, related to an rCBF of 20 ml/100 g/min and approximately 10 ml/100 g/min. Similarly, the relationship between DeltaT(br-a), and CPP or rCBF revealed a characteristic increase of DeltaT(br-a) in the negative direction up to more than -0.30 degrees C assuming a strong flow dependency. CONCLUSION: The temperature difference between brain tissue and arterial blood DeltaT(br-a) mainly reflects the cerebral blood flow-brain tissue oxygenation-metabolism relationship as far as the estimation of the individual lower cerebral autoregulation threshold.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban iracz
Megjelenés:	Acta anaesthesiologica Scandinavica 51 : 7 (2007), p. 872-879. -
További szerzők:	Rieger, A. Holz, Carsten Mikó Irén (1948-) (kutató sebész) Németh Norbert (1975-) (kutatóorvos) Menzel, Matthias (sebész)
Internet cím:	elektronikus változat DOI
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001-es BibID:	BIBFORM018150
Első szerző:	Szabó Zoltán (aneszteziológus és intenzív terápiás szakorvos)
Cím:	High-dose glucose-insulin-potassium after cardiac surgery : a retrospectiva analysis of clinical safety issues / Z. Szabó, E. Hakanson, T. Maros, R. Svedjeholm
Dátum:	2003
ISSN:	0001-5172
Megjegyzések:	Metabolic treatment with insulin or glucose-insulin-potassium (GIK) has received attention in association with myocardial infarction, cardiac surgery and critical care. As a result of insulin resistance during neuroendocrine stress, doses of insulin up to 1 IU kg-1 b.w.h are required to achieve maximal metabolic effects after cardiac surgery. The clinical experience with regard to safety issues of such a high-dose GIK regime in critically ill patients after cardiac surgery is reported. METHODS: Retrospective, observational study involving all patients treated with high-dose GIK after cardiac surgery during one year in a cardiovascular center at a University Hospital. RESULTS: Eighty-nine patients out of 854 adult patients undergoing cardiac surgery were treated with high-dose GIK. Mean age was 69 +/- 1 years, Higgins score 5.3 +/- 0.3. Preoperatively 31.4% had left ventricular function EF< or =0.35 and 32.5% had sustained a myocardial infarct during surgery. Mortality was 5.6% and the average ICU stay was 3.7 +/- 0.5 days. The main indication for GIK was intraoperative heart failure (69.7%). The average glucose infusion rate during the first 6 h was 4.22 +/- 0.15 and 4.91 +/- 0.14 mg kg-1 b.w.min, respectively, in diabetic and non-diabetic patients (P = 0.023). Blood glucose and s-potassium control was acceptable. CONCLUSIONS: The high-dose GIK regime allowed substantial amounts of glucose to be infused both in diabetic and critically ill patients with maintenance of acceptable blood glucose control. Provided careful monitoring, this regime can be safely used in clinical practice and deserves further evaluation for treatment of critically ill patients following cardiac surgery
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Acta Anaesthesiologica Scandinavica. - 47 : 4 (2003), p. 383-390. -
További szerzők:	Hakanson Erik Maros Tamás Miklós (1969-) (szívsebész) Svedjeholm Rolf
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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