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001-es BibID:	BIBFORM036663
Első szerző:	Krätke, Renate
Cím:	All- trans -retinoic acid and all- trans -retinoyl-beta-d -glucuronide alter the development of axolotl embryos ( Ambystoma mexicanum ) in vitro / Renate Krätke, Ralph Rühl, Frank Kirschbaum, Heinz Nau
Dátum:	2000
ISSN:	0340-5761
Megjegyzések:	Retinoids are involved in several physiological processes and are used in the treatment of various skin disorders. Therapy with retinoids during pregnancy may induce severe embryotoxic effects like craniofacial and cardiovascular malformations in the developing embryo. We investigated the effects of all-trans-retinoic acid (ATRA) and all-trans-retinoyl-β-D-glucuronide (ATRAG) in an amphibian embryotoxicity assay with Ambystoma mexicanum (axolotl) as an alternative in vitro method. Embryos were exposed to various concentrations of ATRA or ATRAG for 48 h beginning with the blastula stage. Kinetic investigations in the embryonic tissue were performed during the exposure period. Both retinoids interfered with the development of the axolotl embryos. Dose-dependent effects observed included growth retardation, craniofacial and cardiovascular malformations, as well as neural tube defects. In the axolotl, ATRA induced slightly more pronounced embryotoxic effects than ATRAG. All-trans-retinal was shown to be a major endogenous retinoid in this species. Endogenous levels of all-trans-retinaldehyde were increased during exposure to both ATRA and ATRAG. The glucuronide, however, was only detected in small amounts after ATRAG exposure. The embryotoxic potential of ATRAG could be explained by deglucuronidation to ATRA.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Archives Of Toxicology. - 74 : 3 (2000), p. 173-180. -
További szerzők:	Rühl, Ralph (1969-) (vegyész) Kirschbaum, Frank Nau, Heinz
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM065416
Első szerző:	Muscogiuri, Giovanna
Cím:	Vitamin D and chronic diseases : the current state of the art / Giovanna Muscogiuri, Barbara Altieri, Cedric Annweiler, Giancarlo Balercia, Harjit Pal Bhattoa, Barbara J. Boucher, John J. Cannell, Carlo Foresta, Martin R. Grübler, Kalliopi Kotsa, Luca Mascitelli, Winfried März, Francesco Orio, Stefan Pilz, Giacomo Tirabassi, Annamaria Colao
Dátum:	2017
ISSN:	0340-5761
Megjegyzések:	The objective was to provide the current state ofthe art regarding the role of vitamin D in chronic diseases(osteoporosis, cancer, cardiovascular diseases, dementia,autism, type 1 and type 2 diabetes mellitus, male andfemale fertility). The document was drawn up by paneliststhat provided their contribution according to their own scientificexpertise. Each scientific expert supplied a first draftmanuscript on a specific aspect of the document's topic thatwas subjected to voting by all experts as "yes" (agreementwith the content and/or wording) or "no" (disagreement). The adopted rule was that statements supported by ?75 %of votes would be immediately accepted, while those with<25 % would be rejected outright. Others would be subjectedto further discussion and subsequent voting, where?67 % support or, in an eventual third round, a majorityof ?50 % would be needed. This document finds thatthe current evidence support a role for vitamin D in bonehealth but not in other health conditions. However, subjectswith vitamin D deficiency have been found to be at highrisk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommendvitamin D supplementation as treatment of chronicdiseases, the treatment of vitamin D deficiency shouldbe desiderable in order to reduce the risk of developingchronic diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Vitamin D Musculoskeletal disorders Cancer cardiovascular diseases Dementia autism diabetes mellitus hypogonadism Fertility PCOS Environment Lifestyle Endometriosis
Megjelenés:	Archives Of Toxicology 91 : 1 (2017), p. 97-107. -
További szerzők:	Altieri, Barbara Annweiler, Cedric Balercia, Giancarlo Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Boucher, Barbara Cannell, John J. Foresta, Carlo Grübler, Martin R. Kotsa, Kalliopi Mascitelli, Luca März, Winfried Orio, Francesco Pilz, Stefan Tirabassi, Giacomo Colao, Annamaria
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM036658
Első szerző:	Rühl, Ralph (vegyész)
Cím:	Effects of all-trans-retinoic acid and all-trans-retinoyl glucuronide in two in vitro systems of distinct biological complexity / Ruhl Ralph, Sass Jörn, Nau Heinz, Klug Stephan
Dátum:	2001
ISSN:	0340-5761
Megjegyzések:	In vitro systems are widely used to evaluate the embryotoxic potential of retinoids. The effective concentrations of these retinoids, however, are not consistent in the various in vitro systems used in evaluating embryotoxicity. This may be explained by the different level of complexity for each individual system, which may lead to different concentrations of the substances in the target tissues. To verify this hypothesis we have compared two in vitro systems of distinct biological complexity: the rat whole embryo culture system, and the mouse limb bud organ culture system. The lipid soluble, teratogenic retinoid all-trans-retinoic acid (ATRA), and all-trans-retinoyl-beta-D-glucuronide (ATRAG), an endogenous, water-soluble and biologically active retinoid with limited placental transfer, were compared with regard to their embryotoxic potential in vitro. In both in vitro systems, ATRAG showed a lower degree of embryotoxicity than ATRA. In the limb bud organ culture, ATRAG revealed only slightly less toxicity than ATRA, whereas the effective concentrations of the two compounds in the whole embryo culture system differed by almost two orders of magnitude. During incubation with ATRAG, ATRA is generated by hydrolysis and is found in culture media and exposed tissues. The presence of membrane barriers around the developing embryo in the whole embryo culture system possibly prevents the transfer of ATRAG to the embryo and, therefore, its exposure to the active hydrolysis product ATRA. From these results we conclude that analysis of retinoid concentrations in the culture media and in the exposed tissues is essential for the interpretation of results obtained from in vitro toxicity testing.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Archives Of Toxicology. - 75 : 8 (2001), p. 497-504. -
További szerzők:	Sass, Jörn Nau, Heinz Klug, Stephan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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