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001-es BibID:BIBFORM004870
Első szerző:Krasznai Zoltán (biofizikus)
Cím:Ion channels in T cells : from molecular pharmacology to therapy / Krasznai, Z.
Dátum:2005
Megjegyzések:Ion channels of a variety of cell types, such as cardiac and smooth muscle cells and neurons, serve as targets for many drugs used in therapy. T cells also express an assortment of ion channels that are in the focus of intensive research, as they may provide efficient ways to specifically manipulate T cell function and, consequently, immune responses. T cell activation relies on the operation of voltage-gated and Ca2+-activated potassium channels and Ca2+ release-activated Ca2+ channels. Many peptide toxin and small molecule blockers of these channels are known, but inhibitors of even higher affinity and selectivity would be needed for safe and effective clinical use. The recent discovery that the expression pattern of potassium channels in T cells is subset specific emphasizes the potential that these proteins have in immunomodulation. Compounds that could suppress T cells involved in autoimmunity without affecting T cells in normal immune responses would be of enormous value. In this paper the basic properties of these channels and compounds known to influence their operation are reviewed
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Biophysics
Calcium
Calcium Channels
Cells
Human
Humans
Hungary
immunology
Intermediate-Conductance Calcium-Activated Potassium Channels
Ion Channels
Kv1.3 Potassium Channel
Lymphocyte Activation
metabolism
pharmacology
Potassium
Potassium Channels
Potassium Channels,Voltage-Gated
Proteins
Research
T-Lymphocytes
therapy
Megjelenés:Archivum Immunologiae et Therapiae Experimentalis. - 53 : 2 (2005), p. 127-135. -
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2.

001-es BibID:BIBFORM047793
Első szerző:Váróczy László (belgyógyász, haematológus)
Cím:Changes in the Number of CD8+ T Lymphocytes in the Peripheral Blood of Patients with Various Autoimmune Diseases after Autologous Hematopoietic Stem Cell Transplantations and their Relations to the Survival Times / László Váróczy, Ildikó Kovács, Sándor Baráth, Edit Gyimesi, Árpád Illés, Margit Zeher, Sándor Sipka
Dátum:2013
Megjegyzések:The changes in the number of CD8(+) T lymphocytes were studied before (0 day) and then 30 days after the autologous hematopoietic stem cell transplantations (AHSCT) in 14 therapy refractory patients with autoimmune diseases. The years of survival and the clinical states were also evaluated. The number of CD8(+) T cells was determined by an hematologic automat and by flow cytometry. Longer than 5-year survival times were found in 6 cases, whereas there was no progression (improvement) in 2 cases, and 4 patients were lost. The increase in the number of CD8(+) cytotoxic T cells was gradual in the first 2 months and reached the significantly highest values among all subtypes of lymphocytes. It was of a special interest that in all the 4 patients who died, the numbers of CD8(+) T cells were less than 150/?l on the 30th day after AHSCT, whereas all the 10 patients with a higher cell number survived. These results suggest that the early monitoring of the number (not only the ratio) of regenerating CD8(+) T cells in the peripheral blood can be a useful and quantitative laboratory measurement after AHSCT, and it has a significant relation also to the survival times of transplanted patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
CD8+ T lymphocytes
autologous stem cell transplantation
autoimmune
Megjelenés:Archivum Immunologiae et Therapiae Experimentalis. - 61 : 5 (2013), p. 421-426. -
További szerzők:Kovács Ildikó Baráth Sándor (1977-) (biológus) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
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