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1.

001-es BibID:BIBFORM117961
035-os BibID:(cikkazonosító)27 (scopus)85182418710 (wos)001144630300003
Első szerző:Aggarwal, Rohit
Cím:Safety and tolerability of intravenous immunoglobulin in patients with active dermatomyositis : results from the randomised, placebo-controlled ProDERM study / Aggarwal Rohit, Schessl Joachim, Charles-Schoeman Christina, Bata-Csörgő Zsuzsanna, Dimachkie Mazen M., Griger Zoltan, Moiseev Sergey, Oddis Chester V., Schiopu Elena, Vencovsky Jiri, Beckmann Irene, Clodi Elisabeth, Levine Todd, ProDERM investigators
Dátum:2024
ISSN:1478-6354 1478-6362
Megjegyzések:Abstract Introduction: Dermatomyositis (DM) is an inflammatory myopathy characterized by distinct skin manifestations and muscle weakness. Intravenous immunoglobulin (IVIg) has been used off-label as adjuvant therapy in DM, but is not indicated for DM, due to lack of proven efficacy in a large randomized controlled trial. The objective of the ProDERM (Progress in DERMatomyositis) study was to evaluate the efficacy, safety and long-term tolerability of IVIg (Octagam 10%) in patients with DM in a randomized, placebo-controlled, double-blind, Phase III study. Methods: Adult patients with active DM who were continuing standard therapy at a stable dose were eligible for this study. Patients were randomized 1:1 to receive either 2 g/kg of IVIg or placebo, administered every 4 weeks until week 16 (First Period). Patients were switched to the alternate treatment if they showed clinical deterioration in the First Period. After response assessment at week 16, all patients on placebo and those without deterioration on IVIg entered the open-label Extension Period, receiving 2 g/kg IVIg every 4 weeks for 24 weeks. Results: The primary efficacy endpoint was the proportion of responders in the IVIg vs placebo arm at week 16, where response was defined per 2016 ACR/EULAR Myositis Response Criteria of at least minimal improvement [Total Improvement Score (TIS) ?20] and without deterioration at 2 consecutive visits up to week 16. TIS consists of composite response criteria, combining weighted improvement in 6 core set measures (CSMs), Global Disease Activity (Physician and Patient), manual muscle testing-8 (MMT-8), Health Assessment Questionnaire, extra-muscular disease activity, and muscle enzymes. Secondary endpoints included the mean change in individual CSMs, time to improvement in TIS, time to confirmed deterioration in the First Period, and the overall proportion of patients with deteriorations. Adverse events, including infusion reactions and thromboembolic events, were recorded. Conclusions: The ProDERM study was the first to assess the long-term efficacy and safety of IVIg (Octagam 10%) in a placebo-controlled, blinded, randomized trial in DM. The study aimed to inform on the use of IVIg in the treatment of DM, and results are expected in Q3 2020.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Dermatomyositis
Intravenous immunoglobulin
Myositis
Safety
Tolerability
Megjelenés:Arthritis Research & Therapy. - 26 : 1 (2024), p. 1-13. -
További szerzők:Schessl, Joachim Charles-Schoeman, Christina Bata-Csörgő Zsuzsanna Dimachkie, Mazen M. Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Moiseev, Sergey Oddis, Chester V. Schiopu, Elena Vencovsky, Jiri Beckmann, Irene Clodi, Elisabeth Levine, Todd ProDERM Trial Group
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2.

001-es BibID:BIBFORM089876
Első szerző:Allanore, Yannick
Cím:Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis : an analysis from the EUSTAR database / Yannick Allanore, Sylvie Bozzi, Augustin Terlinden, Doerte Huscher, Caroline Amand, Christina Soubrane, Elise Siegert, László Czirják, Patricia E. Carreira, Eric Hachulla, Elisabetta Zanatta, Mengtao Li, Paolo Airò, Fabian A. Mendoza, Edoardo Rosato, Oliver Distler, EUSTAR Collaborators
Dátum:2020
ISSN:1478-6354 1478-6362
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Arthritis Research & Therapy. - 22 (2020), p. 257-267. -
További szerzők:Bozzi, Sylvie Terlinden, Augustin Huscher, Dörte Amand, Caroline Soubrane, Christina Siegert, Elise Czirják László Carreira, Patricia E. Hachulla, Eric Zanatta, Elisabetta Li, Mengtao Airò, Paolo Mendoza, Fabian A. Rosato, Edoardo Distler, Oliver Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) EUSTAR
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3.

001-es BibID:BIBFORM073990
Első szerző:Balogh Emese (reumatológus)
Cím:Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis / Emese Balogh, Douglas J. Veale, Trudy McGarry, Carl Orr, Zoltan Szekanecz, Chin-Teck Ng, Ursula Fearon, Monika Biniecka
Dátum:2018
ISSN:1478-6354 1478-6362
Megjegyzések:BACKGROUND:In this study, we examined the effect of oxidative stress on cellular energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary rheumatoid arthritis synovial fibroblast cells (RASFC) and human umbilical vein endothelial cells (HUVEC).METHODS:Primary RASFC and HUVEC were cultured with the oxidative stress inducer 4-hydroxy-2-nonenal (4-HNE), and extracellular acidification rate, oxygen consumption rate, mitochondrial function and pro-angiogenic/pro-inflammatory mechanisms were assessed using the Seahorse analyser, complex I-V activity assays, random mutation mitochondrial capture assays, enzyme-linked immunosorbent assays and functional assays, including angiogenic tube formation, migration and invasion. Expression of angiogenic growth factors in synovial tissue (ST) was assessed by IHC in patients with rheumatoid arthritis (RA) undergoing arthroscopy before and after administration of tumour necrosis factor inhibitors (TNFi).RESULTS:In RASFC and HUVEC, 4-HNE-induced oxidative stress reprogrammed energy metabolism by inhibiting mitochondrial basal, maximal and adenosine triphosphate-linked respiration and reserve capacity, coupled with the reduced enzymatic activity of oxidative phosphorylation complexes III and IV. In contrast, 4-HNE elevated basal glycolysis, glycolytic capacity and glycolytic reserve, paralleled by an increase in mitochondrial DNA mutations and reactive oxygen species. 4-HNE activated pro-angiogenic responses of RASFC, which subsequently altered HUVEC invasion and migration, angiogenic tube formation and the release of pro-angiogenic mediators. In vivo markers of angiogenesis (vascular endothelial growth factor, angiopoietin 2 [Ang2], tyrosine kinase receptor [Tie2]) were significantly associated with oxidative damage and oxygen metabolism in the inflamed synovium. Significant reduction in ST vascularity and Ang2/Tie2 expression was demonstrated in patients with RA before and after administration of TNFi.CONCLUSIONS:Oxidative stress promotes metabolism in favour of glycolysis, an effect that may contribute to acceleration of inflammatory mechanisms and subsequent dysfunctional angiogenesis in RA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bioenergetic metabolism
Oxidative stress
Angiogenesis
Rheumatoid arthritis
Megjelenés:Arthritis Research & Therapy. - 20 : 1 (2018), p. 1-15. -
További szerzők:Veale, Douglas J. McGarry, Trudy Orr, Carl Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Ng, Chin Teck Fearon, Ursula Biniecka, Monika
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4.

001-es BibID:BIBFORM088823
Első szerző:Bütikofer, Lukas
Cím:ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis : a EUSTAR analysis / Bütikofer Lukas, Varisco Pierre A., Distler O., Kowal-Bielecka O., Allanore Y., Riemekasten G., Villiger P. M., Adler S., EUSTAR collaborators
Dátum:2020
ISSN:1478-6354 1478-6362
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Arthritis Research & Therapy. - 22 : 1 (2020), p. 1-9. -
További szerzők:Varisco, Pierre A. Distler, Oliver Kowal-Bielecka, Otylia Allanore, Yannick Riemekasten, Gabriela Villiger, P. M. Adler, S. Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) EUSTAR
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5.

001-es BibID:BIBFORM115341
035-os BibID:(WoS)001123624500001 (Scopus)85179364233
Első szerző:Deibel, Elisabeth
Cím:Does the impact of COVID-19 on patients with systemic sclerosis change over time? / Deibel Elisabeth, Carreira Patricia E., Vonk Madelon, del Papa Nicoletta, Becvár Radim, Guillén-Del-Castillo Alfredo, Campochiaro Corrado, Poormoghim Hadi, Liem Sophie, Lazzaroni Maria-Grazia, Giollo Alessandro, Mekinian Arsene, de Vries-Bouwstra Jeska, De Santis Maria, Balbir-Gurman Alexandra, Mihai Carina, De Luca Giacomo, Moiseev Sergey, Zanatta Elisabetta, Foti Rosario, Rednic Simona, Denton Christopher, Cutolo Maurizio, Belloli Laura, Airo Paolo, Garzanova Liudmila, Moroncini Gianluca, Inanc Murat, Panopoulos Stylianos, Tandaipan Jose-Luis, Chatelus Emmanuel, Rosato Edoardo, Kuwana Masataka, Yavuz Sule, Alegre-Sancho Juan J., Smith Vanessa, Szűcs Gabriella, Henes Joerg, Rodríguez-Pintó Ignasi, Atzeni Fabiola, Spierings Julia, Truchetet Marie-Elise, Milchert Marcin, Brito de Araujo Daniel, Riemekasten Gabriela, Bernardino Vera, Martin Thierry, del Galdo Francesco, Vacca Alessandra, Mendoza Fabian, Midtvedt Øyvind, Murdaca Giuseppe, Santiago Tania, Codullo Veronica, Cacciapaglia Fabio, Walker Ulrich, Brunborg Cathrine, Tirelli Francesca, Allanore Yannick, Furst Daniel E., Matucci Marco, Gabrielli Armando, Distler Oliver, Hoffmann-Vold Anna-Maria
Dátum:2023
ISSN:2151-464X 2151-4658
Megjegyzések:Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Methods. Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.Results. A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.Conclusion. The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Arthritis Care And Research. - 76 : 1 (2024), p. 88-97. -
További szerzők:Carreira, Patricia E. Vonk, Madelon C. del Papa, Nicoletta Becvar, Radim Guillén-Del-Castillo, Alfredo Campochiaro, Corrado Poormoghim, Hadi Liem, Sophie Lazzaroni, Maria-Grazia Giollo, Alessandro Mekinian, Arsene de Vries-Bouwstra, Jeska De Santis, Maria Balbir Gurman, Alexandra Mihai, Carina De Luca, Giacomo Moiseev, Sergey Zanatta, Elisabetta Foti, Rosario Rednic, Simona Denton, Christopher Cutolo, Maurizio Belloli, Laura Airò, Paolo Garzanova, Liudmila Moroncini, Gianluca Inanc, M. Panopoulos, Stylianos Tandaipan, José-Luis Chatelus, Emmanuel Rosato, Edoardo Kuwana, Masataka Yavuz, Sule Alegre-Sancho, Juan Jose Smith, Vanessa Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Henes, Jörg Rodríguez-Pintó, Ignasi Atzeni, Fabiola Spierings, Julia Truchetet, Marie-Elise Milchert, Marcin Brito de Araujo, Daniel Riemekasten, Gabriela Bernardino, Vera Martin, Thierry del Galdo, Francesco Vacca, Alessandra Mendoza, Fabian A. Midtvedt, Øyvind Murdaca, Giuseppe Santiago, Tania Codullo, Veronica Cacciapaglia, Fabio Walker, Ulrich Brunborg, Cathrine Tirelli, Francesca Allanore, Yannick Furst, Daniel E. Matucci-Cerinic, Marco Gabrielli, Armando Distler, Oliver Hoffmann-Vold, Anna-Maria
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6.

001-es BibID:BIBFORM038798
Első szerző:Dougados, Maxime
Cím:Nonsteroidal antiinflammatory drug intake according to the Assessment of SpondyloArthritis International Society Score in clinical trials evaluating tumor necrosis factor blockers : example of etanercept in advanced ankylosing spondylitis / Dougados Maxime, Braun Jurgen, Szanto Sandor, Combe Bernard, Geher Pal, Leblanc Véronique, Logeart Isabelle
Dátum:2012
ISSN:2151-464X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Arthritis Care & Research. - 64 : 2 (2012), p. 290-294. -
További szerzők:Braun, Jurgen Szántó Sándor (1968-) (belgyógyász, reumatológus) Combe, Bernard Géher Pál Leblanc, Véronique Logeart, Isabelle
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7.

001-es BibID:BIBFORM082302
Első szerző:Horváth Ágnes (reumatológus)
Cím:Complex assessment of bone mineral density, fracture risk, vitamin D status and bone metabolism in Hungarian systemic sclerosis patients / Ágnes Horváth, Edit Végh, Anita Pusztai, Zsófia Pethő, Attila Hamar, Monika Czókolyová, Harjit Pal Bhattoa, Gábor Nagy, Balázs Juhász, Katalin Hodosi, Andrea Domján, Zoltán Szekanecz, Gabriella Szücs, Szilvia Szamosi
Dátum:2019
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Arthritis Research & Therapy. - 21 : 1 (2019), p. 1-10. -
További szerzők:Végh Edit (1978-) (reumatológus, belgyógyász) Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Pethő Zsófia (1981-) (reumatológus, immunológus) Hamar Attila Béla (1990-) (általános orvos) Czókolyová Mónika (1993-) (molekuláris biológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Juhász Balázs (1973-) (orvos, onkológus) Hódosi Katalin Domján Andrea (1979-) (reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szamosi Szilvia (1975-) (belgyógyász, reumatológus)
Pályázati támogatás:TAMOP-4.2.4.A/2-11/1-2012-14 0001'National Excellence Program'
TAMOP
GINOP-2.3.2- 15-2016-00015
GINOP
GINOP-2.3.2-15-2016-00050
GINP
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8.

001-es BibID:BIBFORM084878
Első szerző:Oláh Csaba (idegsebész)
Cím:Cognitive dysfunction in autoimmune rheumatic diseases / Oláh Csaba, Schwartz Noa, Denton Christopher, Kardos Zsófia, Putterman Chaim, Szekanecz Zoltán
Dátum:2020
ISSN:1478-6354 1478-6362
Megjegyzések:For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cognitive function
Cognitive dysfunction
Rheumatoid arthritis
Systemic lupus erythematosus
Neuropsychiatric lupus
Systemic sclerosis
Megjelenés:Arthritis Research & Therapy. - 22 : 1 (2020), p. 1-7. -
További szerzők:Schwartz, Noa Denton, Christopher Kardos Zsófia Putterman, Chaim Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TAMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00015
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
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9.

001-es BibID:BIBFORM070695
Első szerző:Oláh Csaba (idegsebész)
Cím:Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis / Csaba Oláh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki, Zoltán Szekanecz
Dátum:2017
ISSN:1478-6354 1478-6362
Megjegyzések:Background: Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthycontrol subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging (MRI).Methods: Altogether, 41 female patients with RA undergoing methotrexate (MTX) or biologic treatment and 60age-matched control subjects underwent TCD assessment of the middle cerebral artery (MCA) and basilar artery.Pulsatility index (PI), resistivity (resistance) index (RI) and circulatory reserve capacity (CRC) were determined at rest (r)and after apnoea (a) and hyperventilation (h). The presence of carotid plaques and carotid intima-media thickness(cIMT) were also determined. Intracerebral vascular lesions were investigated by brain MRI.Results: MCA PI and RI values at rest and after apnoea were significantly increased in the total and MTX-treated RApopulations vs control subjects. MCA CRC was also impaired, and basilar artery PI was higher in RA. More patientswith RA had carotid plaques and increased cIMT. Linear regression analysis revealed that left PI(r) and RI(r) correlatedwith disease duration and that left PI(r), RI(r), PI(a), PI(h) and basilar PI correlated with disease activity. Right CRCinversely correlated with 28-joint Disease Activity Score. Disease activity was an independent determinant of left PI(a)and right CRC. Compared with long-term MTX treatment alone, the use of biologics in combination with MTX wasassociated with less impaired cerebral circulation. Impaired cerebral circulation was also associated with measures ofcarotid atherosclerosis.Conclusions: To our knowledge, this is the first study to show increased distal MCA and basilar artery occlusion in RAas determined by TCD. Patients with RA also had CRC defects. We also confirmed increased carotid plaque formationand increased cIMT. Biologics may beneficially influence some parameters in the intracranial vessels.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Arthritis Research & Therapy 19 : 1 (2017), p. 213. -
További szerzők:Kardos Zsófia Sepsi Marianna Sas Attila Kostyál László (1974-) (radiológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Hódosi Katalin Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Tamási László Valikovics Attila Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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10.

001-es BibID:BIBFORM106690
035-os BibID:(scopus)85048288877 (wos)000434672900001
Első szerző:Parkes, Joanna E.
Cím:Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis / Parkes Joanna E., Rothwell Simon, Oldroyd Alexander, Chinoy Hector, Lamb Janine A., Myositis Genetics Consortium (MYOGEN)
Dátum:2018
ISSN:1478-6354 1478-6362
Megjegyzések:Background The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultraviolet (UV) light towards the equator. In this study, we investigated whether differing genetic background in populations could contribute to this distribution of DM. Methods Case data derived from the MYOGEN (Myositis Genetics Consortium) Immunochip study (n =?1769) were used to model the association of DM prevalence and DM-specific autoantibodies with latitude. Control data (n =?9911) were used to model the relationship of human leucocyte antigen (HLA) associated with DM autoantibodies and DM or PM single-nucleotide polymorphisms (suggestive significance in the Immunochip project, P <?2.25???10??5) in healthy control subjects with latitude. All variables were analysed against latitude using ordered logistic regression, adjusted for sex. Results The prevalence of DM, as a proportion of DM and PM combined, and the presence of anti-transcription intermediary factor 1 (anti-TIF1-?) autoantibodies were both significantly negatively associated with latitude (OR 0.96, 95% CI 0.95?0.98, P <?0.001; and OR 0.95, 95% CI 0.92?0.99, P =?0.004, respectively). HLA alleles significantly associated with anti-Mi-2 and anti-TIF1-? autoantibodies also were strongly negatively associated with latitude (OR 0.97, 95% CI 0.96?0.98, P <?0.001 and OR 0.98, 95% CI 0.97?0.99, P <?0.001, respectively). The frequency of five PM- or DM-associated SNPs showed a significant association with latitude (P <?0.05), and the direction of four of these associations was consistent with the latitude associations of the clinical phenotypes. Conclusions These results lend some support to the hypothesis that genetic background, in addition to UV exposure, may contribute to the distribution of DM.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Anti-Mi-2
Anti-TIF1-γ
Dermatomyositis
Latitude
Polymyositis
Ultraviolet light
Megjelenés:Arthritis Research & Therapy. - 20 : 1 (2018), p. 1-5. -
További szerzők:Rothwell, Simon Oldroyd, Alexander Chinoy, Hector Lamb, Janine A. Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Myositis Genetics Consortium (MYOGEN)
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11.

001-es BibID:BIBFORM105679
035-os BibID:(scopus)85138128690 (wos)000852379900003 (cikkazonosító)219
Első szerző:Péter Andrea (kardiológus)
Cím:Subclinical systolic and diastolic myocardial dysfunction in polyphasic polymyositis/dermatomyositis : a 2-year longitudinal study / Péter Andrea, Balogh Ágnes, Csanádi Zoltán, Dankó Katalin, Griger Zoltan
Dátum:2022
ISSN:1478-6354 1478-6362
Megjegyzések:Background Cardiac involvement in patients with idiopathic inflammatory myopathies (IIM) is associated with increased morbidity and mortality risk; however, little is known about the progression of cardiac dysfunction and long-term data are scarce. In the present work, we intended to prospectively study echocardiographic parameters in patients with IIM for 2 years. Methods Twenty-eight IIM patients (41.9?1.6 years) without cardiovascular symptoms were enrolled. Patients with monophasic/polyphasic disease patterns were studied separately and compared to age-matched healthy individuals. Conventional echocardiographic and tissue Doppler imaging (TDI) parameters of systolic [LV: ejection fraction (EF), mitral annulus systolic movement (MAPSE), lateral s·) and diastolic left (mitral inflow velocities, lateral anulus velocities: e·, a·, E/e·) and right ventricular function (fractional area change: FAC, tricuspid annulus plane systolic excursion: TAPSE) were measured at the time of the diagnosis and 2 years later. Results Subclinical LV systolic dysfunction is characterized by reduced lateral s· (10.4 vs. 6.4 cm/s, p<0.05), EF (62.6?0.6%, vs. 51.7?0.7%) and MAPSE (18.5?0.6 vs. 14.5?0.6 mm) could be observed in IIM patients with polyphasic disease course 2 years after diagnosis compared to controls. Furthermore, diastolic LV function showed a marked deterioration to grade I diastolic dysfunction at 2 years in the polyphasic group (lateral e·: 12.9 ?0.6, vs. 7.4?0.3 cm/s; lateral a·: 10.7?0.3, vs. 17.3?0.8 cm/s; p<0.05) supported by larger left atrium (32.1?0.6 vs. 37.8?0.6 mm; p<0.05]. TDI measurements confirmed subclinical RV systolic dysfunction in polyphasic patients 2 years after diagnosis (FAC: 45.6?1.8%, vs. 32.7?1.4%; TAPSE: 22.7?0.5, vs. 18.1?0.3 mm; p<0.05). Similar, but not significant tendencies could be detected in patients with monophasic disease patterns. Polyphasic patients showed significantly (p<0.05) worse results compared to monophasic patients regarding EF (51.7?0.7% vs. 58.1?0.6%), lateral s· (6.4?0.4 cm/sec vs. 8.6?0.4 cm/s,), left atrium (37.8?0.6 mm vs. 33.3?0.8 mm), FAC (32.7?1.4% vs. 41.0?1.6%) and TAPSE (18.1?0.3 mm vs. 21.3?0.7 mm). Conclusions Significant subclinical cardiac dysfunction could be detected in IIM patients with polyphasic disease course 2 years after diagnosis, which identifies them as a high-risk population. TDI is a useful method to detect echocardiographic abnormalities in IIM complementing conventional echocardiography and can recognize the high cardiac risk.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cardiac involvement
Dermatomyositis
Echocardiography
Polymyositis
Tissue Doppler imaging
Megjelenés:Arthritis Research & Therapy. - 24 : 1 (2022), p. 1-11. -
További szerzők:Balogh Ágnes (1984-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM084502
Első szerző:Pethő Zoltán (orvos)
Cím:Erratum to : different expression of [béta] subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes / Pethő Zoltán, Tanner Mark R., Tajhya Rajeev B., Huq Redwan, Laragione Teresina, Panyi Gyorgy, Gulko Pércio S., Beeton Christine
Dátum:2016
ISSN:1478-6354 1478-6362
Tárgyszavak:Orvostudományok Elméleti orvostudományok hozzászólás
folyóiratcikk
Megjelenés:Arthritis Research & Therapy. - 18 : 1 (2016), p. 122. -
További szerzők:Tanner, Mark R. Tajhya, Rajeev B. Huq, Redwan Laragione, Teresina Panyi György (1966-) (biofizikus) Gulko, Pércio S. Beeton, Christine
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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