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001-es BibID:	BIBFORM059038
Első szerző:	Józsa Tamás (gyermeksebész, urológus)
Cím:	Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap / Tamás Józsa, Zoltán Klárik, Ferenc Kiss, Enikő Tóth, Anita Mester, Zoltán Hargitai, Yi-Che Changchien, Magdalena Fossum, Norbert Németh
Dátum:	2016
ISSN:	1008-682X
Megjegyzések:	Testicular torsion may lead to serious ischemia, and the viability depends on the duration of torsion and the effect of ischemia-reperfusion. Testicular decompression and tunica vaginalis fl ap application technique were introduced in 2008 by Kutikov et al. We aimed to examine the impact of this method on the testicular microcirculation and hemorheological parameters in a rat model. Six adult rats underwent bilateral scrotal exploration. Intravaginal torsion of the testis was created by 720° rotation on both sides for 2 h. After detorsion, the right testes underwent tunica albuginea incision and tunica vaginalis fl ap application. Testicular microcirculation was monitored and hematological parameters, erythrocyte deformability, and aggregation were determined. Measurements were performed before and after torsion, directly after detorsion, on the 1st-2nd and 8th postoperative day. After the last sampling, testicles were removed to determine their volume for histological examinations. The microcirculatory parameters demonstrated slight differences between testicles. Apical zone of the left (nondecompressed) testicles had elevated compared to the middle zone (P < 0.05). On the 2nd and 8th day, the microcirculation of the testes normalized but not equally. The erythrocyte aggregation and deformability decreased by the 8th day. Both testicles underwent atrophy and epithelial necrosis, but the volume of the decompressed ones was lower (1.07 ± 0.08 vs 1.25 ± 0.31). Histologically, there was no signifi cant difference in epithelial damage score between decompressed and nondecompressed testes. In conclusion, 2-h ischemia led to alteration in testicular microcirculation, reduction in volume, changes in hemorheological parameters and serious epithelial necrosis both in decompressed and nondecompressed testicles without remarkable differences.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ischemia rat model reperfusion spermatic cord torsion surgical fl aps testicular compartment syndrome testis
Megjelenés:	Asian Journal Of Andrology. - 18 : 3 (2016), p. 462-466. -
További szerzők:	Klárik Zoltán (1985-) Kiss Ferenc (1982-) (kutatóorvos) Tóth Enikő Mester Anita Hargitai Zoltán Chang Chien, Yi-Che (1975-) (pathológus) Fossum, Magdalena Németh Norbert (1975-) (kutatóorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM009377
Első szerző:	Józsa Tamás (gyermeksebész, urológus)
Cím:	Effect of hydrocele on appendix testis in children / Jozsa, T., Telek, A., Kutasy, B., Benyo, M., Csanadi, G., Kovacs, I., Balla, G., Flasko, T., Csernoch, L., Kiss, C.
Dátum:	2009
ISSN:	1745-7262 (Electronic)
Megjegyzések:	The purpose of this study was to investigate the effects of an elevated hydrostatic pressure of hydrocele on the structural integrity and steroid receptor expression pattern of the appendix testis in children. Twenty-six testicular appendages were obtained from boys (aged between 13 and 79 months, mean 40 months) who underwent surgical exploration because of hydrocele or congenital inguinal hernia. The tissue sections of testicular appendages were stained with hematoxylin-eosin. Immunohistochemistry and immunofluorescence laser microscopy were performed using monoclonal mouse anti-human receptors against androgen and estrogen receptors. Patients were divided into three groups: group A (n = 8) represented patients with groin hernia without hydrocele, who served as control group; group B (n = 7) represented patients with communicating hydrocele; and group C (n = 11) represented patients with noncommunicating hydrocele. The tissue sections of appendix testis expressed both androgen and estrogen receptors in all patients in groups A and B, and epithelial destruction was not present. The presence of androgen receptor (two of 11, P < 0.001) and estrogen receptor (four of 11, P = 0.006) was lower and the number of appendix testes with epithelial destruction was higher (eight of 11, P = 0.001) in group C. We demonstrated that groin hernia and communicating hydrocele did not influence the receptor expression pattern and the anatomic structure of testicular appendages, whereas noncommunicating hydrocele caused damage as indicated by the absence of steroid receptors and destruction of the epithelial surface. A better understanding of the physiological role of testicular appendages may change the indications of surgical treatment in patients with noncommunicating hydrocele.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Asian Journal of Andrology. - 11 : 6 (2009), p. 741-745. -
További szerzők:	Telek Andrea (1977-) (élettanász) Kutasy Balázs Benyó Mátyás (1982-) (urológus) Csanádi Gábor (1976-) (urológus, andrológus) Kovács Ilona (1965-) (patológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Flaskó Tibor (1960-) (urológus) Csernoch László (1961-) (élettanász) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:	DOI elektronikus változat
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001-es BibID:	BIBFORM040897
Első szerző:	Kistamás Kornél (biológus)
Cím:	Expression of anti-Mullerian hormone receptor on the appendix testis in connection with urological disorders / Kornél Kistamás, Olga Ruzsnavszky, Andrea Telek, Lívia Kosztka, Ilona Kovács, Beatrix Dienes, László Csernoch, Tamás Józsa
Dátum:	2013
ISSN:	1008-682X
Megjegyzések:	The female internal sex organs develop from the paramesonephric (Mullerian) duct. In male embryos, the regression of the Mullerian duct is caused by the anti-Mullerian hormone (AMH), which plays an important role in the process of testicular descent. The physiological remnant of the Mullerian duct in males is the appendix testis (AT). In our previous study, we presented evidence for the decreased incidence of AT in cryptorchidism with intraoperative surgery. In this report, the expression of the anti-Mullerian hormone receptor type 2 (AMHR2), the specific receptor of AMH, on the AT was investigated in connection with different urological disorders, such as hernia inguinalis, torsion of AT, cysta epididymis, varicocele, hydrocele testis and various forms of undescended testis. The correlation between the age of the patients and the expression of the AMHR2 was also examined. Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry were used to detect the receptor's mRNA and protein levels, respectively. We demonstrate that AMHR2 is expressed in the ATs. Additionally, the presence of this receptor was proven at the mRNA and protein levels. The expression pattern of the receptor correlated with neither the examined urological disorders nor the age of the patients; therefore, the function of the AT remains obscure
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban AMHR appendix testis hernia inguinalis retention testis testicular descent testis retractile
Megjelenés:	Asian Journal of Andrology. - 15 : 3 (2013), p. 400-403. -
További szerzők:	Ruzsnavszky Olga (1983-) (élettanász) Telek Andrea (1977-) (élettanász) Kosztka Lívia (1981-) (élettanász) Kovács Ilona (1965-) (patológus) Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Csernoch László (1961-) (élettanász) Józsa Tamás (1969-) (gyermeksebész, urológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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