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001-es BibID:BIBFORM009570
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Exposure to inhomogeneous static magnetic field ceases mechanical allodynia in neuropathic pain in mice / M. Antal, J. László
Dátum:2009
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioelectromagnetics. - 30 : 6 (2009), p. 438-445. -
További szerzők:László János
Internet cím:elektronikus változat
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2.

001-es BibID:BIBFORM032518
Első szerző:Radzievsky, Alexander A.
Cím:Electromagnetic Millimeter Wave Induced Hypoalgesia : frequency Dependence and Involvement of Endogenous Opioids / Radzievsky A. A., Gordiienko O. V., Alekseev S., Szabo I., Cowan A., Ziskin M. C.
Dátum:2008
ISSN:0909-752X
Megjegyzések:Millimeter wave treatment (MMWT) is based on the systemic biological effects that develop following local skin exposure to low power electromagnetic waves in the millimeter range. In the present set of experiments, the hypoalgesic effect of this treatment was analyzed in mice. The murine nose area was exposed to MMW of "therapeutic" frequencies: 42.25, 53.57, and 61.22 GHz. MMWT-induced hypoalgesia was shown to be frequency dependent in two experimental models: (1) the cold water tail-flick test (chronic non-neuropathic pain), and (2) the wire surface test (chronic neuropathic pain following unilateral constriction injury to the sciatic nerve). Maximum hypoalgesic effect was obtained when the frequency was 61.22 GHz. Other exposure parameters were: incident power density = 13.3 mW/cm(2), duration of each exposure = 15 min. Involvement of delta and kappa endogenous opioids in the MMWT-induced hypoalgesia was demonstrated using selective blockers of delta- and kappa-opioid receptors and the direct ELISA measurement of endogenous opioids in CNS tissue. Possible mechanisms of the effect and the perspectives of the clinical application of MMWT are discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioelectromagnetics. - 29 : 4 (2008), p. 284-295. -
További szerzők:Gordiienko, O. V. Alekseev, Stanislav Szabó Imre (1952-) (orvos) Cowan, A. Ziskin, Marvin C.
Internet cím:DOI
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3.

001-es BibID:BIBFORM036677
Első szerző:Szabó Imre (orvos)
Cím:Millimeter wave induced reversible externalization of phosphatidylserine molecules in cells exposed in vitro / Szabo Imre, Kappelmayer Janos, Alekseev Stanislav I., Ziskin Marvin C.
Dátum:2006
ISSN:0197-8462
Megjegyzések:Center for Biomedical Physics, Temple University School of Medicine, Philadelphia, Pennsylvania
In vitro exposure of refrigerated samples (4 degrees C) of anti-coagulated blood with millimeter waves (MMWs) at incident power densities (IPDs) between 0.55 and 1.23 W/cm2 has been found to induce clot formation. We found a small but statistically significant change in clot size with increasing IPD value. MMW exposure of blood samples starting at room temperature (22 degrees C) did not induce blood coagulation; neither did conventional heating at temperatures up to 40 degrees C. Since cell-free plasma did not clot upon MMW exposure, the role of blood cells was particularly analyzed. Experiments on various mixtures of blood cells with plasma revealed an important role of red blood cells (RBC) in the coagulation process. Plasma coagulation also developed within the MMW beam above dense keratinocyte (HaCaT) monolayers suggesting it lacked cell-type specificity. We hypothesized that alteration of the membrane surface in exposed cells might be responsible for the circumscribed coagulation. The thrombogenic role of externalized phosphatidylserine (PS) molecules is well known. Therefore, we carried out experiments for immunolabeling PS molecules with fluorescein isothiocyanate (FITC)-conjugated Annexin V on exposed cells. Fluorescence microscopy of the adherent human keratinocytes (HaCaT) and murine melanoma cells (B16F10) showed that MMW exposure at an IPD of 1.23 W/cm2 is capable of inducing reversible externalization of PS molecules in cells within the beam area without detectable membrane damage. Nonadherent Jurkat cells exposed to MMW at an IPD of 34.5 mW/cm2 also showed reversible PS externalization with flow cytometry, whether the cell temperature was held constant or permitted to rise. These results suggest that certain biological effects induced by MMWs could be initiated by membrane changes in exposed cells.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioelectromagnetics. - 27 : 3 (2006), p. 233-244. -
További szerzők:Kappelmayer János (1960-) (laboratóriumi szakorvos) Alekseev, Stanislav Ziskin, Marvin C.
Internet cím:Szerző által megadott URL
DOI
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