CCL

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001-es BibID:BIBFORM039218
Első szerző:Holman Endre
Cím:Simultaneous bilateral compared with unilateral percutaneous nephrolithotomy / E. Holman, A. Munim Khan, I. Pásztor, C. Tóth
Dátum:2002
ISSN:1464-4096
Megjegyzések:Objective To compare simultaneous bilateral percutaneous nephrolithotomy (SBPCNL) and unilateral PCNL in separate sessions in patients with bilateral renal stones for several variables before and after surgery.Patients and methods The results from SBPCNL carried out at two centres in different countries on 198 patients (aged 1.25?70 years) were compared with those from 300 patients undergoing unilateral PCNL in separate sessions. At one centre where extracorporeal shockwave lithotripsy (ESWL) was available SBPCNL was used for stones where at least two sessions of ESWL would have been required on each side. Other associated procedures were also used wherever required.Results The stones were cleared bilaterally in one session of SBPCNL in 190 patients; in eight, fragments of < 3 mm remained but were not clinically significant. A second session was required in six patients on one side only. Variables assessed before and after treatment (e.g. hospital stay, analgesia requirements and complications) were not significantly different between SBPCNL and PCNL. The mean (range) total operative duration for SBPCNL was 46 (20?100) min and the hospital stay 4.3 (3?8) days.Conclusion From this experience, SBPCNL is a cost-effective and beneficial solution for selected patients, with clear advantages over separate unilateral PCNL in patients with bilateral stones.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:British Journal of Urology. - 89 : 4 (2002), p. 334-338. -
További szerzők:Munim Khan, A. Pásztor Imre Tóth Csaba (1940-) (urológus, sebész)
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001-es BibID:BIBFORM040182
Első szerző:Horváth Katalin
Cím:A novel approach to the treatment of benign prostatic hyperplasia / Horvath Katalin, Walter Gyorgy, Varga Attila, Romics Imre
Dátum:2006
ISSN:1464-4096
Megjegyzések:OBJECTIVE:To assess the clinical efficacy and safety of the combined alpha1- and postsynaptic alpha2-blocker GYKI-16084 compared to placebo during a 28-day active treatment of patients with benign prostatic hyperplasia (BPH).PATIENTS AND METHODS:After a 28-day placebo run-in phase, 7.5 and 15 mg GYKI-16084 or placebo were administered twice daily for 28 days to patients with BPH in a randomized single-blind Phase II study. Efficacy was primarily determined by changes in the American Urological Association (AUA) symptom scores and maximum urinary flow (Q(max)), while safety was assessed by orthostatic changes and adverse-event profile. A simplified International Index of Erectile Function questionnaire was used to assess effects on erectile function.RESULTS:Data from 63 patients were evaluated; the decrease in the AUA score during the active phase was greater in the 15 mg group (-6.05, -32.7%) than in the placebo (-4.3, 22.7%) or 7.5 mg (-3.55, -19.5%) groups. Q(max) improved in both active treatment groups (+3.3 and +2.16 mL for the 7.5 and 15 mg groups, respectively) compared to placebo (+1.29 mL). None of the drug-related adverse events associated with selective alpha1-blockers were reported.CONCLUSION:The combined alpha1- and postsynaptically selective alpha2-blocker GYKI-16084 significantly improved the AUA symptom scores and increased Q(max) in patients with BPH, without inducing any adverse reaction, orthostatic changes or erectile dysfunction.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
benign prostatic hyperplasia
medical therapy
outcome
Megjelenés:Bju International. - 97 : 6 (2006), p. 1252-1255. -
További szerzők:Walter György Varga Attila (1949-) (urológus, andrológus) Romics Imre
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