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1.

001-es BibID:BIBFORM073532
Első szerző:Barok Márk (biofizikus)
Cím:Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation / Mark Barok, Maija Puhka, Gyorgy Vereb, Janos Szollosi, Jorma Isola, Heikki Joensuu
Dátum:2018
ISSN:1471-2407
Megjegyzések:Background: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) toHER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesizedthat exosome-bound T-DM1 may contribute to the activity of T-DM1.Methods: Exosomes were isolated from the cell culture medium of HER2-positive SKBR-3 and EFM-192A breast cancercells, HER2-positive SNU-216 gastric cancer cells, and HER2-negative MCF-7 breast cancer cells by serial centrifugationsincluding two ultracentrifugations, and treated with T-DM1. T-DM1 not bound to exosomes was removed using HER2-coated magnetic beads. Exosome samples were analyzed by electron microscopy, flow cytometry and Westernblotting. Binding of T-DM1-containing exosomes to cancer cells and T-DM1 internalization were investigated withconfocal microscopy. Effects of T-DM1-containg exosomes on cancer cells were investigated with the AlamarBluecell proliferation assay and the Caspase-Glo 3/7 caspase activation assay.Results: T-DM1 binds to exosomes derived from HER2-positive cancer cells, but not to exosomes derived fromHER2-negative MCF-7 cells. HER2-positive SKBR-3 cells accumulated T-DM1 after being treated with T-DM1-containgexosomes, and treatment of SKBR-3 and EFM-192A cells with T-DM1-containing exosomes resulted in growth inhibitionand activation of caspases 3 and/or 7.Conclusion: T-DM1 binds to exosomes derived from HER2-positive cancer cells, and T-DM1 may be carried toother cancer cells via exosomes leading to reduced viability of the recipient cells. The results suggest a new mechanismof action for T-DM1, mediated by exosomes derived from HER2-positive cancer.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Breast cancer
Trastuzumab-emtansine
T-DM1
HER2
Exosome
Megjelenés:Bmc Cancer. - 18 : 1 (2018), p. 504-516. -
További szerzők:Puhka, Maija Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus) Isola, Jorma Joensuu, Heikki
Pályázati támogatás:GINOP-2.3.2-15-2016-00020
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
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2.

001-es BibID:BIBFORM077341
Első szerző:De Smedt, J.
Cím:Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe) : a randomized controlled trial. / J. De Smedt, S. Van Kelst, V. Boecxstaens, M. Stas, K. Bogaerts, D. Vanderschueren, C. Aura, K. Vandenberghe, D. Lambrechts, P. Wolter, O. Bechter, A. Nikkels, T. Strobbe, G. Emri, V. Marasigan, M. Garmyn
Dátum:2017
ISSN:1471-2407 1471-2407
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:BMC Cancer. - 17 : 1 (2017), p. 1-10. -
További szerzők:Van Kelst, S. Boecxstaens, V. Stas, M. Bogaerts, K. Vanderschueren, D. Aura, Claudia Vandenberghe, K. Lambrechts, D. Wolter, P. Bechter, O. Nikkels, A. Strobbe, T. Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Marasigan, V. Garmyn, M.
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3.

001-es BibID:BIBFORM077342
035-os BibID:(WoS)000427102100007 (Scopus)85031696356
Első szerző:Krizkova, Sona
Cím:An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena / Sona Krizkova, Marta Kepinska, Gabriella Emri, Tomas Eckschlager, Marie Stiborova, Petra Pokorna, Zbynek Heger, Vojtech Adam
Dátum:2018
ISSN:1471-2407
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pharmacology and therapeutics. - 183 (2018), p. 90-117. -
További szerzők:Kepinska, Marta Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Eckschlager, Tomas Stiborova, Marie Pokorna, Petra Heger, Zbynek Vojtech, Adam
Pályázati támogatás:K105132
NKFIH
GINOP-2.3.2-15-2016-00005
GINOP
120206
NKFIH
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4.

001-es BibID:BIBFORM094421
Első szerző:László Brigitta (molekuláris biológus, mikrobiológus)
Cím:Coordinated Action of Human Papillomavirus Type 16 E6 and E7 Oncoproteins on Competitive Endogenous RNA (ceRNA) network members in Primary Human Keratinocytes / Brigitta László, László Antal, Eszter Gyöngyösi, Anita Szalmás, Szilárd Póliska, György Veress, József Kónya
Dátum:2021
ISSN:1471-2407
Megjegyzések:Background: miRNAs and lncRNAs can regulate cellular biological processes both under physiological and pathological conditions including tumour initiation and progression. Interactions between differentially expressed diverse RNA species, as a part of a complex intracellular regulatory network (ceRNA network), may contribute also to the pathogenesis of HPV-associated cancer. The purpose of this study was to investigate the global expression changes of miRNAs, lncRNAs and mRNAs driven by the E6 and E7 oncoproteins of HPV16, and construct a corresponding ceRNA regulatory network of coding and non-coding genes to suggest a regulatory network associated with high-risk HPV16 infections. Furthermore, additional GO and KEGG analyses were performed to understand the consequences of mRNA expression alterations on biological processes. Methods: Small and large RNA deep sequencing were performed to detect expression changes of miRNAs, lncRNAs and mRNAs in primary human keratinocytes expressing HPV16 E6, E7 or both oncoproteins. The relationships between lncRNAs, miRNAs and mRNAs were predicted by using StarBase v2.0, DianaTools-LncBase v.2 and miRTarBase. The lncRNA-miRNA-mRNA regulatory network was visualized with Cytoscape v3.4.0. GO and KEEG pathway enrichment analysis was performed using DAVID v6.8. Results: We revealed that 85 miRNAs in 21 genomic clusters and 41 lncRNAs were abnormally expressed in HPV E6/E7 expressing cells compared with controls. We constructed a ceRNA network with members of 15 lncRNAs ? 43 miRNAs ? 358 mRNAs with significantly altered expressions. GO and KEGG functional enrichment analyses identified numerous cancer related genes, furthermore we recognized common miRNAs as key regulatory elements in biological pathways associated with tumorigenesis driven by HPV16. Conclusions: The multiple molecular changes driven by E6 and E7 oncoproteins resulting in the malignant transformation of HPV16 host cells occur, at least in part, due to the abnormal alteration in expression and function of non-coding RNA molecules through their intracellular competing network.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Bmc Cancer. - 21 : 1 (2021), p. 673. -
További szerzők:Antal László (1984-) (hidrobiológus, biológus-ökológus) Gyöngyösi Eszter (1983-) (molekuláris biológus, mikrobiológus) Szalmás Anita (1978-) (biológus, mikrobiológus, klinikai mikrobiológus) Póliska Szilárd (1978-) (biológus) Veress György (1966-) (biológus, mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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5.

001-es BibID:BIBFORM116118
035-os BibID:(cikkazonosító)1082 (Scopus)85176043308
Első szerző:Lococo, Filippo
Cím:Correction : Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice : the LANTERN study / Filippo Lococo, Luca Boldrini, Charles-Davies Diepriye, Jessica Evangelista, Camilla Nero, Sara Flamini, Angelo Minucci, Elisa De Paolis, Emanuele Vita, Alfredo Cesario, Salvatore Annunziata, Maria Lucia Calcagni, Marco Chiappetta, Alessandra Cancellieri, Anna Rita Larici, Giuseppe Cicchetti, Esther G. C. Troost, Róza Ádány, Núria Farré, Ece Öztürk, Dominique Van Doorne, Fausto Leoncini, Andrea Urbani, Rocco Trisolini, Emilio Bria, Alessandro Giordano, Guido Rindi, Evis Sala, Giampaolo Tortora, Vincenzo Valentini, Stefania Boccia, Stefano Margaritora, Giovanni Scambia
Dátum:2023
ISSN:1471-2407
Tárgyszavak:Orvostudományok Klinikai orvostudományok hozzászólás
folyóiratcikk
Megjelenés:Bmc Cancer. - 23 : 1 (2023), p. 1-2. -
További szerzők:Boldrini, Luca Diepriye, Charles-Davies Evangelista, Jessica Nero, Camilla Flamini, Sara Minucci, Angelo Paolis, Elisa De Vita, Emanuele Cesario, Alfredo Annunziata, Salvatore Calcagni, Maria Lucia Chiappetta, Marco Cancellieri, Alessandra Larici, Anna Rita Cicchetti, Giuseppe Troost, Esther G. C. Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Farré, Núria Öztürk, Ece Doorne, Dominique Van Leoncini, Fausto Urbani, Andrea Trisolini, Rocco Bria, Emilio Giordano, Alessandro Rindi, Guido Sala, Evis Tortora, Giampaolo Valentini, Vincenzo Boccia, Stefania Margaritora, Stefano Scambia, Giovanni
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6.

001-es BibID:BIBFORM113116
035-os BibID:(cikkazonosító)540 (Scopus)85161949040 (WOS)000997803000001
Első szerző:Lococo, Filippo
Cím:Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice : the LANTERN study / Filippo Lococo, Luca Boldrini, Charles-Davies Diepriye, Jessica Evangelista, Camilla Nero, Sara Flamini, Angelo Minucci, Elisa De Paolis, Emanuele Vita, Alfredo Cesario, Salvatore Annunziata, Maria Lucia Calcagni, Marco Chiappetta, Alessandra Cancellieri, Anna Rita Larici, Giuseppe Cicchetti, Esther G. C. Troost, Ádány Róza, Núria Farré, Ece Öztürk, Dominique Van Doorne, Fausto Leoncini, Andrea Urbani, Rocco Trisolini, Emilio Bria, Alessandro Giordano, Guido Rindi, Evis Sala, Giampaolo Tortora, Vincenzo Valentini, Stefania Boccia, Stefano Margaritora, Giovanni Scambia
Dátum:2023
ISSN:1471-2407
Megjegyzések:Background The current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables (e.g., age, sex, TNM stage), new omics data have recently been introduced in clinical practice, thereby making more complex the decision-making process. With the advent of Artificial intelligence (AI) techniques, various omics datasets may be used to create more accurate predictive models paving the way for a better care in lung cancer patients. Methods The LANTERN study is a multi-center observational clinical trial involving a multidisciplinary consortium of five institutions from different European countries. The aim of this trial is to develop accurate several predictive models for lung cancer patients, through the creation of Digital Human Avatars (DHA), defined as digital representations of patients using various omics-based variables and integrating well-established clinical factors with genomic data, quantitative imaging data etc. A total of 600 lung cancer patients will be prospectively enrolled by the recruiting centers and multi-omics data will be collected. Data will then be modelled and parameterized in an experimental context of cutting-edge big data analysis. All data variables will be recorded according to a shared common ontology based on variable-specific domains in order to enhance their direct actionability. An exploratory analysis will then initiate the biomarker identification process. The second phase of the project will focus on creating multiple multivariate models trained though advanced machine learning (ML) and AI techniques for the specific areas of interest. Finally, the developed models will be validated in order to test their robustness, transferability and generalizability, leading to the development of the DHA. All the potential clinical and scientific stakeholders will be involved in the DHA development process. The main goals aim of LANTERN project are: i) To develop predictive models for lung cancer diagnosis and histological characterization; (ii) to set up personalized predictive models for individual-specific treatments; iii) to enable feedback data loops for preventive healthcare strategies and quality of life management. Discussion The LANTERN project will develop a predictive platform based on integration of multi-omics data. This will enhance the generation of important and valuable information assets, in order to identify new biomarkers that can be used for early detection, improved tumor diagnosis and personalization of treatment protocols.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Lung cancer
Artificial intelligence (AI)
Digital human avatars (DHA)
Personalize medicine
Machine learning
System medicine
Precision medicine
Genomics
Radiomics
Big data
Megjelenés:Bmc Cancer. - 23 : 1 (2023), p. 1-8. -
További szerzők:Boldrini, Luca Diepriye, Charles-Davies Evangelista, Jessica Nero, Camilla Flamini, Sara Minucci, Angelo Paolis, Elisa De Vita, Emanuele Cesario, Alfredo Annunziata, Salvatore Calcagni, Maria Lucia Chiappetta, Marco Cancellieri, Alessandra Larici, Anna Rita Cicchetti, Giuseppe Troost, Esther G. C. Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Farré, Núria Öztürk, Ece Doorne, Dominique Van Leoncini, Fausto Urbani, Andrea Trisolini, Rocco Bria, Emilio Giordano, Alessandro Rindi, Guido Sala, Evis Tortora, Giampaolo Valentini, Vincenzo Boccia, Stefania Margaritora, Stefano Scambia, Giovanni
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7.

001-es BibID:BIBFORM007204
Első szerző:Márkász László (gyermekgyógyász)
Cím:Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells / Markasz L., Stuber Gy., Flaberg E., Lernberg A. G., Eksborg S., Oláh É., Skribek H., Székely L.
Dátum:2006
Megjegyzések:Epstein-Barr virus (EBV) is the causative agent of immunosuppression associated lymphoproliferations such as post-transplant lymphoproliferative disorder (PTLD), AIDS related immunoblastic lymphomas (ARL) and immunoblastic lymphomas in X-linked lymphoproliferative syndrome (XLP). The reported overall mortality for PTLD often exceeds 50%. Reducing the immunosuppression in recipients of solid organ transplants (SOT) or using highly active antiretroviral therapy in AIDS patients leads to complete remission in 23-50% of the PTLD/ARL cases but will not suffice for recipients of bone marrow grafts. An additional therapeutic alternative is the treatment with anti-CD20 antibodies (Rituximab) or EBV-specific cytotoxic T-cells. Chemotherapy is used for the non-responding cases only as the second or third line of treatment. The most frequently used chemotherapy regimens originate from the non-Hodgkin lymphoma protocols and there are no cytotoxic drugs that have been specifically selected against EBV induced lymphoproliferative disorders. METHODS: As lymphoblastoid cell lines (LCLs) are well established in vitro models for PTLD, we have assessed 17 LCLs for cytotoxic drug sensitivity. After three days of incubation, live and dead cells were differentially stained using fluorescent dyes. The precise numbers of live and dead cells were determined using a custom designed automated laser confocal fluorescent microscope. RESULTS: Independently of their origin, LCLs showed very similar drug sensitivity patterns against 29 frequently used cytostatic drugs. LCLs were highly sensitive for vincristine, methotrexate, epirubicin and paclitaxel. CONCLUSION: Our data shows that the inclusion of epirubicin and paclitaxel into chemotherapy protocols against PTLD may be justified.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Epstein-Barr
Megjelenés:BMC Cancer [electronic resource]. - 13 : 6 (2006), p. 265. -
További szerzők:Stuber György Flaberg, Emilie Lernberg, Asa Gustafsson Eksborg, Staffan Oláh Éva (1943-2019) (gyermekgyógyász, klinikai genetikus) Skribek, Henriette Székely László
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8.

001-es BibID:BIBFORM049079
Első szerző:Ötvös Rita (vegyész)
Cím:Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines / Rita Ötvös, Henriette Skribek, Lorand L. Kis, Annunziata Gloghini, Laszlo Markasz, Emilie Flaberg, Staffan Eksborg, Jozsef Konya, Lajos Gergely, Antonino Carbone, Laszlo Szekely
Dátum:2011
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
HHV-8
Megjelenés:BMC Cancer [electronic resource]. - 11 (2011), p. 441. -
További szerzők:Skribek, Henriette Kis Lóránd Levente Gloghini, Annunziata Márkász László (1977-) (gyermekgyógyász) Flaberg, Emilie Eksborg, Staffan Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Carbone, Antonino Székely László
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