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001-es BibID:	BIBFORM063676
Első szerző:	Howlett, David R.
Cím:	Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias / David R. Howlett, David Whitfield, Mary Johnson, Johannes Attems, John T. O'Brien, Dag Aarsland, Mitchell K.P. Lai, Jasinda H. Lee, Christopher Chen, Clive Ballard, Tibor Hortobágyi, Paul T. Francis
Dátum:	2015
ISSN:	1015-6305
Megjegyzések:	Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterizedby the presence of ?-synuclein-containing Lewy bodies and Lewy neurites.However, both dementias also show variable degrees of Alzheimer's disease (AD) pathology(senile plaques and neurofibrillary tangles), particularly in areas of the cortex associatedwith higher cognitive functions. This study investigates the contribution of theindividual and combined pathologies in determining the rate of cognitive decline. Cortical?-synuclein, phosphorylated tau (phosphotau) and A? plaque pathology in 34 PDD and 55DLB patients was assessed semi-quantitatively in four regions of the neocortex. The declinein cognition, assessed by Mini Mental State Examination, correlated positively with thecortical ?-synuclein load. Patients also had varying degrees of senile A? plaque andphosphotau pathology. Regression analyses pointed to a combined pathology (A? plaqueplus phosphotau plus ?-synuclein-positive features), particularly in the prefrontal cortex(BA9) and temporal lobe neocortex with the superior and middle temporal gyrus (BA21,22), being a major determining factor in the development of dementia. Thus, cognitivedecline in Lewy body dementias is not a consequence of ?-synuclein-induced neurodegenerationalone but senile plaque and phosphorylated tau pathology also contribute tothe overall deficits.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Brain Pathology. - 25 : 4 (2015), p. 401-408. -
További szerzők:	Whitfield, David Johnson, Mary Attems, Johannes O'Brien, John Aarsland, Dag Lai, Mitchell K.P. Lee, Jasinda H. Chen, Christopher Ballard, Clive G. Hortobágyi Tibor (1965-) (patológus) Francis, Paul T.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM051598
035-os BibID:	PMID:23521156 WOS:000325608000002
Első szerző:	Howlett, David R.
Cím:	Clusterin associates specifically with Aβ40 in Alzheimer's disease brain tissue / David R. Howlett, Tibor Hortobágyi, Paul T. Francis
Dátum:	2013
ISSN:	1015-6305
Megjegyzések:	Genome-wide association studies have pointed to clusterin (apolipoprotein J) as being linked to the occurrence of Alzheimer's disease (AD); studies have identified the protein as a possible biomarker. The association between clusterin and senile plaques in AD brain is well known, and clusterin levels in AD brain are 40% higher than that in control subjects. The present study investigates, immunohistochemically, the association between clusterin and Aβ peptides in AD and control cortex. A unique and specific association between clusterin and Aβ40 was observed in plaques in the cerebral cortex from AD subjects in that only plaques that contained Aβ40 showed clusterin immunoreactivity, while the many plaques with Aβ42 alone lacked clusterin labeling. Cerebrovascular Aβ in AD brain generally lacked Aβ42 but was positively labeled by both the Aβ40 and the clusterin antibodies. In control subjects, however, Aβ40 was absent from plaques, although very occasional plaques were found to be labeled by both the Aβ42 and the clusterin antibodies. Overall, in AD, but not aged control brain, clusterin was associated specifically with the Aβ40 form of Aβ in the brain. The lack of clusterin in association with Aβ42 may be a significant feature in neuronal loss and neurodegeneration in the disease state.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Alzheimer's disease amyloid beta-protein apolipoprotein J biomarker clusterin
Megjelenés:	Brain Pathology. - 23 : 6 (2013), p. 623-632. -
További szerzők:	Hortobágyi Tibor (1965-) (patológus) Francis, Paul T.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM055444
Első szerző:	Jakab A. (orvos)
Cím:	Preoperative diffusion imaging-derived data in prediction of glioma grades / A. Jakab, E. Berenyi, P. P. Molnar
Dátum:	2010
ISSN:	1015-6305
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Brain Pathology. - 20 (2010), p. 63. -
További szerzők:	Berényi E. Molnár Péter Pál (1951-) (pathológus)
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001-es BibID:	BIBFORM055460
Első szerző:	Molnár Péter Pál (pathológus)
Cím:	Temporal and Topographical Changes of Blood-Brain Barrier Function in an Embolic Stroke Model / P. P. Molnár, W. Stoutenger, P. Behrens, D. R. Groothuis
Dátum:	2000
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:	Brain Pathology. - 10 (2000), p. 559-560. -
További szerzők:	Stoutenger, W. Behrens, P. Groothuis, Dennis
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