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1.

001-es BibID:BIBFORM029512
Első szerző:Bácskai Tímea (biológus, neurobiológus)
Cím:Primary afferent fibers establish dye-coupled connections in the frog central nervous system / Bácskai T., Matesz C.
Dátum:2002
ISSN:0361-9230
Megjegyzések:Neurobiotin and Lucifer yellow, indicators of gap junctional coupling, were applied to primary afferent fibers of the frog. Following application of tracers to cervical or lumbar dorsal root fibers, a large number of labeled granule cells were detected in the corpus cerebelli, the brainstem, and the spinal cord. The vestibular nerve was found to be in dye-coupled connection with the granule cells of the auricular lobe of the cerebellum. After application of the tracers to the trigeminal nerve, elicited dye-coupled neurons located mainly in the termination area of the descending limb of the mesencephalic trigeminal nucleus. In control experiments with biotinylated dextrane amine, only primary afferent fibers were labeled. Our results suggest that gap junctional coupling exists between primary afferent fibers and their postsynaptic targets in the frog.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin. - 57 : 3-4 (2002), p. 317-319. -
További szerzők:Matesz Klára (1949-) (anatómus, neurobiológus)
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2.

001-es BibID:BIBFORM004389
Első szerző:Bácskai Tímea (biológus, neurobiológus)
Cím:Dendrodendritic and dendrosomatic contacts between oculomotor and trochlear motoneurons of the frog, Rana esculenta / Tímea Bácskai, Gábor Veress, Gábor Halasi, Ádám Deák, Éva Rácz, György Székely, Clara Matesz
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin. - 75 : 2-4 (2008), p. 419-423. -
További szerzők:Veress Gábor (1971-) (neurobiológus) Halasi Gábor (1976-) (neurobiológus) Deák Ádám (1974-) (állatorvos) Rácz Éva (1982-) (biológus) Székely György (1926-2017) (neurobiológus) Matesz Klára (1949-) (anatómus, neurobiológus)
Internet cím:elektronikus változat
DOI
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3.

001-es BibID:BIBFORM049710
Első szerző:Brancati, Serena B.
Cím:Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats / Serena B. Brancatia, Zoltán S. Zádori, József Németh, Klára Gyires
Dátum:2013
ISSN:0361-9230
Megjegyzések:The aim of the present study was to analyze the potential role of substance P (SP) in gastric mucosaldefense and to clarify the receptors and mechanisms that may be involved in it. Gastric ulceration wasinduced by oral administration of acidified ethanol in male Wistar rats. Mucosal levels of calcitoningene-related peptide (CGRP) and somatostatin were determined by radioimmunoassay. For analysis ofgastric motor activity the rubber balloon method was used. We found that central (intracerebroventricular)injection of SP (9.3?74 pmol) dose-dependently inhibited the formation of ethanol-induced ulcers,while intravenously injected SP (0.37?7.4 nmol/kg) had no effect. The mucosal protective effect of SPwas inhibited by pretreatment with neurokinin 1-, neurokinin 2-, neurokinin 3- and -opioid receptorantagonists, while - and -opioid receptor antagonists had no effect. Endomorphin-2 antiserumalso antagonized the SP-induced mucosal protection. In the gastroprotective dose range SP failed toinfluence the gastric motor activity. Inhibition of muscarinic cholinergic receptors, or the synthesis ofnitric oxide or prostaglandins significantly reduced the effect of SP. In addition, centrally injected SPreversed the ethanol-induced reduction of gastric mucosal CGRP content. It can be concluded, that SPmay induce gastric mucosal protection initiated centrally. Its protective effect is likely to be mediated byendomorphin-2, and vagal nerve may convey the centrally initiated protection to the periphery, whereboth prostaglandins, nitric oxide and CGRP are involved in mediating this effect.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Calcitonin gene-related peptide Endomorphin Gastric ulcer Substance P Tachykinins
Megjelenés:Brain Research Bulletin. - 91 (2013), p. 38-45. -
További szerzők:Zádori Zoltán S. (Farmakológia, gasztrointesztinális farmakológia) Németh József (1954-) (vegyész, analitikus) Gyires Klára
Pályázati támogatás:75965
OTKA
TÁMOP-4.2.1/B-09/1/KMR-2010
TÁMOP
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4.

001-es BibID:BIBFORM036712
Első szerző:Farkas Szabolcs (orvos)
Cím:The decrease of dopamine D2/D3 receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB1 cannabinoid receptors in Parkinson's disease : a preliminary autoradiographic study with the selective dopamine D2/D3 antagonist [3H]raclopride and the novel CB1 inverse agonist [125I]SD7015 / Farkas Szabolcs, Nagy Katalin, Jia Zhisheng, Harkany Tibor, Palkovits Miklós, Donohou Sean R., Pike Victor W., Halldin Christer, Máthé Domokos, Csiba László, Gulyás Balázs
Dátum:2012
ISSN:0361-9230
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin. - 87 : 6 (2012), p. 504-510. -
További szerzők:Nagy Katalin (1960-) (orvosdiagnosztikai laboratóriumi analitikus) Jia, Zhisheng Harkány Tibor Palkovits Miklós Donohue, Sean Pike, Victor Halldin, Christer Máthé Domokos Csiba László (1952-) (neurológus, pszichiáter) Gulyás Balázs
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5.

001-es BibID:BIBFORM029353
Első szerző:Halasi Gábor (neurobiológus)
Cím:Connections of the superior vestibular nucleus with the oculomotor and red nuclei in the rat : an electron microscopic study / Halasi Gábor, Bácskai Timea, Matesz Klára
Dátum:2005
ISSN:0361-9230
Megjegyzések:Phaseolus vulgaris leucoagglutinin (PHA-L) was injected into the individual vestibular nuclei of the rat to study their efferent connections. One of the major differences between the connections of these nuclei was found at the level of the mesencephalon: the eye-moving cranial nerve nuclei received the densest projection from the superior vestibular nucleus (SVN). In the present electron microscopic study, we have found that terminals of SVN origin established symmetric synaptic contacts in the oculomotor nucleus. More than two-thirds of PHA-L-labeled boutons terminated on dendrites, the rest of them established axosomatic contacts. Most of the labeled terminals were GABA-positive, supporting the results of previous physiological experiments, which showed inhibitory effects. In the mesencephalon, the other termination area was found in the red nucleus. The PHA-L-labeled boutons of SVN origin were in close contact with the perikarya and proximal dendrites of the magnocellular part of the red nucleus. The types of synaptic contacts and distribution of terminals of SVN origin were similar to those found in the oculomotor nucleus. Our results indicate that the SVN can modify the activity of the cerebellorubral and corticorubral pathways, exerting inhibitory action on the neurons of the red nucleus.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin. - 66 : 4-6 (2005), p. 532-535. -
További szerzők:Bácskai Tímea (1974-) (biológus, neurobiológus) Matesz Klára (1949-) (anatómus, neurobiológus)
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6.

001-es BibID:BIBFORM018458
Első szerző:Kecskeméti Valéria
Cím:Norfluoxetine and fluoxetine have similar anticonvulsant and Ca channel blocking potencies / Kecskeméti V., Rusznák Z., Riba P., Pál B., Wagner R., Harasztosi C., Nánási P. P., Szűcs G.
Dátum:2005
ISSN:0361-9230
Megjegyzések:Norfluoxetine is the most important active metabolite of the widely used antidepressant fluoxetine but little is known about its pharmacological actions. In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models. Pretreatment with fluoxetine or norfluoxetine (20 mg/kg s.c.), as well as phenytoin (30 mg/kg s.c.) and clonazepam (0.1 mg/kg s.c.) significantly increased both the rate and duration of survival, demonstratinga significant protective effect against pentylenetetrazol-induced epilepsy. These effects of norfluoxetine were similar to those of fluoxetine. According to the calculated combined protection scores, both norfluoxetine and fluoxetine were effective from the concentration of 10 mg/kg,while the highest protective action was observed with clonazepam. Effects of norfluoxetine and fluoxetine on voltage-gated Ca2+ channels were evaluated by measuring peak Ba2+ current flowing through the Ca2+ channels upon depolarization using whole cell voltage clamp in enzymatically isolated rat cochlear neurons. The current was reduced equally in a concentration-dependent manner by norfluoxetine (EC50 = 20.4?2.7M, Hill coefficient = 0.86?0.1) and fluoxetine(EC50 = 22.3?3.6M, Hill coefficient = 0.87?0.1). It was concluded that the efficacy of the two compounds in neuronal tissues was equal, either in preventing seizure activity or in blockingthe neuronal Ca2+ channels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Fluoxetine
Norfluoxetine
Anticonvulsants
Neuronal Ca2+ currents
Voltage clamp
Megjelenés:Brain Research Bulletin. - 67 : 1-2 (2005), p. 126-132. -
További szerzők:Rusznák Zoltán (1965-) (élettanász) Riba Pál Pál Balázs (1975-) (élettanász) Wagner Róbert Harasztosi Csaba Nánási Péter Pál (1956-) (élettanász) Szűcs Géza (1948-) (élettanász)
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7.

001-es BibID:BIBFORM048875
035-os BibID:PMID:24076270
Első szerző:Kecskés Szilvia (anatómus, neurobiológus)
Cím:Termination of trigeminal primary afferents on glossopharyngeal-vagal motoneurons : possible neural networks underlying the swallowing phase and visceromotor responses of prey-catching behavior / Szilvia Kecskes, Clara Matesz, András Birinyi
Dátum:2013
ISSN:0361-9230
Megjegyzések:Prey-catching behavior (PCB) of the frog consists of a sequence of coordinated activity of muscles which is modified by various sensory signals. The aim of the present study was, for the first time, to examine the involvement of the trigeminal afferents in the swallowing phase of PCB. Experiments were performed on Rana esculenta, where the trigeminal and glossopharyngeal (IX)-vagus (X) nerves were labeled simultaneously with different fluorescent dyes. Using confocal laser scanning microscope, close appositions were detected between the trigeminal afferent fibers and somatodendritic components of the IX-X motoneurons of the ambiguus nucleus (NA). Neurolucida reconstruction revealed spatial distribution of the trigeminal afferents in the functionally different parts of the NA. Thus, the visceromotor neurons supplying the stomach, the heart and the lung received about two third of the trigeminal contacts followed by the pharyngomotor and then by the laryngomotor neurons. On the other hand, individual motoneurons responsible for innervation of the viscera received less trigeminal terminals than the neurons supplying the muscles of the pharynx. The results suggest that the direct contacts between the trigeminal afferents and IX-X motoneurons presented here may be one of the morphological substrate of a very quick response during the swallowing phase of PCB. Combination of direct and indirect trigeminal inputs may contribute to optimize the ongoing motor execution.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Nucleus ambiguus
Brainstem
Neuronal labeling
Neurolucida reconstruction
Megjelenés:Brain Research Bulletin. - 99C (2013), p. 109-116. -
További szerzők:Matesz Klára (1949-) (anatómus, neurobiológus) Birinyi András (1960-) (anatómus, neurobiológus)
Pályázati támogatás:K-67641
OTKA
MTA-TKI-11008
Egyéb
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8.

001-es BibID:BIBFORM009078
Első szerző:Lai, Henry H.
Cím:Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder / Lai, H. H., Smith, C. P., Munoz, A., Boone, T. B., Szigeti, G. P., Somogyi, G. T.
Dátum:2008
ISSN:1873-2747 (Electronic)
Megjegyzések:In the present study, the plasticity of the non-adrenergic non-cholinergic (NANC) response was investigated. Isolated rat bladder strips were electrically stimulated and the evoked contractions were isometrically recorded. The NANC part of the contractions were unmasked by applying 500 nM 4-DAMP, a potent muscarinic antagonist. Treatment of the bladder strips with 10 microM carbachol (a cholinergic agonist) increased the muscle tone but did not alter the neurally evoked contractions. However, carbachol decreased: (1) the NANC response from 74.6% to 33.3% of control and (2) the purinergic contractile response to alpha,beta-methylene ATP (alpha,beta-mATP) (10 microM) from 97.0% to 43.4% (p<0.05). Treatment with the cholinesterase inhibitor eserine (10 microM) also significantly decreased the NANC response to 21.1% (p<0.0001). The purinergic receptor antagonist suramin (100 microM) did not affect the neurally evoked contractions, however; subsequent addition of 4-DAMP decreased the contractions to 31%. Activation of the smooth muscle cholinergic receptors (with carbachol or eserine) and purinergic receptors (with alpha,beta-mATP) decreased the NANC contractions and the direct contractile response to alpha,beta-mATP. When the electrically evoked contractions were facilitated by the L-type Ca2+ channel activator, Bay-K 8644 the subsequent application of 4-DAMP did not unmask inhibited NANC contractions. We conclude that activation of muscarinic receptors by cholinergic agonist, carbachol or by endogenous acetylcholine (ACh) induce a cascade of events that leads to diminished purinergic response and consequently an inhibition of the bladder NANC response.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
3-Pyridinecarboxylic acid,
1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl
ester
Adenosine Triphosphate
Animals
Antineoplastic Agents
Atropine
Calcium Channel Agonists
Carbachol
Cholinergic Agonists
Cholinesterase Inhibitors
Electric Stimulation
Female
Muscarinic Antagonists
Muscle Contraction
Muscle Relaxation
Muscle, Smooth
Physostigmine
Piperidines
Rats
Rats, Sprague-Dawley
Receptors, Cholinergic
Suramin
Urinary Bladder
Megjelenés:Brain Research Bulletin. - 77 (2008), p. 420-426. -
További szerzők:Smith, Christopher P. Munoz, Alvaro Boone, Timothy B. Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Somogyi George T.
Internet cím:DOI
elektronikus változat
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9.

001-es BibID:BIBFORM029514
Első szerző:Matesz Klára (anatómus, neurobiológus)
Cím:Efferent connections of the vestibular nuclei in the rat : a comparative neuromorphological study / Matesz K., Bácskai T., Nagy É., Halasi G., Kulik Á.
Dátum:2002
ISSN:0361-9230
Megjegyzések:The efferent connections of the superior, medial, lateral, and descending vestibular nuclei were studied with anterograde tracing methods in rats. The following areas of termination could be discerned: (1) In the diencephalon, labeled terminals were detected in the thalamus. (2) In the mesencephalon, the red nucleus and motor nuclei involved in eye movements were richly supplied by the vestibular nuclei. (3) In the rhombencephalon, extensive intrinsic connections of all vestibular nuclei were demonstrated. Strong commissural connections were found among the medial, superior, and descending vestibular nuclei. The inferior olive received labeled fibers exclusively from the lateral vestibular nuclei. Individual differences were demonstrated in the termination areas in the reticular formation. (4) In the spinal cord, most of the descending vestibular fibers were found in the ipsilateral anterior funiculus.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin. - 57 : 3-4 (2002), p. 313-315. -
További szerzők:Bácskai Tímea (1974-) (biológus, neurobiológus) Nagy É. Halasi Gábor (1976-) (neurobiológus) Kulik Ákos
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10.

001-es BibID:BIBFORM015603
035-os BibID:16144643
Első szerző:Matesz Klára (anatómus, neurobiológus)
Cím:Extracellular matrix molecules and their possible roles in the regeneration offrog nervous system / Clara Matesz, Laszlo Modis, Gabor Halasi, Zsuzsa M. Szigeti, Szabolcs Felszeghy, Timea Bacskai, Gyorgy Szekely
Dátum:2005
ISSN:0361-9230 (Linking)
Megjegyzések:Recent biochemical and histochemical analyses explored different components ofthe extracellular matrix (ECM) in the nervous system, and either permissive ornon-permissive roles in neuronal development and regeneration were suggested. Theaim of this study was to detect the distribution pattern of a few of thesemolecules in the nervous system of intact frogs and during nerve regeneration.The hyaluronan (HA) and tenascin C reactions were negative in the peripheralnerves, but appeared in their entry zones. In the CNS, different populations ofneurons were surrounded with HA and tenascin C-positive material, forming aperineuronal net (PN). The phosphacan reaction was weakly positive in the PNS,and a moderate intensity was detected in the entry zone and in the PN. Lamininand fibronectin immunoreactivity was strong in the PNS, but laminin could not bedetected in the CNS. In animals with cut and regenerating vestibulocochlearnerve, the distribution of the ECM molecules in the CNS and PNScharacteristically changed from that of the normal pattern. Our results showed anon-homogenous distribution of ECM components in the frog nervous system thatcould be associated with their different roles in physiological and pathologicalprocesses.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
0 (Fibronectins)
0 (Laminin)
0 (Tenascin)
9004-61-9 (Hyaluronic Acid)
Animals
Axotomy/methods
Extracellular Matrix/*physiology
Fibronectins/metabolism
Hyaluronic Acid/metabolism
Immunohistochemistry/methods
Laminin/metabolism
Nerve Regeneration/*physiology
Nervous System/cytology/*metabolism
Neurons/metabolism
Rana esculenta
Tenascin/metabolism
Time Factors
egyetemen (Magyarországon) készült közlemény
Vestibulocochlear Nerve/injuries/physiology
Megjelenés:Brain research bulletin. - 66 : 4-6 (2005), p. 526-531. -
További szerzők:Módis László (1939-) (anatómus, kötőszövetbiológus) Halasi Gábor (1976-) (neurobiológus) Máthéné Szigeti Zsuzsa (1976-) (biológus-ökológus) Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Bácskai Tímea (1974-) (biológus, neurobiológus) Székely György (1926-2017) (neurobiológus)
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elektronikus változat
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11.

001-es BibID:BIBFORM004388
Első szerző:Matesz Klára (anatómus, neurobiológus)
Cím:Vestibulotrigeminal pathways in the frog, Rana esculenta / Clara Matesz, Gabriella Kovalecz, Gábor Veress, Ádám Deák, Éva Rácz, Tímea Bácskai
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research Bulletin. - 75 : 2-4 (2008), p. 371-374. -
További szerzők:Kovalecz Gabriella (1973-) (fogszakorvos) Veress Gábor (1971-) (neurobiológus) Deák Ádám (1974-) (állatorvos) Rácz Éva (1982-) (biológus) Bácskai Tímea (1974-) (biológus, neurobiológus)
Internet cím:elektronikus változat
DOI
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12.

001-es BibID:BIBFORM004166
Első szerző:Mészár Zoltán Mihály (agrármérnök)
Cím:Hyaluronan accumulates around differentiating neurons in spinal cord of chicken embryos / Zoltán Mészár, Szabolcs Felszeghy, Gábor Veress, Klára Matesz, György Székely, László Módis
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Brain Research Bulletin 75 : 2-4 (2008), p. 414-418. -
További szerzők:Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Veress Gábor (1971-) (neurobiológus) Matesz Klára (1949-) (anatómus, neurobiológus) Székely György (1926-2017) (neurobiológus) Módis László (1939-) (anatómus, kötőszövetbiológus)
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