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1.

001-es BibID:BIBFORM019560
Első szerző:Aleksza Magdolna
Cím:Increased frequency of intracellular interleukin (IL)-13 and IL-10, but not IL-4, expressing CD4+ and CD8+ peripheral T cells of patients with atopic dermatitis / M. Aleksza, B. Irinyi, A. Lukács, P. Antal-Szalmás, J. Hunyadi, A. Szegedi
Dátum:2002
Megjegyzések:Background A number of studies exist demonstrating the increased expression of type 2 cytokinesand decreased capacity to produce interferon-c (IFN-c) in peripheral blood mononuclear cells(PBMCs) of patients with atopic dermatitis (AD).Objectives To clarify the results of recent studies concerning the role of interleukin (IL)-4 and IL-13in PBMCs of AD patients, we analysed the activation status of lymphocyte subpopulations.Methods We measured the intracellular expression and serum levels of certain type 1 and type 2cytokines, using cell surface and intracellular cytokine staining, flow cytometry and enzyme-linkedimmunosorbent assay techniques.Results The frequency of IL-10 and IL-13 producing CD4+ and CD8+ T cells was significantlyhigher in patients with AD, while the frequency of IFN-c secreting helper and cytotoxic T cells wassignificantly lower in patients with AD than in control subjects. The serum levels of IL-10 and IL-13were also significantly increased. There were no significant differences observed between theexperimental groups in the frequency of IL-4 producing CD4+ and CD8+ cells.Conclusions This study demonstrates a type 2 cytokine production in the CD4+ and CD8+ T cellsof AD patients, which is characterized by an elevated IL-13, but not by IL-4 secretion, and by anincreased level of the immunoregulatory IL-10, which can contribute to a decrease in IFN-cexpression.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
atopic dermatitis
CD4+ cells
CD8+ cells
flow cytometry
interleukin-4
interleukin-13
Megjelenés:British Journal of Dermatology. - 147 : 6 (2002), p. 1135-1141. -
További szerzők:Irinyi Beatrix (1972-) (bőrgyógyász, allergológus) Lukács A. Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Szegedi Andrea (1964-) (bőrgyógyász)
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2.

001-es BibID:BIBFORM071209
Első szerző:Al-Nuaimi, Yusur
Cím:Clock genes modulate the human hair cycle : period1 knock-down in human hair follicle organ culture prolongs anagen / Al-Nuaimi Y., Klatte J. E., Toth B. I., Watson R. E. B., Biro T., Paus R.
Dátum:2010
ISSN:0007-0963
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:British Journal of Dermatology 162 : 4 (2010), p. 914. -
További szerzők:Klatte, J. E. Tóth István Balázs (1978-) (élettanász) Watson, Rachel E. B. Bíró Tamás (1968-) (élettanász) (absztraktok) Paus, Ralf
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3.

001-es BibID:BIBFORM084530
035-os BibID:(WoS)000383620000028 (Scopus)84987814942
Első szerző:Bertolini, Marta
Cím:Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse / Bertolini M., Pretzlaff M., Sulk M., Bähr M., Gherardini J., Uchida Y., Reibelt M., Kinori M., Rossi A., Bíró T., Paus R.
Dátum:2016
ISSN:0007-0963 1365-2133
Megjegyzések:Background Alopecia areata (AA) is an autoimmune disorder whose pathogenesisinvolves the collapse of the relati ve immune privilege (IP) of the hair follicle(HF). Given that vasoactive intestinal peptide (VIP) is an immunoinhibitory neu-ropeptide released by perifollicular sensory nerve ?bres, which play a role in IPmaintenance, it may modulate human HF-IP and thus be therapeutically relevantfor AA.Objectives To answer the following questions: Do human HFs express VIP recep-tors, and does their stimulation protect from or restore experimentally inducedHF-IP collapse? Is VIP signalling defective in AA HFs?Methods Firstly, VIP and VIP receptor (VPAC1, VPAC2) expression in human scalpHFs and AA skin was assessed. In HF organ culture, we then explored whetherVIP treatment can restore and/or protect from interferon-c-induced HF-IP col-lapse, assessing the expression of the key IP markers by quantitative (immuno-)histomorphometry.Results Here we provide the ?rst evidence that VIP receptors are expressed in theepithelium of healthy human HFs at the gene and protein level. Furthermore,VIP receptor protein expression, but not VIP+nerve ?bres, is signi?cantly down-regulated in lesional hair bulbs of patients with AA, suggesting defects in VIPreceptor-mediated signalling. Moreover, we show that VIP protects the HF fromexperimentally induced IP collapse in vitro, but does not fully restore it once col-lapsed.Conclusions These pilot data suggest that insuf?cient VIP receptor-mediated sig-nalling may contribute to impairing HF-IP in patients with AA, and that VIP is apromising candidate ♭HF-IP guardian' that may be therapeutically exploited toinhibit the progression of AA lesions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:British Journal Of Dermatology. - 175 : 3 (2016), p. 531-541. -
További szerzők:Pretzlaff, M. Sulk, M. Bähr, M. Gherardini, Jennifer Uchida, Yohei Reibelt, M. Kinori, M. Rossi, A. Bíró Tamás (1968-) (élettanász) Paus, Ralf
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4.

001-es BibID:BIBFORM055572
Első szerző:Bíró Tamás (élettanász)
Cím:Human sebocytes : the new leptin connection? / T. Bíró
Dátum:2014
ISSN:0007-0963
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztőségi anyag
Megjelenés:British Journal of Dermatology. - 171 : 6 (2014), p. 1288. -
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5.

001-es BibID:BIBFORM038886
035-os BibID:PMID:11903236
Első szerző:Farkas Beatrix
Cím:Terbinafine (Lamisil) treatment of toenail onychomycosis in patients with insulin-dependent and non-insulin-dependent diabetes mellitus : a multicentre trial / B. Farkas, C. Paul, A. Dobozy, J. Hunyadi, A. Horvath, G. Fekete
Dátum:2002
ISSN:0007-0963
Megjegyzések:bibEBI12921 újratöltveBackground Diabetes mellitus (DM) affects an estimated 175 million people world-wide.Approximately one-third of patients with DM have toenail onychomycosis.Objectives To determine the ef?cacy and safety of terbina?ne treatment of toenail onychomycosis inpatients with DM receiving insulin and ? or oral antidiabetic agents. Special interest was focused onpotential drug interactions with oral hypoglycaemic substances.Methods In a multicentre trial, patients suffering from insulin-dependent DM (IDDM) or noninsulin-dependent DM (NIDDM) with toenail onychomycosis were treated for 12 weeks with oralterbina?ne 250 mg daily and followed up to 48 weeks. In addition to clinical, mycological andlaboratory investigations, blood glucose levels were monitored.Results At the end of the trial (week 48), a mycological cure rate of 73% was achieved. The ratesof clinical cure and complete cure (mycological cure plus clinical cure) were 57% and 48%,respectively. There was no statistically signi?cant difference between the NIDDM and IDDM groupswith respect to the cure rates (P > 0á05). No hypoglycaemic episode was reported and none of thepatients had hypoglycaemia during the treatment phase.Conclusions With excellent cure rates and a good tolerability pro?le, terbina?ne should continue tobe a drug of choice for the treatment of
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:The British Journal of Dermatology. - 146 : 2 (2002), p. 254-260. -
További szerzők:Paul, C. Dobozy A. Horváth A. Fekete G. Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus)
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6.

001-es BibID:BIBFORM055571
Első szerző:Fischer, T. W.
Cím:Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and TGF-β2-/IGF-1-mediated regulation of hair cycle in male and female human hair follicles in vitro / T. W. Fischer, E. Herczeg-Lisztes, W. Funk, D. Zillikens, T. Bíró, R. Paus
Dátum:2014
ISSN:0007-0963
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Dermatology. - 171 : 5 (2014), p. 1031-1043. -
További szerzők:Lisztes Erika (1986-) (élettanász) Funk, W. Zillikens, D. Bíró Tamás (1968-) (élettanász) Paus, Ralf
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7.

001-es BibID:BIBFORM100570
035-os BibID:(WoS)000728557700001 (Scopus)85120320631
Első szerző:Goebeler, M.
Cím:Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor : a phase II multicentre, open-label feasibility trial / Goebeler M., Bata-Csörgő Z., De Simone C., Didona B., Remenyik E., Reznichenko N., Stoevesandt J., Ward E. S., Parys W., Haard H., Dupuy P., Verheesen P., Schmidt E., Joly P., ARGX-113-1701 Investigator Study Group
Dátum:2022
ISSN:0007-0963 1365-2133
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:British Journal Of Dermatology. - 186 : 3 (2022), p. 429-439. -
További szerzők:Bata-Csörgő Zsuzsanna De Simone, C. Didona, B. Remenyik Éva (1956-) (bőrgyógyász) Reznichenko, N. Stoevesandt, J. Ward, E. S. Parys, W. Haard, H. Dupuy, P. Verheesen, P. Schmidt E. Joly, P. ARGX-113-1701 Investigator Study Group
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8.

001-es BibID:BIBFORM038687
Első szerző:Gyimesi Edit (klinikai biokémikus, vegyész)
Cím:Basophil CD63 expression assay on highly sensitized atopic donor leucocytes-a useful method in chronic autoimmune urticaria / E. Gyimesi, S. Sipka, K. Dankó, E. Kiss, B. Hídvégi, M. Gál, J. Hunyadi, B. Irinyi, A. Szegedi
Dátum:2004
ISSN:0007-0963
Megjegyzések:AbstractBACKGROUND: The autoimmune subclass of chronic idiopathic urticaria (CU) has been characterized by the occurrence of biologically relevant IgG antibodies against the IgE molecule or the alpha chain of the high-affinity Fcepsilon receptor (FcepsilonRIalpha) on basophils and mast cells. These antibodies are usually detected by autologous serum skin testing and confirmed by histamine release studies, immunoblotting, or enzyme-linked immunosorbent assay, but not always.OBJECTIVES: To detect autoantibodies to the FcepsilonRIalpha in sera of CU patients by a modified serum-induced basophil activation test measured by flow cytometry (FCM) and to evaluate the relationship between the in vitro functional test, the autologous serum skin test (ASST), and the serum levels of IgE, eosinophil cationic protein (ECP) and antithyroid antibodies.METHODS: Sera of 30 patients with CU and 26 patients with systemic autoimmune diseases (systemic lupus erythematosus, dermatomyositis) were tested for CD63 activation marker expression on basophils by FCM. Leucocytes from two highly sensitized atopic donors (D(A1,) D(A2)) and one non-atopic donor (D(NA)) were incubated with patients' sera and double-labelled with anti-IgE and anti-CD63 antibodies. Subsequently, the percentage of CD63-expressing basophils was determined by using FCM. In all CU patients an ASST was carried out and the serum IgE, and ECP levels and antithyroid antibodies were evaluated.RESULTS: Twelve patients had a positive ASST and 14 patients a positive CD63 expression assay. There was a strong correlation between the ASST and CD63 assay. Sera from patients with systemic autoimmune diseases did not raise positive CD63 expression on basophils. There was a moderate negative correlation between the occurrence of atopic serum markers (IgE, ECP) and the ability of sera to induce CD63 expression on basophil cells of D(A2) (P < 0.05). The female sex was preponderant and antithyroid antibodies were more frequent.CONCLUSIONS: Our new technical observation demonstrates that basophils of highly sensitized atopic donors can be successfully used without priming with IL-3 for the in-vitro flow cytofluorimetric diagnosis of CU. With this investigation the characterization of the autoimmune origin of CU is based on an objective in vitro technique.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
autoimmune urticaria
CD63 assay
basophil
diagnosis
egyetemen (Magyarországon) készült közlemény
Megjelenés:British Journal of Dermatology. - 151 : 2 (2004), p. 388-396. -
További szerzők:Sipka Sándor (1945-) (laboratóriumi szakorvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Kiss Emese (1960-) (belgyógyász, immunológus) Hidvégi Bernadett Gál Mónika Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Irinyi Beatrix (1972-) (bőrgyógyász, allergológus) Szegedi Andrea (1964-) (bőrgyógyász)
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9.

001-es BibID:BIBFORM039247
Első szerző:Havlickova, Blanka
Cím:Towards optimization of an organotypic assay system that imitates human hair follicle-like epithelial-mesenchymal interactions / Havlickova, B., Biro, T., Mescalchin, A., Arenberger, P., Paus, R.
Dátum:2004
ISSN:0007-0963
Megjegyzések:Human hair growth can currently be studied in vitro by the use of organ-cultured scalp hair follicles (HFs). However, simplified organotypic systems are needed for dissecting the underlying epithelial-mesenchymal interactions and as screening tools for candidate hair growth-modulatory agents. OBJECTIVES: To optimize the design and culture conditions of previously published organotypic systems that imitate epithelial-mesenchymal interactions in the human HF as closely as possible. MATERIALS AND METHODS: Continuous submerged organotypic 'sandwich' cultures were established. These consist of a pseudodermis (collagen I mixed with and contracted by human interfollicular dermal fibroblasts) on which one of two upper layers is placed: either a mixture of Matrigel basement membrane matrix (BD Biosciences, Bedford, MA, U.S.A.) and follicular dermal papilla fibroblasts (DPC), with outer root sheath keratinocytes (ORSK) layered on the top ('layered' system), or a mixture of Matrigel, DPC and ORSK ('mixed' system). Morphological and functional characteristics of these 'folliculoid sandwiches' were then assessed by routine histology, histomorphometry and immunohistochemistry. RESULTS: In both 'layered' and 'mixed' systems, the ORSK formed spheroid epithelial cell aggregates, which retained their characteristic keratin expression pattern (i.e. cytokeratin 6). In the 'mixed' sandwich model the size of the epithelial cell aggregates was smaller, but the numbers of ORSK were significantly higher than in the 'layered' model at day 14 in the culture. ORSK proliferated better in the 'mixed' than in the 'layered' sandwich system, regardless of the calcium or serum content of the media, whereas apoptosis of ORSK was lowest in the 'mixed' system in serum-free, low calcium medium. The kinetics of proliferation and apoptosis of DPC, which retained their characteristic expression of versican, were similar in both systems. However, proliferation and apoptosis of DPC were higher in the presence of serum and/or under high calcium conditions. CONCLUSIONS: Our results underscore the importance of structural design and medium composition for epithelial-mesenchymal interactions as they occur in the human HF. Specifically, we report a new organotypic submerged 'folliculoid sandwich' system with serum-free, low calcium medium and a mixture of interacting human DPC and ORSK, which offers several advantages over previously available assays. This system allows the standardized assessment of the effects of a test agent on the proliferation, apoptosis and key marker expression of human ORSK and DPC under substantially simplified in vitro conditions which approximate the in vivo situation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Dermatology. - 151 : 4 (2004), p. 753-765. -
További szerzők:Bíró Tamás (1968-) (élettanász) Mescalchin, Alessandra Arenberger, P. Paus, Ralf
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10.

001-es BibID:BIBFORM039260
Első szerző:Holub, B. S.
Cím:The neuropeptide galanin is a novel inhibitor of human hair growth / Holub B. S., Kloepper J. E., Tóth B. I., Bíro T., Kofler B., Paus R.
Dátum:2012
ISSN:0007-0963
Megjegyzések:BACKGROUND: Galanin is a trophic factor of the central and peripheral nervous system that shows widespread distribution in human skin. However, the exact localization and the role of galanin in the hair follicle (HF) remain to be clarified. OBJECTIVES: To characterize galanin expression in human scalp HFs and to examine the effects of galanin on normal human scalp HF growth in organ culture. METHODS: Immunohistochemistry was performed on cryosections of human female scalp skin. Anagen HFs were microdissected and cultured up to 9 days and treated with 100 nmol L(-1) galanin. Staining for Ki-67, TUNEL and Masson-Fontana were used to analyse proliferation, apoptosis and hair cycle staging of the HFs. Functional effects of galanin were tested in serum-free HF organ culture. RESULTS: Galanin-like immunoreactivity was detected in the outer root sheath (ORS) and inner root sheath. Additionally, galanin mRNA was detected in ORS keratinocytes and all HF samples tested. Galanin receptor transcripts (GalR2, GalR3) were also detected in selected samples. Galanin reduced proliferation of hair matrix keratinocytes in situ compared with vehicle-treated controls, shortened the hair growth phase (anagen) in vitro and reduced hair shaft elongation. This was accompanied by the premature development of a catagen-like morphology of galanin-treated HFs. CONCLUSIONS: We present the first evidence that human HFs are both a source and a functionally relevant target of galanin. Due to its hair growth-inhibitory properties in vitro, galanin application deserves further exploration as a potential new treatment strategy for unwanted hair growth (hirsutism, hypertrichosis).
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Dermatology. - 167 : 1 (2012), p. 10-16. -
További szerzők:Kloepper, Jennifer E. Tóth István Balázs (1978-) (élettanász) Bíró Tamás (1968-) (élettanász) Kofler, Barbara Paus, Ralf
Pályázati támogatás:Austrian Research Promotion Agency FFG
Egyéb
822782/THERAPEP
Egyéb
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11.

001-es BibID:BIBFORM038648
035-os BibID:PMID:22834727
Első szerző:Irinyi Beatrix (bőrgyógyász, allergológus)
Cím:Extended diagnostic value of autologous serum skin test and basophil CD63 expression assay in chronic urticaria / B. Irinyi, E. Gyimesi, E. Garaczi, Zs. Bata, L. Kemény, M. Zeher, E. Remenyik, A. Szegedi
Dátum:2013
ISSN:0007-0963
Megjegyzések:Chronic urticaria (CU) is characterised by the occurrence of widespread, short-lived weals, appearing daily or almost daily for at least 6 weeks. (1) There has been strong evidence supporting an autoimmune basis of the disease in approximately 27-50% of CU patients, who have functional autoantibodies against the high affinity IgE receptor and/or IgE. (1) A correct diagnosis of autoimmune CU (ACU) is difficult but important because of the presence of more severe clinical symptoms. Currently, autologous serum skin test (ASST) serves as a screening method, after which more adequate confirmation is gained through functional assays, to identify the ACU group.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
chronic urticaria
CD63
autologous serum skin test
diagnostic value
egyetemen (Magyarországon) készült közlemény
Megjelenés:British Journal of Dermatology 168 : 3 (2013), p. 656-658. -
További szerzők:Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Garaczi Edina Bata Zsuzsanna Kemény L. Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Remenyik Éva (1956-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász)
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12.

001-es BibID:BIBFORM003914
Első szerző:Koch, C.
Cím:Docosahexaenoic acid (DHA) supplementation in atopic eczema : a randomized, double-blind, controlled trial / Koch, C., Dölle, S., Metger, M., Rasche, C., Jungclas, H., Rühl, R., Renz, H., Worm, M.,
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The British Journal of Dermatology. - 158 : 4 (2008), p. 786-792. -
További szerzők:Dölle, S. Metger, M. Rasche, C. Jungclas, H. Rühl, Ralph (1969-) (vegyész) Renz, H. Worm, Margitta
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