CCL

Összesen 34 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM070903
Első szerző:Ambrus Lídia (élettanász)
Cím:Human podocytes express functional thermosensitive transient receptor potential vanilloid (TRPV) channels / Lídia Ambrus, Balázs Kelemen, Tamás Szabó, Tamás Bíró, Balázs István Tóth
Dátum:2017
ISSN:0007-1188
Megjegyzések:BACKGROUND AND PURPOSEHeat sensitive transient receptor potential vanilloid (TRPV) channels are expressed in various epithelial tissues regulating, among else, barrier functions. Their expression is well established in the distal nephron; however, we have no data about their presence in podocytes. Since podocytes are indispensable in the formation of the glomerular filtration barrier, we investigated the presence and function of Ca2+-permeable TRPV1-4 channels in human podocyte cultures.EXPERIMENTAL APPROACHThe expression of TRPV1-4 was investigated at protein (immunocytochemistry, western blot) and mRNA (Q-PCR) level in a conditionally immortalized human podocyte cell line. The channel functionality was assessed by measuring intracellular Ca2+ concentration using fluo-4 Ca2+-indicator dye and patch clamp electrophysiology upon applying various activators and inhibitors.KEY RESULTSThermosensitive TRP channels were expressed in podocytes. The TRPV1 specific agonists capsaicin and resiniferatoxin did not induce any alteration in the intracellular Ca2+ concentration. Cannabidiol, an activator of TRPV2 and TRPV4 induced moderate Ca2+-influxes which were inhibited by both tranilast and HC067047, blockers of TRPV2 and TRPV4, respectively. The TRPV4-specific agonists GSK1016790A and 4?-Phorbol 12,13-didecanoate resulted robust Ca2+-signals which were abolished in the presence of HC067047. Non-specific agonists of TRPV3 induced marked Ca2+ transients. However, TRPV3 blockers, ruthenium red and isopentenyl diphosphate only partially inhibited the responses and TRPV3 silencing was ineffective suggesting remarkable off-target effects of the compounds.CONCLUSION AND IMPLICATIONSOur results indicate the functional presence of TRPV4 and other thermosensitive TRPV channels in human podocytes and raise the possibility of their involvement in the regulation of glomerular filtration barrier.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:British journal of pharmacology. - 174 : 23 (2017), p. 4493-4507. -
További szerzők:Kelemen Balázs (1992-) (biológus) Szabó Tamás (1968-) (gyermekgyógyász) Bíró Tamás (1968-) (élettanász) Tóth István Balázs (1978-) (élettanász)
Pályázati támogatás:76065
OTKA
NKFI K_16 120187
Egyéb
NKFI K_16 120552
Egyéb
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
LP003-2011/2015
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM018442
Első szerző:Bagi Zsolt (orvos)
Cím:Microvascular responsiveness in obesity : implications for therapeutic intervention / Zsolt Bagi, Attila Feher, James Cassuto
Dátum:2012
ISSN:0007-1188
Megjegyzések:Obesity has detrimental effects on the microcirculation. Functional changes in microvascular responsiveness may increase the risk of developing cardiovascular complications in obese patients. Emerging evidence indicates that selective therapeutic targeting of the microvessels may prevent life-threatening obesity-related vascular complications, such as ischemic heart disease, heart failure and hypertension. It is also plausible that alterations in adipose tissue microcirculation contribute to the development of obesity. Therefore, targeting adipose tissue arterioles could represent a novel approach to reducing obesity. This review aims to examine recent studies that have been focused on vasomotor dysfunction of resistance arteries in obese humans and animal models of obesity. Particularly, findings in coronary resistance arteries are contrasted to those obtained in other vascular beds. We provide examples of therapeutic attempts, such as use of statins, angiotensin converting enzyme inhibitors and insulin sensitizers to prevent obesity-related microvascular complications. We further identify some of the important challenges and opportunities going forward.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
obesity
microcirculation
arteriole
coronary
type 2 diabetes mellitus
Megjelenés:British Journal Of Pharmacology. - 165 : 3 (2012), p. 544-560. -
További szerzők:Fehér Attila (1982-) (orvos) Cassuto, James
Pályázati támogatás:R01 HL104126
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM018441
Első szerző:Bagi Zsolt (orvos)
Cím:Increased availability of angiotensin AT1 receptors leads to sustained arterial constriction to angiotensin II in diabetes - role for Rho-kinase activation / Zsolt Bagi, Attila Feher, James Cassuto, Komala Akula, Nazar Labinskyy, Gabor Kaley, Akos Koller
Dátum:2011
ISSN:0007-1188
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
diabetes mellitus
hyperglycaemia
arteriolar constriction
AT1 receptor
Rho-kinase
Megjelenés:British Journal Of Pharmacology. - 163 : 5 (2011), p. 1059-1068. -
További szerzők:Fehér Attila (1982-) (orvos) Cassuto, James Akula, Komala Labinskyy, Nazar Kaley Gábor Koller Ákos
Pályázati támogatás:K71591
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM096063
035-os BibID:(WoS)000655229800001 (Scopus)85106641226
Első szerző:Batta Gyula (biológus)
Cím:Statin-boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential / Gyula Batta, Levente Karpati, Gabriela Fulaneto Henrique, Gabriella Toth, Szabolcs Tarapcsak, Tamas Kovacs, Florina Zakany, Istvan M. Mandity, Peter Nagy
Dátum:2021
ISSN:0007-1188
Megjegyzések:Background and purpose: Cell penetrating peptides are promising tools for delivery of cargo into cells, but factors limiting or facilitating their cellular uptake are largely unknown. We set out to study the effect of the biophysical properties of the cell membrane on the uptake of penetratin, a cell penetrating peptide. Experimental approach: Using labeling with pH-insensitive and pH-sensitive dyes, the kinetics of cellular uptake and endo-lysosomal escape of penetratin were studied by flow cytometry. Key results: We report that escape of penetratin from acidic endo-lysosomal compartments is retarded compared to its total cellular uptake. The membrane dipole potential, known to alter transmembrane transport of charged molecules, is shown to be negatively correlated with the concentration of penetratin in the cytoplasmic compartment. Treatment of cells with therapeutically relevant concentrations of atorvastatin, an inhibitor of HMG-CoA reductase and cholesterol synthesis, significantly increased endosomal escape of penetratin in two different cell types. This effect of atorvastatin correlated with its ability to decrease the membrane dipole potential. Conclusions and implications: These results highlight the importance of the dipole potential in regulating cellular uptake of cell penetrating peptides and suggest a clinically relevant way of boosting this process.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:British Journal Of Pharmacology. - 178 : 18 (2021), p. 3667-3681. -
További szerzők:Kárpáti Levente (1968-) (okleveles vegyész) Henrique, Gabriela Fulaneto Tóth Gabriella Tarapcsák Szabolcs (1989-) (Molekuláris biológus) Kovács Tamás (1985-) (általános orvos) Zákány Florina (1989-) (általános orvos) Mándity István M. Nagy Péter (1971-) (biofizikus)
Pályázati támogatás:2018-1.2.1-NKP
Egyéb
GINOP-2.3.2-15-2016-00020
GINOP
GINOP-2.3.2-15-2016-00044
GINOP
K120302
OTKA
ANN133421
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM020469
Első szerző:Csont Tamás
Cím:Direct myocardial anti-ischaemic effect of GTN in both nitrate-tolerant and nontolerant rats : a cyclic GMP-independent activation of KATP / Tamás Csont, Zoltán Szilvássy, Ferenc Fülöp, Saviana Nedeianu, Tibor Páli, Árpád Tósaki, László Dux, Péter Ferdinandy
Dátum:1999
ISSN:0007-1188
Megjegyzések:Abstract1. We have recently demonstrated that glyceryl trinitrate (GTN) exerts a direct myocardial anti-ischaemic effect in both GTN-tolerant and nontolerant rats. Here we examined if this effect is mediated by GTN-derived nitric oxide (NO) and involves guanosine 3'5' cyclic monophosphate (cyclic GMP) and ATP-sensitive K+ channels (KATP). 2. Rats were treated with 100 mg kg-1 GTN or vehicle s.c. three times a day for 3 days to induce vascular GTN-tolerance or nontolerance. Isolated working hearts obtained from either GTN-tolerant or nontolerant rats were subjected to 10 min coronary occlusion in the presence of 10-7 M GTN or its solvent. 3. GTN improved myocardial function and reduced lactate dehydrogenase (LDH) release during coronary occlusion in both GTN-tolerant and nontolerant hearts. 4. Cardiac NO content significantly increased after GTN administration in both GTN-tolerant and nontolerant hearts as assessed by electron spin resonance. However, cardiac cyclic GMP content measured by radioimmunoassay was not changed by GTN administration. 5. When hearts from both GTN-tolerant and nontolerant rats were subjected to coronary occlusion in the presence of the KATP-blocker glibenclamide (10-7 M), the drug itself did not affect myocardial function and LDH release, however, it abolished the anti-ischaemic effect of GTN. 6. We conclude that GTN opens KATP via a cyclic GMP-independent mechanism, thereby leading to an anti-ischaemic effect in the heart in both GTN-tolerant and nontolerant rats.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Direct myocardial
anti-ischaemic effect
Direct myocardial anti-ischaemic effect
effect of GTN
GTN
cyclic activation of K(ATP)
cyclic GMP-independent activation of K(ATP)
K(ATP)
Megjelenés:British Journal of Pharmacology 128 : 7 (1999), p. 1427-1434. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Fülöp Ferenc (Szeged) Nedeianu, Saviana Páli Tibor Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Dux László Ferdinándy Péter
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM085938
035-os BibID:(WoS)000547613400001 (Scopus)85086253020
Első szerző:Curtin, Nicola
Cím:Repositioning PARP inhibitors for SARS-CoV-2 infection (COVID-19); a new multi-pronged therapy for ARDS? / Curtin Nicola, Bányai Krisztián, Thaventhiran James, Le Quesne John, Helyes Zsuzsanna, Bai Péter
Dátum:2020
ISSN:0007-1188
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
SARS-CoV-2
Megjelenés:British Journal Of Pharmacology. - 177 : 16 (2020), p. 3635-3645. -
További szerzők:Bányai Krisztián Thaventhiran, James Le Quesne, John Helyes Zsuzsanna Bai Péter (1976-) (biokémikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM052173
Első szerző:Czikora Ágnes (molekuláris biológus)
Cím:Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1 / Á. Czikora, E. Lizanecz, P. Bakó, I. Rutkai, F. Ruzsnavszky, J. Magyar, R. Pórszász, T. Kark, A. Facskó, Z. Papp, I. Édes, A. Tóth
Dátum:2012
ISSN:0007-1188
Megjegyzések:Summary Background and purpose: The vanilloid receptor 1 (TRPV1) plays a role in the activation of sensory neurons by various painful stimuli and became a therapeutic target. However, functional TRPV1 expression was also observed in the peripheral arteries affecting microvascular diameter. Experimental approach: Sensory TRPV1 activation was measured by eye wiping tests. Arteriolar TRPV1 mediated smooth muscle specific responses (arteriolar diameter, changes in intracellular Ca2+) were determined in isolated, pressurized skeletal muscle arterioles (from the rat and wild type or TRPV1-/- mice, n = 130) or in isolated canine smooth muscle cells. Vascular pharmacology of TRPV1 agonists (potency, efficacy, kinetics of action and receptor desensitization) was determined in isolated skeletal muscle arteries of the rat. Key results: Capsaicin evoked a similar constriction as norepinephrine, which was absent in TRPV knockout mice and was competitively inhibited by a TRPV1 antagonist AMG9810. Capsaicin activation resulted in an increase in intracellular Ca2+ in the arteriolar wall as well as in isolated smooth muscle cells. Other TRPV1 agonists evoked similar vascular constrictions (MSK-195, JYL-79) or were without effect (resiniferatoxin, JYL-273), although all resulted in a sensory activation (eye wiping). Maximal dose of agonists gave different kinetics of arteriolar response. A complete desensitization (tachyphylaxis) of arteriolar TRPV1 was observed (with the exception of capsaicin). Application of the partial agonist JYL-1511 suggested that about 10% TRPV1 activation is sufficient to evoke vascular tachyphylaxis without sensory activation. Conclusions and implications: Our data suggests that arteriolar TRPV1 has different structure-activity relationship compared to sensory neuron located receptor in the rat.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
vanilloid receptor (TRPV1)
resistance artery
vascular autoregulation
Megjelenés:British Journal of Pharmacology. - 165 : 6 (2012), p. 1801-1812. -
További szerzők:Lizanecz Erzsébet (1978-) (orvos) Bakó P. Rutkai Ibolya (1985-) (molekuláris biológus) Ruzsnavszky Ferenc (1984-) (élettanász) Magyar János (1961-) (élettanász) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Kark Tamás (1981-) (orvos) Facskó Andrea (1953-) (szemész) Papp Zoltán (1965-) (kardiológus, élettanász) Édes István (1952-) (kardiológus) Tóth Attila (1971-) (biológus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Vascularis rizikó- és stroke betegek vizsgálata
K68077
OTKA
K84300
OTKA
ETT 377/2009
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM020691
Első szerző:Erdei Nóra (orvos)
Cím:The levosimendan metabolite OR-1896 elicits vasodilation by activating the KATP and BKCa channels in rat isolated arterioles / Nóra Erdei, Zoltán Papp, Piero Pollesello, István Édes, Zsolt Bagi
Dátum:2006
ISSN:0007-1188
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Pharmacology. - 148 : 5 (2006), p. 696-702. -
További szerzők:Papp Zoltán (1965-) (kardiológus, élettanász) Pollesello, Piero Édes István (1952-) (kardiológus) Bagi Zsolt (1974-) (orvos)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM004076
Első szerző:Farkas S. Attila
Cím:Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart / Farkas A. S., Acsai K., Nagy N., Tóth A., Fülöp F., Seprényi G., Birinyi P., Nánási P. P., Forster T., Csanády M., Papp J. G., Varró A., Farkas A.
Dátum:2008
Megjegyzések:The Na(+)/Ca(2+) exchanger (NCX) may play a key role in myocardial contractility. The operation of the NCX is affected by the action potential (AP) configuration and the intracellular Na(+) concentration. This study examined the effect of selective NCX inhibition by 0.1, 0.3 and 1.0 microM SEA0400 on the myocardial contractility in the setting of different AP configurations and different intracellular Na(+) concentrations in rabbit and rat hearts. EXPERIMENTAL APPROACH: The concentration-dependent effects of SEA0400 on I(Na/Ca) were studied in rat and rabbit ventricular cardiomyocytes using a patch clamp technique. Starling curves were constructed for isolated, Langendorff-perfused rat and rabbit hearts. The cardiac sarcolemmal NCX protein densities of both species were compared by immunohistochemistry. KEY RESULTS: SEA0400 inhibited I(Na/Ca) with similar efficacy in the two species; there was no difference between the inhibitions of the forward or reverse mode of the NCX in either species. SEA0400 increased the systolic and the developed pressure in the rat heart in a concentration-dependent manner, for example, 1.0 microM SEA0400 increased the maximum systolic pressures by 12% relative to the control, whereas it failed to alter the contractility in the rabbit heart. No interspecies difference was found in the cardiac sarcolemmal NCX protein densities. CONCLUSIONS AND IMPLICATIONS: NCX inhibition exerted a positive inotropic effect in the rat heart, but it did not influence the contractility of the rabbit heart. This implies that the AP configuration and the intracellular Na(+) concentration may play an important role in the contractility response to NCX inhibition.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Pharmacology. - 154 : 1 (2008), p. 93-104. -
További szerzők:Acsai Károly Nagy N. (Szeged) Tóth A. Fülöp Ferenc (Szeged) Seprényi G. Birinyi Péter (1981-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Forster Tamás Csanády Miklós (Szeged) Papp J. G. Varró András (1954-) (farmakológus, klinikai farmakológus) Farkas A. (Szeged)
Internet cím:elektronikus változat
DOI
Borító:

10.

001-es BibID:BIBFORM020028
Első szerző:Gönczi Mónika (élettanász)
Cím:Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures / Mónika Gönczi, Norbert Szentandrássy, Ian T. Johnson, Anthony M. Heagerty, Arthur H. Weston
Dátum:2006
ISSN:0007-1188
Megjegyzések:1 In the present study, we investigated the ability of RNA interference technology to suppress TASK-2 potassium channel expression in human embryonic kidney (HEK293) cells stably transfected with TASK-2 cDNA and in rat isolated intact pulmonary arteries. 2 Lipofectamine-induced transfection of a specific siRNA sequence targeted against TASK-2 resulted in a dose- and time-dependent decrease in TASK-2 channel protein expression. In siRNA-transfected cells the TASK-2 peak currents were significantly smaller than in control cells at every investigated pH, while the pH sensitivity was not altered. Using scrambled siRNA as a negative control, there were no significant changes in TASK-2 protein expression or current compared to mock-transfected cells. 3 In TASK-2 siRNA-transfected small pulmonary arteries, but not in scrambled siRNA-treated vessels, myocyte resting membrane potential at pH 7.4 was significantly less negative and the hyperpolarisations in response to increasing pH from 6.4 to 8.4 were significantly smaller compared with control. 4 The application of levcromakalim ( 10 mu M), NS1619 ( 33 mu M) and a potassium channel inhibitor cocktail ( 5 mM 4-aminopyridine, 10 mM tetraethylammonium chloride, 30 mu M Ba2+ and 10 mu M glibenclamide) had similar effects in control and in siRNA-transfected vessels. The TASK-1 (anandamide-sensitive) contribution to resting membrane potential was comparable in each group. Clofilium ( 100 mu M) generated significantly smaller responses in transfected artery segments. 5 These results suggest that RNA interference techniques are effective at inhibiting TASK-2 channel expression in cultured cells and in intact vessels and that TASK-2 channels have a functional role in setting the membrane potential of pulmonary artery myocytes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Pharmacology. - 147 : 5 (2006), p. 496-505. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Johnson, Ian T. Heagerty, Anthony M. Weston, Arthur H.
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM013054
Első szerző:Harmati Gábor (élettanász)
Cím:Effects of β-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes / Harmati G., Bányász T., Bárándi L., Szentandrássy N., Horváth B., Szabó G., Szentmiklósi J., Szénási G., Nánási P., Magyar J.
Dátum:2011
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
isoproterenol
beta adrenerg
canine
cardiomyocyte
ionic current
Megjelenés:British Journal of Pharmacology. - 162 : 4 (2011), p. 890-896. -
További szerzők:Bányász Tamás (1960-) (élettanász) Bárándi László (1984-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Horváth Balázs (1981-) (élettanász) Szabó G. (orvos) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Szénási Gábor Nánási Péter Pál (1956-) (élettanász) Magyar János (1961-) (élettanász)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM040213
Első szerző:Helyes Zsuzsanna
Cím:Effects of the somatostatin receptor subtype 4 selective agonist J-2156 on sensory neuropeptide release and inflammatory reactions in rodents / Z. Helyes, E. Pintér, J. Németh, K. Sándor, K. Elekes, A. Szabó, G. Pozsgai, D. Keszthelyi, L. Kereskai, M. Engström, S. Wurster, J. Szolcsányi
Dátum:2006
ISSN:0007-1188
Megjegyzések:Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitivesensory nerves induce local neurogenic inflammation; somatostatin exerts systemic anti-inflammatory actions presumably viasst4/sst1 receptors. This study investigates the effects of a high affinity, sst4-selective, synthetic agonist, J-2156, on sensoryneuropeptide release in vitro and inflammatory processes in vivo.Experimental approach: Electrically-induced SP, CGRP and somatostatin release from isolated rat tracheae was measuredwith radioimmunoassay. Mustard oil-induced neurogenic inflammation in rat hindpaw skin was determined by Evans blueleakage and in the mouse ear with micrometry. Dextran-, carrageenan- or bradykinin-induced non-neurogenic inflammationwas examined with plethysmometry or Evans blue, respectively. Adjuvant-induced chronic arthritis was assessed byplethysmometry and histological scoring. Granulocyte accumulation was determined with myeloperoxidase assay and IL-1bwith ELISA.Key results: J-2156 (10-2000 nM) diminished electrically-evoked neuropeptide release in a concentration-dependentmanner. EC50 for the inhibition of substance P, CGRP and somatostatin release were 11.6 nM, 14.3nM and 110.7 nM,respectively. J-2156 (1-100 mgkg-1 i.p.) significantly, but not dose-dependently, inhibited neurogenic and non-neurogenicacute inflammatory processes and adjuvant-induced chronic oedema and arthritic changes. Endotoxin-evoked myeloperoxidaseactivity and IL-1b production in the lung, but not IL-1b- or zymosan-induced leukocyte accumulation in the skin weresignificantly diminished by J-2156.Conclusions and implications: J-2156 acting on sst4 receptors inhibits neuropeptide release, vascular components of acuteinflammatory processes, endotoxin-induced granulocyte accumulation and IL-1b synthesis in the lung and synovial andinflammatory cells in chronic arthritis. Therefore it might be a promising lead for the development of novel anti-inflammatorydrugs.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Pharmacology. - 149 : 4 (2006), p. 405-415. -
További szerzők:Pintér E. Németh József (1954-) (vegyész, analitikus) Sándor K. Elekes K. Pozsgai Gábor Keszthelyi Dániel Kereskai László Engström, M. Wurster, S. Szolcsányi János (Pécs)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 2 3 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.