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1.

001-es BibID:BIBFORM061605
Első szerző:Agarwal, Mohit
Cím:Severe Symptomatic Hypocalcemia after Denosumab Administration in an End-Stage Renal Disease Patient on Peritoneal Dialysis with Controlled Secondary Hyperparathyroidism / Mohit Agarwal, Éva Csongrádi, Christian A. Koch, Luis A. Juncos, Vonda Echols, Mihály Tapolyai, Tibor Fülöp
Dátum:2013
Megjegyzések:We report the 1st case of severe, symptomatic hypocalcemia after denosumab (RANKLinhibitor) treatment in a peritoneal dialysis patient with secondary hyperparathyroidismand osteoporosis. A 58-year-old Caucasian female has been receiving chronicambulatory peritoneal dialysis for four years secondary to polycystic kidney disease.Laboratory studies revealed: albumin-corrected calcium 9.0 mg/dL, phosphorus 5 mg/dL,alkaline phosphatase (ALP) 58 U/L [normal, 40-105], albumin 3.4 gm/dL [normal, 3.6-5.4]and intact parathyroid hormone (PTH) 315 pg/mL [normal, 40-72]. Marked osteoporosiswas noted on the DXA scan, preventing her from renal transplantation considerations.She had failed conventional medical treatment, including per os calcium, monthlyergocalciferol (50,000 units/month), activated vitamin-D analog (doxercalciferol) andrenal-failure adjusted alendronate (70 mg twice a month). She was started onsubcutaneous denosumab 60 mg every 6 months. After her first dose, she developed aprogressive drop of calcium, phosphorus, bicarbonate and magnesium, in spite ofmassive escalation of doxercalciferol and calcium supplementation. Hypocalcemianadired at 6.3 mg/dL with symptomatic tetany, requiring a brief hospitalizationapproximately 7 weeks after denosumab treatment. Her elevated PTH rose furthertransiently (647 pg/mL), along with ALP (123 U/L). Bone-mineral parameters normalizedapproximately 3 months after denosumab administration. The observed phenomenonresembled the phenotype of "hungry bone syndrome" observed after surgicalparathyroidectomy.Conclusion: Treatment decisions based on bone densitometry results alone are nottransposable between patients with or without end-stage renal disease. Denosumab maylead to critical hypocalcemia in dialysis patients and further aggravate existing secondaryhyperparathyroidism.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Medicine & Medical Research. - 3 : 4 (2013), p. 1398-1406. -
További szerzők:Csongrádi Éva (1969-) (szakorvos) Koch, Christian A. Juncos, Luis A. Echols, Vonda Tapolyai Mihály (1968-) (nefrológus) Fülöp Tibor (1957-) (kardiológus)
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2.

001-es BibID:BIBFORM061606
Első szerző:Avusula, Ramachandram (orvos)
Cím:Bacterial Peritonitis Following Esophagogastroduodenoscopy in a Patient on Peritoneal Dialysis / Ramachandram Avusula, Michael Shoemaker-Moyle, Minesh B. Pathak, Éva Csongrádi, Tibor Fülöp,
Dátum:2013
Megjegyzések:Aims: To recognize the importance of considering perforation of viscus in thedifferential of peritonitis after upper gastrointestinal endoscopy in peritoneal dialysispatients and to address the potential benefit of antibiotic prophylaxis in PD patientsundergoing upper GI procedures.Presentation of Case: We report the case of a 54-year-old African American femalewith end-stage renal disease on peritoneal dialysis presenting with generalizedabdominal pain, along with nausea and vomiting. Peritoneal fluid revealed a WBC countof 1,499/mm3. Two days earlier, she had undergone an esophagogastroduodenoscopywith biopsy. Broad spectrum antibiotics were started to treat possible peritonitis.Surgical exploration revealed no perforation but murky peritoneal fluid was noted andgram stain showed mixed flora (both gram negative and gram positive rods); however,blood and peritoneal fluid culture grew only Streptococcus pneumoniae.Discussion and Conclusion: An occult perforation, which may not be obvious to thenaked eye or signs of contrast extravasation can occur afteresophagogastroduodenoscopy with manipulations and can lead to peritonitis, especiallyin high-risk patients such as those with end-stage renal disease on peritoneal dialysis.To our knowledge, this is the first reported case of mixed peritonitis attributable tosuspected micro-perforation after esophagogastroduodenoscopy. Whether preprocedureantibiotics are warranted to decrease the occurrence of infectiouscomplications in PD patients undergoing upper gastrointestinal procedures remainsuncertain and not well studied. The prompt recognition of possible mixed bacterialinfection remains essential after these procedures.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Medicine & Medical Research. - 3 : 3 (2013), p. 784-789. -
További szerzők:Shoemaker-Moyle Michael (orvos) Pathak, Minesh B. (orvos) Csongrádi Éva (1969-) (szakorvos) Fülöp Tibor (1957-) (kardiológus)
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3.

001-es BibID:BIBFORM061604
Első szerző:Csongrádi Éva (szakorvos)
Cím:The Efficacy of Intravenous versus Subcutaneous Recombinant Erythropoietin in Obese African-African Patients in a Southeast U.S. Dialysis Cohort / Éva Csongrádi, Michael Shoemaker-Moyle, Lajos Zsom, Catherine Wells, Zsolt Lengvárszky, Mihály Tapolyai, Tibor Fülöp
Dátum:2014
Megjegyzések:Aims: To correct renal anemia, subcutaneous (SC) route of recombinant humanerythropoietin (rhuEPO) administration has been associated with increased efficacy anddecreased dose requirements, when compared with intravenous (IV) route. The effect ofobesity as a potential modifier during rhuEPO administration has not been well explored.Study Design: Single-center, Longitudinal Cohort Study.Place and Duration of Study: University of Mississippi Medical Center OutpatientDialysis Unit, between February and November of 2009.Methodology: We performed IV to SC rhuEPO conversion for 86 in-center dialysispatients and, following a six-month equilibration period, we monitored outcomes over aperiod of three months. We obtained baseline demographic parameters, calculated BodyMass Index (BMI) and monitored iron saturation, ferritin, hemoglobin (Hgb) along withrhuEPO requirements. Patients were divided into 3 categories based on BMI [<25 (n=27),25-35 (n=38), >35 (n= 21) kg/m2]. Results are reported either as percents, means with SDor median with 25-75% interquartile range, as appropriate.Results: The cohort was all African-American, 48.8% male, aged 54.7 (13.3) years andBMI calculated at 29.9 (7.4) kg/m2. Baseline iron saturation was 24 (10.6)%, ferritinmeasured 641 (277) ng/mL. Hgb remained unchanged during the observation period:11.1 (1.3) vs. 11.2 (1.3) gm/dL. Initial rhuEPO weekly dose for the entire cohort was19,729 (17,448) Units/week (U/week); final dose 17,482 (14,860) U/week, with closecorrelation between initial and final doses (r: 0.653, P<0.0001). Weekly rhuEPO doseremained virtually unchanged in BMI categories 1 and 2 [13,927 (10,938) vs. 13,297(10,247) U/week; 20,684 (15,788) vs. 20,997 (17.917)] (P=NS for both) but decreased inthe category 3: 25,459 (24,403) vs. 16,444 (12,749) (P=0.081). However, BMI had noindependent effect in linear regression modeling with multiple covariates (age, BMI, ironsaturation, ferritin) included.Conclusion: Obesity may affect relative efficacy of rhuEPO conversion; additionalstudies may be needed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Medicine & Medical Research. - 4 : 1 (2014), p. 184-193. -
További szerzők:Shoemaker-Moyle Michael (orvos) Zsom Lajos (1968-) (belgyógyász, nefrológus) Wells Catherine (tudományos segédmunkatárs) Lengvárszky Zsolt (matematikus informatikus) Tapolyai Mihály (1968-) (nefrológus) Fülöp Tibor (1957-) (kardiológus)
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4.

001-es BibID:BIBFORM060033
Első szerző:Karras, Spyridon
Cím:Re: Bias, Bones and Vitamin D / Karras Spyridon N., Annweiler Cederic, Boucher Barbara, Bhattoa Harjit, Muscogiuri Giovanna, Pilz Stefan
Dátum:2015
Tárgyszavak:Orvostudományok Klinikai orvostudományok hozzászólás
Megjelenés:British Medical Journal. - 351 (2015), p. 1-2. -
További szerzők:Annweiler, Cedric Boucher, Barbara Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Muscogiuri, Giovanna Pilz, Stefan
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5.

001-es BibID:BIBFORM002285
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Population screening for coeliac disease in primary care by district nurses using a rapid antibody test : diagnostic accuracy and feasibility study / Korponay-Szabó Ilma, Szabados Katalin, Pusztai Jánosné, Uhrin Katalin, Ludmány Éva, Nemes Éva, Kaukinen Katri, Kapitány Anikó, Koskinen Lotta, Sipka Sándor, Imre Anikó, Mäki Markku
Dátum:2007
Megjegyzések:Objective To evaluate the feasibility and diagnostic accuracy of screening for coeliac disease by rapid detection of IgA antibodies to tissue transglutaminase performed in primary care. Design District nurses screened 6 year old children using rapid antibody testing of finger prick blood. They also collected capillary blood samples for laboratory determination of IgA and IgG antibodies to endomysium and IgA antibodies to tissue transglutaminase. Children with positive rapid test results were directly sent for biopsy of the small intestine. Setting Primary care in Jász-Nagykun-Szolnok county, Hungary. Participants 2690 children(77%of 6 year olds living in the county) and 120 nurses. Main outcome measures Positivity for antibodies to endomysium or transglutaminase in the laboratory and coeliac disease confirmed at biopsy. Results 37 children (1.4%, 95% confidence interval 0.9% to 1.8%) had biopsy confirmed coeliac disease. Only five of these children had been diagnosed clinically before screening. Rapid testinghad a 78.1%sensitivity(70.0% to 89.3%) and 100% specificity (88.4% to 100%) for a final diagnosis of coeliac disease by biopsy. Sensitivity was 65.1% (50.2% to 77.6%) and specificity was 100% (99.8% to 100%) compared with combined results of IgA and IgG laboratory tests. Trained laboratory workers detected 30 of the 31 newly diagnosed IgA competent patients with the rapid test kit used blindly. Median time to biopsy after a positive rapid test result was significantly shorter (20 days, range 4-148) than after a positive laboratory result (142 days, 70-256; P<0.001). Children with coeliac disease detected at screening were smaller and had worse health status than their peers but they improved on a gluten-free diet. Conclusions A simple rapid antibody test enabled primary care nurses to detect patients with coeliac disease in the community who were not picked up in clinical care. Extra training is needed to improve sensitivity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Medical Journal 335 : 7632 (2007), p. 1244-1277. -
További szerzők:Szabados Katalin Pusztai Jánosné Uhrin Katalin Ludmány Éva Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Kaukinen, Katri Kapitány Anikó (1979-) (molekuláris biológus) Koskinen, Lotta L. E. Sipka Sándor (1945-) (laboratóriumi szakorvos) Imre Anikó Mäki, Markku
Internet cím:elektronikus változat
DOI
elektronikus változat
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6.

001-es BibID:BIBFORM036794
Első szerző:Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:An explanation of Weber's phenomen / Róbert Póka
Dátum:2002
ISSN:0959-8146
Tárgyszavak:Orvostudományok Klinikai orvostudományok hozzászólás
Weber's phenomen
Megjelenés:British Medical Journal - Rapid Response. - (2002) 07/09. -
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7.

001-es BibID:BIBFORM036793
Első szerző:Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:Value of family history in identifying women at risk of venous thromboembolism during oral contraception / Póka Róbert
Dátum:2001
ISSN:0959-8146
Tárgyszavak:Orvostudományok Klinikai orvostudományok hozzászólás
screening
thrombophilia
oral contraception
Megjelenés:British Medical Journal - Rapid Response. - (2001) 05/15. -
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