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001-es BibID:	bibEBI00019307
Első szerző:	Das, Gokul C.
Cím:	Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity / Das G. C., Bacsi A., Shrivastav M., Hazra T. K., Boldogh I.
Dátum:	2006
Megjegyzések:	Multidrug resistance of cancer cells can be intrinsic or acquired and occurs due to various reasons, including increased repair of genotoxic damage, an enhanced ability to remove/detoxify chemical agents, or reactive oxygen species (ROS), and repression of apoptosis. Human A2780/100 ovarian carcinoma cells exhibit resistance to DNA cross-linking agents, chlorambucil (Cbl), cisplatin (Cpl), melphalan (Mel), and ionizing radiation (IR) compared to the parental cell line, A2780. In the present study, we show that when A2780/100 and A2780 cells were treated with Cbl, GSH was extruded via methionine or cystathionine-inhibitable transporters of intact plasma membrane. GSH loss was followed by a rapid increase in ROS levels. The resistant, but not drug-sensitive cells normalized the intracellular GSH concentration along with ROS levels within 4-6 h after Cbl addition, and survived drug treatment. Normalization of GSH and ROS levels in A2780/100 cells correlated well with elevated gamma-glutamylcysteine synthetase (gamma-GCS) activity (10 +/- 1.8-fold over A2780 cells). Ectopic overexpression of the gamma-GCS heavy subunit in drug-sensitive cells nearly restored GSH and ROS to pre-treatment levels consequently increased cellular resistance to genotoxic agents (Cbl, Cpl, and IR), while overexpression of gamma-GCS light subunit had no such effects. Thus, in our model system, drug-resistant cells have the inherent ability to maintain increased gamma-GCS activity, reestablish physiological GSH, and cellular redox state and maintain increased cellular resistance to DNA cross-linking agents and IR.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Molecular Carcinogenesis 45 : 9 (2006), p. 635-647. -
További szerzők:	Bácsi Attila (1967-) (immunológus) Shrivastav, Meena Hazra, Tapas K. Boldogh István
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001-es BibID:	BIBFORM040207
Első szerző:	Derdák Zoltán
Cím:	Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress / Zoltán Derdák, Péter Fülöp, Edmond Sabo, Rose Tavares, Eric P. Berthiaume, Murray B. Resnick, György Paragh, Jack R. Wands, György Baffy
Dátum:	2006
ISSN:	0143-3334
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Carcinogenesis 27 : 5 (2006), p. 956-961. -
További szerzők:	Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Sabo, Edmond Tavares, Rose Berthiaume, Eric P. Resnick, Murray B. Paragh György (1953-) (belgyógyász) Wands, Jack R. Baffy György
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM069211
Első szerző:	Ragin, Camille
Cím:	Prevalence of HPV Infection in Racial-Ethnic Subgroups of Head and Neck Cancer Patients / Ragin Camille, Liu Jeffrey C., Jones Gieira, Shoyele Olubunmi, Sowunmi Bukola, Kennett Rachel, Groen Harry J. M., Gibbs Denise, Blackman Elizabeth, Esan Michael, Brandwein Margaret S., Devarajan Karthik, Bussu Francesco, Chernock Rebecca, Chien Chih-Yen, Cohen Marc A., Samir El-Mofty, Mikio Suzuki, D'Souza Gypsyamber, Funchain Pauline, Eng Charis, Gollin Susanne M., Hong Angela, Jung Yuh-S., Krüger Maximilian, Lewis James, Morbini Patrizia, Landolfo Santo, Rittà Massimo, Straetmans Jos, Szarka Krisztina, Tachezy Ruth, Worden Francis P., Nelson Deborah, Gathere Samuel, Taioli Emanuela
Dátum:	2017
ISSN:	0143-3334
Megjegyzések:	The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Carcinogenesis 38 : 2 (2017), p. 218-229. -
További szerzők:	Liu, Jeffrey C. Jones, Gieira Shoyele, Olubunmi Sowunmi, Bukola Kennett, Rachel Groen, Harry J. M. Gibbs, Denise Blackman, Elizabeth Esan, Michael Brandwein, Margaret S. Devarajan, Karthik Bussu, Francesco Chernock, Rebecca Chien, Chih-Yen Cohen, Marc A. Samir, El-Mofty Mikio, Suzuki D'Souza, Gypsyamber Funchain, Pauline Eng, Charis Gollin, Susanne M. Hong, Angela Jung, Yuh-S. Krüger, Maximilian Lewis, James Morbini, Patrizia Landolfo, Santo Rittà, Massimo Straetmans, Jos Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Tachezy, Ruth Worden, Francis P. Nelson, Deborah Gathere, Samuel Taioli, Emanuela
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM020773
Első szerző:	Vondalova, Blanarova O.
Cím:	Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway / Vondalova, B. O., Jelinkova, I., Szoor, A., Skender, B., Soucek, K., Horvath, V., Vaculova, A., Andera, L., Sova, P., Szollosi, J., Hofmanova, J., Vereb, G., Kozubik, A.
Dátum:	2011
Megjegyzések:	TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger apoptosis in various cancer cell types. However, many cancer cells are resistant to death receptor-mediated apoptosis. Combination therapy with platinum complexes may affect TRAIL-induced signaling via modulation of various steps in apoptotic pathways. Here, we show that cisplatin or a more potent platinum(IV) complex LA-12 used in 20-fold lower concentration enhanced killing effects of TRAIL in human colon and prostate cancer cell lines via stimulation of caspase activity and overall apoptosis. Both platinum complexes increased DR5 surface expression in colon cancer cells. Small interfering RNA-mediated DR5 silencing rescued cells from sensitizing effects of platinum drugs on TRAIL-induced caspase-8 activation and apoptosis, showing the functional importance of DR5 in the effects observed. In addition, both cisplatin and LA-12 triggered the relocalization of DR4 and DR5 receptors to lipid rafts and accelerated internalization of TRAIL, which may also affect TRAIL signaling. Collectively, modulations of the initial steps of the extrinsic apoptotic pathway at the level of DR5 and plasma membrane are important for sensitization of colon and prostate cancer cells to TRAIL-induced apoptosis mediated by LA-12 and cisplatin
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ACTIVATION Amantadine analogs & derivatives Apoptosis article Biophysics Blotting,Western Cell Line Cell Line,Tumor Cell Separation Cells Cisplatin drug effects Flow Cytometry Fluorescent Antibody Technique Human Humans ligand lipid raft LIPID RAFTS metabolism Microscopy,Confocal Necrosis Neoplasms Organoplatinum Compounds pharmacology physiology Protein Transport Receptors,TNF-Related Apoptosis-Inducing Ligand Research Research Support Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction Support therapy TNF-Related Apoptosis-Inducing Ligand
Megjelenés:	Carcinogenesis. - 32 : 1 (2011), p. 42-51. -
További szerzők:	Jelínková, Iva Szöőr Árpád (1984-) (orvos) Skender, Belma Soucek, Karel Horváth Viktor Vaculova, Alena Andera, Ladislav Sova, Petr Szöllősi János (1953-) (biofizikus) Hofmanova, Jirin Vereb György (1965-) (biofizikus, orvos) Kozubik, Alois
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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