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1.

001-es BibID:BIBFORM065606
Első szerző:Fekete Tünde (immunológus, molekuláris biológus, mikrobiológus)
Cím:Interferon gamma boosts the nucleotide oligomerization domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of rapamycin-dependent manner / Tünde Fekete, Gabor Koncz, Brigitta Szabo, Andrea Gregus, Eva Rajnavölgyi
Dátum:2017
ISSN:1672-7681 2042-0226
Megjegyzések:The cytoplasmic nucleotide oligomerization domain 2 (NOD2) receptor recognizes the bacterial cell wall componentmuramyl dipeptide (MDP). NOD2 ligation initiates the nuclear factor kappa B and the mitogen-activated protein kinasecascades. However, administering MDP alone is insufficient to elicit strong cytokine responses in various immune cells,including dendritic cells (DCs). Because the simultaneous presence of various microbial products and cytokines ininflamed tissues modulates DC function, we initiated this study to examine how interferon gamma (IFNc), a centralmodulator of inflammation, affects the NOD2-mediated signaling pathway in human conventional DCs (cDCs).Synergistic stimulation of DCs with MDP and IFNc increased the expression of CD40, CD80, CD83, CD86, and humanleukocyte antigen DQ proteins and significantly elevated the production of pro-inflammatory cytokines IL-1b, IL-6, IL-12,and tumour necrosis factor (TNF), as well as anti-inflammatory cytokine IL-10. Furthermore, the simultaneous presenceofMDP and IFNc was necessary to decrease IkBa protein levels. By investigating various mechanisms implicated in MDPandIFNc-mediated signaling pathways, we revealed that the increased production of pro-inflammatory cytokines ishighly dependent on the X-linked inhibitor of apoptosis protein (XIAP) but not on cellular IAP1 and IAP2. We also foundthat the NOD2 signaling pathway is regulated by the mammalian target of rapamycin (mTOR) but is not affected byphosphatidylinositol-3 kinase or signal transducer and activator of transcription 1 inhibition. Our results demonstrate, forthe first time, that IFNc positively affects NOD2-mediated signaling in human cDCs, in a manner considerably dependenton XIAP and partially dependent on mTOR.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
dendritic cell
mTOR
NOD2
XIAP
Megjelenés:Cellular And Molecular Immunology 14 : 4 (2017), p. 380-391. -
További szerzők:Koncz Gábor (1970-) (biológus, immunológus) Szabó Brigitta Gregus Andrea (1980-) (biológus) Rajnavölgyi Éva (1950-) (immunológus)
Pályázati támogatás:NN114423
OTKA
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2.

001-es BibID:BIBFORM015831
Első szerző:Kivity, Shaye
Cím:Vitamin D and autoimmune thyroid diseases / Kivity, S., Agmon-Levin, N., Zisappl, M., Shapira, Y., Nagy, E. V., Danko, K., Szekanecz, Z., Langevitz, P., Shoenfeld, Y.
Dátum:2011
ISSN:2042-0226 (Electronic)
Megjegyzések:The role of vitamin D as an immune modulator has been emphasized in recent years, and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus. Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. While VDR gene polymorphism was found to associate with autoimmune thyroid diseases (AITDs), few studies examined levels of vitamin D in these patients and those that did yielded conflicting results. We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls. Serum vitamin D (25-OH) levels were measured in 50 patients with AITDs, 42 patients with non-AITDs and 98 healthy subjects, utilizing the LIAISON chemiluminescence immunoassay (DiaSorin, Saluggia, Italy). Vitamin D deficiency was designated at levels lower than 10 ng/ml. Antithyroid antibodies, thyroid functions and demographic parameters were evaluated in all patients. The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals (72% versus 30.6%; P<0.001), as well as in patients with Hashimoto's thyroiditis compared to patients with non-AITDs (79% versus 52%; P<0.05). Vitamin D deficiency also correlated to the presence of antithyroid antibodies (P=0.01) and abnormal thyroid function tests (P=0.059). Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests, suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation.Cellular & Molecular Immunology advance online publication, 31 January 2011; doi:10.1038/cmi.2010.73.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cellular and Molecular Immunology. - 8 : 3 (2011), p. 243-247. -
További szerzők:Agmon-Levin, Nancy Zisappl, Michael Shapira, Yinon Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Langevitz, Pnina Shoenfeld, Yehuda
Internet cím:DOI
elektronikus változat
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM006790
Első szerző:Sárváry Attila (népegészségtan szakorvos)
Cím:Possible role of factor XIII subunit A in Fcgamma and complement receptor-mediated phagocytosis / Sarvary, A., Szucs, S., Balogh, I., Becsky, A., Bardos, H., Kavai, M., Seligsohn, U., Egbring, R., Lopaciuk, S., Muszbek, L., Adany, R.
Dátum:2004
ISSN:0008-8749
Megjegyzések:Besides its traditional role in hemostasis, factor XIII subunit A (FXIII-A) is supposed to function as a cellular transglutaminase and to be involved in certain intracellular processes, including cytoskeletal remodeling. To investigate its intracellular role, the aim of the present study was to follow changes in FXIII-A production in combination with the receptor-mediated phagocytic activities of monocytes/macrophages and to examine the phagocytic functions of monocytes in patients with FXIII-A deficiency. Human blood monocytes were isolated from the buffy coats of healthy volunteers and cultured for 4 days. The FcgammaR-mediated phagocytosis of sensitized erythrocytes (EA) and the complement receptor (CR)-mediated phagocytosis of complement-coated yeast particles were studied during monocyte/macrophage differentiation. Changes in the gene expression of FXIII-A were detected by real-time quantitative RT-PCR. FXIII-A protein production was investigated with fluorescent image analysis at single cell level and Western immunoblot analysis. Both the FcgammaR and CR-mediated phagocytosis increased during culturing, which peaked on day 3. The phagocytic activity of the cells could be markedly inhibited with monodansylcadaverine, an inhibitor of the transglutaminase-induced crosslinking of proteins. The phagocytosis of EA, complement-coated and uncoated yeast particles was found to be strongly diminished in monocytes of FXIII-A deficient patients. The phagocytic functions of cultured cells showed a change in parallel with the alterations in FXIII-A mRNA expression, as well as with that in FXIII-A in protein synthesis detected by image and Western immunoblot analyses in concert. Our results suggest that FXIII-A plays a role in the Fcgamma and complement receptor-mediated phagocytic activities of monocytes/macrophages.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Blotting, Western
Cadaverine
Enzyme Inhibitors
Erythrocytes
Factor XIII
Female
Humans
Macrophages
Male
Microscopy, Fluorescence
Phagocytosis
RNA
Receptors, Complement 3b
Receptors, IgG
Reverse Transcriptase Polymerase Chain Reaction
Transglutaminases
Megjelenés:Cellular Immunology. - 228 : 2 (2004), p. 81-90. -
További szerzők:Szűcs Sándor (1958-) (biokémikus, vegyész) Balogh Imre Becsky Áron Bárdos Helga (1969-) (megelőző orvostan és népegészségtan szakorvos) Kávai Mária (1930-) (vegyész) Seligsohn, Uri Egbring, Rudolf Lopaciuk, Stanislaw Muszbek László (1942-) (haematológus, kutató orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:elektronikus változat
DOI
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4.

001-es BibID:BIBFORM042727
Első szerző:Somodi Sándor (belgyógyász)
Cím:Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state / Somodi Sándor, Balajthy András, Szilágyi Orsolya, Pethő Zoltán, Harangi Mariann, Paragh György, Panyi György, Hajdu Péter
Dátum:2013
ISSN:0008-8749
Megjegyzések:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the proliferation capacity and functional changes of Kv1.3 channels in T cells from healthy and hypercholestaeremic patients. By means of CFSE-assay (carboxyfluorescein succinimidyl ester) we showed that spontaneous activation rate of lymphocytes in hypercholesterolemia was elevated and the antiCD3/antiCD28 co-stimulation was less effective as compared to the healthy group. Using whole-cell patch-clamping we obtained that the activation and deactivation kinetics of Kv1.3 channels were faster in hypercholesterolemic state but no change in other parameters of Kv1.3 were found (inactivation kinetics, steady-state activation, expression level). We suppose that incorporation of oxLDL species via its raft-rupturing effect can modify proliferative rate of T cells as well as the gating of Kv1.3 channels.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Egészség- és Környezettudomány
Megjelenés:Cellular Immunology. - 281 : 1 (2013), p. 20-26. -
További szerzők:Balajthy András (1988-) (általános orvos) Szilágyi Orsolya (1985-) (molekuláris biológus, biokémikus) Pethő Zoltán (1989-) (orvos) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Panyi György (1966-) (biofizikus) Hajdu Péter (1975-) (biofizikus)
Pályázati támogatás:TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Gyulladásos és egyéb proatherogén tényezők vizsgálata a lipidanyagcsere zavarával járó kórállapotokban
Mecenatura 13/2008
Egyéb
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5.

001-es BibID:BIBFORM052647
Első szerző:Szabó Attila (molekuláris biológus, immunológus, filozófus)
Cím:Finding a fairy in the forest : ELF4, a novel and critical element of type I interferon responses / Attila Szabo, Éva Rajnavolgyi
Dátum:2014
ISSN:1672-7681 2042-0226
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
innate immunity
interferon
Pattern recognition receptors
Megjelenés:Cellular and Molecular Immunology. - 11 : 3 (2014), p. 218-220. -
További szerzők:Rajnavölgyi Éva (1950-) (immunológus)
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