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1.

001-es BibID:BIBFORM050620
Első szerző:Barta Kitti (belgyógyász)
Cím:Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis / Kitti Barta, Árpád Czifra, Csaba Kun, Alida Páll, Julianna Kulcsár, György Paragh, István Lőrincz, Tamás János Padra, Anupam Agarwal, Zarjou Abolfazl, József Balla, Zoltán Szabo
Dátum:2014
ISSN:1342-1751 1437-7799
Megjegyzések:BACKGROUND/AIMS:The prolongation of the QT interval and dispersion could predict ventricular arrhythmias. It is not yet established whether there is a difference between the effects of hemodialysis and hemodiafiltration on QT interval duration and dispersion.METHODS:Data of thirty patients was investigated while they were receiving hemodiafiltration over a period of 3 months; then the same group of patients was evaluated during treatment with conventional hemodialysis for at least another 3 months. Ionic parameters and surface electrocardiograms (ECG) were analyzed five times during each session, and 2D, M-mode echocardiography and Holter ECGs were performed to acquire additional information.RESULTS:QT interval duration (QTmax) and dispersion (QTd) showed a significant increase during hemodialysis, but not during hemodiafiltration. QTmax was 388.66 ? 31.81 ms at the beginning of hemodialysis and increased to 400.66 ? 39.12 ms even at the 30th minute (p < 0.05). QTd was found to be 31.33 ? 10.08 ms before the commencement of hemodialysis with the largest prolongation being seen at the 240th minute (51.33 ? 14.56 ms, p < 0.05). The occurrence of ventricular premature beats was significantly higher during hemodialysis (p = 0.018). The left atrial diameter significantly decreased at the end of hemodiafiltration (at the beginning 45.1 ? 5.25 mm, at the end 40.77 ? 5.76 mm; p < 0.05).CONCLUSION:Our results suggest a beneficial effect of hemodiafiltration on the studied electrocardiographic parameters compared to hemodialysis. The larger decrease in the left atrial diameter suggests a more efficient intracardiac volume-decreasing potential of hemodiafiltration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Hemodiafiltration
Hemodialysis
Ventricular arrhythmias
QT interval
QT dispersion
Megjelenés:Clinical and Experimental Nephrology. - 18 : 6 (2014), p. 952-959. -
További szerzők:Czifra Árpád (1983-) (belgyógyász) Kun Csaba (1969-) (kardiológus) Páll Alida (1983-) (orvos) Kulcsár Júlia (1983-) (orvos) Paragh György (1953-) (belgyógyász) Lőrincz István (1950-) (belgyógyász, kardiológus) Padra János Tamás (1984-) (biológus) Agarwal, Anupam Zarjou, Abolfazl (1979-) (kutató orvos) Balla József (1959-) (belgyógyász, nephrológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Belgyógyászat Kutatócsoport
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2.

001-es BibID:BIBFORM027923
Első szerző:Buglyó Gergely (genetikus)
Cím:WT1 microdeletion and slowly progressing focal glomerulosclerosis in a patient with male pseudohermaphroditism, childhood leukemia, Wilms tumor and cerebellar angioblastoma / Gergely Buglyó, Gábor Méhes, György Vargha, Sándor Biró, János Mátyus
Dátum:2013
ISSN:0301-0430
Megjegyzések:The WT1 gene is currently in focus by pediatric nephrologists as its mutations are associated with nephrotic syndrome, especially as part of complex clinical entities like Denys-Drash or Frasier syndrome. Renal failure may also develop in young WAGR patients, whose condition is attributed to a deletion at chromosomal region 11p13. However, only limited data exist on WT1 microdeletions. A 30-year-old male patient, with a history of genital malformations, a Wilms tumor manifested during the treatment of ALL at an age of 4, and a cerebellar angioblastoma, was referred with proteinuria and a reduced GFR. Kidney biopsy revealed FSGS. Although all WT1 exons were amplified with PCR and sequenced, none of them showed a mutation. However, an FFPE tissue sample of the patient's childhood Wilms tumor showed WT1-positivity restricted to the renal tumor cells, so the WT1 gene was investigated further. Using qRT-PCR, the gene was found to be present in only one copy in the patient's genomic DNA sample, while both copies were detected in both parents. In the patient's sister, the proximal region of WT1 was shown to have an extra copy. Evidence suggests that a heterozygous microdeletion of the gene WT1 is responsible for the patient's disease. It seems reasonable to assume a possible abnormality affecting meiotic crossing over at the WT1 locus in one of the parents.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Clinical Nephrology 79 : 5 (2013), p. 414-418. -
További szerzők:Méhes Gábor (1966-) (patológus) Vargha György (1951-) (orvos) Biró Sándor (1949-) (molekuláris genetikus) Mátyus János (1957-) (belgyógyász, nephrológus)
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3.

001-es BibID:BIBFORM061607
Első szerző:Farah Musa, A.R.
Cím:Cytomegalovirus colitis in a critically ill, dialysis-dependent, acute kidney injury patient without immunosuppressive therapy / Farah Musa A.R., Fülöp T., Kokko K., Kanyicska B., Lewin J. R., Csongrádi É.
Dátum:2015
Megjegyzések:BACKGROUND:Historically, cytomegalovirus (CMV) infection in immunocompetent patients has been considered to have a relatively indolent and self-limited course, not warranting specific treatment.CASE PRESENTATION:We are presenting a 72-year-old African-American male transferred to our intensive care unit (ICU) with methicillin-resistant Staphylococcus aureus bacteremia, respiratory failure, and dialysis-dependent acute kidney injury. While he recovered from bacteremia, he remained difficult to wean from respiratory support, had labile blood pressure, and manifested persistent diarrhea. Stool antigen testing for C. difficile colitis returned repeatedly negative. Flexible sigmoidoscopy described diffuse ulceration, attributed to ischemic colitis. The colon biopsy specimen, however, described tissue-invasive cytomegalovirus (CMV) infection. Polymerase chain reaction (PCR) testing confirmed viremia with 8,900 copies/mL viral DNA. Human immunodeficiency virus antibody and PCR testing were both negative. Absolute lymphocyte count varied between 80 and 450/mm3 during the admission. After IV ganciclovir initiation, diarrhea and respiratory failure resolved, while renal function recovered to the patient'??s baseline.CONCLUSION:The combination of critical illness and recent bacteremia likely represented a state of profound immunosuppression in this formerly healthy patient. CMV colitis may be under-diagnosed in sick ICU patients with renal failure and otherwise unexplained diarrhea. Serum PCR testing may aid the diagnosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical nephrology 84 : 1 (2015), p. 44-49. -
További szerzők:Fülöp Tibor (1957-) (kardiológus) Kokko, K. Kanyicska Béla (tudományos segédmunkatárs) Lewin, Jack R. Csongrádi Éva (1969-) (szakorvos)
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4.

001-es BibID:BIBFORM057333
Első szerző:Harambat, Jérôme
Cím:Adult height in patients with advanced CKD requiring renal replacement therapy during childhood / Jérôme Harambat, Marjolein Bonthuis, Karlijn J. van Stralen, Gema Ariceta, Nina Battelino, Anna Bjerre, Timo Jahnukainen, Valérie Leroy, György Reusz, Ana R. Sandes, Manish D. Sinha, Jaap W. Groothoff, Christian Combe, Kitty J. Jager, Enrico Verrina, Franz Schaefer, ESPN/ERA-EDTA Registry
Dátum:2013
ISSN:1555-9041 1555-905X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Journal of the American Society of Nephrology. - 9 : 1 (2013), p. 92-99. -
További szerzők:Bonthuis, Marjolein van Stralen, Karlijn J. Ariceta, Gema Battelino, Nina Bjerre, Anna Jahnukainen, Timo Leroy, Valérie Reusz György Sandes, Ana R. Sinha, Manish D. Groothoff, Jaap W. Combe, Christian Jager, Kitty J. Verrina, Enrico Schaefer, Franz Szabó Tamás (1968-) (gyermekgyógyász) ESPN/ERA-EDTA Registry
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5.

001-es BibID:BIBFORM054141
Első szerző:Regéczy Nóra
Cím:Membranous glomerulonephritis in a patient with inherited activated protein C resistance / N. Regéczy, G. Lakos, I. Balogh, J. Kappelmayer, E. Kiss
Dátum:2000
ISSN:0301-0430
Megjegyzések:We present a patient with membranous glomerulonephritis, several clinical complications of the antiphospholipid syndrome and ulcerative colitis, but without lupus anticoagulant and antiphospholipid/cofactor antibodies. Immunological studies--other antibodies--were negative and failed to show enough criteria for any autoimmune diseases. Evaluation of her laboratory tests for hereditary thrombophilia revealed a heterozygous form of the Leiden mutation that might be associated with widespread vasculopathy. An interesting possibility is that the inherited activated protein C resistance could be an additional risk factor for vaso-occlusive manifestations appearing as a clinical sign of cardiovascular diseases and nephropathy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Nephrology. - 53 : 5 (2000), p. 390-393. -
További szerzők:Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Balogh István (1972-) (molekuláris biológus, genetikus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss E.
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6.

001-es BibID:BIBFORM002293
Első szerző:Sulowicz, Wladyslaw
Cím:Once-Monthly subcutaneous C.E.R.A. maintains stable hemoglobin control in patients with chronic kidney disease on dialysis and converted directly from epoetin one to three times weekly / Wladyslaw Sulowicz, Francesco Locatelli, Jean-Philippe Ryckelynck, Jozsef Balla, Botond Csiky, Kevin Harris, Patricia Ehrhard, Ulrich Beyer
Dátum:2007
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical journal of the American Society of Nephrology : CJASN 2 : 4 (2007), p. 637-646. -
További szerzők:Locatelli, Francesco Ryckelynck, Jean-Philippe Balla József (1959-) (belgyógyász, nephrológus) Csiky Botond Harris, Kevin Ehrhard, Patricia Beyer, Ulrich
Internet cím:elektronikus változat
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7.

001-es BibID:BIBFORM040399
Első szerző:Vas T.
Cím:Oxidative stress and non-enzymatic glycation in IgA nephropathy / Vas T., Wagner Z., Jenei V., Varga Z., Kovács T., Wittmann I., Schinzel R., Balla G., Balla J., Heidland A., Nagy J.
Dátum:2005
ISSN:0301-0430
Megjegyzések:AIM: Approximately 20-50% of IgA nephropathy patients develop end-stage renal disease. We have previously found enhanced oxidative stress and decreased antioxidant capacity in red blood cells of IgA nephropathy patients. In this study we assess oxidative stress, non-enzymatic glycation, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content in these patients. PATIENTS AND METHODS: Non-enzymatic glycation and oxidative stress were assessed in 88 IgA nephropathy patients by measuring advanced glycation end products, Nepsilon-carboxymethyl-lysine, thiobarbituric acid reactive substances, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content. RESULTS: Advanced glycation end products (2659 +/- 958 a.u.) and Nepsilon-carboxymethyl-lysine (563 +/- 215 ng/ml) were significantly higher in IgA nephropathy patients with decreased renal function compared to those with normal renal function (p < 0.002) or controls (p < 0.001). Thiobarbituric acid-reactive substances in plasma and associated with low-density lipoprotein were significantly elevated and oxidative resistance of low-density lipoprotein was significantly reduced in all groups of IgA nephropathy patients. There was no significant difference in circulating fluorescent advanced glycation end products, Nepsilon-carboxymethyl-lysine, thiobarbituric acid-reactive substances levels, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content between patients with normal vs. impaired glucose metabolism. Low alpha-tocopherol content of low-density lipoprotein was accompanied with decreased oxidative resistance, depletion in polyunsaturated fatty acids, elevated saturated fatty acids and thiobarbituric acid-reactive substances within low-density lipoprotein suggesting enhanced lipid peroxidation. CONCLUSIONS: Decreased oxidative resistance of low-density lipoprotein and enhanced oxidative stress are common features in IgA nephropathy, while increased non-enzymatic glycation occurs as renal function declines.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Nephrology. - 64 : 5 (2005), p. 343-351. -
További szerzők:Wagner Zoltán Jeney Viktória (1971-) (vegyész, kémia tanár) Varga Z. Kovács T. Wittmann István Schinzel, R. Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Balla József (1959-) (belgyógyász, nephrológus) Heidland, A. Nagy J. (orvos)
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8.

001-es BibID:BIBFORM013548
Első szerző:Wanner, Christoph
Cím:Prognostic indicators of renal disease progression in adults with Fabry disease : natural history data from the Fabry Registry / Christoph Wanner, Joao P. Oliveira, Alberto Ortiz, Michael Mauer, Dominique P. Germain, Gabor E. Linthorst, Andreas L. Serra, László Maródi, Renzo Mignani, Bruno Cianciaruso, Bojan Vujkovac, Roberta Lemay, Dana Beitner-Johnson, Stephen Waldek, David G. Warnock
Dátum:2010
Megjegyzések:Background and objectives: These analyses were designed to characterize renal disease progression in untreated adults with Fabry disease. Design, setting, participants, & measurements: Data from the Fabry Registry for 462 untreated adults (121 men and 341 women) who had at least two estimated GFR (eGFR) values over a span of >12 months before starting enzyme replacement therapy were included. Results: Most men (86 of 121, 71%) had more rapid loss of kidney function than the normal adult population (loss of eGFR > -1 ml/min per 1.73 m2 per year), whereas fewer women (133 of 341, 39%) had rapid loss of kidney function. Patients with rapid progression had significantly higher mean averaged urinary protein to urinary creatinine ratios (UP/Cr) than patients with slower progression (1.5 versus 0.2 for men; 1.4 versus 0.5 for women; P < 0.0001). Patients were grouped into quartiles based on averaged UP/Cr; renal function in men declined more rapidly with higher UP/Cr, with the steepest declines observed in men with UP/Cr > 1.5 (mean eGFR slope, -5.6 ml/min per 1.73 m2 per year; n = 30). eGFR slope declined more slowly in women, with the steepest declines observed in women with UP/Cr > 1.2 (mean eGFR slope, -1.3 ml/min per 1.73 m2 per year; n = 85). Regression models of eGFR slope indicated that UP/Cr is the most important indicator of renal disease progression in adult Fabry patients. In women, lower baseline eGFR and age were also associated with renal disease progression. Women who had clinical events had more rapid loss of kidney function. Conclusions: Urinary protein excretion is strongly associated with renal disease progression in men and women with Fabry disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Journal American Society Nephrology. - 5 : 12 (2010), p. 2220-2228. -
További szerzők:Oliveira, Joao Paulo Ortiz, Alberto Mauer, Michael Germain, Dominique P. Linthorst, Gabor E. Serra, Andreas L. Maródi László (1949-) (gyermekgyógyász infektológus, immunológus) Mignani, Renzo Cianciaruso, Bruno Vujkovac, Bojan Lemay, Roberta M. Beitner-Johnson, Dana Waldek, Stephen Warnock, David G.
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