Találati lista | Tudóstér

001-es BibID:	BIBFORM058208
Első szerző:	Jahr, Holger
Cím:	Physicochemical and biomechanical stimuli in cell-based articular cartilage repair / Holger Jahr, Csaba Matta, Ali Mobasheri
Dátum:	2015
ISSN:	1523-3774 1534-6307
Megjegyzések:	Articular cartilage is a unique load-bearing connective tissue with a low intrinsic capacity for repair and regeneration. Its avascularity makes it relatively hypoxic and its unique extracellular matrix is enriched with cations, which increases the interstitial fluid osmolarity. Several physicochemical and biomechanical stimuli are reported to influence chondrocyte metabolism and may be utilized for regenerative medical approaches. In this review article, we summarize the most relevant stimuli and describe how ion channels may contribute to cartilage homeostasis, with special emphasis on intracellular signaling pathways. We specifically focus on the role of calcium signaling as an essential mechanotransduction component and highlight the role of phosphatase signaling in this context.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Current Rheumatology Reports. - 17 : 3 (2015), p. 17-22. -
További szerzők:	Matta Csaba (1980-) (molekuláris biológus, genetikus, angol szakfordító) Mobasheri, Ali
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM071102
Első szerző:	Matta Csaba (molekuláris biológus, genetikus, angol szakfordító)
Cím:	Voltage-dependent calcium channels in chondrocytes : roles in health and disease / Csaba Matta, Róza Zákány, Ali Mobasheri
Dátum:	2015
ISSN:	1523-3774 1534-6307
Megjegyzések:	Chondrocytes, the single cell type in adult articular cartilage, have conventionally been considered to be non-excitable cells. However, recent evidence suggests that their resting membrane potential (RMP) is less negative than that of excitable cells, and they are fully equipped with channels that control ion, water and osmolyte movement across the chondrocyte membrane. Amongst calcium-specific ion channels, members of the voltage-dependent calcium channel (VDCC) family are expressed in chondrocytes where they are functionally active. L-type VDCC inhibitors such as nifedipine and verapamil have contributed to our understanding of the roles of these ion channels in chondrogenesis, chondrocyte signalling and mechanotransduction. In this narrative review, we discuss published data indicating that VDCC function is vital for chondrocyte health, especially in regulating proliferation and maturation. We also highlight the fact that activation of VDCC function appears to accompany various inflammatory aspects of osteoarthritis (OA) and, based on in vitro data, the application of nifedipine and/or verapamil may be a promising approach for ameliorating OA severity. However, very few studies on clinical outcomes are available regarding the influence of calcium antagonists, which are used primarily for treating cardiovascular conditions in OA patients. This review is intended to stimulate further research on the chondrocyte ♭channelome', contribute to the development of novel therapeutic strategies and facilitate the retargeting and repositioning of existing pharmacological agents currently used for other comorbidities for the treatment of OA.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Current Rheumatology Reports. - 17 : 7 (2015), p. 1-11. -
További szerzők:	Zákány Róza (1963-) (anatómus-, kötőszövetbiológus) Mobasheri, Ali
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM040081
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Update on synovitis / Szekanecz Zoltan, Koch Alisa E.
Dátum:	2001
ISSN:	1523-3774
Megjegyzések:	Rheumatoid arthritis (RA) is an inflammatory disorder associated with chronic synovitis, eventually leading to cartilage and bone destruction in the joints. Synovitis is associated with the activation of various cells in the synovium including synovial lining cells, interstitial macrophages, endothelial cells, lymphocytes, and fibroblasts. The key mechanisms underlying synovitis include inflammatory cell adhesion and activation, the production of mediators (such as cytokines, chemokines, and growth factors), angiogenesis, joint destruction, fibrosis, and bone resorption. These important events, as well as the role of inflammatory cells, cell surface molecules, and soluble mediators are updated and discussed in this review. Some aspects and strategies of current or future immunotherapy are also discussed because these animal and human trials provide information on the pathogenesis of inflammatory synovitis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Bone and Bones Cell Adhesion Cell Communication Cell Movement Cytokines Humans Immunotherapy Inflammation Mediators Joints Neovascularization, Physiologic Synovial Membrane Synovitis
Megjelenés:	Current Rheumatology Reports. - 3 : 1 (2001), p. 53-63. -
További szerzők:	Koch, Alisa E.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM096268
035-os BibID:	(WoS)000668894700003 (Scopus)85109084494 (Pubmed)34196873 (cikkazonosító)55
Első szerző:	Vincze Anett
Cím:	Bone Health in Idiopathic Inflammatory Myopathies : diagnosis and Management / Anett Vincze, János Gaál, Zoltán Griger
Dátum:	2021
ISSN:	1523-3774 1534-6307
Megjegyzések:	Purpose of review: This article provides an update on the most recent advances in epidemiology, pathogenesis, diagnostic procedures, and therapeutic approaches for myositis-associated bone diseases, such as osteoporosis and bone fractures. Recent findings: In the recent years, several studies showed that osteoporosis and consequent fractures are a common and frequently underestimated complication in patients with idiopathic inflammatory myopathies (IIM). In younger patients, asymptomatic fractures might present in the early phase of the disease which could increase the risk of development of further fractures. High-risk patients could be selected with early application of combined diagnostic procedures, such as fracture risk scores with steroid dose adjustments and imaging. Recent advances might help clinicians from different fields of medicine in the early recognition and management of myositis-associated osteoporosis, which will potentially improve the quality of life of patients with IIM.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Glucocorticoid Myositis Osteoporosis, bone, fracture risk Vertebral fractures
Megjelenés:	Current Rheumatology Reports. - 23 : 7 (2021), p. 1-11. -
További szerzők:	Gaál János (1965-) (reumatológus, belgyógyász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: