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1.

001-es BibID:BIBFORM021684
Első szerző:Bácsi Attila (immunológus)
Cím:Induction of HIV-1 replication in latently infected syncytiotrophoblast cells by contact with placental macrophages : role of interleukin-6 and tumor necrosis factor-alpha / Bácsi A., Csoma E., Beck Z., Andirkó I., Kónya J., Gergely L., D. Tóth F.
Dátum:2001
ISSN:1079-9907
Megjegyzések:The syncytiotrophoblast (ST) layer of the human placenta has an important role in limiting transplacental viral spread from mother to fetus. Although certain strains of human immunodeficiency virus type 1 (HIV-1) may enter ST cells, the trophoblast does not exhibit permissiveness for HIV-1. The present study tested the possibility that placental macrophages might induce replication of HIV-1 carried in ST cells and, further, that infected ST cells would be capable of transmitting virus into neighboring macrophages. For this purpose, we investigated HIV-1 replication in ST cells grown alone or cocultured with uninfected placental macrophages. The macrophage-tropic Ba-L strain of HIV-1, capable of entering ST cells, was used throughout our studies. We demonstrated that interactions between ST cells and macrophages activated HIV-1 from latency and induced its replication in ST cells. After having become permissive for viral replication, ST cells delivered HIV-1 to the cocultured macrophages, as evidenced by detection of virus-specific antigens in these cells. The stimulatory effect of coculture on HIV-1 gene expression in ST cells was mediated by marked tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) release from macrophages, an effect caused by contact between the different placental cells. Results of this study suggest an interactive role for the ST layer and placental macrophages in the dissemination of HIV-1 among placental tissue. Data reported here may also explain why macrophage-tropic HIV-1 strains are transmitted preferentially during pregnancy.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Interferon And Cytokine Research. - 21 : 12 (2001), p. 1079-1088. -
További szerzők:Csoma Eszter (1978-) (molekuláris biológus, mikrobiológus) Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Andirkó István Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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2.

001-es BibID:BIBFORM014136
Első szerző:Benkő Szilvia (molekuláris biológus)
Cím:The microbial and danger signals that activate Nod-like receptors / Benko S., Philpott D. J., Girardin S. E.
Dátum:2008
ISSN:1043-4666
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cytokine. - 43 : 3 (2008), p. 368-373. -
További szerzők:Philpott, Dana J. Girardin, Stephen E.
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM004706
Első szerző:Eicher, Donald M.
Cím:Oligomerization of IL-2Ralpha / Eicher, D. M., Damjanovich, S., Waldmann, T. A.
Dátum:2002
Megjegyzések:Interleukin (IL) 2 receptor subunit alpha (IL-2Ralpha) increases the affinity of the IL-2 receptor complex while hetero-association of IL-2Rbeta and gamma(c) chains initiates a proliferative signal. We show here that IL-2Ralpha is necessary for receptor clustering required for augmentation of IL-2 signalling. Cells expressing chimeras incorporating the extracellular domain of IL-2Ralpha demonstrated IL-2 independent homo-association of the IL-2Ralpha chimera. Singly or co-transfected IL-2Rbeta and gamma(c) chimeras showed no spontaneous or IL-2-inducible oligomerization. Co-transfection of IL-2Ralpha and IL-2Rbeta (plus minusgamma(c)) chimeras diminished spontaneous IL-2Ralpha chimera oligomerization and permitted IL-2-inducible hetero-oligomerization of receptor components. Homo-association of IL-2Ralpha was also demonstrated by fluorescence resonance energy transfer (FRET). The spontaneous homo-oligomerization property of IL-2Ralpha required the membrane proximal region of the receptor (exon 6) by deletion analysis; the IL-2 inducible oligomerization property of IL-2Ralpha required the second "sushi" domain (exon 4). This work provides insight into the mechanics of this complex receptor system and to other receptor complexes in the immune system that send signals by clustering receptor subunits
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
analysis
Energy Transfer
Fluorescence
Megjelenés:Cytokine. - 17 : 2 (2002), p. 82-90. -
További szerzők:Damjanovich Sándor (1936-2017) (biofizikus) Waldmann, Thomas A.
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4.

001-es BibID:BIBFORM010489
Első szerző:Fodor Mariann (szemész)
Cím:Long-term kinetics of cytokine responses in human tears after penetrating keratoplasty / Fodor Mariann, Gogolák Péter, Rajnavölgyi Éva, Berta András, Kardos László, Módis László, Facskó Andrea
Dátum:2009
Megjegyzések:This was a kinetic study of inflammatory cytokine levels in postoperative tear samples from penetrating keratoplasty (PKP) patients with or without corneal rejection. In a prospective design, nonstimulated tears were collected from the affected eyes of 12 patients at regular intervals for 12-14 months following PKP. Nine patients retained clear grafts, whereas three suffered endothelial rejection of the corneal graft within 14 months. The concentrations of the cytokines IL-1beta, IL-6, TNF-alpha, IL-8, IL-10, and IL-12p70 were measured via cytometric bead array technology. The postoperative concentrations of the cytokines in the tears varied among the patients, but exhibited similar alteration patterns in each eye tested. The concentrations of IL-6 and IL-8 were significantly higher (P = 0.009 and P = 0.01, respectively), whereas those of IL-10, TNF-alpha, and IL-12p70 were significantly lower (P = 0.008, P = 0.006, and P = 0.0009, respectively) in the tear samples from the patients with corneal rejection as compared with those with uncomplicated corneal grafts. The ratios IL-6/IL-10 and IL-8/IL-10 were significantly higher (P = 0.0231 and P = 0.015, respectively), and TNF-alpha/IL-10 was significantly lower (P = 0.045) throughout the examination period in the patients with endothelial rejection. The enhanced release of IL-6 and IL-8 into the tears of patients with corneal graft rejection concomitant with decreased concentrations of IL-10, TNF-alpha, and IL-12p70 may possibly serve as an indicator of the rejection process. However, due to the large variation in the cytokine concentrations, the observed changes in tear composition do not categorically predict the final graft outcome.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
cytokine
Megjelenés:Journal of Interferon and Cytokine Research. - 29 : 7 (2009), p. 375-380. -
További szerzők:Gogolák Péter (1968-) (biológus, immunológus) Rajnavölgyi Éva (1950-) (immunológus) Berta András (1955-) (szemész, gyermekszemész) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Módis László (1964-) (szemész szakorvos, kontaktológus) Facskó Andrea (1953-) (szemész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM002294
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease / Magyar Mária Tünde, Bereczki Dániel, Csípő István, Gyimesi Edit, Csiba László, Valikovics Attila, Balla József, Sipka Sándor
Dátum:2007
Megjegyzések:Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p < 0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p < 0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
atherosclerosis
inflammation
cytokines
Rantes
MCP-1
Megjelenés:Cytokine 37 : 1 (2007), p. 44-50. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Csípő István (1953-) (vegyész) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Csiba László (1952-) (neurológus, pszichiáter) Valikovics Attila Balla József (1959-) (belgyógyász, nephrológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
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6.

001-es BibID:BIBFORM040669
Első szerző:Sipka Sándor (laboratóriumi szakorvos)
Cím:Adenosine inhibits the release of interleukin-1beta in activated human peripheral mononuclear cells / Sandor Sipka, Ildikó Kovács, Sándor Szántó, Gyula Szegedi, László Brugós, Géza Bruckner, A. József Szentmiklósi
Dátum:2005
ISSN:1043-4666
Megjegyzések:The effects of adenosine and subtype-specific activators of adenosine receptors (A1, A2A, A2B and A3) were studied on the release of interleukin-1beta (IL-1beta) from peripheral mononuclear cells, monocytes and lymphocytes. In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release. The rank order of potency in the inhibition of IL-1beta release was CPA=CGS 21680>IB-MECA>adenosine>NECA (in the presence of A1, A2A and A3 receptor inhibitors). The inhibitory actions of CPA, CGS 21680 or IB-MECA were significantly reduced in the presence of DPCPX, ZM 243185 or MRS 1191 as subtype-specific antagonists on A1, A2A and A3 adenosine receptors, respectively. It can be concluded that adenosine inhibits the release of IL-1beta from the activated human peripheral mononuclear cells. In this process A1, A2A and A3 receptors are involved.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adenosine/analogs & derivatives/pharmacology
Calcimycin/pharmacology
Humans
Interleukin-1/blood
Monocytes/drug effects/metabolism
Phenethylamines/pharmacology
Purinergic P1 Receptor Agonists
Tetradecanoylphorbol Acetate/pharmacology
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cytokine. - 31 : 4 (2005), p. 258-263. -
További szerzők:Kovács Ildikó Szántó Sándor (1968-) (belgyógyász, reumatológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Brugós László (1951-) (tüdőgyógyász, klinikai immunológus, allergológus) Bruckner Géza Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos)
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7.

001-es BibID:BIBFORM035764
Első szerző:Szőke Krisztina
Cím:IL-10 Promoter nt-1082A/G Polymorphism and Human Papillomavirus Infection in Cytologic Abnormalities of the Uterine Cervix / Szöke Krisztina, Szalmás Anita, Szládek Györgyi, Veress György, Gergely Lajos, Tóth Ferenc D., Kónya József
Dátum:2004
ISSN:1079-9907
Megjegyzések:The role of A/G polymorphism at nucleotide -1082 in the interleukin-10 (IL-10) promoter was assessed by following the disease course of 253 patients who had had a routine diagnostic Hybrid Capture human papillomavirus (HPV) test because of cytologic or colposcopic abnormalities of the uterine cervix. At baseline, 97 (78%) of the 125 high-risk HPV-positive and 83 (65%) of the 128 HPV-negative patients had equivocal cytologic atypia classified as P3 by the Papanicolaou classification, and the rest of the patients had mild colposcopic atypia with cytologic results of no oncogenic significance. In the high-risk HPV-infected patients, the frequency distribution of the nt -1082 genotypes (A/A: 28%; A/G: 52%; G/G: 20%) did not differ significantly from that in the controls (A/A: 25%; A/G: 51%; G/G: 24%; p = 0.70). On the other hand, the nt -1082 G allele tended to decrease susceptibility to equivocal cytologic atypia unrelated to HPV infection (A/G: OR = 0.56 [95% CI: 0.31-1.02], G/G: OR = 0.27 [95% CI: 0.11-0.63], p for trend = 0.05). With respect to the development of high-grade cervical intraepithelial neoplasia (CIN), the established risk factors, such as high-risk HPV infection (RR = 104.6, 95% CI: 14.2-769.9) and cytologic atypia (RR = 9.6, 95% CI: 2.34-39.7) but not the various nt -1082 genotypes (A/A: reference; A/G: RR = 1.11 [95% CI: 0.59-2.08]; G/G: RR = 0.62 [95% CI: 0.25-1.50]) were found to increase the risk for high-grade CIN. In conclusion, the nt -1082 polymorphism had no influence on the early phase of cervical carcinogenesis but may determine different susceptibilities to cervical abnormalities unrelated to HPV infection.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Interferon And Cytokine Research. - 24 : 4 (2004), p. 245-251. -
További szerzők:Szalmás Anita (1978-) (biológus, mikrobiológus, klinikai mikrobiológus) Szládek Györgyi Veress György (1966-) (biológus, mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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