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001-es BibID:BIBFORM008216
Első szerző:Sipka Sándor ifj. (orvos)
Cím:Oral administration of PCBs induces proinflammatory and prometastatic responses / Sipka, S., Eum, S. Y., Son, K. W., Xu, S., Gavalas, V. G., Hennig, B., Toborek, M.
Dátum:2008
Megjegyzések:Exposure to specific congeners of polychlorinated biphenyls (PCBs) can induce proinflammatory alterations, which may contribute to the formation of blood-borne tumor metastasis. The main aim of the present study was to establish an experimental model of PCB exposure in which PCBs are administered by oral gavage, which resembles the human exposure through the food chain. To determine structure-function relationship, we studied induction of inflammatory responses in the livers, lungs and brains of mice treated with PCB77 (a major coplanar PCB), PCB104 (a non-coplanar PCB with multiple ortho-chlorine substituents), and PCB153 (a major non-coplanar PCB) after a single gavage dose (150 gammamol/kg body weight). The strongest expression of proinflammatory proteins occurred 24 h following the PCB administration independent of the class of PCB congeners. These data indicate that food-chain exposure to PCBs can induce proinflammatory mediators in organs that are potential targets for PCB-induced toxicity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Environmental Toxicology and Pharmacology. - 25 : 2 (2008), p. 251-259. -
További szerzők:Eum, Sung-Yong Son, Kwang Won Xu, Shifen Gavalas, Vasileios G. Hennig, Bernhard Toborek, Michal
Internet cím:DOI
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