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001-es BibID:	BIBFORM116951
035-os BibID:	(scopus)85119325898 (wos)000718879000001
Első szerző:	Földi Mária
Cím:	The characteristics and prognostic role of acute abdominal on-admission pain in acute pancreatitis : A prospective cohort analysis of 1432 cases / Földi Mária, Gede Noémi, Kiss Szabolcs, Vincze Áron, Bajor Judit, Szabó Imre, Szepes Zoltán, Izbéki Ferenc, Gervain Judit, Hamvas József, Vitális Zsuzsanna, Fehér Eszter, Crai Stefan, Sallinen Ville, Ramirez-Maldonado Elena, Meczker Ágnes, Varjú Péter, Poropat Goran, Stimac Davor, Faluhelyi Nándor, Miseta Attila, Nagy Tamás, Márton Zsolt, Vereczkei András, Jenő Hegyi Péter, Párniczky Andrea, Hegyi Péter, Szentesi Andrea, Hungarian Pancreatic Study Group
Dátum:	2021
ISSN:	1090-3801
Megjegyzések:	Introduction Pain is the most common symptom in acute pancreatitis (AP) and is among the diagnostic criteria. Therefore, we aimed to characterize acute abdominal pain in AP. Methods The Hungarian Pancreatic Study Group prospectively collected multicentre clinical data on 1435 adult AP patients between 2012 and 2017. Pain was characterized by its intensity (mild or intense), duration prior to admission (hours), localization (nine regions of the abdomen) and type (sharp, dull or cramping). Results 97.3% of patients (n = 1394) had pain on admission. Of the initial population with acute abdominal pain, 727 patients answered questions about pain intensity, 1148 about pain type, 1134 about pain localization and 1202 about pain duration. Pain was mostly intense (70%, n = 511/727), characterized by cramping (61%, n = 705/1148), mostly starting less than 24 h prior to admission (56.7%, n = 682/1202). Interestingly, 50.9% of the patients (n = 577/1134) had atypical pain, which means pain other than epigastric or belt-like upper abdominal pain. We observed a higher proportion of peripancreatic fluid collection (19.5% vs. 11.0%; p = 0.009) and oedematous pancreas (8.4% vs. 3.1%; p = 0.016) with intense pain. Sharp pain was associated with AP severity (OR = 2.481 95% CI: 1.550?3.969) and increased mortality (OR = 2.263, 95% CI: 1.199?4.059) compared to other types. Longstanding pain (>72 h) on admission was not associated with outcomes. Pain characteristics showed little association with the patient's baseline characteristics. Conclusion A comprehensive patient interview should include questions about pain characteristics, including pain type. Patients with sharp and intense pain might need special monitoring and tailored pain management. Significance Acute abdominal pain is the leading presenting symptom in acute pancreatitis; however, we currently lack specific guidelines for pain assessment and management. In our cohort analysis, intense and sharp pain on admission was associated with higher odds for severe AP and several systemic and local complications. Therefore, a comprehensive patient interview should include questions about pain characteristics and patients with intense and sharp pain might need closer monitoring.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Journal Of Pain. - 26 : 3 (2021), p. 610-623. -
További szerzők:	Gede Noémi Kiss Szabolcs Vincze Áron Bajor Judit Szabó Imre Szepes Zoltán Izbéki Ferenc Gervain Judit Hamvas József Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Fehér Eszter Crai, Stefan Sallinen, Ville Ramírez-Maldonado, Elena Meczker Ágnes Varjú Péter Poropat, Goran Štimac, Davor Faluhelyi Nándor Miseta Attila Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus) Márton Zsolt Vereczkei András Hegyi Péter Jenő (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hegyi Péter (pszichológus) Szentesi Andrea Hungarian Pancreatic Study Group
Pályázati támogatás:	GINOP-2.3.2-15-2016-00048-STAY?ALIVE GINOP GINOP-2.3.2-15-2016-00015-I-KOM GINOP ÚNKP-20-3 Egyéb
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001-es BibID:	BIBFORM020455
Első szerző:	White, John P. M.
Cím:	Severe burn injury induces a characteristic activation of extracellular signal-regulated kinase 1/2 in spinal dorsal horn neurons / John P. M. White, Chin Wing Ko, Antonio Rei Fidalgo, Mario Cibelli, Cleoper C. Paule, Peter J. Anderson, Celia Cruz, Szabolcs Gomba, Klara Matesz, Gabor Veress, Antonio Avelino, Istvan Nagy
Dátum:	2011
ISSN:	1090-3801
Megjegyzések:	We have studied scalding-type burn injury-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in the spinal dorsal horn, which is a recognised marker for spinal nociceptive processing. At 5min after severe scalding injury to mouse hind-paw, a substantial number of phosphorylated ERK1/2 (pERK1/2) immunopositive neurons were found in the ipsilateral dorsal horn. At 1h post-injury, the number of pERK1/2-labelled neurons remained substantially the same. However, at 3h post-injury, a further increase in the number of labelled neurons was found on the ipsilateral side, while a remarkable increase in the number of labelled neurons on the contralateral side resulted in there being no significant difference between the extent of the labelling on both sides. By 6h post-injury, the number of labelled neurons was reduced on both sides without there being significant difference between the two sides. A similar pattern of severe scalding injury-induced activation of ERK1/2 in spinal dorsal horn neurons over the same time-course was found in mice which lacked the transient receptor potential type 1 receptor (TRPV1) except that the extent to which ERK1/2 was activated in the ipsilateral dorsal horn at 5 min post-injury was significantly greater in wild-type animals when compared to TRPV1 null animals. This difference in activation of ERK1/2 in spinal dorsal horn neurons was abolished within 1h after injury, demonstrating that TRPV1 is not essential for the maintenance of ongoing spinal nociceptive processing in inflammatory pain conditions in mouse resulting from at least certain types of severe burn injury.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Pain. - 15 : 7 (2011), p. 683-690. -
További szerzők:	Ko, Chin Wing Fidalgo, Antonio Rei Cibelli, Mario Paule, Cleoper C. Anderson, Peter J. Cruz, Celia Gomba Szabolcs (1933-2016) (pathológus) Matesz Klára (1949-) (anatómus, neurobiológus) Veress Gábor (1971-) (neurobiológus) Avelino, Antonio Nagy István (orvos)
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