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1.

001-es BibID:BIBFORM081138
035-os BibID:(PMID)31103453
Első szerző:Barna Sándor (kutató orvos)
Cím:Evaluation of the tear clearance rate by dacryoscintigraphy in patients with obstructive meibomian gland dysfunction / Sandor Barna, Ildiko Garai, Rudolf Gesztelyi, Adam Kemeny-Beke
Dátum:2019
ISSN:1367-0484
Megjegyzések:Purpose: To measure tear clearance values in patients with meibomian gland dysfunction (MGD) with a dynamic nuclear medicine method, namely, dacryoscintigraphy (DSCI). Methods: Twenty-four MGD patients and 24 healthy volunteers were examined. During DSCI one drop of a solution with 100 MBq/mL99mTc sodium pertechnetate was instilled with a micropipette into the lacrimal lake of both eyes. Measurements were performed according to a dynamic data acquisition protocol, which resulted in summed DSCI images. Data were also evaluated separately in special regions of interest (ROI), and consecutive time activity curves were created. Tear clearance (T?) values were calculated based on the activity curves. In addition, tear osmolarity measurements, tear breakup time (tBUT), and Schirmer I (STI) tests were performed prior to DSCI examination. Results: The T? values were 29.91 ? 11.61 min in MGD patients and 6.26 ? 1.5 min in healthy controls. Tear osmolarity parameters were 308 ? 9.41 mOsm/L and 288.9 ? 6.4 mOsm/L, tBUT values were 5.54 ? 2.73 s and 11.4 ? 2.7 s, while the STI test values were 6.17 ? 2.78mm and 13.58 ? 3.8 mm, respectively. The differences were significant (p < 0.01) in all cases. Conclusions: Although the MGD patients' lacrimal drainage systems were patent their tear clearance values were significantly higher than those of healthy volunteers, which may be caused by decreased drainage of tears from the eyes towards the nasal cavity. The understanding of new features regarding the altered physico-chemical characteristics of MGD tears has been augmented by the results of this study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
dacryoscintigraphy
Tear clearance
Meibomian gland dysfunction
Megjelenés:Contact Lens And Anterior Eye. - 42 : 4 (2019), p. 359-365. -
További szerzők:Garai Ildikó (1966-) (radiológus) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Kemény-Beke Ádám (1968-2021) (szemész)
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2.

001-es BibID:BIBFORM040802
Első szerző:Csutak Adrienne (szemész)
Cím:Plasminogen activator activity and inhibition in rabbit tears after photorefractive keratectomy / Csutak Adrienne Silver David M., Tőzsér József, Facskó Andrea, Berta András
Dátum:2003
ISSN:0014-4835
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Experimental Eye Research. - 77 : 6 (2003), p. 675-680. -
További szerzők:Silver, David M. Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Facskó Andrea (1953-) (szemész) Berta András (1955-) (szemész, gyermekszemész)
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3.

001-es BibID:BIBFORM015666
Első szerző:Csutak Adrienne (szemész)
Cím:Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study / Csutak A., Lengyel I., Jonasson F., Leung I., Geirsdottir A., Xing W., Peto T.
Dátum:2010
ISSN:0950-222X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Eye. - 24 : 10 (2010), p. 1568-1575. -
További szerzők:Lengyel I. Jonasson, Fridbert Leung, Irene Geirsdottir, A. Xing, W. Pető Tünde (1970-) (orvos, szemész)
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4.

001-es BibID:BIBFORM012849
Első szerző:Csutak Adrienne (szemész)
Cím:Urokinase down-regulation by aprotinin in rabbit corneal cells after photorefractive keratectomy / Csutak, A., Silver, D. M., Sperka, T., Kádas, J., Vereb, G., Berta, A., Tözsér, J.
Dátum:2010
Megjegyzések:aPURPOSE: To examine the effect of aprotinin eye drops on urokinase-type plasminogen activator (uPA) gene expression in rabbit corneal cells during wound healing after photorefractive keratectomy (PRK). METHODS: Both eyes of 22 rabbits were subjected to PRK. One eye of each rabbit was treated with antibiotic eye drops five times while the contralateral eye was treated at the same time with antibiotic eye drops and a serine protease inhibitor. The animals were sacrificed at different time frames, and 2-4 rabbits were used for each time point. Half of each cornea was used for the determination of the amount of uPA mRNA after reverse transcription and real-time quantitative polymerase chain reaction, while frozen sections were prepared from the other halves for in situ zymography to detect uPA activity. RESULTS: The level of uPA mRNA in corneal cells was markedly increased in corneal samples obtained hours after PRK. The time-dependent up-regulation of uPA mRNA was strongly dependent on the diameter of the area from which the epithelial cells were removed before the surgery. Independently of the time scale of uPA up-regulation, application of eye drops containing aprotinin significantly diminished the uPA expression. In situ zymography confirmed that aprotinin has also decreased overall uPA activity. CONCLUSIONS: Aprotinin down-regulates uPA gene expression in corneal cells during the wound-healing phase after PRK
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
administration & dosage
Animal
Animals
Aprotinin
article
Cells
Cornea
Down-Regulation
drug effects
enzymology
Gene Expression
Gene Expression Regulation, Enzymologic
genetics
Hungary
methods
Ophthalmic Solutions
Photorefractive Keratectomy
Polymerase Chain Reaction
Rabbits
Research
Research Support
Reverse Transcriptase Polymerase Chain Reactionrna
RNA,Messenger
Serine Proteinase Inhibitors
Solutions
Support
time
Time Factors
Up-Regulation
Urokinase-Type Plasminogen Activator
Wound Healing
OTKA::1
MAB::3.1
Megjelenés:Current Eye Research. - 35 : 9 (2010), p. 806-811. -
További szerzők:Silver, David M. Sperka Tamás (1970-) (biokémikus, vegyész, biológia-kémia szakos tanár) Kádas János (1976-) (molekuláris biológus, biokémikus, kertészmérnök) Vereb György (1965-) (biofizikus, orvos) Berta András (1955-) (szemész, gyermekszemész) Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész)
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5.

001-es BibID:BIBFORM042713
Első szerző:Fodor Mariann (szemész)
Cím:Effect of contact lens wear on the release of tear mediators in keratoconus / Fodor M., Kolozsvári B. L., Petrovski G., Kettesy B. A., Gogolák P., Rajnavölgyi É., Ujhelyi B., Módis L., Petrovski B. É., Szima G. Z., Berta A., Facskó A.
Dátum:2013
Megjegyzések:The release of different cytokines and mediators in tears of patients with keratoconus (KC) wearing contact lenses (CLs) may contribute to the pathology of KC. METHODS: Cohort study was established in patients with KC wearing rigid gas permeable (RGP) CL (group I), patients with ametropia wearing silicone hydrogel (Si-Hi) CL (group II) and ametropic patients wearing RGP CL (group III). RESULTS: Our findings indicate that before CL wear, the release of epidermal growth factor (EGF) and tissue-type plasminogen activator (t-PA) was attenuated, whereas matrix metalloproteinase (MMP)-9, interleukin (IL)-6, chemokine (C-C motif) ligand 5 (CCL5), IL-13, and plasminogen activator inhibitor (PAI)-1 were enhanced in KC compared with ametropes. An increasing linear trend over time was found for MMP-9, EGF, and CXCL8 in KC and MMP-9, MMP-13, IL-6, and CXCL8 in group III. Significant differences were observed in the linear trend over time between groups I and III for MMP-13 and tissue inhibitor of metalloproteinases (TIMP)-1; between groups I and II for MMP-9 and CXCL8; and between groups III and II for MMP-9, CXCL8, and MMP-13. In KC, the release of MMP-9 at week 6 and nerve growth factor (NGF) at 10 min was higher, but NGF at week 2 was lower than that in group II. The release of MMP-13 and NGF at week 2 and 6 were lower in the KC group as compared with group III, and similarly, with IL-6 and CXCL8 at week 2 and PAI at all time points. CONCLUSIONS: Contact lens wear can influence the levels and dynamics of various mediators in the tears of patients with KC that might have an impact on the progression of the disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Eye and Contact Lens. - 39 : 2 (2013), p. 147-152. -
További szerzők:Kolozsvári Bence Lajos (1977-) (szemész) Petrovski, Goran (1975-) (orvos) Kettesy Beáta (1974-) (szemész) Gogolák Péter (1968-) (biológus, immunológus) Rajnavölgyi Éva (1950-) (immunológus) Ujhelyi Bernadett (1981-) (szemész) Módis László (1964-) (szemész szakorvos, kontaktológus) Petrovski Beáta (1977-) (szociológus, epidemiológus) Szima Georgina Zita (1987-) Berta András (1955-) (szemész, gyermekszemész) Facskó Andrea (1953-) (szemész)
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6.

001-es BibID:BIBFORM053228
Első szerző:Hassan, Ziad (szemész)
Cím:Examination of ocular biomechanics with a new Scheimpflug technology after corneal refractive surgery / Ziad Hassan, Laszlo Modis Jr., Eszter Szalai, Andras Berta, Gabor Nemeth
Dátum:2014
ISSN:1367-0484
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Contact Lens and Anterior Eye. - 37 : 5 (2014), p. 337-341. -
További szerzők:Módis László (1964-) (szemész szakorvos, kontaktológus) Szalai Eszter (1984-) (orvos) Berta András (1955-) (szemész, gyermekszemész) Németh Gábor (1975-) (szemész)
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7.

001-es BibID:BIBFORM049103
Első szerző:Johnsen, Erik O.
Cím:Reply to comment on "Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy" by Johnsen et al. [Exp. Eye Res. 98 (2012) 28-36] / Erik O. Johnsen, Réka Albert, Bjørn Nicolaissen, Goran Petrovski, Morten C. Moe
Dátum:2012
ISSN:0014-4835
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztői levél
neural
stem cell
progenitor cell
retina
ciliary body epithelium
proliferative vitreoretinopathy
Megjelenés:Experimental Eye Research. - 105 (2012), p. 81-82. -
További szerzők:Albert Réka (1986-) Nicolaissen, Bjorn Petrovski, Goran (1975-) (orvos) Moe, Morten C.
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8.

001-es BibID:BIBFORM037065
Első szerző:Johnsen, Erik O.
Cím:Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy / Johnsen E. O., Froen R. C., Albert R., Omdal B. K., Sarang Z., Berta A., Nicolaissen B., Petrovski G., Moe M. C.
Dátum:2012
ISSN:0014-4835
Megjegyzések:In addition to the ability for self-renewal and functional differentiation, neural stem/progenitor cells (NSCs) can respond to CNS injuries by targeted migration. In lower vertebrates, retinal injury is known to activate NSCs in the ciliary marginal zone (CMZ). Cells expressing markers of NSCs are also present in the ciliary body epithelium (CE) and in Müller glia in the peripheral retina (PR) of the adult human eye. However, these cells seem to be quiescent in the adult human eye and recent reports have shown that CE cells have limited properties of NSCs. In order to further clarify whether NSCs exist in the adult human eye, we tested whether NSC-like cells could be activated in eyes with proliferative vitreoretinopathy (PVR). The PR and CE were studied for NSC-associated markers in human enucleated control eyes and eyes with confirmed PVR, as well as in a mouse model of PVR. Furthermore, cells isolated from vitreous samples obtained during vitrectomies for retinal detachment were directly fixed or cultured in a stem cell-promoting medium and compared to cells cultured from the post-mortem retina and CE. In situ characterization of the normal eyes revealed robust expression of markers present in NSCs (Nestin, Sox2, Pax6) only around peripheral cysts of the proximal pars plana region and the PR, the latter population also staining for the glial marker GFAP. Although there were higher numbers of dividing cells in the CE of PVR eyes than in controls, we did not detect NSC-associated markers in the CE except around the proximal pars plana cysts. In the mice PVR eyes, Nestin activation was also found in the CE. In human PVR eyes, proliferation of both non-glial and glial cells co-staining NSC-associated markers was evident around the ora serrata region. Spheres formed in 7/10 vitreous samples from patients with PVR compared to 2/15 samples from patients with no known PVR, and expressed glial - and NSC-associated markers both after direct fixation and repetitive passages. In conclusion, the adult human eye may harbor two different populations of neuroepithelial stem/progenitor cells; a non-glial population located in the proximal pars plana around peripheral cysts in addition to a population with Müller glia characteristics. Yet, we only found that the glial population was able to respond to retinal injury by targeted migration into the vitreous.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Experimental Eye Research. - 98 (2012), p. 28-36. -
További szerzők:Froen, Rebecca C. Albert Réka (1986-) Omdal, Bente K. Sarang Zsolt (1976-) (mikrobiológus) Berta András (1955-) (szemész, gyermekszemész) Nicolaissen, Bjorn Petrovski, Goran (1975-) (orvos) Moe, Morten C.
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9.

001-es BibID:BIBFORM076571
Első szerző:Németh Gábor (szemész)
Cím:Long-Term Changes in Backscattered Light Measurements in Keratoconus Corneas Treated with Collagen Cross-Linking / Nemeth Gabor, Hassan Jasmin, Modis Laszlo, Hassan Ziad
Dátum:2017
ISSN:0271-3683
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Current Eye Research. - 43 : 1 (2017), p. 18-26. -
További szerzők:Hassan, Jasmin Módis László (1964-) (szemész szakorvos, kontaktológus) Hassan, Ziad (1962-) (szemész)
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10.

001-es BibID:BIBFORM013623
Első szerző:Németh Gábor (szemész)
Cím:A comparison of accommodation amplitudes in pseudophakic eyes measured with three different methods / Nemeth G., Tsorbatzoglou A., Vamosi P., Sohajda Z., Berta A.
Dátum:2008
ISSN:0950-222X
Megjegyzések:PURPOSE: To compare the accommodative amplitudes with three different methods in pseudophakic eyes with different types of intraocular lenses (IOLs). METHODS: Fifty-one pseudophakic eyes of 44 patients (age: 72.02+/-8.53 years) were studied. One of two different types of IOL were implanted (N=30, three-piece Alcon Acrysof MA60AC and N=21, one-piece Alcon Acrysof SA60AT) in-the-bag after standard phacoemulsification. The time of the examinations was 13.85+/-7.35 months postoperatively. We measured the amplitude of accommodation with three different methods: (1) subjective minus-lenses-to-blur method; (2) a new optical device (ACMaster, Carl Zeiss, Jena, Germany) using partial coherence interference (PCI) technique under physiological stimulus; and (3) objective anterior chamber depth measuring with a standard A-scan ultrasonic device (Ultrascan Imaging System, Alcon Laboratories, Forth Worth, TX, USA) before and after pharmacological relaxation of ciliary muscle. RESULTS: We measured -0.83+/-0.63 D amplitude of accommodation with subjective minus-lenses-to-blur method. The IOL position did not change significantly during physiological accommodation effort measured with PCI method (-0.026+/-0.134 mm). The change in the IOLs position between near fixating and after ciliary muscle relaxation was -0.18+/-0.28 mm measured with ultrasound. There were no significant differences between values of one-piece and three-piece IOL groups. CONCLUSION: The amplitude of accommodation measured by subjective and objective methods are different and are not comparable with each other. We did not observe any difference between values of examined two types of IOLs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Eye. - 22 : 1 (2008), p. 65-69. -
További szerzők:Tsorbatzoglou, Alexis (1970-) (szemész) Vámosi Péter (1964-) (szemorvos) Sohajda Zoltán (1969-) (szemész) Berta András (1955-) (szemész, gyermekszemész)
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11.

001-es BibID:BIBFORM037064
Első szerző:Shahdadfar, Aboulghassem
Cím:Ex vivo expanded autologous limbal epithelial cells on amniotic membrane using a culture medium with human serum as single supplement / Shahdadfar Aboulghassem, Haug Kristiane, Pathak Meeta, Drolsum Liv, Olstad Ole Kristoffer, Johnsen Erik O., Petrovski Goran, Moe Morten C., Nicolaissen Bjorn
Dátum:2012
ISSN:0014-4835
Megjegyzések:In patients with limbal stem cell deficiency (LSCD), transplantation of ex vivo expanded human limbal epithelial cells (HLECs) can restore the structural and functional integrity of the corneal surface. However, the protocol for cultivation and transplantation of HLECs differ significantly, and in most protocols growth additives such as cholera toxins, exogenous growth factors, hormones and fetal calf serum are used. In the present article, we compare for the first time human limbal epithelial cells (HLECs) cultivated on human amniotic membrane (HAM) in a complex medium (COM) including fetal bovine serum to a medium with human serum as single growth supplement (HSM), and report on our first examinations of HLECs expanded in autologous HSM and used for transplant procedures in patients with LSCD. Expanded HLECs were examined by genome-wide microarray, RT-PCR, Western blotting, and for cell viability, morphology, expression of immunohistochemical markers and colony forming efficiency. Cultivation of HLECs in HSM produced a multilayered epithelium where cells with markers associated with LESCs were detected in the basal layers. There were few transcriptional differences and comparable cell viability between cells cultivated in HSM and COM. The p63 gene associated with LESCs were expressed 3.5 fold more in HSM compared to COM, and Western blotting confirmed a stronger p63α band in HSM cultures. The cornea-specific keratin CK12 was equally found in both culture conditions, while there were significantly more CK3 positive cells in HSM. Cells in epithelial sheets on HAM remaining after transplant surgery of patients with LSCD expressed central epithelial characteristics, and dissociated cells cultured at low density on growth-arrested fibroblasts produced clones containing 21 ± 12% cells positive for p63α (n = 3). In conclusion, a culture medium without growth additives derived from animals or from animal cell cultures and with human serum as single growth supplement may serve as an equivalent replacement for the commonly used complex medium for ex vivo expansion of HLECs on HAM.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Experimental Eye Research. - 97 : 1 (2012), p. 1-9. -
További szerzők:Haug, Kristiane Pathak, Meeta Drolsum, Liv Olstad, Ole Kristoffer Johnsen, Erik O. Petrovski, Goran (1975-) (orvos) Moe, Morten C. Nicolaissen, Bjorn
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12.

001-es BibID:BIBFORM060017
Első szerző:Steiber Zita (orvos, szemész)
Cím:Plasminogen activator inhibitor type 2 in human tears and blood during pregnancy / Steiber Z., Tozser J., Silver D.M., Jakab A., Németh G., Berta A., Csutak A.
Dátum:2015
Megjegyzések:Purpose: During pregnancy, systemic blood levels of plasminogen activator inhibitors (PAIs), estradiol (E2) and progesterone (P4) are expected to rise with gestational age. This work examines whether a corresponding rise in PAIs occurs in tears. Methods: Tear and blood samples were collected opportunistically from women during pregnancy: PAI-2 and PAI-1 levels were measured using enzyme-linked immunosorbent assay (ELISA) tests. Blood levels of E2 and P4 were measured using chemiluminescence immunoassays. Results: Levels of PAI-2 from tears of pregnant women did not increase and did not correlate with gestation. Levels of PAI-2, E2 and P4 in blood significantly increased over gestation. Tear PAI-2 levels did not correlate with blood levels of PAI-2, E2 or P4. Although blood levels of PAI-1 increased with gestation, tear levels of PAI-1 were below the ELISA detection limit, similar to the situation for non-pregnant subjects. Conclusions: Tear PAI-2 levels are dissociated from the progression of pregnancy and the concomitant elevated systemic blood PAI-2, E2 and P4 levels, indicating the possibility of local control of proteolysis in the eye during pregnancy in the absence of wounding or surgery on the eye.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Gestation
Human Tears
Pregnancy
Proteolysis
Tear Enzymes
Megjelenés:International Journal of Ophthalmology & Eye Science. - 3 : 7 (2015), p. 121-125. -
További szerzők:Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Silver, David M. Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Németh Gábor (1975-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Csutak Adrienne (1971-) (szemész)
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