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001-es BibID:	BIBFORM023077
Első szerző:	Jakab Attila (szülész-nőgyógyász, endokrinológus)
Cím:	Intracytoplasmic sperm injection : a novel selection method for sperm with normal frequency chromosomal aneuploidies / Jakab A., Sakkas D., Delpiano E., Cayli S., Kovanci E., Ward D., Revelli A., Huszár G.
Dátum:	2005
ISSN:	0015-0282
Megjegyzések:	To test a newly invented intracytoplasmic sperm injection (ICSI) sperm selection method based on sperm hyaluronic acid (HA) binding. Design: Comparison of chromosomal disomy and diploidy frequencies in sperm arising from semen and in HA-bound sperm. Setting: Academic andrology laboratory. Patient(s): Men presenting for semen analysis. Intervention(s): Washed sperm fractions of 32 semen samples were applied to Petri dishes or glass slides coated with immobilized HA. The unbound sperm were rinsed gently, and the HA-bound sperm were removed with an ICSI pipette. The control sperm population was the unselected sperm. Both HA-selected and unselected sperm were treated with fluorescence in situ hybridization with centromeric probes for the X, Y, and 17 chromosomes. Main Outcome Measure(s): Chromosomal disomy and diploidy frequencies. Result(s): In the HA-bound sperm (495?2,079 per man, 41,670 in all) compared with unselected sperm (4,770 per man, 162,210 in all), the chromosomal disomy frequencies were reduced to 0.16% from 0.52%, diploidy to 0.09% from 0.51%, and sex chromosome disomy to 0.05% from 0.27% (a 5.4-fold reduction vs. 4-fold respective increase in ICSI offspring). Conclusion(s): The HA sperm selection method for ICSI, which is based on a relationship between sperm receptors for zona pellucida and HA, will likely reduce the potential genetic complications and adverse public health effects of ICSI.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Sperm maturity chromosomal aneuploidies ICSI sperm selection genetic integrity paternal contribution
Megjelenés:	Fertility And Sterility. - 84 : 6 (2005), p. 1665-1673. -
További szerzők:	Sakkas, Denny Delpiano, Elena Cayli, Sevil Kovanci, Ertug Ward, David Revelli, Alberto Huszár Gábor
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM023078
Első szerző:	Zavaczki Zoltán
Cím:	Dimensional assessment of X-bearing and Y-bearing haploid and disomic human sperm with the use of fluorescence in situ hybridization and objective morphometry / Zavaczki Z., Celik-Ozenci C., Ovari L., Jakab A., Sati G. L., Ward D. C., Huszar G.
Dátum:	2006
ISSN:	0015-0282
Megjegyzések:	To explore the dimensional attributes of haploid and disomic X-bearing and Y-bearing spermatozoa. Design: Morphometric evaluation of more than 2,000 X-bearing and Y-bearing spermatozoa after identification of the genotype with fluorescence in situ hybridization. Setting: Academic clinical and research andrology laboratory. Main Outcome Measure(s): Sperm head area, perimeter, long axis, short axis, shape factor, elliptical form factor (long axis/short axis), and tail length. Result(s): We found no differences in dimensions or dimensional distributions between X-bearing and Y-bearing spermatozoa, whether in the native or the decondensed state, or in oligozoospermic or normozoospermic men. There were inconsistent differences and a 70% overlap in the dimensions of haploid and disomic spermatozoa. The other 30% of sperm with disomic nuclei were either smaller or larger compared to haploid spermatozoa. Conclusion(s): There are no differences, or distinguishing characteristics, in dimensions or dimensional distri- butions between X-bearing and Y-bearing spermatozoa. Dimensional attributes do not discriminate between dysomic and haploid spermatozoa.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Sperm X-bearing spermatozoa dimensional attributes haploid dosomic
Megjelenés:	Fertility And Sterility. - 85 : 1 (2006), p. 121-127. -
További szerzők:	Celik-Ozenci, Ciler Óvári László (szülész-nőgyógyász, sebész) Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Sati, Leyla G. Ward, David Huszár Gábor
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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