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001-es BibID:	BIBFORM015664
Első szerző:	Barok Márk (biofizikus)
Cím:	Characterization of a novel, trastuzumab resistant human breast cancer cell line / Barok Mark, Balazs Margit, Lazar Viktoria, Rakosy Zsuzsa, Toth Eniko, Treszl Andrea, Vereb Gyorgy, Colbern G. T., Park J. W., Szollosi Janos
Dátum:	2010
ISSN:	1945-0508
Megjegyzések:	HER2-positive breast cancers represent a distinct phenotype and are intrinsically more aggressive than HER2-negative tumors. Although HER2-targeted therapies have been rationally developed, resistance to these treatments represents a process understood poorly. There are few experimental models that allow studying the molecular mechanism of resistance. Our aim was to characterize a trastuzumab resistant breast cancer cell line (B585) that was established from an invasive ductal carcinoma. B585 grows only in immunodeficient mice as a xenograft. CGH and FISH were used to define cytogenetic alterations, gene-expression analysis and immunohistochemistry were applied to detect RNA and protein expression. By array-CGH focused amplifications were identified for C-MYC, EGFR, ErbB2, CCND1 and TOP2-A oncogenes. ErbB2 was co-amplified with TOP2-A. mRNA overexpression was detected for the amplified genes. ErbB2 protein was overexpressed and showed heterogeneous distribution. In summary, molecular cytogenetic analysis and expression profiling of B585 revealed several new alterations. Based on the experiments performed in SCID mice and the genotypic/phenotypic characteristics, this new in vivo breast cancer xenograft is a valuable model to investigate molecular mechanism of trastuzumab resistance
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis Animals Antibodies Antibodies,Monoclonal Antineoplastic Agents article Biophysics Breast Neoplasms Carcinoma Carcinoma,Ductal,Breast Cell Line Cell Line,Tumor Comparative Genomic Hybridization Disease Models,Animal Drug Resistance,Neoplasm drug therapy EGFR ErbB2 Female Gene Expression Gene Expression Profiling genetics Human Humans Hungary Immunohistochemistry In Situ Hybridization,Fluorescence metabolism Mice Mice,Scid Oncogenes Phenotype Receptor,erbB-2 Research Research Support rna Support therapeutic use therapy Trastuzumab resistance OTKA::1 MAB::3.1
Megjelenés:	Frontiers In Bioscience (elite edition). - 1 : 2 (2010), p. 627-640. -
További szerzők:	Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Lázár Viktória (1981-) (molekuláris biológus) Rákosy Zsuzsa (1978-) (sejtbiológus, molekuláris biológus, genetikus) Tóth Enikő Treszl Andrea (1974-) (molekuláris biológus) Vereb György (1965-) (biofizikus, orvos) Colbern, Gail T. Park, John W. Szöllősi János (1953-) (biofizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM028757
Első szerző:	Simon Tünde (biokémikus, molekuláris biológus)
Cím:	Histamine regulates relevant murine dendritic cell functions via H4 receptor / Simon T., Laszlo V., Lang O., Buzas E., Falus A.
Dátum:	2011
Megjegyzések:	Histamine, produced by dendritic cells (DCs) or by other cells of the immune system, may have significant impact on DC activities. We investigated the influence of histamine and histamine H4 receptor (H4R) on some relevant functions of DCs. Histamine significantly decreased the antigen presentation capacity of splenic DCs, and this effect was reversed by a H4R antagonist. Furthermore, enhanced antigen presentation was detected in H4R-/- DCs. Prolonged histamine treatment during DC differentiation stimulated migration, albeit the increase was not significant. H4R-deficient DCs possessed significantly lower migration capacity than their wild-type counterparts. Monitoring in vivo and in vitro DC cytokine production revealed that a H4R agonist in combination with LPS, increased IL-1 beta mRNA expression, and a H4R antagonist reversed this effect. In H4R-deficient mice we detected decreased mRNA expression of some DC-derived cytokines including IFN-gamma and IL-10. Upon CFA stimulation, genotype-dependent differences were found in the expression of IL-6 and IFN-gamma. Our data suggest that H4R plays a crucial role in variety of functions of murine DCs.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban dendritikus sejt hisztamin
Megjelenés:	Frontiers In Bioscience (elite edition). - 3 (2011), p. 1414-1424. -
További szerzők:	László Valéria Láng Orsolya Buzás Edit Falus András
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM007126
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Chemokines and angiogenesis in rheumatoid arthritis / Szekanecz, Z., Pakozdi, A., Szentpetery, A., Besenyei, T., Koch, A. E.
Dátum:	2009
ISSN:	1945-0494 (Print)
Megjegyzések:	In rheumatoid arthritis, chemokines mediate the migration of inflammatory leukocytes into the synovium. Among the four known chemokine families, CXC, CC chemokines and fractalkine seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important during the perpetuation of inflammation underlying rheumatoid arthritis. In this review, authors discuss the role of the most important chemokines and chemokine repetors in arthritis-associated neovascularization. The process and regulation of angiogenesis are described in this context as well. Apart from discussing the pathogenic role of chemokines and chemokine receptors in arthritic vessel formation, authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Frontiers in Bioscience (Elite Edition). - 1 (2009), p. 44-51. -
További szerzők:	Pákozdi Angéla Szentpétery Ágnes (1978-) (reumatológus) Besenyei Tímea (1980-) (reumatológus, belgyógyász) Koch, Alisa E.
Internet cím:	elektronikus változat elektronikus változat
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001-es BibID:	BIBFORM030298
Első szerző:	Vízkeleti Laura (molekuláris biológus, genetikus)
Cím:	Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma / Vizkeleti Laura, Ecsedi Szilvia, Rákosy Zsuzsa, Bégány Ágnes, Emri Gabriella, Tóth Réka, Orosz Adrienn, Szőllősi Attila Gábor, Méhes Gábor, Ádány Róza, Balázs Margit
Dátum:	2012
ISSN:	1945-0494
Megjegyzések:	The 7q31 locus contains several genes affected in cancer progression. Although evidences exist regarding its impact on tumorigenesis, the role of genetic alterations and the expressions of locus-related genes are still controversial. Our study aimed to define the 7q31 copy number alterations in primary melanomas, primary-metastatic tumor pairs and cell lines. Data were correlated with clinical-pathological parameters. Genetic data show that 7q31 copy number distribution was heterogeneous in both primary and metastatic tumors. Extra copies were highly accompanied by chromosome 7 polisomy, and significantly increased in primary lesions with poor prognosis. Additionally, we determined the mRNA and protein levels of the locus-related CAV1 and TES genes. TES mRNA level was associated with metastatic location. CAV1 mRNA and protein levels were significantly higher in thicker tumors, however, lack of protein was also observed in a subpopulation of thin lesions. Expressions of CAV1 and TES were not associated with 7q31 alterations. In conclusion, 7q31 amplification can predict unfavorable outcome. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány
Megjelenés:	Frontiers in Bioscience (elite edition) E4 : 1 (2012), p. 1802-1812. -
További szerzők:	Ecsedi Szilvia (1982-) (molekuláris biológus, genetikus) Rákosy Zsuzsa (1978-) (sejtbiológus, molekuláris biológus, genetikus) Bégány Ágnes (1954-2011) (bőrgyógyász, kozmetológus, klinikai onkológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Tóth Réka Orosz Adrienn Szöllősi Attila Gábor (1982-) (élettanász) Méhes Gábor (1966-) (patológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Daganatprogresszió genetikai markerei
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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