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1.

001-es BibID:BIBFORM095571
035-os BibID:(WoS)000627328400001 (Scopus)85102438552 (PubMed)33716672 (cikkazonosító)614947
Első szerző:Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:Topographical Organization of M-Current on Dorsal and Median Raphe Serotonergic Neurons / Tsogbadrakh Bayasgalan, Andrea Csemer, Adrienn Kovacs, Krisztina Pocsai, Balazs Pal
Dátum:2021
ISSN:1662-5102
Megjegyzések:Dorsal and median raphe nuclei (DR and MR, respectively) are members of the reticular activating system and play important role in the regulation of the sleepwakefulness cycle, movement, and affective states. M-current is a voltage-gated potassium current under the control of neuromodulatory mechanisms setting neuronal excitability. Our goal was to determine the proportion of DR and MR serotonergic neurons possessing M-current and whether they are organized topographically. Electrophysiological parameters of raphe serotonergic neurons influenced by this current were also investigated. We performed slice electrophysiology on genetically identified serotonergic neurons. Neurons with M-current are located rostrally in the DR and dorsally in the MR. M-current determines firing rate, afterhyperpolarization amplitude, and adaptation index (AI) of these neurons, but does not affect input resistance, action potential width, and high threshold oscillations.These findings indicate that M-current has a strong impact on firing properties of certain serotonergic neuronal subpopulations and it might serve as an effective contributor to cholinergic and local serotonergic neuromodulatory actions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Cellular Neuroscience. - 15 (2021), p. 614947. -
További szerzők:Csemer Andrea (1994-) (molekuláris biológus) Kovács Adrienn (1989-) (molekuláris biológus) Pocsai Krisztina (1978-) (élettanász) Pál Balázs (1975-) (élettanász)
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2.

001-es BibID:BIBFORM095575
035-os BibID:(cikkazonosító)707789 (WoS)000683012200001 (Scopus)85112145519 (PubMed)34381336
Első szerző:Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:Alteration of mesopontine cholinergic function by the lack of KCNQ4 subunit / Bayasgalan T., Stupniki S., Kovács A., Csemer A., Szentesi P., Pocsai K., Dionisio L., Spitzmaul G., Pál B.
Dátum:2021
ISSN:1662-5102
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Cellular Neuroscience. - 15 (2021), p. 707789. -
További szerzők:Stupniki, S. Kovács Adrienn (1989-) (molekuláris biológus) Csemer Andrea (1994-) (molekuláris biológus) Szentesi Péter (1967-) (élettanász) Pocsai Krisztina (1978-) (élettanász) Dionisio, L. Spitzmaul, G. Pál Balázs (1975-) (élettanász)
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3.

001-es BibID:BIBFORM060223
Első szerző:Bordás Csilla
Cím:The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice / Bordas Csilla, Kovacs Adrienn, Pal Balazs
Dátum:2015
ISSN:1662-5102
Megjegyzések:The pedunculopontine nucleus is known as a cholinergic nucleus of the reticular activating system, participating in regulation of sleep and wakefulness. Besides cholinergic neurons, it consists of GABAergic and glutamatergic neurons as well. According to classical and recent studies, more subgroups of neurons were defined. Groups based on the neurotransmitter released by a neuron are not homogenous, but can be further subdivided. The PPN neurons do not only provide cholinergic and non-cholinergic inputs to several subcortical brain areas but they are also targets of cholinergic and other different neuromodulatory actions. Although cholinergic neuromodulation has been already investigated in the nucleus, one of its characteristic targets, the M-type potassium current has not been described yet. Using slice electrophysiology, we provide evidence in the present work that cholinergic neurons possess M-current, whereas GABAergic neurons lack it. The M-current contributes to certain functional differences of cholinergic and GABAergic neurons, as spike frequency adaptation, action potential firing frequency or the amplitude difference of medium afterhyperpolarizations (AHPs). Furthermore, we showed that high threshold membrane potential oscillation with high power, around 20 Hz frequency is a functional property of almost all cholinergic cells, whereas GABAergic neurons have only low amplitude oscillations. Blockade of the M-current abolished the oscillatory activity at 20 Hz, and largely diminished it at other frequencies. Taken together, the M-current seems to be characteristic for PPN cholinergic neurons. It provides a possibility for modulating gamma band activity of these cells, thus contributing to neuromodulatory regulation of the reticular activating system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
M-current
Neuromodulation
oscillatory activity
pedunculopontine nucleus
spike frequency adaptation
Megjelenés:Frontiers in Cellular Neuroscience. - 9 (2015), Article ID 121. -
További szerzők:Kovács Adrienn (1989-) (molekuláris biológus) Pál Balázs (1975-) (élettanász)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM067497
Első szerző:Dócs Klaudia (orvos)
Cím:The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation / Klaudia Dócs, Zoltán Mészár, Sándor Gonda, Attila Kiss-Szikszai, Krisztina Holló, Miklós Antal, Zoltán Hegyi
Dátum:2017
ISSN:1662-5102
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Frontiers in Cellular Neuroscience. - 11 (2017), p. 1-13. -
További szerzők:Mészár Zoltán Mihály (1977-) (agrármérnök) Gonda Sándor (1984-) (gyógyszerész) Kiss-Szikszai Attila (1975-) (vegyész) Holló Krisztina (1967-) (vegyész) Antal Miklós (1951-) (orvos, anatómus) Hegyi Zoltán (1983-) (molekuláris biológus)
Pályázati támogatás:MTA-TKI 242
MTA
KTIA_NAP_13-1-2013-001
Egyéb
PD 108467
OTKA
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM070540
Első szerző:Kovács Adrienn (molekuláris biológus)
Cím:Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN) / Kovács Adrienn, Pál Balázs
Dátum:2017
Megjegyzések:Slow inward currents (SICs) are known as excitatory events of neurons caused by astrocytic glutamate release and consequential activation of neuronal extrasynaptic NMDA receptors. In the present article we investigate the role of these astrocyte-dependent excitatory events on a cholinergic nucleus of the reticular activating system (RAS), the pedunculopontine nucleus (PPN). It is well known about this and other elements of the RAS, that they do not only give rise to neuromodulatory innervation of several areas, but also targets neuromodulatory actions from other members of the RAS or factors providing the homeostatic drive for sleep. Using slice electrophysiology, optogenetics and morphological reconstruction, we revealed that SICs are present in a population of PPN neurons. The frequency of SICs recorded on PPN neurons was higher when the soma of the given neuron was close to an astrocytic soma. SICs do not appear simultaneously on neighboring neurons, thus it is unlikely that they synchronize neuronal activity in this structure. Occurrence of SICs is regulated by cannabinoid, muscarinic and serotonergic neuromodulatory mechanisms. In most cases, SICs occurred independently from tonic neuronal currents. SICs were affected by different neuromodulatory agents in a rather uniform way: if control SIC activity was low, the applied drugs increased it, but if SIC activity was increased in control, the same drugs lowered it. SICs of PPN neurons possibly represent a mechanism which elicits network-independent spikes on certain PPN neurons; forming an alternative, astrocyte-dependent pathway of neuromodulatory mechanisms.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
astrocyte
neuromodulation
optogenetics
pedunculopontine nucleus
slow inward current
Megjelenés:Frontiers in cellular neuroscience. - 11 : 16 (2017), p. 1-16. -
További szerzők:Pál Balázs (1975-) (élettanász)
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6.

001-es BibID:BIBFORM062053
Első szerző:Pál Balázs (élettanász)
Cím:Astrocytic Actions on Extrasynaptic Neuronal Currents / Balázs Pál
Dátum:2015
ISSN:1662-5102
Megjegyzések:In the last few decades, knowledge about astrocytic functions has significantly increased. It was demonstrated that astrocytes are not passive elements of the central nervous system (CNS), but active partners of neurons. There is a growing body of knowledge about the calcium excitability of astrocytes, the actions of different gliotransmitters and their release mechanisms, as well as the participation of astrocytes in the regulation of synaptic functions and their contribution to synaptic plasticity. However, astrocytic functions are even more complex than being a partner of the "tripartite synapse," as they can influence extrasynaptic neuronal currents either by releasing substances or regulating ambient neurotransmitter levels. Several types of currents or changes of membrane potential with different kinetics and via different mechanisms can be elicited by astrocytic activity. Astrocyte-dependent phasic or tonic, inward or outward currents were described in several brain areas. Such currents, together with the synaptic actions of astrocytes, can contribute to neuromodulatory mechanisms, neurosensory and -secretory processes, cortical oscillatory activity, memory, and learning or overall neuronal excitability. This mini-review is an attempt to give a brief summary of astrocyte-dependent extrasynaptic neuronal currents and their possible functional significance.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
astrocyte-neuron interactions
gliotransmitters
slow inward current
slow outward current
tonic current
Megjelenés:Frontiers in Cellular Neuroscience. - 9 : 474(2015), p. 1-11. -
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7.

001-es BibID:BIBFORM091619
035-os BibID:(cikkazonosító)243
Első szerző:Perényi Helga
Cím:Physical Activity Protects the Pathological Alterations of Alzheimer's Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways / Perényi Helga, Szegeczki Vince, Horváth Gabriella, Hinnah Barbara, Tamás Andrea, Radák Zsolt, Ábrahám Dóra, Zákány Róza, Reglodi Dora, Juhász Tamás
Dátum:2020
ISSN:1662-5102 1662-5102
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Cellular Neuroscience. - 14 (2020), p. 1-14. -
További szerzők:Szegeczki Vince (1992-) Horváth Gabriella Hinnah Barbara Tamás Andrea (Idegtudomány) (Pécs) Radák Zsolt Ábrahám Dóra Zákány Róza (1963-) (anatómus-, kötőszövetbiológus) Reglődi Dóra (Idegtudományok) Juhász Tamás (1976-) (biológus, orvosbiológus)
Pályázati támogatás:Bridging Fund
OTKA
NKFIK115874
OTKA
PD109644
OTKA
K119759
OTKA
NKFIHFK129190
NKFIH
GINOP2.3.2-15-2016-00050
GINOP
UNKP-16-4-IV
Egyéb
EFOP-3.6.2-16-2017-00008
EFOP
EFOP3.6.3-VEKOP-16-2017-00009
EFOP
EFOP-3.6.1.-16-2016-00004
EFOP
OTKA-NN 114458
OTKA
TÁMOP 4.2.4
TÁMOP
ÚNKP-19-3
Egyéb
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8.

001-es BibID:BIBFORM077810
035-os BibID:(PMID)26388735
Első szerző:Skrapits Katalin
Cím:Lateral hypothalamic orexin and melanin-concentrating hormone neurons provide direct input to gonadotropin-releasing hormone neurons in the human / Katalin Skrapits, Vivien Kanti, Zsófia Savanyú, Csilla Maurnyi, Ottó Szenci, András Horváth, Beáta Á. Borsay, László Herczeg, Zsolt Liposits, Erik Hrabovszky
Dátum:2015
ISSN:1662-5102 1662-5102
Megjegyzések:Hypophysiotropic projections of gonadotropin-releasing hormone (GnRH)-synthesizing neurons form the final common output way of the hypothalamus in the neuroendocrine control of reproduction. Several peptidergic neuronal systems of the medial hypothalamus innervate human GnRH cells and mediate crucially important hormonal and metabolic signals to the reproductive axis, whereas much less is known about the contribution of the lateral hypothalamic area to the afferent control of human GnRH neurons. Orexin (ORX)- and melanin-concentrating hormone (MCH)-synthesizing neurons of this region have been implicated in diverse behavioral and autonomic processes, including sleep and wakefulness, feeding and other functions. In the present immunohistochemical study, we addressed the anatomical connectivity of these neurons to human GnRH cells in post-mortem hypothalamic samples obtained from autopsies. We found that 38.9 ± 10.3% and 17.7 ± 3.3% of GnRH-immunoreactive (IR) perikarya in the infundibular nucleus of human male subjects received ORX-IR and MCH-IR contacts, respectively. On average, each 1 mm segment of GnRH dendrites received 7.3 ± 1.1 ORX-IR and 3.7 ± 0.5 MCH-IR axo-dendritic appositions. Overall, the axo-dendritic contacts dominated over the axo-somatic contacts and represented 80.5 ± 6.4% of ORX-IR and 76.7 ± 4.6% of MCH-IR inputs to GnRH cells. Based on functional evidence from studies of laboratory animals, the direct axo-somatic and axo-dendritic input from ORX and MCH neurons to the human GnRH neuronal system may convey critical metabolic and other homeostatic signals to the reproducive axis. In this study, we also report the generation and characterization of new antibodies for immunohistochemical detection of GnRH neurons in histological sections.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
human
hypothalamus
immunohistochemistry
melanin-concentrating hormone
orexin
Megjelenés:Frontiers in Cellular Neuroscience. - 9 (2015), p. 1-13. -
További szerzők:Kanti Vivien Savanyú Zsófia Maurnyi Csilla Szenci Ottó Horváth András Borsay Beáta Á. (1982-) (igazságügyi orvosszakértő) Herczeg László (1954-) (igazságügyi orvosszakértő) Liposits Zsolt Hrabovszky Erik
Pályázati támogatás:OTKA K83710
OTKA
OTKA K112669
OTKA
OTKA K100722
OTKA
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9.

001-es BibID:BIBFORM063917
Első szerző:Somogyi Attila
Cím:A novel form of compensation in the Tg2576 amyloid mouse model of Alzheimer disease / Attila Somogyi, Zoltán Katonai, Alán Alpár, Ervin Wolf
Dátum:2016
ISSN:1662-5102
Megjegyzések:One century after its first description, pathology of Alzheimer's disease (AD) is still poorly44 understood. Amyloid-related dendritic atrophy and membrane alterations of susceptible brain45 neurons in AD, and in animal models of AD are widely recognized. However, little effort has46 been made to study the potential effects of combined morphological and membrane47 alterations on signal transfer and synaptic integration in neurons that build up affected neural48 networks in AD. In this study spatial reconstructions and electrophysiological measurements49 of layer II/III pyramidal neurons of the somatosensory cortex from wild-type (WT) and50 transgenic (TG) human amyloid precursor protein (hAPP) overexpressing Tg2576 mice were51 used to build faithful segmental cable models of these neurons. Local synaptic activities were52 simulated in various points of the dendritic arbors and properties of subthreshold dendritic53 impulse propagation and predictors of synaptic input pattern recognition ability were54 quantified and compared in modeled WT and TG neurons.55 Despite the widespread dendritic degeneration and membrane alterations in mutant mouse56 neurons, surprisingly little, or no change was detected in steady-state and 50Hz sinusoidal57 voltage transfers, current transfers, and local and propagation delays of PSPs travelling along58 dendrites of TG neurons. Synaptic input pattern recognition ability was also predicted to be59 unaltered in TG neurons in two different soma-dendritic membrane models investigated. Our60 simulations predict the way how subthreshold dendritic signaling and pattern recognition are61 preserved in TG neurons: Amyloid-related membrane alterations compensate for the62 pathological effects that dendritic atrophy has on subthreshold dendritic signal transfer and63 integration in layer II/III somatosensory neurons of this hAPP mouse model for AD. Since64 neither propagation of single PSPs nor integration of multiple PSPs (pattern recognition)65 changes in TG neurons, we conclude that AD-related neuronal hyperexcitability cannot be66 accounted for by altered subthreshold dendritic signaling in these neurons but67 hyperexcitability is related to changes in active membrane properties and network connectivity
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Alzheimer's disease
human amyloid precursor protein
computer 28 simulations
mouse somatosensory cortex
compensation
electrotonic analysis
29 conservation of dendritic signaling
synaptic integration
Megjelenés:Frontiers in Cellular Neuroscience. - 10 : 152 (2016), p. [38]. -
További szerzők:Katonai Zoltán Alpár Alán Wolf Ervin (1961-) (fizikus, neurobiológus)
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