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001-es BibID:	BIBFORM004809
Első szerző:	Bereczki Dániel (neurológus)
Cím:	Cortical spreading edema in persistent visual migraine aura / Daniel Bereczki, József Kollár, Norbert Kozák, Kornél Viszokay, Zoltán Barta, Judit Sikula, Mária Tünde Magyar
Dátum:	2008
Megjegyzések:	We present imaging evidence of the spreading of cortical edema with reversibly restricted water diffusion from the left occipital to the temporoparietal cortex in persistent visual migraine aura in a 58-year-old man.The right-sided visual field defect lasting for 15 days was associated with discoupling of glucose metabolism and blood flow and the decreased apparent diffusion coefficient also suggested cytotoxic edema. At 8 weeks no signs were present, and magnetic resonance imaging became normal; therefore, long-lasting restricted cortical water diffusion, even if coupled with hypometabolism and edema, can be reversible in persistent visual migraine aura.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban diffusion weighted imaging migraine aura metabolic depression spreading edema
Megjelenés:	Headache. - 48 : 8 (2008), p. 1226-1241. -
További szerzők:	Kollár József (1950-) (radiológus) Kozák Norbert (1978-) (neurológus) Viszokay Kornél Barta Zoltán (1974-) (nukleáris medicina szakorvos) Sikula Judit (1954-) (radiológus) Magyar Mária Tünde (1970-) (neurológus)
Internet cím:	elektronikus változat DOI
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001-es BibID:	BIBFORM066474
Első szerző:	Marics Balázs (okleveles táplálkozástudományi szakember, dietetikus)
Cím:	Diet-induced obesity enhances TRPV1-mediated neurovascular reactions in the dura mater / Marics B., Peitl B., Pázmándi K., Bácsi A., Németh J., Oszlács O., Jancsó G., Dux M.
Dátum:	2017
ISSN:	0017-8748
Megjegyzések:	Objective: Exploring the pathophysiological changes in transient receptor potential vanilloid 1 (TRPV1) receptor of the trigeminovascular system in high-fat, high-sucrose (HFHS) diet-inducedobesity of experimental animals.Background: Clinical and experimental observations suggest a link between obesity and migraine. Accumulating evidence indicates that metabolic and immunological alterations associated with obesity may potentially modulate trigeminovascular functions. A possible target for obesity-induced pathophysiological changes is the TRPV1/capsaicin receptor which is implicated in the pathomechanism of headaches in a complex way.Methods: Male Sprague-Dawley rats were fed a regular (n = 25) or HFHS diet (n = 26) for 20 weeks. At the end of the dietary period, body weight of the animals was normally distributed in both groups and it was significantly higher in animals on HFHS diet. Therefore, experimental groups were regarded as control and HFHS diet-induced obese groups. Capsaicin-induced changes in meningeal blood flow and release of calcitonin gene-related peptide (CGRP) from dural trigeminal afferents were measured in control and obese rats. The distribution of TRPV1- and CGRP-immunoreactive meningeal sensory nerves was also compared in whole mount preparations of the dura mater. Metabolic parameters of the animals were assessed by examining glucose and insulin homeostasis as well as plasma cytokine concentrations.Results: HFHS diet was accompanied by reduced food consumption and greater fluid and energy intakes in addition to increased body weight of the animals. HFHS diet increased fasting blood glucose and insulin concentrations as well as levels of circulating proinflammatory cytokines interleukin-1? and interleukin-6. In obese animals, dural application of the archetypal TRPV1 agonist capsaicin resulted in significantly augmented vasodilatory and vasoconstrictor responses as compared to controls. Diet-induced obesity was also associated with enhanced basal and capsaicin- induced CGRP release from meningeal afferents ex vivo. Except for minor morphological changes, the distribution of dural TRPV1- and CGRP-immunoreactive afferents was similar in control and obese animals.Conclusions: Our results suggest that obesity induced by long-term HFHS diet results in sensitization of the trigeminovascular system. Changes in TRPV1-mediated vascular reactions and CGRP release are pathophysiological alterations that may be of relevance to the enhanced headache susceptibility of obese individuals.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban headache obesity transient receptor potential vanilloid 1 calcitonin gene-related peptide meningeal blood flow trigeminal nociception
Megjelenés:	Headache 57 : 3 (2017), p. 441-454. -
További szerzők:	Peitl Barna (1972-) (orvos, farmakológus) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Bácsi Attila (1967-) (immunológus) Németh József (1954-) (vegyész, analitikus) Oszlács Orsolya Jancsó Gábor Dux Mária
Pályázati támogatás:	OTKA K-101873 OTKA OTKA K119597 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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