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001-es BibID:	BIBFORM041935
Első szerző:	Bányász Tamás (élettanász)
Cím:	Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes / Tamas Banyasz, Balazs Horvath, Zhong Jian, Leighton T. Izu, Ye Chen-Izu
Dátum:	2012
ISSN:	1547-5271
Megjegyzések:	OBJECTIVE: The L-type Ca(2+) current (I(Ca,L)) and the Na(+)/Ca(2+) exchange current (I(NCX)) are major inward currents that shape the cardiac action potential (AP). Previously, the profile of these currents during the AP was determined from voltage-clamp experiments that used Ca(2+) buffer. In this study, we aimed to obtain direct experimental measurement of these currents during cardiac AP with Ca(2+) cycling. METHOD: A newly developed AP-clamp sequential dissection method was used to record ionic currents in guinea pig ventricular myocytes under a triad of conditions: using the cell's own AP as the voltage command, using internal and external solutions that mimic the cell's ionic composition, and, importantly, not using any exogenous Ca(2+) buffer. RESULTS: The nifedipine-sensitive current (I(NIFE)), which is composed of I(Ca,L) and I(NCX), revealed hitherto unreported features during the AP with Ca(2+) cycling in the cell. We identified 2 peaks in the current profile followed by a long residual current extending beyond the AP, coinciding with a residual depolarization. The second peak and the residual current become apparent only when Ca(2+) is not buffered. Pharmacological dissection of I(NIFE) by using SEA0400 shows that I(Ca,L) is dominant during phases 1 and 2 whereas I(NCX) contributes significantly to the inward current during phases 3 and 4 of the AP. CONCLUSION: These data provide the first direct experimental visualization of I(Ca,L) and I(NCX) during cardiac the AP and Ca(2+) cycle. The residual current reported here can serve as a potential substrate for afterdepolarizations when increased under pathologic conditions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Heart Rhythm. - 9 : 1 (2012), p. 134-142. -
További szerzők:	Horváth Balázs (1981-) (élettanász) Jian, Zhong Izu, Leighton T. Chen-Izu, Ye
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001-es BibID:	BIBFORM070274
Első szerző:	Di Biase, Luigi
Cím:	Initial international multicenter human experience with a novel epicardial access needle embedded with a real-time pressure/frequency monitoring to facilitate epicardial access : feasibility and safety / Di Biase Luigi, Burkhardt J. David, Reddy Vivek, Romero Jorge, Neuzil Petr, Petru Jan, Sadiva Lucie, Skoda Jan, Ventura Miguel, Carbucicchio Corrado, Dello Russo Antonio, Csanadi Zoltan, Casella Michela, Fassini Gaetano M., Tondo Claudio, Sacher Frederic, Theran Mike, Dukkipati Srinivas, Koruth Jacob, Jais Pierre, Natale Andrea
Dátum:	2017
ISSN:	1547-5271
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Heart Rhythm 14 : 7 (2017), p. 981-988. -
További szerzők:	Burkhardt, J. David Reddy, Vivek Romero, Jorge Neuzil, Petr Petru, Jan Sadiva, Lucie Skoda, Jan Ventura, Miguel Carbucicchio, Corrado Dello Russo, Antonio Csanádi Zoltán (1960-) (kardiológus) Casella, Michela Fassini, Gaetano M. Tondo, Claudio Sacher, Frederic Theran, Mike Dukkipati, Srinivas Koruth, Jacob Jais, Pierre Natale, Andrea
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001-es BibID:	BIBFORM084740
Első szerző:	Jost Norbert
Cím:	Role of Na+/Ca2+ exchanger (NCX) in cardiac automaticity and ventricular repolarization assessed by ORM-10962, a novel highly selective NCX inhibitor / Jost Norbert László, Kohajda Zsófia, Nagy Norbert, Geramipour Amir Mohammad, Varga Richárd Sándor, Hornyik Tibor, Horváth Balázs, Kormos Anita, Acsai Károly, Levijoki J., Pollesello P., Koskelainen T., Otsomaa L., Tóth András, Baczkó István, Nanasi P. P., Papp Gyula Julius, Virág László, Varró András
Dátum:	2016
ISSN:	1547-5271
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Heart Rhythm. - 13 : 5 Suppl. (2016), p. S6-S7. -
További szerzők:	Kohajda Zsófia Nagy Norbert Geramipour, Amir Varga Richárd Sándor Hornyik Tibor Horváth Balázs (1981-) (élettanász) Kormos Anita Acsai Károly Levijoki, Jouko Pollesello, Piero Koskelainen, Tuula Otsomaa, Leena Tóth András Baczkó István Nánási Péter Pál (1956-) (élettanász) Papp Gy. Julius (Szeged) Virág László (élettanász Szeged) Varró András (1954-) (farmakológus, klinikai farmakológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM050537
Első szerző:	Nagy-Baló Edina (kardiológus)
Cím:	Predictors of cerebral microembolization during phased radiofrequency ablation of atrial fibrillation : analysis of biophysical parameters from the ablation generator / Edina Nagy-Balo, Alexandra Kiss, Catherine Condie, Mark Stewart, Istvan Edes, Zoltan Csanadi
Dátum:	2014
ISSN:	1547-5271
Megjegyzések:	Background: Pulmonary vein isolation with phased radiofrequency current and use of a pulmonary vein ablation catheter (PVAC) has recently been associated with a high incidence of clinically silent brain infarcts on diffusion-weighted MRI, and a high microembolic signal (MES) count detected by transcranial Doppler. Objective: to investigate the potential correlation between different biophysical parameters of energy delivery (ED) and MES generation during PVAC ablation.Methods: MES counts during consecutive PVAC ablations were recorded for each ED and time-stamped for correlation with temperature, power and impedance data from the GENius 14.4 generator. Additionally, catheter-tissue contact was characterized by the template deviation score, calculated by comparing the temperature curve with an ideal template representing good contact, and by the respiratory contact failure score, to quantify temperature variations indicative of intermittent contact due to respiration.Results: A total of 834 EDs during 48 PVAC ablations were analyzed. A significant incease in MES count was associated with a lower average temperature, a temperature integral over 62 ?C, a higher average power, the total energy delivered, higher respiration and template deviation scores (p<0.0001), and simultaneous ED to the most proximal and distal poles of the PVAC (p<0.0001).Conclusions: MES generation during ablation is related to different indicators of poor electrode-tissue contact, the total power delivered and the interaction between the most distal and the most proximal electrodes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban atrial fibrillation pulmonary vein isolation GENius generator PVAC catheter cerebral microembolization transcranial Doppler
Megjelenés:	Heart Rhythm. - 11 : 6 (2014), p. 977-983. -
További szerzők:	Kiss Alexandra (1987-) (általános orvos) Condie, Catherine Stewart, Mark Édes István (1952-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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