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1.

001-es BibID:BIBFORM036287
035-os BibID:PMID:16795968
Első szerző:Altorjay Áron
Cím:Morphological changes in the lower esophageal sphincter influencing the result of antireflux surgical interventions in chronic gastroesophageal reflux disease / Áron Altorjay, Anna Szilagyi, Gabriella Arato, Balazs Paal, Arpad Juhasz, Gábor Kecskes, István Altorjay, János Kiss, Pal Nagy
Dátum:2006
ISSN:0172-6390
Megjegyzések:BACKGROUND/AIMS: It is still unclear whether long-term reflux episodes result in morphological changes in the lower esophageal sphincter or not. If the answer is supposedly yes, do these changes influence the postoperative functional results following antireflux surgery? METHODOLOGY: Between 1 January 2002 and 2004, we performed antireflux surgery on 85 patients. Muscle samples were taken from the lower esophageal sphincter (LES) in 57 patients on operation. Patients with endoscopic findings of moderate or severe reflux esophagitis--Los Angeles B, C, D--were excluded. Control samples were obtained from muscle tissue at the gastroesophageal junction that had been removed from 16 patients undergoing gastric or esophageal resection. Histologic (hematoxylin and eosin and Giemsa), and immunohistologic (S-100 Protein, NCL-SERCA2, alpha-SMA) and electronmicroscopic analysis were used to evaluate the specimens. The number of smooth muscle cell nuclei in these intraoperative biopsies was used to compare the results of antireflux operations (Visick I and II-III). RESULTS: In 19% (11/57) of the reflux-type LES muscle samples perivascular inflammatory infiltration has been noted and in 6 of these cases (6/57 = 11%) this has incorporated marked intramuscular and adventitial granulocyte infiltration. In one patient (1/57 = 2%) eosinophil infiltration of the myenteric plexus and the ganglion has been revealed. Significantly lower Schwann and smooth muscle cell count could be detected in LES muscle samples taken from patients with GERD (p < 0.05). The analysis of the values of the 9 patients in Visick groups II and III at two months after surgery, has shown a significant decrease in the number of smooth muscle cell nuclei as compared to those patients in Visick group I (p < 0.01). CONCLUSIONS: Our results draw attention to the morphological changes occurring in the LES muscles of reflux patients. The enteric ganglionitis induced by GERD may result in various functional esophageal diseases. The histologic changes--that very much resemble hypertrophy--developing in LES muscles may serve as a reason for symptoms after antireflux surgery, presumably for the most common complaint of dysphagia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hepato-Gastroenterology 53 : 69 (2006), p. 342-347. -
További szerzők:Szilágyi Anna Tünde (1981-) Arató Gabriella Paál Balázs Juhász Árpád Kecskés Gábor Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Kiss János (sebész) Nagy Pál (patológus)
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2.

001-es BibID:BIBFORM033815
Első szerző:András Csilla (onkológus szakorvos)
Cím:Correlations between Clinicopathological Parameters and Molecular Signatures of Primary Tumors for Patients with Stage T3N0 Colorectal Adenocarcinomas: A Single Center Retrospective Study on 100 Cases / Csilla András, László Tóth, Csaba Molnár, Miklós Tanyi, Zoltán Csiki, Balázs Dezső, János Pósán, Amir-Houshang Shemirani, Emese Csiki, János Szántó
Dátum:2012
ISSN:0172-6390
Megjegyzések:Background/Aims: To examine the clinical and protein expression characteristics of tumor tissues for prediction of prognosis in colorectal cancer (CRC). Methodology: We retrospectively analyzed the clinicopathological data of patients with stage T3N0 CRC, operated between 1997-2003 and the surgical materials for the relation between disease prognosis and p53, p21, p16, β-catenin, E-cadherin, EGFR, hMLH1, hMSH2 and TS protein expressions. Results: A significantly shorter 3-year disease free survival was observed in patients under the age of 50. The worst 5-year overall survival (OS) observed for patients over 70. Tumor localization and number of processed lymph nodes significantly affected prognosis. The EGFR, hMSH2 and TS expressions and the 5-fluorouracyl treatment were not found to be of prognostic value; p53 and p21 positivity had significantly worse survival. When catenin membrane expression disappeared on tumor cells, the 5-year OS rate decreased and time to metastasis shortened significantly. Membrane catenin expression, processed lymph nodes number and age were detected as independent prognostic markers. Conclusions: These results suggest that the evaluation of a clinicopathological profile, based on age, tumor localization, number of examined lymph nodes, p53, p21 and E-cadherin catenin expression appears to be useful in identifying high risk patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hepato-Gastroenterology. - 59 : 116 (2012), p. 1091-1097. -
További szerzők:Tóth László (1971-) (patológus) Molnár Csaba (1979-) (pathológus) Tanyi Miklós (1968-) (sebész) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Dezső Balázs (1951-) (pathológus) Pósán János (1976-) (sebész) Shemirani, Amir-Houshang (1971-) (kutató orvos, laboratórium szakorvos) Csiki Emese (1986-) (onkoradiológus) Szántó János (1949-) (onkológus szakorvos)
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DOI
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3.

001-es BibID:BIBFORM087112
Első szerző:Árkosy Péter (általános sebész, mellkassebész)
Cím:Complex Treatment of Pancreatic Cancer / P. Árkosy, A. Enyedi, R. Kotán, L. Sasi Szabó, Zs. Szentkereszty, P. Sápy
Dátum:2006
ISSN:0172-6390
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Hepato-Gastroenterology. - 53 : Suppl1 (2006), p. 194-195. -
További szerzők:Enyedi Attila (1975-) (sebész) Kotán Róbert (1975-) (sebész) Sasi Szabó László András (1974-) (sebész) Szentkereszty Zsolt (1961-) (sebész) Sápy Péter (1942-) (sebész)
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4.

001-es BibID:BIBFORM019255
Első szerző:Árkosy Péter (általános sebész, mellkassebész)
Cím:New reconstructive surgery of remnant pancreas in cases of cancer of Vater's papilla / Peter Árkossy, Peter Tóth, Istvan Kovács, Peter Sápy
Dátum:2002
ISSN:0172-6390
Megjegyzések:BACKGROUND/AIMS: The radical surgical procedure for treatment of the carcinoma of papilla of Vater is the pancreatoduodenectomy. The mortality rate of the surgery highly decreased in the last decade, nevertheless there are complications related to the complication of anastomosis of the remnant pancreas. METHODOLOGY: The authors introduce a new reconstructional procedure to decrease the complications. After the removal of the pancreatic head and body an end-to-side anastomosis was performed between the pancreatic duct and a Roux-en jejunal loop. The second anastomosis of the procedure was an end-to-side choledochojejunostomy, the third was an end-to-side duodenojejunostomy. The duodenojejunostomy is about 40 cm from the pancreatic anastomosis, keeping food far from the pancreas with the help of peristaltic waves. This method was applied in 6 patients. RESULTS: It was found that the new reconstructional procedure had generally favorable results without complication. CONCLUSIONS: This method of reconstruction allows for spontaneous closure and safe drainage of potential insufficient pancreaticojejunostomy. The recovered patients support future favorable usage of this new reconstructional surgical procedure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hepato-Gastroenterology. - 49 : 43 (2002), p. 255-257. -
További szerzők:Tóth Péter (sebész) Kovács István (sebész) Sápy Péter (1942-) (sebész)
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5.

001-es BibID:BIBFORM040859
Első szerző:Bodnár Zsolt (sebész)
Cím:The abdominal compartment syndrome (ACS) in general surgery / Zsolt Bodnár, Sándor Sipka, Zoltán Hajdu
Dátum:2008
Megjegyzések:BACKGROUND: The abdominal compartment syndrome is a life threatening clinical entity which can develop within the first 12 hours of intensive care unit admission in high-risk surgical patients. The aim of this paper is to show the definitions, ethiology, pathophysiology, diagnosis and treatment of this serious, not only surgical problem. METHODOLOGY: The mortality due to the abdominal compartment syndrome is extremely high (38-71%). It can be defined as adverse physiologic consequences that occur as a result of an acute increase in the intraabdominal pressure. The most common causes are retroperitoneal haemorrhage, visceral oedema, pancreatitis, bowel obstruction, tense ascites, peritonitis, tumor. The mostly affected systems are cardiovascular, pulmonary, renal, central nervous systems and splanchnic organs. The gold standard diagnostic method is the continuous intra-abdominal pressure monitoring. The treatment consists of adequate fluid resuscitation and surgical decompression. RESULTS: We show three typical short case reports treated by the above mentioned theories. CONCLUSIONS: Intraabdominal hypertension and abdominal compartment syndrome are frequent clinical findings among acute general surgical patients. Patients with comparable demographics and acute severity of illness are more likely to die if intraabdominal hypertension or abdominal compartment syndrome is present. We conclude that the early recognition and surgical decompression is urgent.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hepato-Gastroenterology. - 55 : 88 (2008), p. 2033-2038. -
További szerzők:Sipka Sándor (1945-) (laboratóriumi szakorvos) Hajdú Zoltán (sebész)
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6.

001-es BibID:BIBFORM006272
Első szerző:Furka Andrea (sebész)
Cím:Surgical treatment of liver metastases from breast cancer / Andrea Furka, László Halász, Zsolt Szentkereszty, János Pósán, Csilla András, Péter Sápy
Dátum:2008
Megjegyzések:The resection of colorectal liver metastases is currently a well accepted and effective treatment. In the past decade liver metastases of breast cancer have been treated more frequently by surgical intervention. Methodology: The authors retrospectively studied the data of 17 operated patients, and investigated the clinical features of liver metastases, lymph node involvement ofprimary tumor, the indications of operations, and early and late results of the treatment. Results: The solitary metastasis and demarcated multipÍe metastases, whichseemed (by CT scan) to be operable by Ro resection were among the surgical indications. Different segment resections, 3 laparoscopic resections and one hemihepatectomy were performed. There were no deaths in the peri-operative period, though there were two minor postoperative complications in two cases. AlI patients received chemotherapy. By follow-up, three breast cancer patients died, whose average survival rate was 19.25 months. The other patients' average Jollow- up time was 15.17 months, without relapse. Conclusions: In conclusion it appears that in selected cases resection of liver metastases can be safely performed and the survival rate is reasonable.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Breast cancer
Liver metastasis
Liver resection
Survival rate
Megjelenés:Hepato-Gastroenterology. - 55 : 85 (2008), p. 1416-1418. -
További szerzők:Halász László Szentkereszty Zsolt (1961-) (sebész) Pósán János (1976-) (sebész) András Csilla (1961-) (onkológus szakorvos) Sápy Péter (1942-) (sebész)
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7.

001-es BibID:BIBFORM019276
Első szerző:Hallay Judit (aneszteziológus, intenzív terápiás szakorvos, gyermekgyógyász)
Cím:Early jejunal nutrition and changes in the immunological parameters of patients with acute pancreatitis / J. Hallay, G. Kovács, K. Szatmári, A. Bakó, Zs. Szentkereszty, G. Lakos, S. Sipka, P. Sápy
Dátum:2001
ISSN:0172-6390
Megjegyzések:BACKGROUND/AIMS: We have compared the effects of glutamine-rich Stresson Multi Fibre and of Nutrison Fibre nutrients on the changes of some immunological parameters of 16 patients with acute pancreatitis. Laboratory parameters included: total protein, albumin, prealbumin, retinol binding protein, IgG, IgA, IgM, IgE, complement components: C3, C4, acute phase proteins: C-reactive protein, transferrin, CD-markers of peripheral lymphocytes and activity of peripheral phagocytes. METHODOLOGY: Nine patients were supplied with Stresson Multi Fibre and 7 patients with Nutrison Fibre, using a nasojejunal tube. The levels of serum proteins were measured with laser nephelometry, the CD markers of lymphocytes with flow cytometry and the phagocytic activity with chemiluminescence. RESULTS: The treatment with glutamine-rich Stresson resulted in significant elevations in the serum levels of IgG, retinol binding protein, compared to the effects of Nutrison Fibre. In addition, the recovery of treated patients was significantly shorter in the Stresson Multi Fibre group than in the Nutrison Fibre group. CONCLUSIONS: The Stresson Multi Fibre nutrient treatment of patients treated for acute pancreatitis seems to have clinical benefit based upon the fast recovery of IgG, IgM proteins which take part in the immunological defense mechanisms.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hepato-Gastroenterology. - 48 : 41 (2001), p. 1488-1492. -
További szerzők:Kovács Gábor (orvos) Szatmári Katalin Bakó Andrea Szentkereszty Zsolt (1961-) (sebész) Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Sápy Péter (1942-) (sebész)
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8.

001-es BibID:BIBFORM019273
Első szerző:Hallay Judit (aneszteziológus, intenzív terápiás szakorvos, gyermekgyógyász)
Cím:Changes in the nutritional state and immune-serological parameters of esophagectomized patients fed jejunaly with glutamine-poor and glutamine-rich nutriments / Hallay J., Kovács G., Sz. Kiss S., Farkas M., Lakos G., Sipka S., Bodolay E., Sápy P.
Dátum:2002
ISSN:0172-6390
Megjegyzések:In our former study we investigated the effect of glutamine-rich (I) and glutamine-poor (II) jejunal diet in operated patients with acute pancreatitis. In the glutamine-rich diet group clinical benefit and fast recovery of IgG, IgM, serum proteins, retinol-binding protein, albumin could be measured. In the present study the effects of the two types of jejunal diets I and II have been compared on the basis of changes in some immune parameters of 36 patients treated with subtotal esophagectomy for malignancy. METHODOLOGY: In randomized controlled trial data of two groups, I. patients with glutamine-rich Stresson Multi Fibre diet (23 patients) and II. patients with Nutrison Multi Fibre glutamine-poor diet (13 patients) were analyzed. Levels of serum proteins were measured by laser nephelometry, CD markers of lymphocytes by flow cytometry, phagocyte activity by chemiluminescence. RESULTS: Level of proteins decreased on the 2nd postoperative day in both groups, then gradually increased postoperatively. In increase of level of serum protein, retinol-binding protein, prealbumin there was no difference between the two groups. CONCLUSIONS: In patients treated with subtotal esophagectomy, the glutamine-rich enteric diet did not result in faster recovery in levels of prealbumin, retinol-binding protein, immunoglobulins and in outcome of patients than the glutamine-poor nutriment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hepato-Gastroenterology. - 49 : 48 (2002), p. 1555-1559. -
További szerzők:Kovács Gábor (orvos) Kiss Sándor, Sz. (1946-) (sebész) Farkas Mónika Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Sipka Sándor (1945-) (laboratóriumi szakorvos) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Sápy Péter (1942-) (sebész)
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9.

001-es BibID:BIBFORM016879
Első szerző:Hallay Judit (aneszteziológus, intenzív terápiás szakorvos, gyermekgyógyász)
Cím:Hepatobiliary response in postoperative lipid therapy in gastrointestinal surgery / Judit Hallay, Anna V. Oláh, Béla Fülesdi, Márta Kocsor, Tamás Végh, Gábor Kovács, István Takács, Péter Sápy, Dániel Nagy, István G. Telessy
Dátum:2010
ISSN:0172-6390
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
parenteral nutrition
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hepato-Gastroenterology. - 57 : 102-103 (2010), p. 1069-1073. -
További szerzők:Oláh Anna (1956-) (klinikai biokémikus, vegyész) Fülesdi Béla (1961-) (aneszteziológus) Kocsor Márta Végh Tamás (1975-) (aneszteziológus, intenzív terápiás szakorvos) Kovács Gábor (orvos) Takács István (1963-) (sebész) Sápy Péter (1942-) (sebész) Nagy Dániel Télessy István G.
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10.

001-es BibID:BIBFORM006339
Első szerző:Hallay Judit (aneszteziológus, intenzív terápiás szakorvos, gyermekgyógyász)
Cím:Use of three lumen catheter facilitates bowel movement after Pancreato-duodenectomy / Hallay Judit, Micskei Csaba, Fülesdi Béla, Kovács Gábor, Szentkereszty Zsolt, Takács István, Sipka Sándor, Bodolay Edit, Sápy Péter
Dátum:2008
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
jejunal nutrition; Bowel movement; Pancreato-duodenectomy;
Megjelenés:Hepato-Gastroenterology. - 55 : 84 (2008), p. 1099-1102. -
További szerzők:Micskei Csaba Fülesdi Béla (1961-) (aneszteziológus) Kovács Gábor (Fehérgyarmat orvos) Szentkereszty Zsolt (1961-) (sebész) Takács István (1963-) (sebész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Sápy Péter (1942-) (sebész)
Internet cím:elektronikus változat
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11.

001-es BibID:BIBFORM019278
Első szerző:Kerekes László (sebész, háziorvos)
Cím:Evaluation of hemostatic changes and blood antioxidant capacity in acute and chronic pancreatitis / Kerekes László, Árkossy Péter, Altorjay István, Huszka Mariann, Kappelmayer János, Tóth Péter, Szentkereszty Zsolt, Sápy Péter
Dátum:2001
ISSN:0172-6390
Megjegyzések:We examined changes in hemostasis, in levels of total antioxidant capacity, and pancreatic enzymes (amylase, lipase) in patients with pancreatitis 1, 3 and 7 days after admission to the clinic, in order to evaluate the inflammatory processes in acute and chronic pancreatitis and to identify new prognostic markers. METHODOLOGY: The rate of CD62 expression--a marker of platelet hyperactivity--and the rate of platelet-leukocyte aggregates were measured by flow cytometry. The connection between the parameters measured and the severity of pancreatitis and also the differences of the parameters in acute and chronic pancreatitis were investigated. RESULTS: On the basis of previous studies it was assumed, that there is a connection between the level of parameters measured and the inflammatory process in the pancreas, and also between the defending processes of the body against free radicals. CONCLUSIONS: Based on our results, we suggest to extend the laboratory measurements to the investigation of hemostatic parameters. The measurement of plasma level of fibrinogen, von Willebrand factor and the rate of platelet activation is especially important.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hepato-Gastroenterology. - 48 : 42 (2001), p. 1746-1749. -
További szerzők:Árkosy Péter (1962-) (általános sebész, mellkassebész) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Huszka Mariann Kappelmayer János (1960-) (laboratóriumi szakorvos) Tóth Péter (sebész) Szentkereszty Zsolt (1961-) (sebész) Sápy Péter (1942-) (sebész)
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12.

001-es BibID:BIBFORM036298
035-os BibID:PMID:15966211
Első szerző:Lakatos Péter (Semmelweis Egyetem)
Cím:Clinical presentation of Crohn's disease : association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery / Peter Laszlo Lakatos, Ferenc Szalay, Zsolt Tulassay, Tamas Molnar, Agota Kovacs, Beata Gasztonyi, Janos Papp, the Hungarian IBD Study Group, Laszlo Lakatos
Dátum:2005
ISSN:0172-6390
Megjegyzések:Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population. METHODOLOGY: 564 CD patients (m/f: 278/286, age: 37.4 (SD 12.7) yrs, duration: 8.4 (7.1) yrs) were included. Disease phenotype was determined according to Vienna classification. Familial disease, extraintestinal manifestations (EIM), need for surgery and smoking habits were also analyzed. RESULTS: Familial IBD was present in 73 (12.9%) patients. Age at onset and presence of EIMs was associated with familial disease. Penetrating (44.6% vs. <10 yrs: 29.1%, P<0.0001) and ileocolonic disease (54.4% vs. 42.8%, P=0.03) were more common in patients with a disease duration of > or =10 yrs. In a logistic regression model female gender, colonic/ileocolonic location, smoking and familial IBD were independent risk factors for EIMs, while ileal and non-inflammatory disease increased the risk for resections. Smoking was also associated with frequent relapses. CONCLUSIONS: Familial IBD was associated with the presence of EIMs, while ileal involvement and noninflammatory behavior independently increased the risk for surgery. Since penetrating and extensive disease was more frequent in patients with longer disease duration our data support a possible change in location and behavior during the course of disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hepato-Gastroenterology. - 52 : 63 (2005), p. 817-822. -
További szerzők:Szalay Ferenc (belgyógyász) Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Molnár Tamás (orvos Szeged) Kovács Ágota Gasztonyi Beáta Papp János (Budapest) Lakatos László (Veszprém) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) The Hungarian IBD Study Group
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