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1.

001-es BibID:BIBFORM015547
Első szerző:Bálint Bálint László (kutató orvos)
Cím:Genome-wide localization of histone 4 arginine 3 methylation in a differentiation primed myeloid leukemia cell line / Balint Balint Laszlo, Gabor Petra, Nagy Laszlo
Dátum:2005
ISSN:0171-2985
Megjegyzések:Methylation of arginine residues in proteins is involved in modulation of various protein-protein interactions. At the chromatin level H4R3 methylation provides a signal integration step during myeloid differentiation. In order to globally characterize the role of arginine methylation in signal integration and developmental processes we decided to map genomic loci marked by protein arginine methyl transferase 1 (PRMT1) via histone H4 arginine 3 methylation. For this, we used the myeloid leukemia cell line, HL60, which is known to differentiate along the monocyte/macrophage or granulocyte lineage. We used chromatin immunoprecipitation with an antibody specific for the H4 arginine 3 methyl epitope followed by cloning to isolate genomic loci marked by this modification. After sequencing and in silico analysis we found that all of the genomic hits identified were intronic or within 5 kb of 5' ends of specific genes. The locations identified were enriched in conserved transcription factor binding sites of POU2F1, MEF-2 and FOXL1 factors. A significant number of the genes in the proximity of the identified genomic loci are involved in signaling pathways and developmental processes including immune response of myeloid cells.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunobiology. - 210 : 2-4 (2005), p. 141-152. -
További szerzők:Gábor Petra Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:Egyéb
OTKA
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2.

001-es BibID:BIBFORM036743
035-os BibID:PMID:20708295
Első szerző:Balogh Zoltán (belgyógyász, gasztroenterológus, diabetológus)
Cím:Obesity abrogates the concentration-dependent effect of leptin on endogenous cholesterol synthesis in human monocytes / Zoltán Balogh, Gabriella Fóris, Gabriella Kónya, György Paragh Jr., Tamás Köbling, János T. Padra, Zsolt Sarang, György Paragh
Dátum:2011
ISSN:0171-2985
Megjegyzések:Leptin the cytokine-like hormone is involved not only in local inflammations, but it regulates cholesterol biosynthesis in human monocytes. Since, monocyte-membrane composition in obesity shows considerable difference from control cells, our aim was to elucidate the concentration dependence of the effect of leptin in OW monocytes, and the downstream signaling of high and low leptin concentrations. Control and OW monocytes were stimulated with leptin in the presence or absence of different inhibitors. Our results are as follows: a concentration-dependent biphasic effect could only be detected in control monocytes whereas in OW cells only elevated cholesterol synthesis was found. The signal pathway of 50 ng/mL leptin stimulation involves Ca(2+) signal, activation of PI3K, MAPK and HMG CoA reductase. In the 500 ng/mL leptin-stimulated control monocytes the suppression of cholesterol synthesis was dependent on the Ca(2+) signal, the H-7 sensitive cPKC and PI3K activation, whereas in OW monocytes only PI3K was involved in increased cholesterol synthesis. We conclude that leptin-signaling in OW monocytes is characterized by Ca(2+) influx, abrogation of H-7 sensitive cPKC activation, and by PI3K mediated PKC activation.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunobiology 216 : 3 (2011), p. 431-435. -
További szerzők:Fóris Gabriella (1937-) (belgyógyász) Kónya Gabriella (1982-) (molekuláris biológus) Paragh György Jr. (1978-) (bőrgyógyász) Köbling Tamás (1978-) (belgyógyász) Padra János Tamás (1984-) (biológus) Sarang Zsolt (1976-) (mikrobiológus) Paragh György (1953-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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3.

001-es BibID:BIBFORM042249
Első szerző:Czimmerer Zsolt (molekuláris biológus)
Cím:Identification of novel markers of alternative activation and potential endogenous PPARgamma ligand production mechanisms in human IL-4 stimulated differentiating macrophages / Czimmerer Zsolt, Varga Tamas, Poliska Szilard, Nemet Istvan, Szanto Attila, Nagy Laszlo
Dátum:2012
ISSN:0171-2985
Megjegyzések:We analyzed global gene expression profiles of IL-4 induced alternatively activated as well as IFNγ+TNFα stimulated classically activated human monocyte derived macrophages and identified novel IL-4 regulated alternative activation marker genes including MS4A4A, SLA, CD180, and ENPP2. Transcription factor prediction analysis of IL-4 regulated genes suggested that the regulated genes are involved in a complex regulation of lipid metabolism, defense against cell metabolism derived reactive oxygen species, and basal expression of inflammation linked genes. Both an in silico transcription activation prediction as well as experimental data suggested the presence of alternative macrophage activation specific endogenous PPARγ ligand producing mechanisms. We found the induction of three enzymes whose activity can potentially generate endogenous PPARγ ligands in an IL-4 dependent manner. These are MAOA, ENPP2, and ALOX15 producing 5-methoxy-indole acetate, lysophosphatidic acid (LPA) and 13-hydroxyoctadienoic acid (13-HODE), and/or 15-hydroxyeicosatetraenoic acid (15-HETE), respectively. Our data suggest that global gene expression profiling, combined with computational transcription activity prediction, can lead to identification of transcriptional networks that underpin cellular subtype specification.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Immunobiology. - 217 : 12 (2012), p. 1301-1314. -
További szerzők:Varga Tamás (1971-) (biológus) Póliska Szilárd (1978-) (biológus) Német István (1982-) (Ph.D. hallgató, molekuláris biológus) Szántó Attila (1976-) (orvos, biokémikus) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:NK72730
OTKA
K100196
OTKA
REGPOT-2008-1-01/MOLMEDREX/229920
FP7
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Magreceptor természetes ligandok azonosítása
TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM047642
035-os BibID:PMID:11563675
Első szerző:Horváth Anna
Cím:High level of anticholesterol antibodies (ACHA) in HIV patients. Normalization of serum ACHA concentration after introduction of HAART / Anna Horváth, Dénes Bánhegyi, Adrien Bíró, Eszter Ujhelyi, Amarilla Veres, Laura Horváth, Zoltán Prohászka, Attila Bácsi, Vera Tarján, László Romics, István Horváth, Ferenc D. Tóth, George Füst, István Karádi
Dátum:2001
ISSN:0171-2985
Megjegyzések:Anticholesterol antibodies (ACHA) are natural antibodies against the 3~-OH group of cholesterol.Since lipid disorders are common in HIV infection and HAART may further enhance dislipidaemia,we determined by using an ELISA method serum ACHA concentrations in HIV patients and healthyHIV-seronegative controls.ACHA levels were almost 4 times higher in the sera of 46 patients than in 110 controls. No differencein the specificity of ACHA was found between HIV-seropositive and HIV-seronegative sera.Binding ofACHA to cholesterol-coated plates from a HIV-seropositive serum was dose-dependentlyinhibited by preincubation with HIV-l BA-L preparation. Serum concentration of ACHA was significantlyhigher in the patients with low serum cholesterol levels than in those with normal cholesterol levelseHAART induced a marked drop ofACHA concentration. We found a significant negative correlationbetween the length of HAART and the ACHA levels. By contrast, HAART did not significantlyinfluence total IgG concentration and titers of antibodies against 60 kD heat shock protein.Our findings indicate that high levels ofACHA in HIV-infection may contribute to the developmentof hypocholesterolaemia frequently observed in this disease.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunobiology. - 203 : 5 (2001), p. 756-768. -
További szerzők:Bánhegyi Dénes Bíró Adrienn Ujhelyi Eszter Veres Amarilla Horváth Laura Prohászka Zoltán Bácsi Attila (1967-) (immunológus) Tarján Vera Romics László Horváth István Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus)
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5.

001-es BibID:BIBFORM049592
035-os BibID:PMID:23870824
Első szerző:Kis-Tóth Katalin (immunológus)
Cím:Monocyte-derived dendritic cell subpopulations use different types of matrix metalloproteinases inhibited by GM6001 / Katalin Kis-Toth, Ildiko Bacskai, Peter Gogolak, Anett Mazlo, Istvan Szatmari, Eva Rajnavolgyi
Dátum:2013
ISSN:0171-2985
Megjegyzések:Matrix metalloproteinases (MMPs) are endopeptidases with the potential to cleave extracellular matrix, support tissue renewal and regulate cell migration. Functional activities of MMPs are regulated by tissue inhibitors of MMPs (TIMPs) and disruption of the MMP-TIMP balance has pathological consequences. Here we studied the expression and secretion of MMPs and TIMPs in CD1a(-) and CD1a(+) monocyte-derived dendritic cell (DC) subpopulations. Our results showed that monocytes express TIMPs but lack MMPs, whereas upon differentiation to moDCs and in response to activation signals the expression of MMPs is increased and that of TIMPs is decreased. MMP-9 is expressed dominantly in the CD1a(-) subpopulation, while MMP-12 is preferentially expressed in CD1a(+) cells. Experiments performed with the synthetic MMP inhibitor GM6001 revealed that this drug efficiently inhibits the migration of moDCs through inactivation of MMPs. We conclude that modulation of MMP activity by GM6001 emerges as a novel approach to manipulate DC migration under inflammatory conditions. (C) 2013 Elsevier GmbH. All rights reserved.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
CD1a
Dendritic cell
Immunotherapy
Matrix metalloproteinase
Tissue inhibitor of matrix
Metalloproteinase
Megjelenés:Immunobiology. - 218 : 11 (2013), p. 1361-1369. -
További szerzők:Bacskai Ildikó (1985-) (immunológus) Gogolák Péter (1968-) (biológus, immunológus) Türk-Mázló Anett (1989-) (molekuláris biológus) Szatmári István (1971-) (biológus) Rajnavölgyi Éva (1950-) (immunológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0023-"VÉD-ELEM"
TÁMOP
NK 101538
OTKA
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6.

001-es BibID:BIBFORM065677
Első szerző:Mihály Johanna (biológus, vegyész)
Cím:TSLP expression in the skin is mediated via RAR-RXR pathways / Johanna Mihály, Janine Gericke, Renata Lucas, Angel R. de Lera, Susana Alvarez, Dániel Törőcsik, Ralph Rühl
Dátum:2016
ISSN:0171-2985
Megjegyzések:TSLP is an important trigger and initiator for various atopic diseases mainly atopic dermatitis (AD). Activators of nuclear hormone receptors like bioactive vitamin A and D derivatives are known to induce TSLP up-regulation in the skin. In this study, various combinations of synthetic specific agonists and antagonists of the retinoic acid receptors (RARs), retinoid X receptors (RXRs) and vitamin D receptor (VDR) were topically administered to mice. The aim of the study was to elucidate via which nuclear hormone receptor pathways TSLP is regulated and how this regulation is connected to the development and phenotype of atopic dermatitis. TSLP expression was monitored using QRT-PCR and serum TSLP levels using ELISA. Synthetic agonists of the VDR and RAR? as well as the natural agonist all-trans retinoic acid (ATRA) increased TSLP expression in the skin, while an RXR agonist was not active. Treatments with antagonists of RXRs and RARs in addition to RAR?-agonists reduced skin TSLP expression. Strong activation was found after a combination of a VDR and an RXR agonist (ca. 5 times induction) and even stronger by an RAR? and an RXR agonist treatment (ca. 48 times induction). We conclude that besides VDR-mediated signaling mainly RAR?-RXR mediated pathways in the skin are important patho-physiological triggers for increased skin TSLP expression. We conclude that topical synthesized retinoids stimulated by internal or external triggers or topically applied induce TSLP production and are thereby important triggers for atopic dermatitis prevalence.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
TSLP
RAR
RXR
Retinoic acid
Vitamin A
Vitamin D
Megjelenés:Immunobiology 221 : 2 (2016), p. 161-165. -
További szerzők:Gericke, Janine (1982-) (táplálkozástudományi szakember) Lucas, Renata de Lera, Ángel R. Álvarez, Susana Töröcsik Dániel (1979-) (bőrgyógyász) Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:K 109362
OTKA
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7.

001-es BibID:BIBFORM049597
035-os BibID:PMID:23973299 WOS:000325840200014
Első szerző:Nagy Gergely (molekuláris biológus)
Cím:A novel method to predict regulatory regions based on histone mark landscapes in macrophages / Gergely Nagy, Bence Dániel, Dávid Jónás, László Nagy, Endre Barta
Dátum:2013
ISSN:0171-2985
Megjegyzések:Macrophages as phagocytes and professional antigen presenting cells play critical roles in both innate and adaptive immunity. Main transcription factors acting during their differentiation and function are known, but the behavior and co-operation of these factors still remained unexplored. We introduce a new approach to map nucleosome-free regions using exclusively active enhancer and core promoter marking histone modification ChIP-seq data. We could detect approximately 56,000 potential active enhancers/promoters showing different lengths and histone modification shapes. Beside the highly enriched PU.1 and C/EBP sites, we could also detect binding sites for RUNX and AP-1, as well as for the MiT (MITF-TFE) family and MEF2 proteins. The PU.1 and C/EBP transcription factors are known for transforming cells into macrophages. The other transcription factors found in this study can play a role in macrophages as well, since it is known that the MiT family proteins are responsible for phagocytic activity and the MEF2 proteins specify monocytic differentiation over the granulocyte direction. Our results imply that this method can provide novel information about transcription factor organization at enhancers and core promoters as well as about the histone modifications surrounding regulatory regions in any immune or other cell types.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
BWA
Burrows-Wheeler Alignment Tool
CRE
ChIP
DMEM
Dulbecco's modified Eagle's medium
ENCODE
Enhancer
FAIRE
HLH
HOMER
HTH
Histone modification
IGV
Macrophage
NFR
NOR
Nucleosome-free region
PU.1
Promoter
SRA
TSS
bZIP
basic leucine zipper
cAMP response element
chromatin immunoprecipitation
encyclopedia of DNA elements
formaldehyde-assisted isolation of regulatory elements
helix-loop-helix
helix-turn-helix
hypergeometric optimization of motif EnRichment
integrative genomics viewer
nucleosome occupied region
nucleosome-free region
sequence read archive
transcription start site
Megjelenés:Immunobiology. - 218 : 11 (2013), p. 1416-1427. -
További szerzők:Dániel Bence (1987-) (molekuláris biológus) Jonás Dávid Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Barta Endre (1963-) (molekuláris biológus)
Pályázati támogatás:K100196
OTKA
TÁMOP422_2012_002
TÁMOP
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM051527
Első szerző:Nagy László (molekuláris sejtbiológus, biokémikus)
Cím:EMDS 2012 : 26th Meeting of the European Society for Macrophage and Dendritic Cell Biology in Debrecen, Hungary, September 1-3, 2012 / László Nagy, Éva Rajnavolgyi
Dátum:2013
ISSN:0171-2985
Megjegyzések:The EMDS Meeting has established itself as a regular key event on the calendars of macrophage and dendritic cells biologists in Europe during the past two decades. The Societies' 26th Annual Meeting was held in Debrecen, in a University town in Hungary composed of 250,000 inhabitants and more than 30,000 students. 2012 was the centennial year of the establishment of the Royal University of Debrecen back in 1912, while the roots of higher education in Debrecen can be traced back to a far as 1538 when the Reformed (Calvinist) Church established its college in the city. The field of Immunology has set roots in Debrecen early on as well, with both, basic research and as well as clinical immunology.
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztőségi anyag
macrophage
dendritic cell
Megjelenés:Immunobiology. - 218 : 11 (2013), p. 1311. -
További szerzők:Rajnavölgyi Éva (1950-) (immunológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM049606
Első szerző:Nagy Zsuzsanna (okleveles középiskolai kémia-fizika szakos tanár)
Cím:Pro-inflammatory cytokines negatively regulate PPARγ mediated gene expression in both human and murine macrophages via multiple mechanisms / Zsuzsanna S. Nagy, Zsolt Czimmerer, Attila Szanto, Laszlo Nagy
Dátum:2013
ISSN:0171-2985
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Doktori iskola
Megjelenés:Immunobiology. - 218 : 11 (2013), p. 1336-1344. -
További szerzők:Czimmerer Zsolt (1981-) (molekuláris biológus) Szántó Attila (1976-) (orvos, biokémikus) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:K 100196
OTKA
TÁMOP-422/2012-0023
TÁMOP
MTA János Bolyai Research Fellowship
Egyéb
NKTH-OTKA-EU 7KP (Marie Curie actions) Reintegration Grant (OTKA MB08C 84630 HUMAN MB08-3-2011-0002)
OTKA
TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
Molekuláris Sejt- és Immunbiológiai Doktori Iskola
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10.

001-es BibID:BIBFORM054135
Első szerző:Sarang Zsolt (mikrobiológus)
Cím:Macrophages engulfing apoptotic thymocytes produce retinoids to promote selection, differentiation, removal and replacement of double positive thymocytes / Zsolt Sarang, Éva Garabuczi, Gergely Joós, Beáta Kiss, Katalin Tóth, Ralph Rühl, Zsuzsa Szondy
Dátum:2013
ISSN:0171-2985
Megjegyzések:The thymus provides the microenvironment in which thymocytes develop into mature T-cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T-cells is a basic requirement for mature T-cell functions, and those thymocytes that do not recognize or respond too strongly to the peptide-loaded self-MHC molecules found in the thymus undergo apoptosis. As a result, 95% of the thymocytes produced will die and be subsequently cleared by macrophages. This review describes a complex crosstalk between developing thymocytes and engulfing macrophages which is mediated by retinoids produced by engulfing macrophages. The interaction results in the harmonization of the rate of cell death of dying double positive cells with their clearance and replacement, and in promotion of the differentiation of the selected cells in the thymus.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunobiology. - 218 : 11 (2013), p. 1354-1360. -
További szerzők:Garabuczi Éva (1982-) (biokémikus, molekuláris biológus) Joós Gergely Kiss Beáta (1984-) (biokémikus, molekuláris biológus) Tóth Katalin Ágnes (1977-) (biokémikus, molekuláris biológus) Rühl, Ralph (1969-) (vegyész) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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11.

001-es BibID:BIBFORM003921
Első szerző:Szántó Attila (orvos, biokémikus)
Cím:The many faces of PPARgamma : anti-inflammatory by any means? / Szántó, A., Nagy, L.
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunobiology. - 213 : 9-10 (2008), p. 789-803. -
További szerzők:Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Internet cím:elektronikus változat
DOI
Borító:

12.

001-es BibID:BIBFORM002766
Első szerző:Székely Andrea
Cím:Nutrition and immune system : certain fatty acids differently modify membrane composition and consequently kinetics of KV1.3 channels of human peripheral lymphocytes/ Szekely A., Kitajka K., Panyi G., Marian T., Gaspar R., Krasznai Z.
Dátum:2007
Megjegyzések:Potassium (K(+)) channels of human peripheral lymphocytes play a considerable role in the signalling processes required for immune responses. Modification of the fatty acid composition of the membrane influences the functions of various membrane enzymes and ion channels. We set out to establish how the incorporation of fatty acids with different carbon chain lengths and degrees of unsaturation into the cell membrane influences the function of K(V)1.3 channels of lymphocytes, thereby potentially modifying the immune responses of the cells. The incorporation of the fatty acids into the cell membrane was monitored by gas chromatography. Whole-cell patch-clamp experiments demonstrated that the polyunsaturated linoleic acid, arachidonic acid and docosahexaenoic acid all decreased the activation and inactivation time constants of the K(V)1.3 channels, but did not affect the voltage-dependence of steady-state activation and steady-state inactivation of the channels. Treatment with the saturated palmitic acid, stearic acid and the monounsaturated oleic acid did not result in significant changes in the biophysical parameters of K(V)1.3 gating studied. We conclude that the incorporation of fatty acids unsaturated to different degrees into the cell membrane of lymphocytes influenced the rate of gating transitions but not the equilibrium distribution of the channels between different states. This effect depended on the degree of unsaturation and the chain length of the fatty acids: no effects of saturated and monounsaturated fatty acids (16:0, 18:0 and 18:1) were observed whereas treatment with polyunsaturated fatty acids (18:2, 20:4 and 22:6) resulted in significant changes in the channel kinetics
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biophysics
Cell Membrane
Cells
chemistry
Chromatography
Dietary Fats
Enzymes
Fatty Acids
Human
Humans
Hungary
Immune System
immunology
Ion Channels
Kinetics
Kv1.3 Potassium Channel
Lymphocyte Subsets
Lymphocytes
metabolism
pharmacology
physiology
Potassium
Research
Support
Megjelenés:Immunobiology. - 212 : 3 (2007), p. 213-227. -
További szerzők:Kitajka Klára Panyi György (1966-) (biofizikus) Márián Teréz (1950-) (radiobiológus) Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus)
Internet cím:DOI
elektronikus változat
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