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1.

001-es BibID:BIBFORM068923
Első szerző:Antal-Szalmás Péter (laboratóriumi szakorvos)
Cím:Spare CD14 molecules on human monocytes enhance the sensitivity for low LPS concentrations / Antal-Szalmás Péter, Poppelier Miriam J. J. G, Sümegi Andrea, van der Bruggen Tjomme, Verhoef Jan, van Kessel Kok P. M., van Strijp Jos A. G
Dátum:2004
ISSN:0165-2478
Megjegyzések:Human monocytes express on their plasma membrane relatively large number of CD14 molecules, known to play a crucial role in thelipopolisaccharide (LPS)-mediated cellular activation. Indirect data (J. Biol. Chem. 270 (1995) 9904) suggest that not all of these CD14molecules participate in LPS-signaling, but the importance of these spare receptors and the exact number of CD14 involved in activation upondifferent LPS-stimuli is not known. Using different concentrations of a blocking anti-CD14 monoclonal antibody (mAb 60bca) we createdmonocytes with graded amounts of CD14. The exact number of occupied and free receptors was quantitated by flow cytometry and specialmAb-labeled standard beads. The number of free CD14 molecules per monocyte in the presence of 10, 3.33, 0.73, 0.25 and 0.041 g/mlmAb was 0, 13 100, 49 300, 97 700 and 165 900. Stimulation of these partially blocked monocytes with 0.1, 1, 10 and 100 ng/ml ReLPS inthe presence of 3% human serum revealed that already 13 100 and 97 700 CD14 molecules provided a maximal Tumor necrosis factor (TNF ) mRNA response using 100 and 10 ng/ml ReLPS, while the activation totally depended on the number of available CD14 moleculesin the case of 1 and 0.1 ng/ml ReLPS. Our data imply that the number of CD14 molecules available for LPS-binding influence the cellularresponse. In the presence of higher concentrations of LPS only fractions of CD14 participate in the cell activation, while the presence of thespare receptors enhance the sensitivity against lower LPS amounts.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
CD14
Megjelenés:Immunology Letters 93 : 1 (2004), p. 11-15. -
További szerzők:Poppelier, Miriam J. J. G Sümegi Andrea (1969-) (biológus) van der Bruggen, Tjomme Verhoef, Jan Kessel, Kok P. M., van Strijp, Jos A. G., van
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2.

001-es BibID:BIBFORM035804
Első szerző:Bánhegyi Dénes
Cím:Significant decrease of the enhancement/neutralization index in HIV patients during highly active antiretroviral therapy (HAART) / Bánhegyi Dénes, Bácsi Attila, Tóth Ferenc D., Prohászka Zoltán, Horváth Anna, Beck Zoltán, Kónya József, Füst George
Dátum:2003
ISSN:0165-2478
Megjegyzések:Authors studied the effect of highly active antiretroviral therapy (HAART) on balance of the antibodies that enhance or neutralize growth of HIV-1(IIIB) strain in MT-4 cells in the presence or absence of human complement. Sequential serum samples were collected from 28 patients in advanced stage of HIV disease before and during HAART. The balance of the enhancing and neutralizing antibodies was expressed by an index value (E/N I). Samples with an E/N I of <0.5 (twofold decrease in virus production) were considered as neutralizing, whereas samples with an E/N I>2.0 (twofold increase in virus production) were considered as enhancing. At the beginning of HAART serum samples from eight patients enhanced, and samples from only two patients neutralized the virus in the presence of complement, median (25th-75th percentile) value of E/N I was 1.32 (0.79-2.29). E/N I significantly (P<0.0001) dropped to 0.37 (0.19-0.57) during the follow-up period of 18.5 (10.5-23.5) months under HAART. Similar changes were detected when serum samples were tested with no complement added. The E/N I values were also markedly decreased when cultures inoculated with mixtures of HIV and purified IgG prepared from serum pools taken before and during HAART, respectively, were compared. In the last samples of 20/28 patients, neutralization was measured even in the presence of complement while enhancement was found with none of these samples. These findings suggest that HAART results in disappearance of enhancing antibodies and switches the E/N I toward neutralization.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunology Letters. - 89 : 1 (2003), p. 25-30. -
További szerzők:Bácsi Attila (1967-) (immunológus) Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Prohászka Zoltán Horváth Anna Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Füst György (Budapest)
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3.

001-es BibID:BIBFORM043076
035-os BibID:PMID:23500533
Első szerző:Baráth Sándor (biológus)
Cím:Conductor of regulatory cells : does vitamin D restore the shifted balance of the distinct regulatory cell types in undifferentiated connective tissue disease? / Sándor Baráth, Gábor Nagy, Éva Zöld, István Csípő, Edit Gyimesi, Margit Zeher, Edit Bodolay
Dátum:2013
ISSN:0165-2478
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters 153 : 1-2 (2013), p. 71-72. -
További szerzők:Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Zöld Éva (1978-) (belgyógyász) Csípő István (1953-) (vegyész) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus)
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4.

001-es BibID:BIBFORM082468
Első szerző:Bene László (biofizikus)
Cím:Adaptive threshold-stochastic resonance (AT-SR) in MHC clusters on the cell surface / László Bene, Miklós Bagdány, László Damjanovich
Dátum:2019
ISSN:0165-2478
Megjegyzések:Highly conserved 2D receptor clusters (membrane rafts) of immunological signaling molecules with MHCI and MHCII antigens as their cores have been observed in the past on the surface of T- and B-cell lines of lymphoid origin, as well as on cells from patients with colon tumor and Crohn's disease. Conservativity is related to the ever presence of MHCI molecules. Although they are suspected to play a role in maintaining these clusters and facilitating transmembrane signaling, their exact role has been left largely enigmatic. Here we are suggesting stochastic resonance (SR), or "noise-assisted signal detection", as a general organizing principle for transmembrane signaling events evoked by processes like immune recognition and cytokine binding taking place in these clusters. In the conceptual framework of SR, in immune recognition as a prototype of transmembrane signaling, the sea of self-peptide-MHC complexes around a nonself-peptide presenting MHC is conceived as a source of quickly fluctuating unspecific signal ("athermal noise") serving the extra energy for amplifying the weak sub-threshold specific signal of the nonself-peptide presenting MHC. This same noise is also utilized for a readjustment of the threshold ? and also the sensitivity and specificity ? of detection by a closed loop feedback control of the TcR-CD8 (CD4) proximity on the detecting T-cell. The weak sub threshold specific signal of nonself-peptide presenting MHC is amplified by the superposing unspecific signals of the neighboring self peptide-MHC complexes towards the T-cell receptor as the detector. Because in a successful detection event both self- and nonself-peptides are detected simultaneously, the principle of coincidence (or lock-in) detection is also realized. The ever presence of MHC islands gets a natural explanation as a source of extra power ? in a form of "athermal noise" ? needed for coincidence detection and frequency encoding the evoked downstream signals. The effect is quite general, because the actual type of molecules surrounding a chief signaling molecule ? like nonself-peptide holding MHC, interleukin-2 and -15 cytokine receptors (IL-2R/15R) ? as the fluctuating interaction energy sources is immaterial. The model applies also for other types of signaling, such as those evoked by cytokine binding. The phenomenon of SR can also be interpreted as sampling of a low frequency, specific signal with a high frequency unspecific signal, the "noise". Recipes for identifying other forms of SR in membrane clusters with biophysical tools are recommended.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Immunology Letters. - 217 (2019), p. 65-71. -
További szerzők:Bagdány Miklós Damjanovich László (1960-) (általános sebész)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Sebészet Kutatócsoport
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM026778
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Methimazole blocks Graves' IgG but not interferon-gamma HLA-DR expression by thyroid cells / Edit Bodolay, Peter Suranyi, Ferenc Juhasz, Valeria Stenszky, Csaba Balazs, Nadir R. Farid
Dátum:1988
Megjegyzések:We have expanded our early observation that a potent Graves' IgG preparation induces HLA-DR expression on thyroid cells, by showing that four randomly-selected Graves' IgG's were also capable of inducing DR antigens on thyroid cells. The effect of Graves' IgG was specific to thyroid cells, as it did not induce MHC Class II molecule expression on endothelial cells whereas interferon-gamma and immune complexes did so. The anti-thyroid drug methimazole was capable of rapidly reducing Graves' IgG-induced DR expression but to a much lesser extent than brought about by interferon-gamma. We conclude that Graves' IgG propagates thyroid-specific autoaggression by continued induction of DR antigens and than an important means whereby methimazole brings about remission is by reducing this induction.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunol Letters. - 18 : 3 (1988), p. 167-172. -
További szerzők:Surányi Péter Juhász Ferenc Stenszky Valéria Balázs Csaba Farid, Nadir R.
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6.

001-es BibID:BIBFORM021868
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Cytotoxic endothelial cell antibodies in mixed connective tissue disease / Edit Bodolay, Ferenc Boján, Gyula Szegedi, Valeria Stenszky, N. R. Farid
Dátum:1989
Megjegyzések:We examined the presence of anti-endothelial cell antibodies in the sera of 44 patients with mixed connective tissue disease (MCTD). Warm antibodies against endothelial cells were found in 45.4% of patients; the presence of these antibodies was positively correlated with anti-monocyte antibodies (P less than 0.01) but not with anti-lymphocytic antibodies. Strong correlations were found between the presence of these antibodies and abnormalities of pulmonary ventilatory capacity, neurophysiologic and myocardial function. Anti-endothelial antibodies were related to the high rate of spontaneous abortion noted in female MCTD patients. The identification of the antigen identified by MCTD sera in endothelial cells would help in understanding disease manifestations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunol Letters. - 20 : 2 (1989), p. 163-168. -
További szerzők:Boján Ferenc (1946-1997) (orvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Stenszky Valéria Farid, Nadir R.
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7.

001-es BibID:BIBFORM021861
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Expression of HLA-DR antigens by thyroid cells : the effect of Graves' IgG / Edit Bodolay, Gyula Szegedi, Péter Surányi, Ferenc Juhász, Valéria Stenszky, Csaba Balázs, Nadir R. Farid
Dátum:1987
Megjegyzések:We have investigated factors which influence HLA-DR expression on thyroid cells. While bTSH (100 mU/ml) did not enhance HLA-DR expression, it increased when brought about by IFN-gamma. Graves' IgG showed a dose-dependent (0.1-2 mg/ml) increase in DR expression and at a concentration of 2 mg/ml prolonged the time for which DR was expressed. The pathway of DR induction by Graves' IgG apparently differs from that by IFN-gamma. The humoral response in Graves' disease, by inducing DR expression, may be instrumental in propagating thyroid specific autoimmunity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology letters. - 15 : 1 (1987), p. 77-81. -
További szerzők:Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Surányi Péter Juhász Ferenc Stenszky Valéria Balázs Csaba Farid, Nadir R.
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DOI
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8.

001-es BibID:BIBFORM004703
035-os BibID:(scopus)0037013728 (wos)000176059200014
Első szerző:Damjanovich Sándor (biofizikus)
Cím:Does mosaicism of the plasma membrane at molecular and higher hierarchical levels in human lymphocytes carry information on the immediate history of cells? / Damjanovich, S., Matyus, L., Damjanovich, L., Bene, L., Jenei, A., Matko, J., Gaspar, R., Szollosi, J.
Dátum:2002
Megjegyzések:A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic origin of these supramolecular formations is analyzed, contrasting this concept to the mobility of the cell surface proteins. A model is offered which, on the one hand, allows the mobility in a restricted way even among microdomain-confined receptor proteins through 'swapping partners'. On the other hand, the lack of mixing molecular components of protein clusters will be analyzed, when homo-and hetero-associations are studied through cell fusion experiments. The most frequently studied cell surface patterns have included lipid raft organized HLA class I and II, ICAM-1, tetraspan molecules, IL2 and IL15 and other receptors, as well. On the contrary coated pit-associated transferrin receptors would not mix with the above lipid raft associated receptor patterns, although transferrin receptor would readily oligomerize into homo-associates. The functional consequences of these superstructures are also analyzed. On the 30th anniversary of the Singer-Nicolson fluid mosaic membrane model one has to pay tribute to the authors, because of their deep insight emphasizing also the mosaicism of the membranes in general and that of the plasma membrane, in particular.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
analysis
Biophysics
Cell Fusion
Cells
Human
Hungary
Lymphocytes
Proteins
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters. - 82 : 1-2 (2002), p. 93-99. -
További szerzők:Mátyus László (1956-) (biofizikus) Damjanovich László (1960-) (általános sebész) Bene László (1963-) (biofizikus) Jenei Attila (1966-) (biofizikus) Matkó János (1952-) (biológus) Gáspár Rezső (1944-) (biofizikus) Szöllősi János (1953-) (biofizikus)
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elektronikus változat
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9.

001-es BibID:BIBFORM005175
Első szerző:Dóczy-Bodnár Andrea (biofizikus)
Cím:A biophysical approach to IL-2 and IL-15 receptor function : localization, conformation and interactions / Bodnar, A., Nizsaloczki, E., Mocsar, G., Szaloki, N., Waldmann, T. A., Damjanovich, S., Vamosi, G.
Dátum:2008
Megjegyzések:Interleukin-2 and interleukin-15 (IL-2, IL-15) are key participants in T and NK cell activation and function. Sharing the beta and gamma receptor subunits results in several common functions: e.g. the promotion of T cell proliferation. On the other hand, due to their distinct alpha receptor subunits, they also play opposing roles in immune processes such as activation induced cell death and immunological memory. Divergence of signaling pathways must ensue already at the plasma membrane where the cytokines interact with their receptors. Therefore understanding molecular details of receptor organization and mapping interactions with other membrane proteins that might influence receptor conformation and function, are of key importance. Biophysical/advanced microscopic methods (fluorescence resonance energy transfer (FRET), fluorescence crosscorrelation spectroscopy (FCCS), near-field scanning optical microscopy (NSOM), X-ray crystallography, surface plasmon resonance, NMR spectroscopy) have been instrumental in clarifying the details of receptor structure and organization from the atomic level to the assembly and dynamics of supramolecular clusters. In this short review some important contributions shaping our current view of IL-2 and IL-15 receptors are presented.
Tárgyszavak:Orvostudományok Elméleti orvostudományok Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
analysis
Antibodies
Apoptosis
Biophysics
blood
Carcinoma
Cell Differentiation
Cell Fusion
Cell Line
Cell Membrane
Cell Proliferation
Cells
Complement
Confocal microscopy
Dendritic Cells
Diffusion
Energy Transfer
Epidermal Growth Factor
Fibroblasts
Fluorescence
Fluorescence correlation spectroscopy
Fluorescence Resonance Energy Transfer
FRET
Homeostasis
Human
Hungary
IL-2 and IL-15 receptors
In Vitro
Insulin
Interleukin-15
Interleukin-2
Kinetics
Lymphocytes
Lymphoma
Melanoma
Membrane Microdomains
Membrane Proteins
metabolism
methods
Mice
Microscopy
Near-field scanning optical microscopy
Phagocytosis
Phosphorylation
Photobleaching
Protein-protein interactions
Proteins
Receptor patterns
Research
Signal Transduction
Structure determination
Support
therapy
transmembrane signaling
Tyrosine
X-ray crystallography
Megjelenés:Immunology Letters. - 116 : 2 (2008), p. 117-125. -
További szerzők:Nizsalóczki Enikő Mocsár Gábor (1981-) (biofizikus) Szalóki Nikoletta (1981-) (biológus) Waldmann, Thomas A. Damjanovich Sándor (1936-2017) (biofizikus) Vámosi György (1967-) (biofizikus)
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elektronikus változat
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10.

001-es BibID:BIBFORM054138
Első szerző:Duró Edina
Cím:Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation / Edina Duró, Anna Pallai, Krisztina Köröskényi, Zsolt Sarang, Zsuzsa Szondy
Dátum:2014
ISSN:0165-2478
Megjegyzések:Timed initiation of apoptotic cell death followed by efficient removal mediated by professional macrophages is a key mechanism in maintaining tissue homeostasis. Besides phagocytosis, clearance of apoptotic cells also involves suppression of inflammatory responses by apoptotic cells mediated by both direct inhibition of pro-inflammatory cytokine production and release of soluble anti-inflammatory factors, which act in a paracrine or autocrine fashion to amplify or sustain the anti-inflammatory response. Previous work has demonstrated that during engulfment of apoptotic cells adenosine is produced in sufficient amounts to trigger both adenosine A2A receptors (A2ARs) and A3 receptors (A3Rs). Adenosine bound to A2ARs of macrophages activated the adenylate cyclase pathway to suppress the apoptotic-cell induced, NO-dependent formation of neutrophil migration factors. Here we show by using A3R null engulfing macrophages that the adenosine produced triggers the A3Rs as well, which attenuate the A2AR signaling by inhibiting adenylate cyclase. As a result, the balance in the activation of A2ARs and A3Rs determines the amounts of NO and consequently the levels of neutrophil chemoattractants formed. Since during phagocytosis of apoptotic cells the expression of A2ARs increases, while that of A3Rs decreases, on long term adenosine suppresses the proinflammatory responses in engulfing macrophages.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunology Letters 162 : 2 Part B (2014), p. 292-301. -
További szerzők:Pallai Anna (1983-) (biokémikus, molekuláris biológus) Köröskényi Krisztina (1979-) (biokémikus, molekuláris biológus) Sarang Zsolt (1976-) (mikrobiológus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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11.

001-es BibID:BIBFORM014824
Első szerző:Erdős Melinda (infektológus, gyermekimmunológus)
Cím:Genetically acquired class-switch recombination defects : the multi-faced hyper-IgM syndrome / Erdős Melinda, Anne Durandy, Maródi László
Dátum:2005
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters. - 97 : 1 (2005), p. 1-6. -
További szerzők:Durandy, Anne Maródi László (1949-) (gyermekgyógyász infektológus, immunológus)
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DOI
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12.

001-es BibID:BIBFORM010350
035-os BibID:(scopus)67349251235 (wos)000267233000008
Első szerző:Friedländer Elza (biofizikus)
Cím:Corrigendum to ?ErbB-directed immunotherapy: Antibodies in current practice and promising new agents" [Immunol. Lett. 116/2 (2008) 126-140] / Friedlander, E., Barok, M., Szollosi, J., Vereb, G.
Dátum:2009
ISSN:0165-2478
Tárgyszavak:Orvostudományok Elméleti orvostudományok hozzászólás
folyóiratcikk
Antibodies
Megjelenés:Immunology Letters. - 124 : 1 (2009), p. 55-56. -
További szerzők:Barok Márk (1976-) (biofizikus) Szöllősi János (1953-) (biofizikus) Vereb György (1965-) (absztraktok, könyvfejezetek)
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