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1.

001-es BibID:BIBFORM008925
Első szerző:Bágyi Kinga (fogszakorvos)
Cím:Role of pathogenic oral flora in postoperative pneumonia following brain surgery / Bágyi Kinga, Haczku Angela, Márton Ildikó, Szabó Judit, Gáspár Attila, Andrási Melinda, Varga Imre, Tóth Judit, Klekner Álmos
Dátum:2009
Megjegyzések:Post-operative pulmonary infection often appears to result from aspiration of pathogens colonizing the oral cavity. It was hypothesized that impaired periodontal status and pathogenic oral bacteria significantly contribute to development of aspiration pneumonia following neurosurgical operations. Further, the prophylactic effects of a single dose preoperative cefazolin on the oral bacteria were investigated. Methods: A matched cohort of 18 patients without postoperative lung complications was compared to 5 patients who developed pneumonia within 48 hours after brain surgery. Patients waiting for elective operation of a single brain tumor underwent dental examination and saliva collection before surgery. Bacteria from saliva cultures were isolated and periodontal disease was scored according to type and severity. Patients received 15 mg/kg cefazolin intravenously at the beginning of surgery. Serum, saliva and bronchial secretion were collected promptly after the operation. The minimal inhibitory concentrations of cefazolin regarding the isolated bacteria were determined. The actual antibiotic concentrations in serum, saliva and bronchial secretion were measured by capillary electrophoresis upon completion of surgery. Bacteria were isolated again from the sputum of postoperative pneumonia patients. Results: The number and severity of coexisting periodontal diseases were significantly greater in patients with postoperative pneumonia in comparison to the control group (p = 0.031 and p = 0.002, respectively). The relative risk of developing postoperative pneumonia in high periodontal score patients was 3.5 greater than in patients who had low periodontal score (p < 0.0001). Cefazolin concentration in saliva and bronchial secretion remained below detectable levels in every patient. Conclusion: Presence of multiple periodontal diseases and pathogenic bacteria in the saliva are important predisposing factors of postoperative aspiration pneumonia in patients after brain surgery. The low penetration rate of cefazolin into the saliva indicates that its prophylactic administration may not be sufficient to prevent postoperative aspiration pneumonia. Our study suggests that dental examination may be warranted in order to identify patients at high risk of developing postoperative respiratory infections.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
pneumonia
egyetemen (Magyarországon) készült közlemény
Megjelenés:BMC Infectious Diseases. - 9 (2009), p. 104-113. -
További szerzők:Haczku Angela Márton Ildikó (1954-) (fogszakorvos) Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Gáspár Attila (1970-) (vegyész, kémikus) Andrási Melinda (1979-) (gyógyszerész) Varga Imre (1960-) (tüdőgyógyász) Tóth Judit (1958-) (onkológus szakorvos) Klekner Álmos (1970-) (idegsebész)
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2.

001-es BibID:BIBFORM005483
Első szerző:Boyko, Nadiya V.
Cím:Commensals of Mucous Surfaces Used to Control Nosocomial Diseases : efficacy and Possible Acting Mechanisms / N. Boyko, J. Szabó, H. Koval, A. Kulja, K. Kritsky, I. Kalapos, E. Rajnavölgyi
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:International Journal of Infectious Diseases. - 12 : 3 (2008), p. 369. -
További szerzők:Szabó J. Koval, H. Kulja András (1965-) (biológus, biológia-kémia szakos középiskolai tanár) Kritsky, K. Kalapos István (1954-) (orvos, élettanász) Rajnavölgyi Éva (1950-) (immunológus)
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3.

001-es BibID:BIBFORM062414
Első szerző:Ebrahimi, Fatemeh
Cím:Asymptomatic faecal carriage of ESBL producing Enterobacteriaceae in Hungarian healthy individuals and in long-term care applicants : a shift towards CTX-M producers in the community / Fatemeh Ebrahimi, Julianna Mózes, Júlia Mészáros, Ágnes Juhász, László Majoros, Krisztina Szarka, Gábor Kardos
Dátum:2016
Megjegyzések:Background: Faecal carriage of extended-spectrum beta- lactamase (ESBL) producing Enterobacteriaceae28 in healthy individuals was examined and compared to previous results obtained in such individuals a few29 years earlier.30 Methods: Faecal samples from 779 individuals screened for employment purposes and from 22531 applicants to long-term care (LTC) were screened between November 2013 and May 2014.32 Results: The overall rate of fecal carriage was 3.0% (30/1004). The carriage rate was significantly higher33 in applicants for LTC (5.3% vs. 2.3%; p=0.019). All isolates carried CTX-M ESBLs, with an34 overwhelming dominance of blaCTX-M-15 (84.4%) in both groups and in both E. coli and Klebsiella35 pneumoniae.36 Conclusions: The prevalences were comparable to those in the earlier study, but a marked decrease of the37 diversity of ESBL genes in E. coli from the employment screening group was found, suggesting that the38 ESBL-producing isolates originating from diverse sources are being replaced by highly successful blaCTX39M-15 producing strains.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
extended-spectrum beta-lactamases, Klebsiella pneumoniae, Escherichia coli
Megjelenés:Infectious Diseases 48 : 7 (2016), p. 557-559. -
További szerzők:Mózes Julianna (1982-) (orvosdiagnosztikai laboratóriumi analitikus, okleveles népegészségügyi szakember) Mészáros Júlia Juhász Ágnes Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:TÁMOP 4.2.4. A/2-11-1-2012-0001
TÁMOP
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4.

001-es BibID:BIBFORM099912
035-os BibID:(WoS)000787774100002 (Scopus)85121006331
Első szerző:Fagyas Miklós (orvos)
Cím:Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients / Fagyas Miklós, Fejes Zsolt, Sütő Renáta, Nagy Zsuzsanna, Székely Borbála, Pócsi Marianna, Ivády Gergely, Bíró Edina, Bekő Gabriella, Nagy Attila, Kerekes György, Szentkereszty Zoltán, Papp Zoltán, Tóth Attila, Kappelmayer János, Nagy Béla
Dátum:2022
ISSN:1201-9712
Megjegyzések:Objectives Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to predict the severity and mortality of COVID-19. Methods Serum ACE2 activity was measured in COVID-19 (110 critically ill and 66 severely ill subjects at hospital admission and 106 follow-up samples) and in 32 non-COVID-19 severe sepsis patients. Associations between ACE2, inflammation-dependent biomarkers, pre-existing comorbidities, and clinical outcomes were studied. Results Initial ACE2 activity was significantly higher in critically ill COVID-19 patients (54.4 [36.7-90.8] mU/L) than in severe COVID-19 (34.5 [25.2-48.7] mU/L; P<0.0001) and non-COVID-19 sepsis patients (40.9 [21.4-65.7] mU/L; P=0.0260) regardless of comorbidities. Circulating ACE2 activity correlated with inflammatory biomarkers and was further elevated during the hospital stay in critically ill patients. Based on ROC-curve analysis and logistic regression test, baseline ACE2 independently indicated the severity of COVID-19 with an AUC value of 0.701 (95% CI [0.621-0.781], P<0.0001). Furthermore, non-survivors showed higher serum ACE2 activity vs. survivors at hospital admission (P<0.0001). Finally, high ACE2 activity (?45.4 mU/L) predicted a higher risk (65 vs. 37%) for 30-day mortality (Log-Rank P<0.0001). Conclusions Serum ACE2 activity correlates with COVID-19 severity and predicts mortality.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
SARS-CoV-2
ACE2
inflammation
COVID-19 disease
biomarker
outcome
sepsis
Megjelenés:International Journal Of Infectious Diseases. - 115 (2022), p. 8-16. -
További szerzők:Fejes Zsolt (1988-) (molekuláris biológus) Sütő Renáta (1986-) (aneszteziológus) Nagy Zsuzsanna (1986-) (élettanász) Székely Borbála Pócsi Marianna (1989-) (klinikai laboratóriumi kutató) Ivády Gergely (1979-) (laboratóriumi szakorvos) Bíró Edina Bekő Gabriella Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Szentkereszty Zoltán Papp Zoltán (1965-) (kardiológus, élettanász) Tóth Attila (1971-) (biológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
TKP2020-IKA-04
Egyéb
TKP2020-NKA-04
Egyéb
ÚNKP-21-3-I-DE-255
Egyéb
ÚNKP-21-5-DE-458
Egyéb
BO/00069/21/5
Egyéb
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5.

001-es BibID:BIBFORM074742
Első szerző:Fidler Gábor (molekuláris biológus, genetikus)
Cím:Validation of a simplex PCR assay enabling reliable identification of clinically relevant Candida species / Fidler Gabor, Leiter Eva, Kocsube Sandor, Biro Sandor, Paholcsek Melinda
Dátum:2018
ISSN:1471-2334 1471-2334
Megjegyzések:Background: Fungal bloodstream infections (BSI) may be serious and are associated with drastic rise in mortality and health care costs. Candida spp. are the predominant etiological agent of fungal sepsis. The prompt and species-level identification of Candida may influence patient outcome and survival. The aim of this study was to develop and evaluate the CanTub-simplex PCR assay coupled with Tm calling and subsequent high resolution melting (HRM) analysis to barcode seven clinically relevant Candida species. Methods: Efficiency, coefficient of correlation and the limit of reliable detection were estimated on purified Candida EDTA-whole blood (WB) reference panels seeded with Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, Candida krusei, Candida guilliermondii, Candida dubliniensis cells in a 6-log range. Discriminatory power was measured on EDTA-WB clinical panels on three different PCR platforms; LightCycler?96, LightCycler? Nano, LightCycler? 2.0. Inter- and intra assay consistencies were also calculated. Results: The limit of reliable detection proved to be 0.2?2 genomic equivalent and the method was reliable on broad concentration ranges (106 ?10 CFU) providing distinctive melting peaks and characteristic HRM curves. The diagnostic accuracy of the discrimination proved to be the best on Roche LightCycler?2.0 platform. Repeatability was tested and proved to be % C.V.: 0.14 ? 0.06 on reference- and % C.V.: 0.14 ? 0.02 on clinical-plates accounting for a very high accuracy. Reproducibility was % C.V.: 0.11 between reference- and % C.V.: 0.12between clinicalpanels which is highly acceptable. Conclusion: Our assay demonstrates recent advances on Tm calling and HRM analysis for the molecular identification of relevant Candida species. This unique, simplex PCR assay may be capable to outperform conventional phenotypic methods by reducing time and providing accurate and reliable results directly from blood (2 h) or from whole blood culture bottles (12?24 h).
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Candida
High resolution melting
Tm calling
Species level identification
Simplex PCR
Megjelenés:BMC Infectious Diseases. - 18 : 393 (2018), p. 1-13. -
További szerzők:Leiter Éva (1976-) (biológus) Kocsubé Sándor Biró Sándor (1949-) (molekuláris genetikus) Paholcsek Melinda (1984-) (molekuláris biológus, genetikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00042
GINOP
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6.

001-es BibID:BIBFORM050849
Első szerző:Iturriza-Gomara, Miren
Cím:Rotavirus surveillance in europe, 2005-2008 : web-enabled reporting and real-time analysis of genotyping and epidemiological data / M. Iturriza-Gómara, T. Dallman, K. Bányai, B. Böttiger, J. Buesa, S. Diedrich, L. Fiore, K. Johansen, N. Korsun, A. Kroneman, M. Lappalainen, B. László, L. Maunula, J. Matthinjnssens, S. Midgley, Z. Mladenova, M. Poljsak-Prijatelj, P. Pothier, F. M. Ruggeri, A. Sanchez-Fauquier, E. Schreier, A. Steyer, I. Sidaraviciute, A. N. Tran, V. Usonis, M. Van Ranst, A. de Rougemont, J. Gray
Dátum:2009
ISSN:0022-1899
Megjegyzések:The first European rotavirus surveillance network, EuroRotaNet, comprising 16 laboratories in 15 European countries, has been established. Methods. Fecal samples from gastroenteritis cases positive for group A rotavirus antigen were collected from multiple European countries from 2005 to mid-2008 and were subjected to G and P genotyping. Epidemiological data collected included age, sex, geographical location, setting, dates of onset and sample collection, and clinical symptoms. Results. A total of 8879 rotavirus-positive samples were characterized: 2129 cases were from the 2005-2006 season, 4030 from the 2006-2007 season, and 2720 from the ongoing 2007-2008 season. A total of 30 different G and P type combinations of strains circulated in the region from 2005 through 2008. Of these strains, 90% had genotypes commonly associated with human infections-G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]-and 1.37% represented potential zoonotic introductions. G1P[8] remained the most prevalent genotype in Europe as a whole, but the incidence of infection with G1P[8] rotavirus strains was <50% overall, and all 3 seasons were characterized by a significant diversity of cocirculating strains. The peak incidence of rotavirus infection occurred from January through May, and 81% of case patients were aged <2.5 years. Conclusions. Data gathered through EuroRotaNet will provide valuable background information on the rotavirus strain diversity in Europe before the introduction of rotavirus vaccines, and the network will provide a robust method for surveillance during vaccine implementation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Infectious Diseases. - 200 : Suppl. 1 (2009), p. S215-S221. -
További szerzők:Dallman, T. Bányai Krisztián Böttiger, B. Buesa, J. Diedrich, S. Fiore, L. Johansen, K. Korsun, N. Kroneman, A. Lappalainen, Marit László Brigitta (1983-) (molekuláris biológus, mikrobiológus) Maunula, L. Matthijnssens, Jelle Midgley, S. Mladenova, Z. Poljsak-Prijatelj, M. Pothier, P. Ruggeri, F. M. Sanchez-Fauquier, A. Schreier, Elisabeth Steyer, A. Sidaraviciute-Ivaskeviciene, I. Tran, A. N. Usonis, V. Ranst, M., Van Rougemont, A., de Gray, J.
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7.

001-es BibID:BIBFORM078695
035-os BibID:(WoS)000482346000010 (Scopus)85065641534
Első szerző:Karlsson, Ingrid
Cím:Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals / Ingrid Karlsson, Jeanette Linnea Tingstedt, Gülşen Özkaya Şahin, Mikkel Hansen, Zsofia Szojka, Marcus Buggert, Antonio Biague, Zacharias da Silva, Fredrik Månsson, Joakim Esbjörnsson, Hans Norrgren, Patrik Medstrand, Anders Fomsgaard, Marianne Jansson, Sweden-Guinea-Bissau Cohort Research Group
Dátum:2019
ISSN:0022-1899
Megjegyzések:Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cross-Reactive Antibodies
HIV-2 infection
HIV-1 Envelope Glycoprotein
ADCC
Megjelenés:Journal Of Infectious Diseases. - 219 : 11 (2019), p. 1749-1754. -
További szerzők:Tingstedt, Jeanette Linnea Şahin, Gülşen Özkaya Hansen, Mikkel Szojka Zsófia (1991-) (molekuláris biológus) Buggert, Marcus Biague, Antonio da Silva, Zacharias Månsson, Fredrik Esbjörnsson, Joakim Norrgren, Hans Medstrand, Patrik Fomsgaard, Anders Jansson, Marianne Sweden-Guinea-Bissau Cohort Research Group
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8.

001-es BibID:BIBFORM077691
035-os BibID:(cikkazonosító)253
Első szerző:Kolozsvári László Róbert (háziorvos)
Cím:Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study / László Róbert Kolozsvári, József Kónya, John Paget, Francois G. Schellevis, János Sándor, Gergő József Szőllősi, Szilvia Harsányi, Zoltán Jancsó, Imre Rurik
Dátum:2019
ISSN:1471-2334
Megjegyzések:Background: Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae. Methods: The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman's rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices). Results: According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p < 0.001). Living with children significantly increased the AMR of the S. pneumoniae (OR = 1.23, p = 0.019). In the cohorts of adult or paediatric practices, neither the age nor other variables influenced the AMR of the S. aureus and S. pneumoniae. At practice level, the prescribed volume of penicillins significantly correlated with the resistance rates of the S. aureus isolates to penicillin (rho = 0.57, p = 0.008). The volume of prescribed macrolides, lincosamides showed positive significant correlations with the S. pneumoniae resistance rates to clarithromycin and/or clindamycin in all practices (rho = 0.76, p = 0.001) and in the adult practices (rho = 0.63, p = 0.021). Conclusions: The age is an important influencing factor of antimicrobial resistance. The results also suggest that there may be an association between the antibiotic prescribing of the primary care providers and the antibiotic resistance of the commensal S. aureus and S. pneumoniae. The role of the primary care physicians in the appropriate antibiotic prescribing is very important to avoid the antibiotic resistance.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antimicrobial resistance
Antibacterial resistance
Commensal
Healthy population
Patient-related factors
Staphylococcus aureus
Streptococcus pneumoniae
Megjelenés:BMC Infectious Diseases. - 19 (2019), p. 1-8. -
További szerzők:Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Paget, John Schellevis, Francois G. Sándor János (1966-) (orvos-epidemiológus) Szőllősi Gergő József (1991-) (népegészségügyi ellenőr, népegészségügyi szakember) Kolozsváriné Harsányi Szilvia (1983-) (okleveles egészségpolitikai szakértő) Jancsó Zoltán (1973-) (orvos, háziorvos szakorvos, foglalkozás-orvostan szakorvos) Rurik Imre (1953-) (háziorvos, foglalkozás-egészségügyi szakorvos, urológus)
Pályázati támogatás:223083
FP7
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9.

001-es BibID:BIBFORM040239
Első szerző:Majoros László (szakorvos, klinikai mikrobiológus)
Cím:Slow response of invasive Candida krusei infection to amphotericin B in a clinical time-kill study / Majoros L., Szegedi I., Kardos G., Erdész C., Kónya J., Kiss C.
Dátum:2006
ISSN:0934-9723
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Clinical Microbiology & Infectious Diseases. - 25 : 12 (2006), p. 803-806. -
További szerzők:Szegedi István (1969-) (hematológus, onkológus, nefrológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Erdész Csaba Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Kiss Csongor (1956-) (hematológus, onkológus)
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10.

001-es BibID:BIBFORM090202
035-os BibID:(WoS)000616697100011 (Scopus)85098777092
Első szerző:Nagy Béla Jr. (labordiagnosztikai szakorvos)
Cím:A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient / Nagy Béla, Fejes Zsolt, Szentkereszty Zoltán, Sütő Renáta, Várkonyi István, Ajzner Éva, Kappelmayer János, Papp Zoltán, Tóth Attila, Fagyas Miklós
Dátum:2021
ISSN:1201-9712
Megjegyzések:Endothelial cells express surface angiotensin-converting enzyme 2 (ACE2), the main receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that promotes the infection of endothelial cells showing activation and damage. Bronchoalveolar lavage fluid from coronavirus disease-2019 (COVID-19) subjects showed a critical imbalance in the renin-angiotensin-aldosterone system with the upregulated expression of ACE2. Recently, intravenous recombinant ACE2 was reported as an effective therapy in severe COVID-19 by blocking the viral entry to target cells. Here, we present a case of a critically ill COVID-19 patient with acute respiratory distress syndrome where circulating ACE2 was first measured to monitor disease prognosis. ACE2 activity increased about 40-fold over the normal range and showed a distinct time course as compared to 2-3-fold higher levels of endothelium biomarkers. Although the level of soluble E-selectin followed the clinical status of our patient similar to ferritin and IL-6 levels, the dramatic rise in serum ACE2 activity may act as an endogenous nonspecific protective mechanism against SARS-CoV-2 infection that preceded the recovery of our patient.
Tárgyszavak:Orvostudományok Klinikai orvostudományok esettanulmány
folyóiratcikk
COVID-19
ACE2
Endothelial cell
Inflammation
Biomarker
Megjelenés:International Journal Of Infectious Diseases. - 103 (2021), p. 412-414. -
További szerzők:Fejes Zsolt (1988-) (molekuláris biológus) Szentkereszty Zoltán Sütő Renáta (1986-) (aneszteziológus) Várkonyi István (1973-) (orvos) Ajzner Éva (1968-) (laboratóriumi szakorvos) Kappelmayer János (1960-) (laboratóriumi szakorvos) Papp Zoltán (1965-) (kardiológus, élettanász) Tóth Attila (1971-) (biológus) Fagyas Miklós (1984-) (orvos)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
GINOP-2.3.2-15-2016-00043
GINOP
FK128809
Egyéb
K132623
Egyéb
ED_18-1-2019-0028
Egyéb
ÚNKP-20-4-II-DE-197
Egyéb
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11.

001-es BibID:BIBFORM059207
Első szerző:Paholcsek Melinda (molekuláris biológus, genetikus)
Cím:Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia / Melinda Paholcsek, Gabor Fidler, Jozsef Konya, Laszlo Rejto, Gabor Mehes, Evelin Bukta, Juergen Loeffler, Sandor Biro
Dátum:2015
ISSN:1471-2334
Megjegyzések:Background: We assessed the diagnostic value of standard clinical methods and combined biomarker testing(galactomannan assay and polymerase chain reaction screening) in a prospective case?control study to detectinvasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia.Methods: In this observational study 162 biomarker analyses were performed on samples from 27 febrile neutropenicepisodes. Sera were successively screened for galactomannan antigen and for Aspergillus fumigatus specific nucleic acidtargets. Furthermore thoracic computed tomography scanning was performed along with bronchoscopy with lavagewhen clinically indicated. Patients were retrospectively stratified to define a case-group with "proven" or "probable"invasive pulmonary aspergillosis (25.93 %) and a control-group of patients with no evidence for of invasive pulmonaryaspergillosis (74.07 %). In 44.44 % of episodes fever ceased in response to antibiotic treatment (group II). Empiricalantifungal therapy was administered for episodes with persistent or relapsing fever (group I). 48.15 % of patientsdied during the study period. Postmortem histology was pursued in 53.85 % of fatalities.Results: Concordant negative galactomannan and computed tomography supported by a polymerase chainreaction assay were shown to have the highest discriminatory power to exclude invasive pulmonary aspergillosis.Bronchoalveolar lavage was performed in 6 cases of invasive pulmonary aspergillosis and in 15 controls. Althoughbronchoalveolar lavage proved negative in 93 % of controls it did not detect IPA in 86 % of the cases. Remarkablypost mortem histology convincingly supported the presence of Aspergillus hyphae in lung tissue from a single casewhich had consecutive positive polymerase chain reaction assay results but was misdiagnosed by both computedtomography and consistently negative galactomannan assay results. For the galactomannan enzyme-immunoassay thediagnostic odds ratio was 15.33 and for the polymerase chain reaction assay it was 28.67. According to Cohen's kappaour in-house polymerase chain reaction method showed a fair agreement with the galactomannan immunoassay.Combined analysis of the results from the Aspergillus galactomannan enzyme immunoassay together with thosegenerated by our polymerase chain reaction assay led to no misdiagnoses in the control group.Conclusion: The data from this pilot-study demonstrate that the consideration of standard clinical methods combinedwith biomarker testing improves the capacity to make early and more accurate diagnostic decisions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Invasive pulmonary aspergillosis
Biomarkers
Combination testing
Acute leukemia
Neutropenic fever
Megjelenés:BMC Infectious Diseases. - 15 : 1 (2015), p. 251. -
További szerzők:Fidler Gábor (1987-) (molekuláris biológus, genetikus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Rejtő László (1963-) (belgyógyász, haematológus) Méhes Gábor (1966-) (patológus) Bukta Evelin Loeffler, Juergen Biró Sándor (1949-) (molekuláris genetikus)
Pályázati támogatás:SROP-4.2.2.B-15/1/KONV-2015-0001
Egyéb
TÁMOP-4.2.4.A/ 2-11/1-2012-0001
TÁMOP
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12.

001-es BibID:BIBFORM116181
035-os BibID:(Scopus)85176106626
Első szerző:Rossi, Giuseppe
Cím:Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients : EPICOVIDEHA findings / Giuseppe Rossi, Jon Salmanton-García, Chiara Cattaneo, Francesco Marchesi, Julio Dávila-Valls, Sonia Martín-Pérez, Federico Itri, Alberto López-García, Andreas Glenthøj, Maria Gomes da Silva, Caroline Besson, Monia Marchetti, Barbora Weinbergerová, Ozren Jaksic, Moraima Jiménez, Yavuz M. Bilgin, Jaap Van Doesum, Francesca Farina, Pavel Žák, Luisa Verga, Graham P. Collins, Valentina Bonuomo, Jens Van Praet, Marcio Nucci, Stef Meers, Ildefonso Espigado, Nicola S. Fracchiolla, Toni Valković, Christian Bjørn Poulsen, Natasha Čolović, Giulia Dragonetti, Marie-Pierre Ledoux, Carlo Tascini, Caterina Buquicchio, Ola Blennow, Francesco Passamonti, Marina Machado, Jorge Labrador, Rafael F. Duarte, Martin Schönlein, Lucia Prezioso, Iker Falces-Romero, Austin Kulasekararaj, Carolina Garcia-Vidal, Noemí Fernández, Ghaith Abu-Zeinah, Irati Ormazabal-Vélez, Tatjana Adžić-Vukičević, Klára Piukovics, Igor Stoma, Annarosa Cuccaro, Gabriele Magliano, Tomáš Szotkowski, Tomás-José González-López, Shaimaa El-Ashwah, Rui Bergantim, Uluhan Sili, Johan Maertens, Fatih Demirkan, Cristina De Ramón, Verena Petzer, Maria Ilaria Del Principe, Milan Navrátil, Michelina Dargenio, Guldane Cengiz Seval, Michail Samarkos, Zdeněk Ráčil, László Imre Pinczés, Tobias Lahmer, Alessandro Busca, Gustavo-Adolfo Méndez, Antonio Vena, Monika M. Biernat, Maria Merelli, Maria Calbacho, Aleksandra Barać, Martina Bavastro, Alessandro Limongelli, Osman Ilhan, Dominik Wolf, Gökçe Melis Çolak, Ramón García-Sanz, Ziad Emarah, Bojana Mišković, Stefanie K. Gräfe, Miloš Mladenović, Tommaso Francesco Aiello, Lucía Núñez-Martín-Buitrago, Anna Nordlander, Elena Arellano, Giovanni Paolo Maria Zambrotta, Emanuele Ammatuna, Alba Cabirta, Maria Vittoria Sacchi, Raquel Nunes Rodrigues, Ditte Stampe Hersby, Michaela Hanakova, Laman Rahimli, Raul Cordoba, Oliver A. Cornely, Livio Pagano, Collaborators
Dátum:2023
ISSN:1201-9712
Megjegyzések:Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts. ? 2023 The Author(s)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
Elderly
Hematological malignancy
High-risk patient
SARS-CoV-2
Megjelenés:International Journal Of Infectious Diseases. - 137 (2023), p. 98-110. -
További szerzők:Salmanton-García, Jon Cattaneo, Chiara Marchesi, Francesco Dávila-Valls, Julio Martín-Pérez, Sonia Itri, Federico López-García, Alberto Glenthj, Andreas Gomes Da Silva, Maria Besson, Caroline Marchetti, Monia Weinbergerová, Barbora Jaksic, Ozren Jiménez, Moraima Bilgin, Yavuz M. van Doesum, Jaap Farina, Francesca Žák, Pavel Verga, Luisa Collins, Graham Bonuomo, Valentina van Praet, Jens Nucci, Marcio Meers, Stef Espigado, Ildefonso Fracchiolla, Nicola S. Valkovic, Toni Poulsen, Christian Bjørn Colovic, Natasa Dragonetti, Giulia Ledoux, Marie-Pierre Tascini, Carlo Buquicchio, Caterina Blennow, Ola Passamonti, Francesco Machado, Marina Labrador, Jorge Duarte, Rafael F. Schönlein, Martin Prezioso, Lucia Falces-Romero, Iker Kulasekararaj, Austin Garcia-Vidal, Carolina Fernández, Noemí Abu-Zeinah, Ghaith Ormazabal-Vélez, Irati Adžić-Vukičević, Tatjana Piukovics Klára Stoma, Igor Cuccaro, Annarosa Magliano, Gabriele Szotkowski, Tomáš González-López, Tomás José El-Ashwah, Shaimaa Bergantim, Rui Sili, Uluhan Maertens, Johan Demirkan, Fatih De Ramón, Cristina Petzer, Verena Del Principe, Maria Ilaria Navrátil, Milan Dargenio, Michelina Seval, Guldane Cengiz Samarkos, Michail Ráčil, Zdenĕk Pinczés László Imre (1990-) (általános orvos) Lahmer, Tobias Busca, Alessandro Méndez, Gustavo-Adolfo Vena, Antonio Biernat, Monika M. Merelli, Maria Calbacho, Maria Barać, Aleksandra Bavastro, Martina Limongelli, Alessandro Ilhan, Osman Wolf, Dominik Çolak, Gökçe Melis García-Sanz, Ramón Emarah, Ziad Mišković, Bojana Gräfe, Stefanie K. Mladenović, Miloš Aiello, Tommaso Francesco Núñez-Martín-Buitrago, Lucía Nordlander, Anna Arellano, Elena Zambrotta, Giovanni Paolo Maria Ammatuna, Emanuele Cabirta, Alba Sacchi, Maria Vittoria Rodrigues, Raquel Nunes Hersby, Ditte Stampe Hanáková, Michaela Rahimli, Laman Cordoba, Raul Cornely, Oliver Andreas Pagano, Livio
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