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001-es BibID:BIBFORM073991
Első szerző:Varga Viktória Evelin (biológus)
Cím:Changes in serum afamin and vitamin E levels after selective LDL apheresis / Varga Viktória Evelin, Lőrincz Hajnalka, Szentpéteri Anita, Juhász Lilla, Seres Ildikó, Paragh György Jr., Balla József, Paragh György, Harangi Mariann
Dátum:2018
ISSN:0733-2459
Megjegyzések:Background: Human afamin is a plasma vitamin E-binding glycoprotein partially associatedwith ApoA1-containing HDL subfractions. In a previous study, the serum vitamin Edecreased after LDL apheresis, while vitamin E/cholesterol ratio significantly increased. Weaimed to study the effect of LDL apheresis on serum afamin level.Methods: The serum level of afamin and oxidized LDL were measured by enzyme-linkedimmunosorbent assay in six severe heterozygous FH patients before and after their first LDLapheresis treatments and in seven healthy controls. We also investigated the changes in HDLsubfractions and ApoA1, ?- and ?-tocopherol levels during the treatment. HDL subfractionswere detected by an electrophoretic method on polyacrylamide gel (Lipoprint). Serum ?- and?-tocopherol levels were detected by gas chromatography-mass spectrometry.Results: The first treatment sessions decreased serum afamin levels by an average of 9.4%.Total cholesterol, LDL-C, HDL-C and ApoA1 levels decreased by 52.6; 61.8; 10.5 and14.1%, respectively. We found that ?- and ?-tocopherol levels markedly decreased (by 34.1and 32.9%, respectively), while ?- tocopherol/cholesterol and ?-tocopherol/cholesterol ratiossignificantly increased (by 41.4 and 40.3%, respectively). Furthermore, oxidized LDL levelssignificantly decreased and there was a shift towards the larger HDL subfractions.Conclusion: LDL apheresis moderately decreases the circulating levels of afamin parallel tolowering HDL-C and ApoA1 levels. Tocopherol levels decreases markedly compared toafamin levels, however, beneficial changes in vitamin E/cholesterol ratios, oxidized LDLlevels and HDL subfraction distribution were detected. These additional effects of LDLapheresis may result in further cardiovascular risk reduction in FH patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
LDL apheresis
vitamin E
afamin
ApoA1
Familial Hypercholesterolemia
Megjelenés:Journal Of Clinical Apheresis. - 33 : 5 (2018), p. 569-575. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Szentpéteri Anita (1988-) (biológus) Juhász Lilla (1990-) (általános orvos) Seres Ildikó (1954-) (biokémikus) Paragh György Jr. (1978-) (bőrgyógyász) Balla József (1959-) (belgyógyász, nephrológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
OTKA-115723
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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