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001-es BibID:BIBFORM060256
Első szerző:Csoma Eszter (molekuláris biológus, mikrobiológus)
Cím:WU and KI polyomaviruses in respiratory, blood and urine samples from renal transplant patients / Eszter Csoma, Beáta Mészáros, László Asztalos, Lajos Gergely
Dátum:2015
ISSN:1386-6532
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
KIPyV
WUPyV
Human polyomaviruses
Immunocompromised patients
Renal transplanta
Megjelenés:Journal Of Clinical Virology. - 64 (2015), p. 28-33. -
További szerzők:Mészáros Beáta (1985-) (molekuláris biológus, mikrobiológus) Asztalos László (1951-) (sebész) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:PD109108
OTKA
TÁMOP-4.2.4.A/ 2-11/1-2012-0001
TÁMOP
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2.

001-es BibID:BIBFORM037881
Első szerző:Csoma Eszter (molekuláris biológus, mikrobiológus)
Cím:Novel human polyomaviruses in pregnancy : higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9 / Csoma Eszter, Sápy Tamás, Mészáros Beáta, Gergely Lajos
Dátum:2012
ISSN:1386-6532
Megjegyzések:BACKGROUND: Immunosuppression due to pregnancy may lead to higher susceptibility to infections and reactivation of latent infections, such as BK polyomavirus (BKPyV). There is lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU (WUPyV) and KI (KIPyV) during pregnancy. OBJECTIVES: To study whether pregnancy results in higher prevalence of HPyV9, WUPyV, KIPyV and their correlation with BKPyV. STUDY DESIGN: Plasma, urine and throat swab samples from 100 pregnant and 100 non pregnant women were screened for the presence of WUPyV, KIPyV, HPyV9 and BKPyV by PCR. RESULTS: No WUPyV DNA was detected in plasma, urine and respiratory samples from pregnant and non pregnant women. KIPyV DNA was found in two plasma samples from non pregnant women (2%) and not detected in other samples from neither pregnant nor non pregnant women. HPyV9 DNA was determined in all sample types of pregnant and non pregnant women, respectively. There were no significant differences between pregnant and non pregnant women in HPyV9 DNA frequencies for plasma (2% vs. 6%), urine (3% vs. 2%) and respiratory samples (2% vs. 2%). Prevalence of BKPyV in urine samples was significantly higher (p=0.039) in pregnant women (13%) then in non pregnant women (4%); co infection with KIPyV and/or HPyV9 was not detected. CONCLUSIONS: In contrast with BKPyV, infection with WUPyV, KIPyV and HPyV9 was not detected more frequently during pregnancy. To the best of our knowledge HPyV9 was detected first in respiratory samples in our study
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Clinical Virology. - 55 : 3 (2012), p. 262-265. -
További szerzők:Sápy Tamás (1970-) (szülész-nőgyógyász) Mészáros Beáta (1985-) (molekuláris biológus, mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:K73145
OTKA
TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
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3.

001-es BibID:BIBFORM039987
035-os BibID:PMID:22841750
Első szerző:László Brigitta (molekuláris biológus, mikrobiológus)
Cím:Surveillance of human rotaviruses in 2007-2011, Hungary : exploring the genetic relatedness between vaccine and field strains / Brigitta László, József Kónya, Eszter Dandár, Judit Deák, Ágnes Farkas, Jim Gray, Gábor Grósz, Miren Iturriza-Gomara, Ferenc Jakab, Ágnes Juhász, Péter Kisfali, Julianna Kovács, György Lengyel, Vito Martella, Béla Melegh, Júlia Mészáros, Péter Molnár, Zoltán Nyúl, Hajnalka Papp, László Pátri, Erzsébet Puskás, Ildikó Sántha, Ferenc Schneider, Katalin Szomor, András Tóth, Erzsébet Tóth, György Szűcs, Krisztián Bányai
Dátum:2012
ISSN:1386-6532
Megjegyzések:The availability of rotavirus vaccines has resulted in an intensification of post vaccine strain surveillance efforts worldwide to gain information on the impact of vaccines on prevalence of circulating rotavirus strains. OBJECTIVES: In this study, the distribution of human rotavirus G and P types in Hungary is reported. In addition, the VP4 and VP7 genes of G1P[8] strains were sequenced to monitor if vaccine-derived strains were introduced and/or some strains/lineages were selected against. STUDY DESIGN: The study was conducted in 8 geographic areas of Hungary between 2007 and 2011. Rotavirus positive stool samples were collected from diarrheic patients mostly <5 years of age. Viral RNA was amplified by multiplex genotyping RT-PCR assay, targeting the medically most important G and P types. When needed, sequencing of the VP7 and VP4 genes was performed. RESULTS: In total, 2380 strains were genotyped. During the 5-year surveillance we observed the dominating prevalence of genotype G1P[8] (44.87%) strains, followed by G4P[8] (23.4%), G2P[4] (14.75%) and G9P[8] (6.81%) genotypes. Uncommon strains were identified in a low percentage of samples (4.12%). Phylogenetic analysis of 318 G1P[8] strains identified 55 strains similar to the Rotarix strain (nt sequence identities; VP7, up to 97.9%; VP4, up to 98.5%) although their vaccine origin was unlikely. CONCLUSIONS: Current vaccines would have protected against the majority of identified rotavirus genotypes. A better understanding of the potential long-term effect of vaccine use on epidemiology and evolutionary dynamics of co-circulating wild type strains requires continuous strain surveillance.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal Of Clinical Virology 55 : 2 (2012), p. 140-146. -
További szerzők:Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Dandár Eszter (Budapest) Deák Judit (mikrobiológus) Farkas Ágnes (Budapest) Gray, Jim Grósz Gábor (Budapest) Iturriza-Gomara, Miren Jakab Ferenc Juhász Ágnes Kisfali Péter Kovács Julianna Lengyel György Martella, Vito Melegh Béla Mészáros Júlia Molnár Péter (Budapest orvos) Nyúl Zoltán Papp Hajnalka Pátri László Puskás Erzsébet Sántha Ildikó (Miskolc) Schneider Ferenc Szomor Katalin (Budapest) Tóth András (Budapest) Tóth Erzsébet (Nyíregyháza) Szűcs György Bányai Krisztián
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4.

001-es BibID:BIBFORM024608
Első szerző:Rezes Szilárd (fül-orr-gégész)
Cím:Human bocavirus and rhino-enteroviruses in childhood otitis media with effusion / Rezes S., Söderlund-Venermo M., Roivainen M., Kemppainen K., Szabó Z., Sziklai I., Pitkäranta A.
Dátum:2009
Megjegyzések:Viral respiratory infections play an important role in the pathogenesis of otitis media with effusion (OME) in children. The most common human rhinoviruses (HRVs) have been detected in middle ear effusions (MEE), but there is only limited data available about the closely related human enteroviruses (HEVs). The newly discovered human bocavirus (HBoV) has not, however, been identified in MEE of OME children. OBJECTIVES: The aim of our study was to determine the presence of HBoV and HRV/HEV and the rate of coinfection in a set of MEE samples collected from OME children. STUDY DESIGN: Seventy-five MEE samples from 54 children with no acute respiratory symptoms were studied with reverse transcription polymerase chain reaction (RT-PCR) for detection of HRV/HEV and quantitative PCR for detection of HBoV. RESULTS: Twenty-six (35%) of 75 MEE samples were positive for viral nucleic acid, 22 (29%) for HEV, 10 (13%) for HRV and 2 (3%) for HBoV. There was no statistically significant difference between mucoid and serous effusions in the rate of virus detection. Forty-three percent of bilateral cases showed a contra-lateral difference in viral finding. CONCLUSIONS: Our results suggest that these common respiratory viruses can be associated with OME in children. Whether these viruses are causative etiologic factors of MEE persistence or merely remnants of previous infections is not known.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Clinical Virology. - 46 : 3 (2009), p. 234-237. -
További szerzők:Söderlund-Venermo, Maria Roivainen, Merja Kemppainen, Kaisa Szabo Zsolt Sziklai István (1954-) (fül-orr-gégész) Pitkäranta, Anne
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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