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001-es BibID:	BIBFORM039246
Első szerző:	Bíró Tamás (élettanász)
Cím:	Recent advances in understanding of vanilloid receptors : a therapeutic target for treatment of pain and inflammation in skin / Biro, T., Acs, G., Acs, P., Modarres, S., Blumberg, P. M.
Dátum:	1997
Megjegyzések:	C-fiber sensory afferent neurons, which contain neuropeptides such as calcitonin-gene related peptide and substance P, mediate a wide variety of physiologic responses, including chemogenic pain, thermoregulation, and neurogenic inflammation. Capsaicin, the pungent constituent in red pepper, functions to activate and then, at higher doses and longer times, desensitize this class of neurons, This latter response provides the basis for the therapeutic application of capsaicin, A major advance in the field has been the identification of resiniferatoxin, a phorbol-related diterpene, as an analog of capsaicin that is ultrapotent but with differential selectivity, In particular, resiniferatoxin is only similar in potency for induction of pain but is much more effective for desensitization, Structure-activity analysis in whole animal experiments provides further evidence for dissociation of biologic endpoints, strongly arguing for the existence of vanilloid receptor subclasses, Using resiniferatoxin, we have been able to define specific, high-affinity receptors for capsaicin both in animal models such as rats and in man, Of great importance, the pharmacologic characterization in cultured dorsal root ganglion cells of the high-affinity resiniferatoxin-binding site and of tile physiologic response believed to be directly coupled to the receptor, viz, calcium uptake, differed in structure-activity and in cooperativity. We conclude that multiple high-affinity vanilloid receptor subclasses mediate vanilloid response; moreover, the resiniferatoxin-selective subclass of vanilloid receptors is not the voltage-independent, cation-nonselective ion channel as previously believed, Optimization of ligands for the individual vanilloid receptor subclasses should revolutionize this therapeutic area.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Investigative Dermatology Symposium Proceedings. - 2 : 1 (1997), p. 56-60. -
További szerzők:	Ács Géza (1939-) (traumatológus) Ács Péter Modarres, Shayan Blumberg, Peter M.
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM039248
Első szerző:	Conrad, Franziska
Cím:	Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding / Conrad Franziska, Ohnemus Ulrich, Bodo Eniko, Biro Tamas, Tychsen Birte, Gerstmayer Bernhard, Bosio Andreas, Schmidt-Rose Thomas, Altgilbers Silke, Bettermann Albrecht, Saathoff Matthias, Meyer Wilfried, Paus Ralf
Dátum:	2005
ISSN:	1087-0024
Megjegyzések:	In this study, it was investigated how estrogens (17-beta-estradiol, E2) affect the estrogen receptor (ER) expression and gene regulation of male versus female human scalp hair follicles in vitro. Anagen VI follicles from frontotemporal scalp skin were microdissected and organ-cultured for up to 9 d in the presence of E2 (1-100 nm). Immunohistochemistry was performed for ERbeta-expression, known to be predominant in human scalp hair follicles, and for TGF-beta2-expression (as negative key hair growth modulator), and E2-responsive genes in organ-cultured human scalp hair follicles (48 h, 10 nM) were explored by cDNA microarray, using a commercial skin focus chip (Memorec, Cologne, Germany). The distribution pattern of ERbeta and TGF-beta2-immunoreactivity differed between male and female hair follicles after 48 h culture. Of 1300 genes tested, several genes were regulated sex-dependent differently. The study reveals substantial sex-dependent differences in the response of frontotemporal human scalp hair follicles to E2. Recognition and systematic dissection of the E2-dependent gene regulation will be crucial for the development of more effective, gender-tailored management strategies for female versus male pattern balding.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Investigative Dermatology Symposium Proceedings. - 10 : 3 (2005), p. 243-246. -
További szerzők:	Ohnemus, Ulrich Bodó Enikő Bíró Tamás (1968-) (élettanász) Tychsen, Birte Gerstmayer, Bernhard Bosio, Andreas Schmidt-Rose, Thomas Altgilbers, Silke Bettermann, Albrecht Saathoff, Matthias Meyer, Wilfried Paus, Ralf
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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