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001-es BibID:BIBFORM063334
Első szerző:Alafuzoff, Irina
Cím:Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions : an inter-laboratory study by the BrainNet Europe consortium / Irina Alafuzoff, Maria Pikkarainen, Manuela Neumann, Thomas Arzberger, Safa Al-Sarraj, Istvan Bodi, Nenad Bogdanovic, Orso Bugiani, Isidro Ferrer, Ellen Gelpi, Stephen Gentleman, Giorgio Giaccone, Manuel B. Graeber, Tibor Hortobagyi, Paul G. Ince, James W. Ironside, Nikolaos Kavantzas, Andrew King, Penelope Korkolopoulou, Gábor G. Kovács, David Meyronet, Camelia Monoranu, Tatjana Nilsson, Piero Parchi, Efstratios Patsouris, Tamas Revesz, Wolfgang Roggendorf, Annemieke Rozemuller, Danielle Seilhean, Nathalie Streichenberger, Dietmar R. Thal, Stephen B. Wharton, Hans Kretzschmar
Dátum:2015
ISSN:0300-9564
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neural Transmission. - 122 : 7 (2015), p. 957-972. -
További szerzők:Pikkarainen, Maria Neumann, Manuela Arzberger, Thomas Al-Sarraj, Safa Bódi István (1967-) (neuropatológus) Bogdanovic, Nenad Bugiani, Orso Ferrer, Isidro Gelpi, Ellen Gentleman, Stephen Giaccone, Giorgio Graeber, Manuel Hortobágyi Tibor (1965-) (patológus) Ince, Paul Ironside, James W. Kavantzas, Nikolaos King, Andrew Korkolopoulou, Penelope Kovács Gábor Géza (1969-) (neurológus) Meyronet, David Monoranu, Camelia Nilsson, Tatjana Parchi, Piero Patsouris, Efstratios Révész Tamás Roggendorf, Wolfgang Rozemuller, Annemieke Seilhean, Danielle Streichenberger, Nathalie Thal, Dietmar R. Wharton, Stephen B. Kretzschmar, Hans
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001-es BibID:BIBFORM047792
035-os BibID:PMID:23619992
Első szerző:Frecska Ede (pszichiáter)
Cím:A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity / Ede Frecska, Attila Szabo, Michael J. Winkelman, Luis E. Luna, Dennis J. McKenna
Dátum:2013
ISSN:0300-9564
Megjegyzések:N,N-dimethyltryptamine (DMT) is classified as a naturally occurring serotonergic hallucinogen of plant origin. It has also been found in animal tissues and regarded as an endogenous trace amine transmitter. The vast majority of research on DMT has targeted its psychotropic/psychedelic properties with less focus on its effects beyond the nervous system. The recent discovery that DMT is an endogenous ligand of the sigma-1 receptor may shed light on yet undiscovered physiological mechanisms of DMT activity and reveal some of its putative biological functions. A three-step active uptake process of DMT from peripheral sources to neurons underscores a presumed physiological significance of this endogenous hallucinogen. In this paper, we overview the literature on the effects of sigma-1 receptor ligands on cellular bioenergetics, the role of serotonin, and serotoninergic analogues in immunoregulation and the data regarding gene expression of the DMT synthesizing enzyme indolethylamine-N-methyltransferase in carcinogenesis. We conclude that the function of DMT may extend central nervous activity and involve a more universal role in cellular protective mechanisms. Suggestions are offered for future directions of indole alkaloid research in the general medical field. We provide converging evidence that while DMT is a substance which produces powerful psychedelic experiences, it is better understood not as a hallucinogenic drug of abuse, but rather an agent of significant adaptive mechanisms that can also serve as a promising tool in the development of future medical therapies.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neural Transmission. - 120 : 9 (2013), p. 1295-1303. -
További szerzők:Szabó Attila (1981-) (molekuláris biológus, immunológus, filozófus) Winkelman, Michael J. Luna, Luis Eduardo McKenna, Dennis J.
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