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1.

001-es BibID:BIBFORM001452
Első szerző:Baiou, Djalil
Cím:Neurochemical characterisation of insulin receptor-expressing primary sensory neurons in wild type and vanilloid type 1 transient receptor potential receptor knock-out mice / Baiou D., Santha P., Avelino A., Charrua A., Bácskai T., Matesz K., Cruz F., Nagy I.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of comparative neurology 503 : 2 (2007), p. 334-347. -
További szerzők:Sántha Péter Avelino, Antonio Charrua, Ana Bácskai Tímea (1974-) (biológus, neurobiológus) Matesz Klára (1949-) (anatómus, neurobiológus) Cruz, Francisco Nagy István (orvos)
Internet cím:elektronikus változat
DOI
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2.

001-es BibID:BIBFORM050853
035-os BibID:PMID:23293933
Első szerző:Bánáti Miklós (neurológus, Pécs)
Cím:Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system / M. Banati, P. Csecsei, E. Koszegi, H. H. Nielsen, G. Suto, L. Bors, A. Trauninger, T. Csepany, C. Rozsa, G. Jakab, T. Molnar, A. Berthele, S. R. Kalluri, T. Berki, Z. Illes
Dátum:2013
ISSN:1351-5101
Megjegyzések:Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity. METHODS: Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC). RESULTS: Thirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P < 0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P = 0.01 versus HS, P = 0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P = 0.01 and P < 0.05, respectively). CONCLUSION: Antibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
anti-Saccharomyces cerevisiae
aquaporin 4
gliadin
intrinsic factor
multiple sclerosis
myelitis
neuromyelitis optica
optic neuritis
parietal cell
transglutaminase
Megjelenés:European Journal of Neurology. - 20 : 11 (2013), p. 1492-1495. -
További szerzők:Csécsei Péter (1992-) (neurológus) Kőszegi E. (neurológus, Pécs) Nielsen, Helle H. Sütő Gábor Bors László (Neurológus, Pécs) Trauninger Anita (Pécs orvos) Csépány Tünde (1956-) (neurológus, pszichiáter) Rózsa Csilla Jakab Gabriella Molnár T. Berthele, A. Kalluri, Sudhakar Reddy Berki Tímea Illés Zsolt (neurológus, Pécs)
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3.

001-es BibID:BIBFORM106780
Első szerző:Baracchini, Claudio
Cím:Practice recommendations for neurovascular ultrasound investigations of acute stroke patients in the setting of the COVID-19 pandemic : an expert consensus from the European Society of Neurosonology and Cerebral Hemodynamics / Baracchini C., Pieroni A., Kneihsl M., Azevedo E., Diomedi M., Pascazio L., Wojczal J., Lucas C., Bartels E., Bornstein N. M., Csiba L., Valdueza J., Tsivgoulis G., Malojcic B.
Dátum:2020
ISSN:1351-5101
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Neurology. - 27 : 9 (2020), p. 1776-1780. -
További szerzők:Pieroni, Alessio Kneihsl, M. Azevedo, Elsa Diomedi, M. Pascazio, L. Wojczal, J. Lucas, Christina Bartels, Eva Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Valdueza, José M. Tsivgoulis, Georgios Malojcic, Branko
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4.

001-es BibID:BIBFORM036709
Első szerző:Baracchini, Claudio
Cím:CCSVI and MS : a statement from the European Society of neurosonology and cerebral hemodynamics / Baracchini Claudio, Valdueza José M., Del Sette Massimo, Baltgaile Galina, Bartels Eva, Bornstein Natan M., Klingelhoefer Juergen, Molina Carlos, Niederkorn Kurt, Siebler Mario, Sturzenegger Matthias, Ringelstein Bernd E., Russell David, Csiba Laszlo
Dátum:2012
ISSN:0340-5354
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurology. - 259 : 12 (2012), p. 2585-2589. -
További szerzők:Valdueza, José M. Del Sette, Massimo Baltgaile, Galina Bartels, Eva Bornstein, Natan M. Klingelhoefer, Juergen Molina, Carlos Niederkorn, Kurt Siebler, Mario Sturzenegger, Matthias Ringelstein, E. Bernd Russell, David Csiba László (1952-) (neurológus, pszichiáter)
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5.

001-es BibID:BIBFORM029352
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:Quantitative morphological analysis of the motoneurons innervating muscles involved in tongue movements of the frogRana esculenta / Birinyi András, Székely György, Csapó Krisztina, Matesz Klára
Dátum:2004
ISSN:0021-9967
Megjegyzések:We give an account of an effort to make quantitative morphological distinctions between motoneurons of the frog innervating functionally different groups of muscles involved in the movements of the tongue. The protractor, retractor, and inner muscles of the tongue were considered on the basis of their major action during the prey-catching behavior of the frog. Motoneurons were selectively labeled with cobalt lysin through the nerves of the individual muscles, and dendritic trees of successfully labeled neurons were reconstructed. Each motoneuron was characterized by 15 quantitative morphological parameters describing the size of the soma and dendritic tree and 12 orientation variables related to the shape and orientation of the dendritic field. The variables were subjected to multivariate discriminant analysis to find correlations between form and function of these motoneurons. According to the morphological parameters, the motoneurons were classified into three functionally different groups weighted by the shape of the perikaryon, mean diameter of stem dendrites, and mean length of dendritic segments. The most important orientation variables in the separation of three groups were the ellipses describing the shape of dendritic arborization in the horizontal, frontal, and sagittal planes of the brainstem. These findings indicate that characteristic geometry of the dendritic tree may have a preference for one array of fibers over another.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Comparative Neurology. - 470 : 4 (2004), p. 409-421. -
További szerzők:Székely György (1926-2017) (neurobiológus) Csapó Krisztina Matesz Klára (1949-) (anatómus, neurobiológus)
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6.

001-es BibID:BIBFORM029093
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:Synaptic targets of commissural interneurons in the lumbar spinal cord of neonatal rats / Birinyi A., Viszokay K., Wéber I., Kiehn O., Antal M.
Dátum:2003
ISSN:0021-9967
Megjegyzések:There is strong evidence that commissural interneurons, neurons with axons that extend to the contralateral side of the spinal cord, play an important role in the coordination of left/right alternation during locomotion. In this study we investigated the projections of commissural interneurons to motor neurons and other commissural interneurons on the other side of the spinal cord in neonatal rats. To establish whether there are direct contacts between axons of commissural interneurons and motor neurons, we carried out two series of experiments. In the first experiment we injected biotinylated dextran amine (BDA) into the lateral motor column to retrogradely label commissural interneurons that may have direct projections to motor neurons. Stained neurons were recovered in the ventromedial areas of the contralateral gray matter in substantial numbers. In the second experiment BDA was injected into the ventromedial gray matter on one side of the lumbar spinal cord, whereas motor neurons were simultaneously labeled on the opposite side by applying biocytin onto the ventral roots. BDA injections into the ventromedial gray matter labeled a strong axon bundle that arose from the site of injection, crossed the midline in the ventral commissure, and extensively arborized in the contralateral ventral gray matter. Many of these axons made close appositions with dendrites and somata of motor neurons and also with commissural interneurons retrogradely labeled with BDA. The results suggest that commissural interneurons may establish monosynaptic contacts with motor neurons on the opposite side of the spinal cord. Our findings also indicate that direct reciprocal connections between commissural interneurons on the two sides of the spinal cord may also exist.
Tárgyszavak:Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Comparative Neurology. - 461 : 4 (2003), p. 429-440. -
További szerzők:Viszokay Kornél Wéber Ildikó (1972-) (biológus, neurobiológus) Kiehn, Ole Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:046121
OTKA
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7.

001-es BibID:BIBFORM029088
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:Zinc co-localizes with GABA and glycine in synapses in the lamprey spinal cord / Birinyi A., Parker D., Antal M., Shupliakov O.
Dátum:2001
ISSN:0021-9967
Megjegyzések:The presence of zinc in synaptic terminals in the lamprey spinal cord was examined utilizing a modification of the Timm's sulfide silver method and with the fluorescent marker 6-methoxy-8-quinolyl-p-toluenesulfonamide (TSQ). Axons labeled with a Timm's staining method were predominantly located in the lateral region of the dorsal column. This correlated with a maximum of TSQ fluorescence in this region of the spinal cord. Single labeled terminals accumulating Timm reaction product were also found throughout the gray matter and fiber tracts. At the ultrastructural level, zinc was located in a population of synaptic terminals that co-localized gamma-aminobutyric acid (GABA) and glycine. Possible effects of Zn2+ on neuronal activity were examined. In spinobulbar interneurons, which receive GABAergic input in the dorsal column, zinc potentiated responses to GABA application, but it did not affect responses to GABA in motoneurons. Responses in motoneurons to pressure application of glycine were also not affected by Zn2+. Zinc, however, potentiated monosynaptic glycinergic inhibitory postsynaptic potentials (IPSPs) evoked in motoneurons by inhibitory locomotor network interneurons and increased frequency, but not amplitude of spontaneous miniature IPSPs recorded in the presence of tetrodotoxin (TTX), suggesting presynaptic effects. Glutamate responses and the amplitude of monosynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons were reduced by zinc. These effects appeared to be mediated largely postsynaptically through an effect on the N-methyl-D-aspartate (NMDA) component of the glutamatergic input. Our results thus show that free zinc is present in inhibitory synaptic terminals in the lamprey spinal cord, and that it may function as a modulator of inhibitory synaptic transmission.
Tárgyszavak:Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Comparative Neurology. - 433 : 2 (2001), p. 208-221. -
További szerzők:Parker, David (1960-) (vegyész) Antal Miklós (1951-) (orvos, anatómus) Shupliakov, Oleg
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8.

001-es BibID:bibEBI00019271
Első szerző:Buzás Péter
Cím:Model-based analysis of excitatory lateral connections in the visual cortex / Buzás P., Kovács K., Ferecskó A. S., Budd J. M. L., Eysel U. T., Kisvárday Z.F.
Dátum:2006
Megjegyzések:Excitatory lateral connections within the primary visual cortex are thought to link neurons with similar receptive field properties. Here we studied whether this rule can predict the distribution of excitatory connections in relation to cortical location and orientation preference in the cat visual cortex. To this end, we obtained orientation maps of areas 17 or 18 using optical imaging and injected anatomical tracers into these regions. The distribution of labeled axonal boutons originating from large populations of excitatory neurons was then analyzed and compared with that of individual pyramidal or spiny stellate cells. We demonstrate that the connection patterns of populations of nearby neurons can be reasonably predicted by Gaussian and von Mises distributions as a function of cortical location and orientation, respectively. The connections were best described by superposition of two components: a spatially extended, orientation-specific and a local, orientation-invariant component. We then fitted the same model to the connections of single cells. The composite pattern of nine excitatory neurons (obtained from seven different animals) was consistent with the assumptions of the model. However, model fits to single cell axonal connections were often poorer and their estimated spatial and orientation tuning functions were highly variable. We conclude that the intrinsic excitatory network is biased to similar cortical locations and orientations but it is composed of neurons showing significant deviations from the population connectivity rule.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of comparative neurology. - 499 : 6 (2006), p. 861-881. -
További szerzők:Kovács Krisztina Ferecskó, Alex S. Budd, Julian M. L. Eysel, Ulf T. Kisvárday Zoltán (1957-) (biológus, neurobiológus)
Internet cím:DOI
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9.

001-es BibID:BIBFORM032363
Első szerző:Csépány Tünde (neurológus, pszichiáter)
Cím:MRI findings in central nervous system systemic lupus erythematosus are associated with immunoserological parameters and hypertension / Csepany, T., Bereczki, D., Kollar, J., Sikula, J., Kiss, E., Csiba, L.
Dátum:2003
Megjegyzések:Involvement of the brain is one of the most important complications of systemic lupus erythematosus (SLE). To investigate the correlation between abnormal cranial MRI findings and age, duration of SLE, neuropsychiatric (NP) manifestations, hypertensive status, and the presence of antiphospholipid antibodies (PA) in patients with SLE we evaluated the MRI results of 81 SLE patients in nine NP clinical subgroups.Immunoserological status was described by the presence of lupus anticoagulant (LA), and anticardiolipin antibodies (aCL). The MRI findings were categorized as normal [41], cerebral atrophy [15], small subcortical hyperintensity [7], and infarct larger than 10mm [18]. Mean age differed among the clinical subgroups (ANOVA, p = 0.002), whereas there was no age difference among the subgroups based on MRI and immunoserological results. Patients with hypertension (33/81) were a mean of 6 years older at the time of examination (p = 0.033) and had stroke more frequently, than normotensive ones (p = 0.0015). MRI abnormalities were more frequent in patients with LA positivity (p < 0.01) than in those without these antibodies, and in the hypertensive than in the normotensive subgroup (p = 0.00041). The presence of PA was associated with abnormal MRI even after controlling for the effect of age and hypertensive status (p = 0.011). In our study the MRI findings in central nervous system SLE were independent of the age of patients and the age at the diagnosis of SLE, and were not influenced by the duration of SLE; however, they were associated with immunoserological parameters and hypertension.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
multiple sclerosis
autoimmunity
iron
prolactin
ferritin
Megjelenés:Journal of Neurology. - 250 : 11 (2003), p. 1348-1354. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Kollár József (1950-) (radiológus) Sikula Judit (1954-) (radiológus) Kiss Emese (1960-) (belgyógyász, immunológus) Csiba László (1952-) (neurológus, pszichiáter)
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10.

001-es BibID:BIBFORM015606
035-os BibID:15258802
Első szerző:Csépány Tünde (neurológus, pszichiáter)
Cím:Miller Fisher syndrome : a presenting clinical manifestation of lung cancer in apreviously apparently healthy individual / Tunde Csepany, Judit Boczan, Maria T. Magyar, Sandor Molnar, Laszlo Csiba, Judit Decsy, Judit Toth, Szabolcs Felszeghy, Szabolcs Szakall, Zsolt Szentkereszty, Daniel Bereczki
Dátum:2004
ISSN:0340-5354 (Linking)
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
0 (KRT7 protein, human)
0 (Keratin-7)
0 (Tumor Markers, Biological)
68238-35-7 (Keratins)
Adenocarcinoma/*secondary
Brain/pathology/physiopathology
Brain Neoplasms/*secondary
Cerebrospinal Fluid/cytology
Diagnosis, Differential
Facial Nerve/pathology/physiopathology
Humans
Keratin-7
Keratins/metabolism
Lateral Ventricles/pathology
Lung/pathology/physiopathology
Lung Neoplasms/*pathology
Male
Meningeal Neoplasms/secretion
Middle Aged
Miller Fisher Syndrome/cerebrospinal fluid/*etiology/pathology
egyetemen (Magyarországon) készült közlemény
Oculomotor Nerve/pathology/physiopathology
Tumor Markers, Biological/metabolism
Megjelenés:Journal of Neurology. - 251 : 7 (2004), p. 898-900. -
További szerzők:Boczán Judit (1972-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Molnár Sándor (1973-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Décsy Judit Tóth Judit (1964-) (radiológus) Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Szakáll Szabolcs Szentkereszty Zsolt (1961-) (sebész) Bereczki Dániel (1960-) (neurológus)
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elektronikus elérés
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11.

001-es BibID:BIBFORM098800
035-os BibID:(WoS)000687051800001 (Scopus)85112773766
Első szerző:De Oliveira Miranda, Camila (PhD hallgató)
Cím:Morphological and neurochemical characterization of glycinergic neurons in laminae of the mouse spinal dorsal horn / Miranda Camila Oliveira, Hegedüs Krisztina, Wildner Hendrik, Zeilhofer Hanns Ulrich, Antal Miklós
Dátum:2022
ISSN:0021-9967
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Comparative Neurology. - 530 : 3 (2022), p. 607-626. -
További szerzők:Hegedűs Krisztina Wildner, Hendrik Zeilhofer, Hanns Ulrich Antal Miklós (1951-) (orvos, anatómus)
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12.

001-es BibID:BIBFORM119146
035-os BibID:(scopus)85177103067 (wos)001030569800001
Első szerző:Diouf, Ibrahima
Cím:Effectiveness of multiple disease-modifying therapies in relapsing-remitting multiple sclerosis : causal inference to emulate a multiarm randomised trial / Diouf Ibrahima, Malpas Charles B., Sharmin Sifat, Roos Izanne, Horakova Dana, Kubala Havrdova Eva, Patti Francesco, Shaygannejad Vahid, Ozakbas Serkan, Eichau Sara, Onofrj Marco, Lugaresi Alessandra, Alroughani Raed, Prat Alexandre, Duquette Pierre, Terzi Murat, Boz Cavit, Grand'Maison Francois, Sola Patrizia, Ferraro Diana, Grammond Pierre, Yamout Bassem, Altintas Ayse, Gerlach Oliver, Lechner-Scott Jeannette, Bergamaschi Roberto, Karabudak Rana, Iuliano Gerardo, McGuigan Christopher, Cartechini Elisabetta, Hughes Stella, Sa Maria Jose, Solaro Claudio, Kappos Ludwig, Hodgkinson Suzanne, Slee Mark, Granella Franco, de Gans Koen, McCombe Pamela A., Ampapa Radek, van der Walt Anneke, Butzkueven Helmut, Sánchez-Menoyo José Luis, Vucic Steve, Laureys Guy, Sidhom Youssef, Gouider Riadh, Castillo-Trivino Tamara, Gray Orla, Aguera-Morales Eduardo, Al-Asmi Abdullah, Shaw Cameron, Al-Harbi Talal M., Csepany Tunde, Sempere Angel P., Trevino Frenk Irene, Stuart Elizabeth A., Kalincik Tomas
Dátum:2023
ISSN:0022-3050
Megjegyzések:Background Simultaneous comparisons of multiple disease-modifying therapies for relapsing-remitting multiple sclerosis (RRMS) over an extended follow-up are lacking. Here we emulate a randomised trial simultaneously comparing the effectiveness of six commonly used therapies over 5 years. Methods Data from 74 centres in 35 countries were sourced from MSBase. For each patient, the first eligible intervention was analysed, censoring at change/discontinuation of treatment. The compared interventions included natalizumab, fingolimod, dimethyl fumarate, teriflunomide, interferon beta, glatiramer acetate and no treatment. Marginal structural Cox models (MSMs) were used to estimate the average treatment effects (ATEs) and the average treatment effects among the treated (ATT), rebalancing the compared groups at 6-monthly intervals on age, sex, birth-year, pregnancy status, treatment, relapses, disease duration, disability and disease course. The outcomes analysed were incidence of relapses, 12-month confirmed disability worsening and improvement. Results 23 236 eligible patients were diagnosed with RRMS or clinically isolated syndrome. Compared with glatiramer acetate (reference), several therapies showed a superior ATE in reducing relapses: natalizumab (HR=0.44, 95% CI=0.40 to 0.50), fingolimod (HR=0.60, 95% CI=0.54 to 0.66) and dimethyl fumarate (HR=0.78, 95% CI=0.66 to 0.92). Further, natalizumab (HR=0.43, 95% CI=0.32 to 0.56) showed a superior ATE in reducing disability worsening and in disability improvement (HR=1.32, 95% CI=1.08 to 1.60). The pairwise ATT comparisons also showed superior effects of natalizumab followed by fingolimod on relapses and disability. Conclusions The effectiveness of natalizumab and fingolimod in active RRMS is superior to dimethyl fumarate, teriflunomide, glatiramer acetate and interferon beta. This study demonstrates the utility of MSM in emulating trials to compare clinical effectiveness among multiple interventions simultaneously.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
MULTIPLE SCLEROSIS
STATISTICS
Megjelenés:Journal Of Neurology Neurosurgery And Psychiatry. - 94 : 12 (2023), p. 1004-1011. -
További szerzők:Malpas, Charles B. Sharmin, Sifat Roos, Izanne Horakova, Dana Kubala Havrdova, Eva Patti, Francesco Shaygannejad, Vahid Ozakbas, Serkan Eichau, Sara Onofrj, Marco Lugaresi, Alessandra Alroughani, Raed Prat, Alexandre Duquette, Pierre Terzi, Murat Boz, Cavit Grand'Maison, Francois Sola, Patrizia Ferraro, Diana Grammond, Pierre Yamout, Bassem Altintas, Ayse Gerlach, Oliver Lechner-Scott, Jeannette Bergamaschi, Roberto Karabudak, Rana Iuliano, Gerardo McGuigan, Christopher Cartechini, Elisabetta Hughes, Stella Sá, Maria José Solaro, Claudio Kappos, Ludwig Hodgkinson, Suzanne Slee, Mark Granella, Franco de Gans, Koen McCombe, Pamela Ampapa, Radek Walt, Anneke van der Butzkueven, Helmut Sanchez-Menoyo, Jose Vucic, Steve Laureys, Guy Sidhom, Youssef Gouider, Riadh Castillo Triviño, Tamara Gray, Orla Aguera-Morales, Eduardo Al-Asmi, Abdullah Shaw, Cameron Al-Harthi, Helal F. Csépány Tünde (1956-) (neurológus, pszichiáter) Sempere, Perez A. Trevino-Frenk, Irene Stuart, Elizabeth A. Kalincik, Tomas
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