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001-es BibID:	BIBFORM058763
Első szerző:	Lampé Rudolf (szülész-nőgyógyász)
Cím:	Phagocytic index of neutrophil granulocytes and monocytes in healthy and preeclamptic pregnancy / Rudolf Lampé, Ágnes Kövér, Sándor Szűcs, László Pál, Ervin Árnyas, Róza Ádány, Robert Póka
Dátum:	2015
ISSN:	0165-0378
Megjegyzések:	Neutrophil granulocytes and monocytes have been intensively studied, but there is no scientific data on one of their most important functions, namely the phagocyte function in pregnancy and preeclampsia. The aim of this study was to examine this function. Twenty-five healthy pregnant, 25 preeclamptic pregnant, and 20 healthy, non-pregnant women were enrolled into our study. Cells were isolated from peripheral blood samples, marked and evaluated for the phagocytic index with an immunofluorescent microscope after phagocytosing the zymosan molecules. The phagocytic function of monocytes and neutrophil granulocytes decreased significantly in healthy pregnancy compared with non-pregnant women and in preeclampsia, and it decreased significantly compared with healthy pregnancy. Decreased phagocytic function in healthy pregnancy can be a part of the maternal immunosuppression, which is essential for the protection of the hemiallograft fetus. Further reduction of phagocytic function may be one of the immunoregulatory abnormalities found in preeclampsia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban reproduktív immunológia
Megjelenés:	Journal Of Reproductive Immunology 107 (2015), p. 26-30. -
További szerzők:	Kövér Ágnes (1989-) (szociológus) Szűcs Sándor (1958-) (biokémikus, vegyész) Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Árnyas Ervin (1974-) (biológus-ökológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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001-es BibID:	BIBFORM019848
Első szerző:	Lampé Rudolf (szülész-nőgyógyász)
Cím:	Granulocyte superoxide anion production and regulation by plasma factors in normal and preeclamptic pregnancy / Lampé Rudolf, Szűcs Sándor, Ádány Róza, Póka Robert
Dátum:	2011
ISSN:	0165-0378
Megjegyzések:	Data on the respiratory burst activity of granulocytes from healthy and preeclamptic women have remained contradictory. To investigate the role of reactive oxygen species in the etiology of preeclampsia we measured superoxide anion generation by granulocytes from non-pregnant, healthy, and preeclamptic women. We also examined the reciprocal effects of heat-inactivated and non-inactivated plasma on superoxide production. Superoxide generation was measured by ferricytochrome-c reduction. Superoxide production induced by either phorbol-12,13-dibutirate or N-formyl-methionyl-leucyl-phenylalanine was significantly decreased in granulocytes from normal pregnant women compared with non-pregnant and preeclamptic women. The phorbol-12,13-dibutirate-induced superoxide generation by granulocytes from non-pregnant and preeclamptic women was significantly inhibited by plasma from healthy pregnant women. The N-formyl-methionyl-leucyl-phenylalanine-stimulated superoxide production by granulocytes from non-pregnant and preeclamptic women was suppressed only by non-inactivated plasma, not heat-inactivated plasma from healthy pregnant women. Plasma from preeclamptic women did not influence the phorbol-12,13-dibutirate- and N-formyl-methionyl-leucyl-phenylalanine-induced superoxide production by control granulocytes. The phorbol-12,13-dibutirate-induced superoxide generation by granulocytes from healthy pregnant women was significantly increased by the effect of plasma from non-pregnant and preeclamptic women, but when stimulating with N-formyl-methionyl-leucyl-phenylalanine only non-inactivated plasma caused the same enhancement. These data indicate that reduced superoxide generation in normal pregnancy may be caused by maternal immunosuppressive factors present in plasma. The failure to reduce superoxide production in preeclampsia may be partly responsible for the endothelial dysfunction characteristic of that condition.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban superoxide anion granulocyte preeclampsia
Megjelenés:	Journal of Reproductive Immunology. - 89 : 2 (2011), p. 199-206. -
További szerzők:	Szűcs Sándor Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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001-es BibID:	BIBFORM004565
Első szerző:	Lampé Rudolf (szülész-nőgyógyász)
Cím:	Effect of normal and preeclamptic plasma on superoxide-anion production of neutrophils from healthy non-pregnant women / Lampé Rudolf, Szűcs Sándor, Ormos Márk, Ádány Róza, Póka Róbert
Dátum:	2008
Megjegyzések:	This study has examined whether production of superoxide-anion by granulocytes differs between non-pregnant, healthy pregnant and preeclamptic pregnant women. First, we assessed superoxide-anion production in 13 non-pregnant women, 11 healthy pregnant women and 14 preeclamptic pregnant women. Then, we examined the effect of plasma samples of healthy pregnant and preeclamptic pregnant women on superoxide production by neutrophils separated from healthy pregnant women. Superoxide generation was measured by ferricytochrome-c reduction. Phorbol-12,13-dibutyrate- and n-formyl-methionyl-leucyl-phenylalanine-stimulated superoxide-anion production was significantly decreased in healthy pregnant women's granulocytes compared with non-pregnant women. There was no significant difference between granulocyte superoxide-anion production in preeclamptic pregnant and non-pregnant women. When neutrophils from non-pregnant women were incubated in plasma from healthy pregnant women, the granulocyte phorbol-12,13-dibutyrate-stimulated superoxide-anion production was significantly inhibited. With the same stimulator, there were no significant differences between superoxide-anion production of neutrophils incubated in autologous, non-pregnant and preeclamptic pregnant plasma. If n-formyl-methionyl-leucyl-phenylalanine was used for stimulation, there were no significant differences in the superoxide-anion production of granulocytes in either group. Granulocyte superoxide-anion production decreases during pregnancy; this decrease does not occur in preeclampsia, and may cause endothelial damage. It is conceivable that there are unidentified factors in maternal circulation which inhibit superoxide-anion production by granulocytes in healthy pregnant women.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban preeclampsia
Megjelenés:	Journal of Reproductive Immunology. - 79 : 1 (2008), p. 63-69. -
További szerzők:	Szűcs Sándor (1958-) (biokémikus, vegyész) Ormos Márk (1980-) (orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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001-es BibID:	BIBFORM055860
Első szerző:	Tóth Ferenc, D. (mikrobiológus, élettanász)
Cím:	Placental macrophage contact induces complete replicative cycle of human immunodeficiency virus in latently infected syncytiotrophoblast cells: role of interleukine-6 and tumor necrosis factor-β / D. Tóth Ferenc, Bácsi Attila, Csoma Eszter, Beck Zoltán, Andirkó István, Ebbesen Peter
Dátum:	2002
Tárgyszavak:	Természettudományok Biológiai tudományok idézhető absztrakt
Megjelenés:	American Journal of Reproductive Immunology. - 48 : 3 (2002), p. 144. -
További szerzők:	Bácsi Attila (1967-) (immunológus) Csoma Eszter (1978-) (molekuláris biológus, mikrobiológus) Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Andirkó István Ebbesen, Peter
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