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001-es BibID:	BIBFORM037091
Első szerző:	Oláh Anna (klinikai biokémikus, vegyész)
Cím:	Current Questions on Proteinuria and Albuminuria / V. Oláh Anna, Fodor Bertalan, Mátyus János
Dátum:	2012
Megjegyzések:	According to current clinical trials, albumin excretion not only indicates kidney damage but it is also a risk factor for the progression of kidney disease and future cardiovascular events. While proteinuria is considered as a marker of kidney function, microalbuminuria, first of all, indicates cardiovascular risk. Sensitivity of the laboratory tests is method dependent, some of the previously used tests do not meet the clinical requirements, and the error of urine collection makes the results misleading. To avoid these preanalytical problems, recent guidelines suggest the calculation of albumin and creatinine ratio (ACR) and protein and creatinine ratio (PCR) from the values measured from the first morning urine, as these ratios correlate well with the corresponding results of properly collected 24-hour urine. For the clinical diagnosis of albuminuria, the sensitive immunoturbidimetric assays are recommended. Because of poor sensitivity, urinary albumin dipsticks are not recommended for the measurement of albuminuria. For the diagnosis of proteinuria, wide-range urinary protein reagents are available with high sensitivity. The traceability of calibrator to a reference material is a critical requirement. For these reasons, proteinuria and albuminuria of a patient should be monitored in the same laboratory, using a fixed method and cut-off value. Protein, albumin, and creatinine should be measured from the same urine sample, practically using the same analyzer. The ACR values should be reported together with gender-dependent reference ranges. As the PCR range is wider, the same cut-off value can be used for men and women. We discuss the interpretation and diagnostic algorithm of proteinuria and albuminuria.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ACR Albuminuria cardiovascular disease chronic kidney disease Proteinuria protein creatinine
Megjelenés:	Journal of Clinical Metabilism and Diabetes. - 3 : 1 (2012), p. 26-32. -
További szerzők:	Fodor Bertalan Mátyus János (1957-) (belgyógyász, nephrológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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