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001-es BibID:	bibEBI17137
Első szerző:	Klekner Álmos (idegsebész)
Cím:	Cefazolin prophylaxis in neurosurgery monitored by capillary electrophoresis / Klekner, Á., Gáspár, A., Kardos, Sz., Szabó, J., Csécsei, Gy.
Dátum:	2003
Megjegyzések:	Prophylactic use of antibiotics to prevent postoperative infections is a routine method in neurosurgery. Little is known about the period of effectiveness of antibiotics applied only for the purposes of operation. The actual concentration of cefazolin was determined in the serum, in the contents of wound drains, and in the cerebrospinal fluid in a 24-hour postoperative period after the administration of 1 g of cefazolin just prior to skin incision in 8 patients undergoing lumbar discectomy and 11 patients undergoing craniectomy. The concentration of the antibiotic was then compared with the minimal inhibitory concentration values of cefazolin for 10 different bacterial species. For evaluating the concentration of cefazolin, capillary electrophoresis was used, which is a new clinical application of this separation technique. Results showed that the antibiotic was effective against bacterial breeding in the serum and in the drainage up to 12 hours. The drug concentration in the cerebrospinal fluid remained less than the value of the serum, and it exceeded the minimal inhibitory concentration values only for approximately 5 hours.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of Neurosurgical Anesthesiology. - 15 : 3 (2003), p. 249-254. -
További szerzők:	Gáspár Attila (1970-) (vegyész, kémikus) Kardos Szilvia Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Csécsei György (1948-2005) (idegsebész)
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001-es BibID:	BIBFORM046017
Első szerző:	Menzel, Matthias (sebész)
Cím:	Brain tissue oxygen monitoring for assessment of autoregulation : preliminary results suggest a new hypothesis / Menzel M., Soukup J., Henze D., Clausen T., Marx T., Hillman A., Mikó I., Grond S., Rieger A.
Dátum:	2003
ISSN:	0898-4921
Megjegyzések:	Brain tissue oxygen monitoring (P(ti)O2 (Neurotrend, Codman, Germany) was employed in addition to standard intracranial pressure (ICP) and cerebral perfusion pressure (CPP) monitoring in seven patients with severe neuronal damage of heterogeneous etiology. The correlation between P(ti)O2 changes and CPP fluctuations during periods of 30 minutes were analyzed, when CPP was above 70 mmHg and lower than 100 mmHg. A new ratio, the CPP-oxygen-reactivity (COR) index was calculated as COR=delta p(ti)O2 %/delta CPP%. The patient COR values were compared to those found in the brain of six noninjured anesthetized piglets. The analysis was performed to determine the significance of synchronous fluctuations of CPP and P(ti)O2, when CPP is above the lower threshold of autoregulation. The correlation between CPP variations and p(ti)O2 variations was found to be strong (R(mean)) = 0.74 +/- 0.17) in the patients and was weak in the uninjured animals (R(mean)) =0.38 +/- 0.43). The COR (mean) was 2.05 +/- 0.57 in patients and 0.78 +/- 0.6 in the animals. In the injured brain of our patients, we observed an unexpectedly close correlation between P(ti)O2 and CPP variations when CPP levels were within a therapeutically targeted range (70 to 100 mmHg). In a porcine model, we could not find this relationship in the noninjured brain. We speculate that an increased COR might be indicative for an impaired local pressure autoregulation. The preliminary data suggest that COR values above "1" might be pathologic. However, the reported sample sizes are too small to provide sufficient statistical power to justify inferential statistical analyses. As such, results are presented with descriptive statistics only, and should be regarded as a hypothesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Neurosurgical Anesthesiology. - 15 : 1 (2003), p. 33-44. -
További szerzők:	Soukup, Jens Henze, Dirk Clausen, Tobias Marx, T. Hillman, A. Mikó Irén (1948-) (kutató sebész) Grond, S. Rieger, Andreas
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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