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001-es BibID:	BIBFORM024504
Első szerző:	Nemes Judit (fogszakorvos)
Cím:	p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma / Judit A. Nemes, Zoltán Nemes, Ildikó J. Márton
Dátum:	2005
Megjegyzések:	AbstractBACKGROUND: Previous research on the prognostic relevance of p21(WAF1/CIP1) in oral squamous cell carcinomas (OSCC) yielded inconclusive and contradictory data.OBJECTIVES: To investigate the prognostic significance of p21(WAF1/CIP1) expression, its relationship to p53 accumulation, proliferation-associated proteins Ki-67 and cyclin D1 in relation to survival and clinicopathological features in OSCC.METHODS: Surgical specimens taken from 106 randomly selected patients were studied by immunohistochemistry. Expression of the protein of interest was correlated with clinical data.RESULTS: p21(WAF1/CIP1) expression was found in 61.3% of OSCCs. Expression of p21(WAF1/CIP1) significantly correlated with tumor size (P = 0.005), lymph node involvement (P = 0.002), clinical stage (P < 0.001), and tumor site (P = 0.002). Patients with tumors showing p21(WAF1/CIP1) immunopositivity had decreased 2-year survival (P = 0.018). Expression of p21(WAF1/CIP1) was not related to age, gender, risk factors (tobacco, alcohol), dental status, or tumor differentiation grade. The p21(WAF1/CIP1) expression positively correlated with proliferation-related variables Ki-67 (P = 0.010) and cyclin D1 (P < 0.001), but not with p53 expression.CONCLUSIONS: The expression of p21(WAF1/CIP1) was found to be associated with poorer prognosis and tumor aggressivity in OSCC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban OSCC cyclin D1 Ki-67 oral p21 p53 squamous cell carcinoma
Megjelenés:	Journal of oral pathology & medicine. - 34 : 5 (2005), p. 274-279. -
További szerzők:	Nemes Zoltán (1942-) (patológus) Márton Ildikó (1954-) (fogszakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM008848
Első szerző:	Zidverc-Trajkovic, Jasna
Cím:	Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome / Jasna Zidverc-Trajkovic, Dragan Stanimirovic, Radmila Obrenovic, János Tajti, László Vécsei, János Gardi, József Németh, Milija Mijajlovic, Nadezda Sternic, Ljiljana Jankovic
Dátum:	2009
Megjegyzések:	Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban burning mouth syndrome calcitonin gene-related
Megjelenés:	Journal of Oral Pathology and Medicine. - 38 : 1 (2009), p. 29-33. -
További szerzők:	Stanimirovic, Dragan Obrenovic, Radmila Tajti János Vécsei László (1954-) (neurológus) Gardi János Németh József (1954-) (vegyész, analitikus) Mijajlovic, Milija Sternic, Nadezda Jankovic, Ljiljana
Internet cím:	elektronikus változat elektronikus változat DOI
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