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1.

001-es BibID:BIBFORM010623
Első szerző:Boms, Neta
Cím:Effect of smoking cessation on visually evoked cerebral blood flow response in healthy volunteers / Neta Boms, Yaniv Yonai, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:2010
ISSN:1018-1172 (Print)
Megjegyzések:In our previous study, impaired visually evoked flow velocity response was demonstrated in young chronic smokers. Our aim was to study whether impaired cerebrovascular reactivity is reversible 6?18 months after smoking cessation. Methods: Flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries in 15 smokers, 15 former smokers and 15 nonsmokers. The stimulation protocol consisted of 10 cycles with a resting phase of 20 s (baseline) and a stimulating phase of 40 s for each cycle. Relative changes of flow velocity were expressed in relation to baseline. Breath holding index, visual evoked potential and intima-media thickness were also examined. Results: Repeated measures ANOVA revealed marked difference in the flow velocity time courses between the 3 groups (p ! 0.01). The flow response was significantly worse in former smokers than in nonsmokers (p ! 0.002), however, no significant difference was found between former and current smokers (p = 0.0556). Conclusion: This is the first transcranial Doppler study demonstrating long-term impairment of visually evoked cerebrovascular response af-ter smoking cessation. These findings indicate that the impairment of neurovascular coupling caused by smoking is due to structural changes of the vessels, rather than acute effect of smoking.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Transcranial Doppler
Hemodynamics
Vasoreactivity
Neurovascular coupling
Visual stimulation
Cerebral blood flow
Smoking
Megjelenés:Journal of Vascular Research. - 47 : 3 (2010), p. 214-220. -
További szerzők:Yonai, Yaniv Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:K 68864
OTKA
ETT 260/2009
EGYÉB
ETT 197-05/2010
EGYÉB
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2.

001-es BibID:BIBFORM075463
Első szerző:Ghanem, Souleiman
Cím:Carotid-Jugular Fistula Model to Study Systemic Effects and Fistula-Related Microcirculatory Changes / Souleiman Ghanem, Bence Tanczos, Adam Deak, Laszlo Bidiga, Norbert Nemeth
Dátum:2018
ISSN:1018-1172
Megjegyzések:BACKGROUND: Arteriovenous fistulae impair the distal circulation, but their effects at the microcirculatory level are not well understood. This study presents the carotid-jugular fistula (CJF) as a model to evaluate fistula-related microcirculatory and systemic changes. MATERIALS AND METHODS: Female Wistar rats were anesthetized and divided into a fistula group (FG, n = 10) and a sham group (SG, n = 6). End-to-end anastomosis was performed between the right carotid artery and the jugular vein in the FG. The hemodynamic status was followed for 6 weeks. On the sixth postoperative week, liver and kidney microcirculation was measured using laser Doppler; then microcirculatory changes were assessed after occlusion of the carotid artery. At the end of the experiment, histological samples were taken and the weights of the organs were measured. RESULTS: The heart rate and systolic blood pressure decreased significantly due to the CJF. Laser Doppler showed a reduction in liver blood flow units (BFU) in the FG in comparison with the SG (p = 0.01), and they increased (p < 0.01) after occlusion of the fistula. Kidney BFU showed slight changes only. The comparative morphological study revealed significant increases in heart weight (p < 0.001) and left ventricular hypertrophy (p = 0.008) in the FG. CONCLUSION: Beside hemodynamic and morphologic changes, a CJF causes a deterioration in the microcirculation of the liver rather than of the kidney, but occlusion of the CJF immediately reverses these changes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Vascular Research. - 55 : 5 (2018), p. 268-277. -
További szerzők:Tánczos Bence (1987-) (biológus) Deák Ádám (1974-) (állatorvos) Bidiga László (1977-) (patológus) Németh Norbert (1975-) (kutatóorvos)
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3.

001-es BibID:BIBFORM069486
Első szerző:Ivic, Ivan
Cím:Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice / Ivic I., Fulop B. D., Juhasz T., Reglodi D., Toth G., Hashimoto H., Tamas A., Koller A.
Dátum:2017
Megjegyzések:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide in the VIP/secretin/glucagon peptide superfamily. Two active forms, PACAP1-38 and PACAP1-27, act through G protein-coupled receptors, the PAC1 and VPAC1/2 receptors. Effects of PACAP include potent vasomotor activity. Vasomotor activity and organ-specific vasomotor effects of PACAP-deficient mice have not yet been investigated; thus, the assessment of its physiological importance in vasomotor functions is still missing. We hypothesized that backup mechanisms exist to maintain PACAP pathway activity in PACAP knockout (KO) mice. Thus, we investigated the vasomotor effects of exogenous vasoactive intestinal peptide (VIP) and PACAP polypeptides in PACAP wild-type (WT) and PACAP-deficient (KO) male mice.METHODS:Carotid and femoral arteries were isolated from 8- to 12-week-old male WT and PACAP-KO mice. Vasomotor responses were measured with isometric myography.RESULTS:In the arteries of WT mice the peptides induced relaxations, which were significantly greater to PACAP1-38 than to PACAP1-27 and VIP. In KO mice, PACAP1-38 did not elicit relaxation, whereas PACAP1-27 and VIP elicited significantly greater relaxation in KO mice than in WT mice. The specific PAC1R and VPAC1R antagonist completely blocked the PACAP-induced relaxations.CONCLUSION:Our data suggest that in PACAP deficiency, backup mechanisms maintain arterial relaxations to polypeptides, indicating an important physiological role for the PACAP pathway in the regulation of vascular tone.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Carotid arteries
Femoral arteries
PAC1 receptor
PACAP-KO mice
Pituitary adenylate cyclase-activating polypeptide
VPAC1/VPAC2 receptors
Vasoactive intestinal peptide
Vasomotor responses
Megjelenés:Journal of Vascular Research 54 : 3 (2017), p. 180-192. -
További szerzők:Fülöp Balázs Dániel (Orvosi alapkutatások) Juhász Tamás (1976-) (biológus, orvosbiológus) Reglődi Dóra (Idegtudományok) Tóth Gábor (Szeged) Hashimoto, Hitoshi Tamás Andrea (Idegtudomány) (Pécs) Koller Ákos
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4.

001-es BibID:BIBFORM099972
Első szerző:Rácz A.
Cím:Thromboxane A2 Contributes to the Mediation of Flow-Induced Responses of Skeletal Muscle Venules : role of Cyclooxygenases 1 and 2 / Racz A., Veresh Z., Erdei N., Bagi Z., Koller A.
Dátum:2009
ISSN:1018-1172
Megjegyzések:Background: It has been shown that increases in intraluminal flow elicit dilation in venules, but the mediation of response is not yet clarified. We hypothesized that - in addition to nitric oxide (NO) and dilator prostaglandins (PGI(2)/ PGE(2)) - thromboxane A(2) (TxA(2)) contributes to the mediation of flow-induced responses of venules. Methods and results: Isolated rat gracilis muscle venules (259 +/- 11 microm at 10 mm Hg) dilated as a function of intraluminal flow, which was augmented in the presence of the TxA(2) receptor antagonist SQ 29,548 or the TxA(2) synthase inhibitor ozagrel. In the presence of SQ 29,548, indomethacin or Nomega-nitro-L-arginine methyl-ester decreased flow-induced dilations, whereas in their simultaneous presence dilations were abolished. The selective cyclooxygenase (COX) 1 inhibitor SC 560 reduced, whereas the selective COX-2 inhibitor NS 398 enhanced flow-induced dilations. Immunohistochemistry showed that both COX-1 and COX-2 are present in the wall of venules. Conclusion: In skeletal muscle venules, increases in intraluminal flow elicit production of constrictor TxA(2), in addition to the dilator NO and PGI(2)/PGE(2), with an overall effect of limited dilation. These mediators are likely to have important roles in the multiple feedback regulation of wall shear stress in venules during changes in blood flow velocity and/or viscosity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Venule
Shear stress
Nitric oxide
Prostaglandins
Cyclooxygenases 1 and 2
Thromboxane A 2 synthase
Megjelenés:Journal Of Vascular Research. - 46 : 5 (2009), p. 397-405. -
További szerzők:Veresh Zoltán Erdei Nóra (1979-) (orvos) Bagi Zsolt (1974-) (orvos) Koller Ákos
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5.

001-es BibID:BIBFORM020451
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Nitric oxide, peroxynitrite and cGMP in atherosclerosis-induced hypertension in rabbits : beneficial effects of cicletanine / Zoltán Szilvássy, Tamás Csont, Tibor Páli, Marie-Thérèse Droy-Lefaix, Péter Ferdinandy
Dátum:2001
ISSN:1018-1172
Megjegyzések:AbstractWe studied the effect of the furopyridine derivative antihypertensive drug, cicletanine, on blood pressure, vascular nitric oxide (NO) and cyclic guanosine 3':5'-monophosphate (cGMP) content in the aorta and the renal and carotid arteries, aortic superoxide production, and serum nitrotyrosine level in hypertensive/atherosclerotic rabbits. The effect of cicletanine was compared to that of furosemide. Rabbits were fed a normal or a cholesterol-enriched (1.5%) diet over 8 weeks. On the 8th week, the rabbits were treated per os with 2 x 50 mg/kg daily doses of cicletanine, furosemide, or vehicle for 5 days (n = 5-6 in each groups). The cholesterol diet increased mean arterial blood pressure (MABP) from 86 +/- 1 to 94 +/- 2 mm Hg (p < 0.05). Cicletanine decreased MABP in atherosclerotic rabbits to 85 +/- 1 mm Hg (p < 0.05), but it did not affect MABP in normal animals. Furosemide was without effect in both groups. In normal animals, NO content (assessed by electron spin resonance after in vivo spin trapping) in the aorta and the renal and carotid arteries was increased by cicletanine, and the drug increased cGMP in the renal artery as measured by radioimmunoassay. The cholesterol-enriched diet decreased both vascular NO and cGMP and increased aortic superoxide production assessed by lucigenin-enhanced chemiluminescence and serum nitrotyrosine determined by ELISA. In atherosclerotic animals, cicletanine increased NO and cGMP content in the aorta and the renal and carotid arteries and decreased aortic superoxide production and serum nitrotyrosine. Furosemide did not influence these parameters. We conclude that cicletanine lowers blood pressure in hypertensive/atherosclerotic rabbits. The antihypertensive effect of the drug in atherosclerosis may be based on its beneficial effects on the vascular NO-cGMP system and on the formation of reactive oxygen species.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
nitric oxide
peroxynitrite
cGMP
atherosclerosis-induced
atherosclerosis-induced hypertension
cicletanine
Megjelenés:Journal of Vascular Research. - 38 : 1 (2001), p. 39-46. -
További szerzők:Csont Tamás Páli Tibor Droy-Lefaix, Marie-Thérèse Ferdinándy Péter
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM052722
035-os BibID:PMID: 23969947
Első szerző:Szklenár Mónika
Cím:Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits / Monika Szklenar, Janine Kalkowski, Verena Stangl, Mario Lorenz, Ralph Rühl
Dátum:2013
ISSN:1018-1172
Megjegyzések:Eicosanoids and docosanoids have been shown to be involved in atherosclerosis. Polyunsaturated fatty acids (PUFAs) are important nutrients that are metabolized by lipoxygenases and cyclooxygenases to various mono-hydroxy metabolites which can be further metabolized by specific enzymes to more complex eicosanoids and docosanoids. In this study a high-performance liquid chromatography methodology was established and rabbits were fed with a control or a high-cholesterol diet to induce atherosclerotic lesions to determine pro- or anti-inflammatory lipid mediators in atherosclerotic vessels. In aortic samples from atherosclerotic rabbits we determined for the first time various eicosanoids/docosanoids and observed an increased concentration of 12-lipoxygenase metabolites. Increased levels of 12-hydroxyeicosatetraenoic acid (12-HETE) in high-cholesterol versus control animals as well as increased ratios of 12-HETE/arachidonic acid ratios indicate that 12-lipoxygenase metabolites may have importance in atherosclerosis. In addition, decreased concentrations of the 5-lipoxygenase metabolite leukotriene B4 levels were detected in high-cholesterol animals. A positive correlation of total plaque area with plasma levels of 12-HETE and a negative correlation with aortic levels of endogenous PPARγ-ligand 13-oxo-octadecadienoic acid were found. This study let us conclude that the cholesterol content in the diet might influence atherosclerosis via increased 12-lipoxygenase- and cyclooxygenase-mediated pathways and reduced 5-lipoxygenase pathways.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Vascular Research. - 50 : 5 (2013), p. 372-382. -
További szerzők:Kalkowski, Janine Stangl, Verena Lorenz, Mario Rühl, Ralph (1969-) (vegyész)
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