CCL

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1.

001-es BibID:BIBFORM077738
035-os BibID:(WoS)000469213300008 (Scopus)85066271383 (PubMed)30517027
Első szerző:Almássy János (élettanász, biológus, angol-magyar szakfordító)
Cím:Brief structural insight into the allosteric gating mechanism of BK (Slo1) channel / János Almássy, Péter P. Nánási
Dátum:2019
ISSN:0008-4212
Megjegyzések:The big conductance Ca2+-dependent K+ channel, also known as BK, MaxiK, Slo1, or KCa1.1, is a ligand- and voltage-gated K+ channel. Although structure-function studies of the past decades, involving mutagenesis and electrophysiological measurements, revealed fine details of the mechanism of BK channel gating, the exact molecular details remained unknown until the quaternary structure of the protein has been solved at a resolution of 3.5 ?A using cryo-electron microscopy. In this short review, we are going to summarize these results and interpret the gating model of the BK channel in the light of the recent structural results.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
BK channel
Megjelenés:Canadian Journal Of Physiology And Pharmacology. - 97 : 6 (2019), p. 498-502. -
További szerzők:Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:OTKA K115307
OTKA
GINOP-2.3.2-15-2016-00040
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM012829
Első szerző:Grenczer Maria (gyógyszerész)
Cím:Effect of asymmetry of concentration-response curves on the results obtained by the receptorial responsiveness method (RRM) : an in silico study / Grenczer Maria, Zsuga Judit, Majoros Laszlo, Pinter Akos, Kemeny-Beke Adam, Juhasz Bela, Tosaki Arpad, Gesztelyi Rudolf
Dátum:2010
ISSN:0008-4212
Megjegyzések:The receptorial responsiveness method (RRM) was proposed to estimate changes in the concentration of an agonist in the microenvironment of its receptor. Usually, this is done by providing the equieffective concentration of another agonist for the same receptor or for a largely overlapping postreceptorial signaling ("test agonist"). The RRM is a special nonlinear regression algorithm to analyze a concentration-response (E/c) curve that represents the simultaneous actions of a single agonist concentration to be estimated and of increasing concentrations of the test agonist. The aim of this study was to explore whether asymmetry of the E/c curve to be analyzed influences the reliability of the RRM. For this purpose, computer simulation was performed by constructing symmetric and asymmetric E/c curves using the operational model of agonism, and then these curves were analyzed with the RRM. To perform the RRM, 2 types of equations were used: one involving the Hill equation, the simplest model of the E/c relationship, and one containing the Richards equation, an advanced model properly handling E/c curve asymmetry. Results of this study indicate that E/c curve asymmetry does not significantly influence the accuracy of the estimates provided by the RRM. Thus, when using the RRM, it is not necessary to replace the Hill equation with the Richards equation to obtain useful estimates. Furthermore, it was found that estimation of a high concentration of a high-efficacy agonist can fail when the RRM is performed with a low-efficacy test agonist in a system characterized by a small operational slope factor.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekulatudomány
concentration-response curve
symmetry
operational model
efficacy
slope
concentration estimation
receptorial responsiveness method
RRM
Megjelenés:Canadian Journal Of Physiology And Pharmacology. - 88 : 11 (2010), p. 1074-1083. -
További szerzők:Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Pintér Ákos (1967-) (matematikus) Kemény-Beke Ádám (1968-2021) (szemész) Juhász Béla (1978-) (kísérletes farmakológus) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1 KONV-2010-0007
TÁMOP
Kardiovaszkuláris megbetegedések génterápiás befolyásolása
TÁMOP-4.2.2-08/1-2008-0007
TÁMOP
PD 78223
OTKA
K 72315
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM012828
Első szerző:Grenczer Maria (gyógyszerész)
Cím:The influence of affinity, efficacy, and slope factor on the estimates obtained by the receptorial responsiveness method (RRM) : a computer simulation study / Grenczer Maria, Pinter Akos, Zsuga Judit, Kemeny-Beke Adam, Juhasz Bela, Szodoray Peter, Tosaki Arpad, Gesztelyi Rudolf
Dátum:2010
ISSN:0008-4212
Megjegyzések:The receptorial responsiveness method (RRM) was proposed to characterize changes in the concentration of degradable agonists in the microenvironment of their receptors. The characterization is done by providing concentrations of a stable agonist for the same receptor that is equieffective with the change in concentration to be characterized. RRM is based on the analysis of concentration-effect (E/c) curves reflecting the simultaneous action of the degradable and the stable agonist. In the present study, we investigated whether dissimilar affinity and (or) efficacy of the coacting agonists as well as the steepness of the E/c curves influence the reliability of RRM. E/c curves were simulated based on the operational model and then analyzed with RRM. We found that dissimilarity in affinity of the coacting agonists did not affect the accuracy of RRM estimates. In contrast, accuracy of the estimation depended on the magnitude of the concentration to be assessed, the operational slope factor, and the operational efficacy ratio of the coacting agonists. However, our results suggest that proper choice of a stable agonist for a degradable one can help to ensure reliable results, since information about the change in concentration of a degradable agonist is otherwise difficult to obtain.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekulatudomány
concentration estimation
affinity
efficacy
slope
receptorial responsiveness method
RRM
Megjelenés:Canadian Journal Of Physiology And Pharmacology. - 88 : 11 (2010), p. 1061-1073. -
További szerzők:Pintér Ákos (1967-) (matematikus) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Kemény-Beke Ádám (1968-2021) (szemész) Juhász Béla (1978-) (kísérletes farmakológus) Szodoray Péter (1973-) (belgyógyász, orvos) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Kardiovaszkuláris megbetegedések génterápiás befolyásolása
TÁMOP-4.2.2-08/1-2008-0007
TÁMOP
PD 78223
OTKA
K 72315
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM083233
035-os BibID:(WoS)000477613400010 (Scopus)85069844683 (PubMed)31091413
Első szerző:Hegyi Bence (élettanász)
Cím:Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and [beta]-adrenergic stimulation / Hegyi Bence, Chen-Izu Ye, Izu Leighton T., Bányász Tamás
Dátum:2019
ISSN:0008-4212
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Canadian Journal Of Physiology And Pharmacology. - 97 : 8 (2019), p. 773-780. -
További szerzők:Chen-Izu, Ye Izu, Leighton T. Bányász Tamás (1960-) (élettanász)
Pályázati támogatás:K101196
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM076044
035-os BibID:(WoS)000436909600011 (Scopus)85054071643 (PubMed)29769426
Első szerző:Horváth Balázs (élettanász)
Cím:Effect of the intracellular calcium concentration chelator BAPTA acetoxy-methylester on action potential duration in canine ventricular myocytes / B. Horvath, N. Szentandrassy, R. Veress, D. Baranyai, K. Kistamas, J. Almassy, A. Toth, J. Magyar, T. Banyasz, P. P. Nanasi
Dátum:2018
Megjegyzések:Intracellular calcium concentration ([Ca2+]i) is often buffered by using the cell-permeant acetoxy-methylester form of the Ca2+ chelator BAPTA (BAPTA-AM) under experimental conditions. This study was designed to investigate the time-dependent actions of extracellularly applied BAPTA-AM on action potential duration (APD) in cardiac cells. Action potentials were recorded from enzymatically isolated canine ventricular myocytes with conventional sharp microelectrodes. The effect of BAPTA-AM on the rapid delayed rectifier K+ current (IKr) was studied using conventional voltage clamp and action potential voltage clamp techniques. APD was lengthened by 5 ?M BAPTA-AM - but not by BAPTA - and shortened by the Ca2+ ionophore A23187 in a time-dependent manner. The APD-lengthening effect of BAPTA-AM was strongly suppressed in the presence of nisoldipine, and enhanced in the presence of BAY K8644, suggesting that a shift in the [Ca2+]i-dependent inactivation of L-type Ca2+ current may be an important underlying mechanism. However, in the presence of the IKr-blocker dofetilide or E-4031 APD was shortened rather than lengthened by BAPTA-AM. Similarly, the APD-lengthening effect of 100 nM dofetilide was halved by the pretreatment with BAPTA-AM. In line with these results, IKr was significantly reduced by extracellularly applied BAPTA-AM under both conventional voltage clamp and action potential voltage clamp conditions. This inhibition of IKr was partially reversible and was not related to the Ca2+ chelator effect BAPTA-AM. The possible mechanisms involved in the APD-modifying effects of BAPTA-AM are discussed. It is concluded that BAPTA-AM has to be applied carefully to control [Ca2+]i in whole cell systems because of its direct inhibitory action on IKr.
Tárgyszavak:idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
calcium chelators
intracellular calcium concentration
action potential duration
cardiac ion currents
potassium ion
currents
ventricular myocytes
Megjelenés:Journal of Physiology and Pharmacology. - 69 : 1 (2018), p. 99-107. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Veress Roland (1992-) (molekuláris biológus) Baranyai Dóra Kistamás Kornél (1986-) (biológus) Almássy János (1981-) (élettanász, biológus, angol-magyar szakfordító) Tóth A. (farmakológus) Magyar János (1961-) (élettanász) Bányász Tamás (1960-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:NKFIHK-115397
NKFIH
NKFIH-K109736
NKFIH
NKFIH-PD120794
NKFIH
OTKA ANN-113273
OTKA
GINOP-2.3.2-15-2016-00040
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
UNKP-17-4-III-DE-201
UNKP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

6.

001-es BibID:BIBFORM057408
Első szerző:Horváth Balázs (élettanász)
Cím:Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes / Balázs Horváth, Bence Hegyi, Kornél Kistamás, Krisztina Váczi, Tamás Bányász, János Magyar, Norbert Szentandrássy, Péter P. Nánási
Dátum:2015
ISSN:0008-4212
Megjegyzések:The present study was designed to investigate the influence of cytosolic Ca2+concentration ([Ca2+]i) on action potential duration (APD) and on the incidence of earlyafterdepolarizations (EADs) in canine ventricular cardiomyocytes. Action potentials (AP)of isolated cells were recorded using conventional sharp microelectrodes and concomitant[Ca2+]i was monitored by the fluorescent dye, Fura-2. EADs were evoked at 0.2 Hz pacingrate by inhibiting the rapid delayed rectifier K+ current with dofetilide, by activating thelate sodium current with veratridine, or by activating the L-type calcium current with BAYK8644. These interventions progressively prolonged the AP and resulted in initiation ofEADs. Reducing [Ca2+]i by application of the cell-permeant Ca2+ chelator BAPTA-AMlengthened the AP at 1 Hz if it was applied alone or in the presence of veratridine and BAYK8644. BAPTA-AM, however, shortened the AP after pretreating the cells with dofetilide.The incidence of the evoked EADs was decreased by BAPTA-AM strongly in dofetilideand moderately in veratridine, while it was increased by BAPTA-AM in the presence ofBAY K8644. Based on these experimental data changes in [Ca2+]i have marked effects onAPD as well as on EAD incidence, however, the underlying mechanisms may be differentdepending on the mechanism of EAD generation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
early afterdepolarizations
action potential duration
intracellular Ca2+ concentration
arrhythmogenesis,
canine myocytes
electrophysiology,
fluorescent Ca2+ indicator dyes
Ca2+ chelators
Megjelenés:Canadian Journal of Physiology and Pharmacology. - 93 : 7 (2015), p. 527-534. -
További szerzők:Hegyi Bence (1987-) (élettanász) Kistamás Kornél (1986-) (biológus) Váczi Krisztina (1987-) (élettanász) Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:K100151
OTKA
K109736
OTKA
K101196
OTKA
PD101171
OTKA
NK104331
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Élettan Kutatócsoport
TÁMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

7.

001-es BibID:BIBFORM057409
Első szerző:Kistamás Kornél (biológus)
Cím:Changes in intracellular calcium concentration influence beat-to-beat variability of action potential duration in canine ventricular myocytes / K. Kistamas, N. Szentandrassy, B. Hegyi, K. Vaczi, F. Ruzsnavszky, B. Horvath, T. Banyasz, P.P. Nanasi, J. Magyar
Dátum:2015
ISSN:0867-5910
Megjegyzések:The aim of the present work was to study the influence of changes in intracellular calcium concentration ([Ca2+]i) onbeat-to-beat variability (short term variability, SV) of action potential duration (APD) in isolated canine ventricularcardiomyocytes. Series of action potentials were recorded from enzymatically isolated canine ventricular cells usingconventional microelectrode technique. Drug effects on SV were evaluated as relative SV changes determined byplotting the drug-induced changes in SV against corresponding changes in APD and comparing these data to theexponential SV-APD function obtained with inward and outward current injections. Exposure of myocytes to the Ca2+chelator BAPTA-AM (5 ?M) decreased, while Ca2+ ionophore A23187 (1 ?M) increased the magnitude of relative SV.Both effects were primarily due to the concomitant changes in APD. Relative SV was reduced by BAPTA-AM undervarious experimental conditions including pretreatment with veratridine, BAY K8644, dofetilide or E-4031.Contribution of transient changes of [Ca2+]i due to Ca2+ released from the sarcoplasmic reticulum (SR) was studied using10 ?M ryanodine and 1 ?M cyclopiazonic acid: relative SV was reduced by both agents. Inhibition of the Na+-Ca2+exchanger by 1 ?M SEA0400 increased relative SV.It is concluded that elevation of [Ca2+]i increases relative SVsignificantly. More importantly, Ca2+ released from the SR is an important component of this effect.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
intracellular calcium concentration
short term variability
action potential duration
cardiac ion currents
myocytes
Megjelenés:Journal of Physiology and Pharmacology. - 66 : 1 (2015), p. 73-81. -
További szerzők:Szentandrássy Norbert (1976-) (élettanász) Hegyi Bence (1987-) (élettanász) Váczi Krisztina (1987-) (élettanász) Ruzsnavszky Ferenc (1984-) (élettanász) Horváth Balázs (1981-) (élettanász) Bányász Tamás (1960-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Magyar János (1961-) (élettanász)
Pályázati támogatás:K100151
OTKA
K109736
OTKA
K101196
OTKA
PD101171
OTKA
NK104331
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Élettan Kutatócsoport
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM057407
Első szerző:Kistamás Kornél (biológus)
Cím:Oxidative shift in tissue redox potential increases beat-to-beat variability of action potential duration / Kornél Kistamás, Bence Hegyi, Krisztina Váczi, Balázs Horváth, Tamás Bányász, János Magyar, Norbert Szentandrássy, Péter P. Nánási
Dátum:2015
ISSN:0008-4212
Megjegyzések:Profound changes of tissue redox potential occur in the heart under conditions ofoxidative stress associated frequently with cardiac arrhythmias. Since beat-to-beat variability(short term variability, SV) of action potential duration (APD) is a good indicator of arrhythmiaincidence, the aim of the present work was to study the influence of redox changes on SV inisolated canine ventricular cardiomyocytes using conventional microelectrode technique. Theredox potential was shifted toward a reduced state using a reductive cocktail (containingdithiothreitol, glutathione and ascorbic acid) while oxidative changes were initiated bysuperfusion with H2O2. Redox effects were evaluated as changes in relative SV determined bycomparing SV changes to the concomitant APD changes. Exposure of myocytes to the reductivecocktail decreased SV significantly without any detectable effect on APD. Application of H2O2increased both SV and APD, but the enhancement of SV was the greater, so relative SVincreased. Longer exposure to H2O2 resulted in development of early afterdepolarizationsaccompanied by tremendously increased SV. Pretreatment with the reductive cocktail preventedboth elevation of relative SV and the development of afterdepolarizations. The results suggestthat the increased beat-to-beat variability during an oxidative stress contributes to generation ofcardiac arrhythmias.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
redox potential
short term variability
action potential duration
beat-to-beat variability
canine myocytes
Megjelenés:Canadian Journal of Physiology and Pharmacology. - 93 : 7 (2015), p. 563-568. -
További szerzők:Hegyi Bence (1987-) (élettanász) Váczi Krisztina (1987-) (élettanász) Horváth Balázs (1981-) (élettanász) Bányász Tamás (1960-) (élettanász) Magyar János (1961-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász)
Pályázati támogatás:K100151
OTKA
K109736
OTKA
K101196
OTKA
PD101171
OTKA
NK104331
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Élettan Kutatócsoport
TAMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

9.

001-es BibID:BIBFORM015745
Első szerző:Machackova, Jarmila
Cím:Molecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetes / Jarmila Machackova, Barta Judit, Naranjan S. Dhalla
Dátum:2005
Megjegyzések:The heart very often becomes a victim of endocrine abnormalities such as thyroid hormone imbalance and insulindeficiency, which are manifested in a broad spectrum of cardiac dysfunction from mildly compromised function tosevere heart failure. These functional changes in the heart are largely independent of alterations in the coronary arteries and instead reside at the level of cardiomyocytes. The status of cardiac function reflects the net of underlying subcellular modifications induced by an increase or decrease in thyroid hormone and insulin plasma levels. Changes in the contractile and regulatory proteins constitute molecular and structural alterations in myofibrillar assembly, called myofibrillar remodeling.These alterations may be adaptive or maladaptive with respect to the functional and metabolic demands on the heart as a consequence of the altered endocrine status in the body. There is a substantial body of information to indicate alterations in myofibrillar proteins including actin, myosin, tropomyosin, troponin, titin, desmin, and myosin-binding protein C in conditions such as hyperthyroidism, hypothyroidism, and diabetes. The present article is focussed on discussion how myofibrillar proteins are altered in response to thyroid hormone imbalance and lack of insulin or its responsiveness, and how their structural and functional changes explain the contractile defects in the heart.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
hyperthyroidism
diabetic cardiomyopathy
insulin deficiency
insulin resistance
myofibrillar remodeling
Megjelenés:Canadian Journal of Physiology and Pharmacology 83 : 12 (2005), p. 1071-1091. -
További szerzők:Barta Judit (1975-) (kardiológus) Dhalla, Naranjan S.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

10.

001-es BibID:BIBFORM077837
035-os BibID:(PMID)29792814 (WoS)000438114100006 (Scopus)85049826983
Első szerző:Nánási Péter Pál ifj. (sejtbiológus)
Cím:Perspectives of a myosin motor activator agent with increased selectivity / Péter Nánási Jr., István Komáromi, János Almássy
Dátum:2018
ISSN:0008-4212
Megjegyzések:Clinical treatment of heart failure is still not fully solved. A novel class of agents, the myosin motor activators, acts directly on cardiac myosin resulting in an increased force generation and prolongation of contraction. Omecamtiv mecarbil, the lead molecule of this group, is now in human 3 phase displaying promising clinical performance. However, omecamtiv mecarbil is not selective to myosin, since it readily binds to and activates cardiac ryanodine receptors (RyR-2), an effect that may cause complications is case of overdose. In this study, in silico analysis was performed to investigate the docking of omecamtiv mecarbil and other structural analogues to cardiac myosin heavy chain and RyR-2 in order to select the structure which has a higher selectivity to myosin over RyR-2. In silico docking studies revealed that omecamtiv mecarbil has comparable affinity to myosin and RyR-2: the respective K values are 0.60 and 0.87 ?M. Another compound CK-1032100 has much lower affinity to RyR-2 than omecamtiv mecarbil, while it still has a moderate affinity to myosin. It was concluded that further research starting from the chemical structure of CK-1032100 may result a better myosin activator burdened probably less by the RyR-2 binding side effect. It also is possible, however, that the selectivity of omecamtiv mecarbil to myosin over RyR-2 cannot be substantially improved, because similar moieties seem to be responsible for the high affinity to both myosin and RyR-2.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Inotropic agents
Myosin activators
Omecamtiv mecarbil
Ryanodine receptor
Cytosolic Ca 2+
Megjelenés:Canadian Journal of Physiology and Pharmacology. - 96 : 7 (2018), p. 676-680. -
További szerzők:Komáromi István (1957-) (vegyész, molekuláris biológus, biokémikus) Almássy János (1981-) (élettanász, biológus, angol-magyar szakfordító)
Pályázati támogatás:NKFIH PD112199
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM063953
Első szerző:Nánási Péter Pál ifj. (sejtbiológus)
Cím:The myosin activator omecamtiv mecarbil : a promising new inotropic agent / Péter Nánási Jr., Krisztina Váczi, Zoltán Papp
Dátum:2016
ISSN:0008-4212
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Canadian Journal of Physiology and Pharmacology. - 94 : 10 (2016), p. 1033-1039. -
További szerzők:Váczi Krisztina (1987-) (élettanász) Papp Zoltán (1965-) (kardiológus, élettanász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

12.

001-es BibID:BIBFORM072166
Első szerző:Nánási Péter Pál (élettanász)
Cím:Beat-to-beat variability of cardiac action potential duration : underlying mechanism and clinical implications / Péter P. Nánási, János Magyar, András Varró, Balázs Ördög
Dátum:2017
Megjegyzések:Abstract: Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of variouscardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, theunderlying mechanisms are not fully understood at present. The magnitude of SV is basically determined by the intensity ofcell-to-cell coupling in multicellular preparations and by the duration of the action potential (APD). To compensate for theAPD-dependent nature of SV, the concept of relative SV (RSV) has been introduced by normalizing the changes of SV to theconcomitant changes in APD. RSV is reduced by ICa, IKr, and IKs while increased by INa, suggesting that ion currents involved inthe negative feedback regulation of APD tend to keep RSV at a low level. RSV is also influenced by intracellular calciumconcentration and tissue redox potential. The clinical implications of APD variability is discussed in detail.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
action potential duration
arrhythmia
ion channels
beat-to-beat variability
Megjelenés:Canadian journal of physiology and pharmacology 95 : 10 (2017), p. 1230-1235. -
További szerzők:Magyar János (1961-) (élettanász) Varró András (1954-) (farmakológus, klinikai farmakológus) Ördög Balázs
Pályázati támogatás:K115397
OTKA
K109736
OTKA
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DOI
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