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1.

001-es BibID:BIBFORM023039
Első szerző:Bereczki Dániel (neurológus)
Cím:A possible role of decreased oxidative resistance of low-density lipoproteins in the early formation of carotid atherosclerosis / Bereczki D., Balla G., Csiba L., Jeney V., Valikovics A., Magyar T., Balla J.
Dátum:2001
ISSN:0306-9877
Megjegyzések:Ischaemic stroke ranks among the most important causes of death and disability in developed countries. Abnormal lipid metabolism is among the several factors that have a role in the pathogenesis of atherosclerosis. We hypothesize that the decreased resistance of low-density lipoproteins against oxidative stress is an independent risk factor for cerebral atherosclerosis and suggest testing this hypothesis by ultrasonographic evaluation of the carotid artery and correlating this finding to plasma values of compounds that play a role in lipid metabolism. By measuring the oxidative resistance of low-density of lipoprotein the risk for ischaemic stroke can be predicted.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Hypotheses. - 56 : 6 (2001), p. 694-696. -
További szerzők:Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Csiba László (1952-) (neurológus, pszichiáter) Jeney Viktória (1971-) (vegyész, kémia tanár) Valikovics Attila Magyar T. Balla József (1959-) (belgyógyász, nephrológus)
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2.

001-es BibID:BIBFORM034851
Első szerző:Csernátony Zoltán (ortopéd sebész, traumatológus)
Cím:The "rotational preconstraint" : kinetic model of a possible new mechanism in the etiopathogenesis of scoliosis / Csernátony Z., Szepesi K., Gáspár L., Dezső Zs., Jónás Z.
Dátum:2000
Megjegyzések:This model provides a novel view of the etiology of some scolioses and can answer some of the biomechanical questions regarding pathogenesis of dorsal curves. According to our findings, paravertebral muscular imbalance is likely to favour such a pathological condition which, with the interference of the postural reflexes and the body weight-related vertical loading, might lead to the formation of a true scoliotic curve. Review of earlier research studies in the light of our findings reveals controversy in some authors' reported results and their own interpretations and seems to generally support our theory
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Hypotheses 54 : 2 (2000), p. 203-206. -
További szerzők:Szepesi Kálmán (1938-) (ortopéd sebész) Gáspár Levente (1948-) (ortopéd és baleseti sebész) Dezső Zsigmond Jónás Zoltán (1963-) (ortopéd és baleseti sebész)
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3.

001-es BibID:BIBFORM034881
Első szerző:Csernátony Zoltán (ortopéd sebész, traumatológus)
Cím:Contradictions of derotation in scoliosis surgery using the CD principle / Csernátony Z., Szepesi K., Gáspár L., Kiss L.
Dátum:2002
Megjegyzések:Current literature has increasingly emphasized the problem of derotation in scoliotic deformities. The Cotrel-Dubousset (CD) principle as a means of correcting rotation has been questioned by various authors. This paper aims to draw attention, using algebraic methods, to the importance of the remaining rotational deformities, and to suggest the introduction of the notion 'rotational balance'.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Hypotheses. - 58 : 6 (2002), p. 498-502. -
További szerzők:Szepesi Kálmán (1938-) (ortopéd sebész) Gáspár Levente (1948-) (ortopéd és baleseti sebész) Kiss László (1978-) (ortopéd sebész, traumatológus)
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4.

001-es BibID:BIBFORM034884
Első szerző:Csernátony Zoltán (ortopéd sebész, traumatológus)
Cím:Multilevel callus distraction : a novel idea to shorten the lengthening time / Csernátony Z., Kiss L., Manó S., Gáspár L., Szepesi K.
Dátum:2003
ISSN:0306-9877
Megjegyzések:Lower extremity inequality is a common problem in everyday orthopaedic practice. The leg discrepancy can lead to variety of other problems, i.e., spinal problems. Surgical intervention is very demanding and requires patient compliance. Wagner's and Ilizarov's elongation technique are most commonly used worldwide, but it gives satisfactory results only in a long period of time and as we know there could be several inconvenient outcomes. Our idea aims at shortening this time period, and avoiding some of the inconvenient outcomes. Unfortunately we do not have the opportunity to go further in our investigations, but we hope that someone interested in this field will have an idea which would make continuation possible.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Hypotheses. - 60 : 4 (2003), p. 494-497. -
További szerzők:Kiss László (1978-) (ortopéd sebész, traumatológus) Manó Sándor (1977-) (gépészmérnök, számítógépes tervezőmérnök) Gáspár Levente (1948-) (ortopéd és baleseti sebész) Szepesi Kálmán (1938-) (ortopéd sebész)
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5.

001-es BibID:BIBFORM010564
035-os BibID:WOS:000264742800019
Első szerző:Hidasi Eszter (neurológus)
Cím:Peripheral nerves are progressively involved in multiple sclerosis : a hypothesis from a pilot study of temperature sensitized electroneurographic screening / Eszter Hidasi, Péter Diószeghy, Tünde Csépány, Ferenc Mechler, Dániel Bereczki
Dátum:2009
Megjegyzések:Multiple sclerosis (MS) is primarily a disease of the central nervous system. Although the involvement of the peripheral nervous system in MS was suggested over 100 years ago, the issue is still controversial, and it is generally accepted that except for the optic nerve the peripheral nerves are left unaffected by the disease. We hypothesize, that an electroneurographical study if thorough enough, may reveal differences in some nerve conduction parameters between MS patients and healthy subjects. Second, we assume that the sensitivity of nerve conduction measurements might be increased if performed at a range of temperatures, reflecting a differential effect of cooling and warming on the peripheral nerve conduction parameters in MS patients and controls. Finally, we expect that the differences in these parameters between controls and MS patients will increase with the progression of the disease. To test these hypotheses in a pilot study, we performed a detailed analysis of the motor and sensory nerve conduction features of the right median nerve in 13 MS patients and 13 controls at 5 C increments between 20 and 40 C, and repeated these measurements after 3 years. The motor latencies were 0.3-0.6 ms longer in MS patients compared to the controls both initially and 3 years later (0.058 < p < 0.09). The durations and areas of the compound motor action potential (CMAP) appeared more sensitive to changes in temperature in the MS group (0.057 < p < 0.1). The change in both distal motor latency and sensory latency per unit change in temperature decreased significantly in 3 years within the MS but not in the control group. These results suggest a mild and progressive involvement of the PNS in MS. Most differences in this pilot study were on the border of statistical significance therefore our hypotheses should be confirmed in studies with larger sample size.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Medical Hypotheses. - 72 : 5 (2009), p. 562-566. -
További szerzők:Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Csépány Tünde (1956-) (neurológus, pszichiáter) Mechler Ferenc (1933-) (neurológus) Bereczki Dániel (1960-) (neurológus)
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6.

001-es BibID:BIBFORM064480
Első szerző:Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:FNDC5/irisin, a molecular target for boosting reward-related learning and motivation / Judit Zsuga, Gabor Tajti, Csaba Papp, Bela Juhasz, Rudolf Gesztelyi
Dátum:2016
ISSN:0306-9877
Megjegyzések:Interventions focusing on the prevention and treatment of chronic non-communicable diseases are onrise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributesto the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physicalinactivity and harmful use of alcohol), behaviors that underlie the evolution of major noncommunicablediseases (e.g. cardiovascular diseases, cancer, diabetes and chronic respiratory diseases).Given that dopaminergic neurons of the mesocortico-limbic system are tightly associated with rewardrelatedprocesses and motivation, their dysfunction may fundamentally influence behavior. While nicotineand alcohol alter dopamine neuron function by influencing some receptors, mesocortico-limbic systemdysfunction was associated with elevation of metabolic set-point leading to hedonic over-eating.Although there is some empirical evidence, precise molecular mechanism for linking physical inactivityand mesocortico-limbic dysfunction per se seems to be missing; identification of which may contribute tohigher success rates for interventions targeting lifestyle changes pertaining to physical activity.In the current article, we compile evidence in support of a link between exercise and the mesocorticolimbicsystem by elucidating interactions on the axis of muscle ? irisin ? brain derived neurotrophic factor(BDNF) ? and dopaminergic function of the midbrain. Irisin is a contraction-regulated myokineformed primarily in skeletal muscle but also in the brain. Irisin stirred considerable interest, when itsability to induce browning of white adipose tissue parallel to increasing thermogenesis was discovered.Furthermore, it may also play a role in the regulation of behavior given it readily enters the central nervoussystem, where it induces BDNF expression in several brain areas linked to reward processing, e.g.the ventral tegmental area and the hippocampus. BDNF is a neurotropic factor that increases neuronaldopamine content, modulates dopamine release relevant for neuronal plasticity and increased neuronalsurvival as well as learning and memory. Further linking BDNF to dopaminergic function is BDNF's abilityto activate tropomyosin-related kinase B receptor that shares signalization with presynaptic dopamine-3receptors in the ventral tegmental area.Summarizing, we propose that the skeletal muscle derived irisin may be the link between physicalactivity and reward-related processes and motivation. Moreover alteration of this axis may contributeto sedentary lifestyle and subsequent non-communicable diseases. Preclinical and clinical experimentalmodels to test this hypothesis are also proposed.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Hypotheses 90 (2016), p. 23-28. -
További szerzők:Tajti Gábor (1988-) (gyógyszerész, biofizikus, sejtbiológus) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Juhász Béla (1978-) (kísérletes farmakológus) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
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7.

001-es BibID:BIBFORM037837
Első szerző:Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:Asymmetric dimethylarginine : a molecule responsible for the coexistence of insulin resistance and atherosclerosis via dual nitric oxide synthase inhibition / Zsuga Judit, Gesztelyi Rudolf, Török János, Kéki Sándor, Bereczki Dániel
Dátum:2005
ISSN:0306-9877
Megjegyzések:Asymmetric dimethylarginine (ADMA) has been recently identified as the major endogenous inhibitor of soluble nitric oxide synthase. Its systemic accumulation was observed in conjunction with atherosclerosis and several cardiovascular and metabolic diseases. Here, we propose that ADMA causes insulin resistance by the inhibition of the neuronal isoform of nitric oxide synthase, while the simultaneously observed atherosclerosis is the consequence of endothelial nitric oxide synthase (NOS) inhibition. Our hypothesis rests on animal models in which experimental insulin resistance was induced by intraportal administration of non-selective and selective neuronal nitric oxide synthase inhibitors, N-methyl-L-arginine (L-NMMA) or 7-nitroindazole. In these models, loss of hepatic nitric oxide productions is presumed to hinder a very potent insulin sensitizing mechanism referred to as meal induced sensitization that is anatomically linked to the nitrergic fibers of the anterior hepatic plexus. Cause and effect relationship between ADMA and insulin resistance has been proposed previously by others however the nature of this relationship has not been elucidated in detail. In our hypothesis, we suggest that ADMA by inhibiting both the neuronal and the endothelial forms of NOS, results both in insulin resistance and in accelerated atherosclerosis, therefore ADMA is the molecule responsible for the coexistence of these two conditions. We also suggest animal models and human studies to test our hypothesis, the results of which may offer novel approaches in the prevention of insulin resistance and atherosclerosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Hypotheses. - 65 : 6 (2005), p. 1091-1098. -
További szerzők:Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Török János Kéki Sándor (1964-) (polimer kémikus) Bereczki Dániel (1960-) (neurológus)
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