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1.

001-es BibID:BIBFORM030290
Első szerző:Farkas Szabolcs (orvos)
Cím:[125I]SD-7015 reveals fine modalities of CB1 cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease / Farkas Szabolcs, Nagy Katalin, Palkovits Miklós, Kovács Gábor G., Jia Zhisheng, Donohue Sean, Pike Vic, Halldin Christer, Máthé Domokos, Harkany Tibor, Gulyás Balázs, Csiba László
Dátum:2012
ISSN:0197-0186
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurochemistry International. - 60 : 3 (2012), p. 286-291. -
További szerzők:Nagy Katalin (1960-) (orvosdiagnosztikai laboratóriumi analitikus) Palkovits Miklós Kovács Gábor Géza (1969-) (neurológus) Jia, Zhisheng Donohue, Sean Pike, Victor Halldin, Christer Máthé Domokos Harkány Tibor Gulyás Balázs Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:68864
OTKA
62893
OTKA
Internet cím:Szerző által megadott URL
DOI
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2.

001-es BibID:BIBFORM007318
Első szerző:Gulyás Balázs
Cím:A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system / Balázs Gulyás, Boglárka Makkai, Péter Kása, Károly Gulya, Lidia Bakota, Szilvia Várszegi, Zsuzsa Beliczai, Jan Andersson, László Csiba, Andrea Thiele, Thomas Dyrks, Tetsuya Suhara, Kazutoshi Suzuki, Makato Higuchi, Christer Halldin
Dátum:2009
ISSN:0197-0186 (Print)
Megjegyzések:The binding of two radiolabelled analogues(N-(5-[125I]Iodo-2-phenoxyphenyl)-N-(2,5-dimethoxybenzyl)acetamide ([125I]desfluoro-DAA1106)and N-(5-[125I]Fluoro-2-phenoxyphenyl)-N-(2-[125I]Iodo-5-methoxybenzyl)acetamide ([125I]desmethoxy-DAA1106)of the peripheral benzodiazepine receptor(PBR)(or TSPO,18 kDa translocator protein)ligand DAA1106 was examined by in vitro autoradiography on human post mortem whole hemisphere brain slices obtained from Alzheimer's disease (AD)patients and age-matched controls. Both [125I]desfluoro-IDAA1106 and [125I]desmethoxy-IDAA1106 were effectively binding to various brain structures. The binding could be blocked by the unlabelled ligand as well as by other PBR specific ligands. With both radiolabelled compounds, the binding showed regional inhomogeneity and the specific binding values proved to be the highest in the hippocampus, temporal and parietal cortex, the basal ganglia and thalamus in the AD brains. Compared with age-matched control brains, specific binding in several brain structures (temporal and parietal lobes, thalamus and white matter) in Alzheimer brains was significantly higher, indicating that the radioligands can effectively label-activated microglia and the up-regulated PBR/TSPO system in AD. Complementary immunohistochemical studies demonstrated reactive microglia activation in the AD brain tissue and indicated that increased ligand binding coincides with increased regional microglia activation due to neuroinflammation. These investigations yield further support to the PBR/TSPO binding capacity of DAA1106 in human brain tissue, demonstrate the effective usefulness of its radioiodinated analogues as imaging biomarkers in post mortem human studies, and indicate that its radiolabelled analogues, labelled with short half-time bioisotopes, can serve as prospective in vivo imaging biomarkers of activated microglia and the up-regulated PBR/TSPO system in the human brain.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Peripheral benzodiazepine receptor (PBR)
TSPO (18 kDa translocator protein)
DAA1106
I-125
PK11195
Vinpocetine
Human brain
Whole hemisphere autoradiography
Receptor binding
Megjelenés:Neurochemistry International. - 54 : 1 (2009), p. 28-36. -
További szerzők:Makkai Boglárka Kása Péter Gulya Károly Bakota Lidia Várszegi Szilvia Beliczai Zsuzsa Andersson, Jan Csiba László (1952-) (neurológus, pszichiáter) Thiele, Andrea Dyrks, Thomas Suhara, Tetsuya Suzuki, Kazutoshi Higuchi, Makato Halldin, Christer
Internet cím:DOI
elektronikus változat
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3.

001-es BibID:BIBFORM034001
Első szerző:Serfőző Zoltán
Cím:Chronic inhibition of nitric oxide synthase activity by NG-nitro-l-arginine induces nitric oxide synthase expression in the developing rat cerebellum / Serfőző Zoltán, Lontay Beáta, Kukor Zoltán, Erdődi Ferenc
Dátum:2012
ISSN:0197-0186
Megjegyzések:Studies on chronic inhibition of nitric oxide synthase (NOS) in the CNS suggest a plastic change in nitric oxide (NO) synthesis in areas related to motor control, which might protect the animal from the functional and behavioral consequences of NO deficiency. In the present study, the acute and chronic effect of the substrate analogue inhibitor NG-nitro-L-arginine (L-NNA) was examined on NO production, NOsensitive cyclic guanosine monophosphate (cGMP) levels and the expression of NOS isoforms in the developing rat cerebellum. Acute intraperitoneal administration of the inhibitor (5-200 mg/kg) to 21- day-old rats reduced NOS activity and NO concentration dose dependently by 70-90% and the tissue cGMP level by 60-80%. By contrast, chronic application of L-NNA between postnatal days 4-21 diminished the total NOS activity and NO concentration only by 30%, and the tissue cGMP level by 10-50%. Chronic treatment of 10 mg/kg L-NNA induced neuronal (n)NOS expression in granule cells, as revealed by in situ hybridization, NADPH-diaphorase histochemistry and Western-blot, but it had no significant influence on tissue cGMP level or on layer formation of the cerebellum. However, a higher concentration (50 mg/kg) of L-NNA decreased the intensity of the NADPH-diaphorase reaction in granule cells, significantly reduced cGMP production, and retarded layer formation and induced inducible (i)NOS expression & activity in glial cells. Treatments did not affect endothelial (e)NOS expression. The administration of the biologically inactive isomer D-NNA (50 mg/kg) or saline was ineffective. The present findings suggest the existence of a concentration-dependent compensatory mechanism against experimentally-induced cronich inhibition of NOS, including nNOS or iNOS up-regulation, which might maintain a steady-state NO level in the developing cerebellum.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurochemistry International. - 60 : 6 (2012), p. 605-615. -
További szerzők:Lontay Beáta (1975-) (biokémikus) Kukor Zoltán Erdődi Ferenc (1953-) (biokémikus)
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DOI
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4.

001-es BibID:BIBFORM032396
Első szerző:Shujaa, N.
Cím:a2-Adrenoceptor agonist-induced inhibition of gastric motor activity is mediated by a2A-adrenoceptor subtype in the mouse / N. Shujaa, M. Al-Khrasani, Z. S. Zádori, M. Rossi, P. Mátyus, J. Németh, L. Hein, K. Gyires
Dátum:2011
ISSN:0197-0186
Megjegyzések:Therole ofa2-adrenoceptors in regulationof gastricmotility has beenwell documented.However, onlyfewdata are available on the adrenoceptor subtype that mediates this effect. The purpose of the present workwas to identify the a2-adrenoceptor subtype(s) responsible for the inhibition of gastric motor activity inisolated fundus strip of the mouse. It was shown that (i) the electrically evoked contraction of the gastricfundus strip of the mouse was inhibited by the non-selective a2-adrenoceptor stimulant clonidine (EC50:0.019 0.001 mM), the a2A-adrenoceptor subtype selective agonist oxymetazoline (EC50: 0.004 0.001 mM)and the a2B-adrenoceptor subtype preferring ST-91 (EC50: 0.029 0.004 mM), (ii) the inhibitory effect ofclonidine (1 mM), oxymetazoline (0.1 mM) and ST-91 (1 mM) on the contractions of gastric fundus strip wasreversed by the non-selective a2-adrenoceptor antagonist idazoxan and a2A-adrenoceptor antagonist BRL44408, but not by the a2B/2C-adrenoceptor antagonist ARC-239. (iii) Clonidine and ST-91 inhibited theelectrically induced gastric contractions in C57BL/6 wild type mice as well as in a2B- and a2C-adrenoceptordeficient mice in a concentration-dependent manner; however, neither of themwas effective in a2A-deficientmice. As a conclusion, it was first demonstrated that the inhibitory effect of a2-adrenoceptor agonists on thegastric motor activity of isolated stomach strip of the mouse is mediated purely by a2A-adrenoceptors.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Gastric fundus strip a2-Adrenoceptor subtype deficient mice
Megjelenés:Neurochemistry International. - 58 : 6 (2011), p. 708-713. -
További szerzők:Al-Khrasani, Mahmoud Zádori Zoltán S. (Farmakológia, gasztrointesztinális farmakológia) Rossi, Mauro Mátyus Péter (1962-) (vegyész) Németh József (1954-) (vegyész, analitikus) Hein L. Gyires Klára
Internet cím:DOI
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